UY31460A1 - Procedimiento de preparacion de compuestos morfinicos - Google Patents

Procedimiento de preparacion de compuestos morfinicos

Info

Publication number
UY31460A1
UY31460A1 UY31460A UY31460A UY31460A1 UY 31460 A1 UY31460 A1 UY 31460A1 UY 31460 A UY31460 A UY 31460A UY 31460 A UY31460 A UY 31460A UY 31460 A1 UY31460 A1 UY 31460A1
Authority
UY
Uruguay
Prior art keywords
compounds
morphine
compound
beta
separation
Prior art date
Application number
UY31460A
Other languages
English (en)
Inventor
Alain Dlubala
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39099817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY31460(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of UY31460A1 publication Critical patent/UY31460A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/02—Purification; Separation; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento de preparacion de compuestos morfínicos con un contenido bajo en compuestos a-B(Beta) insaturados, que comprende poner en contacto el compuesto morfínico bruto con una base, a un pH superior a 13 y en condiciones que permiten la reaccion de adicion de Michael sobre el o los compuestos a-B(Beta) insaturados presentes; separacion del compuesto morfínico; y separacion del producto de adicion formado del compuesto morfínico; y separacion del producto de adicion formado del compuesto morfínico, y composicion que comprende al menos 99% en peso seco de compuesto morfínico o de una de sus sales aceptables farmacéuticamente y un compuesto a-B(Beta)-insaturado en una cantidad inferior a 100 ppm.
UY31460A 2007-11-09 2008-11-07 Procedimiento de preparacion de compuestos morfinicos UY31460A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0758923A FR2923484B1 (fr) 2007-11-09 2007-11-09 Procede de preparation de composes morphiniques
US2194908P 2008-01-18 2008-01-18

Publications (1)

Publication Number Publication Date
UY31460A1 true UY31460A1 (es) 2009-07-17

Family

ID=39099817

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31460A UY31460A1 (es) 2007-11-09 2008-11-07 Procedimiento de preparacion de compuestos morfinicos

Country Status (21)

Country Link
US (1) US8455509B2 (es)
EP (1) EP2231673A1 (es)
JP (1) JP2011503040A (es)
KR (1) KR20100083815A (es)
CN (1) CN101868462A (es)
AR (1) AR069225A1 (es)
AU (1) AU2008348675A1 (es)
BR (1) BRPI0820300A2 (es)
CA (1) CA2705251A1 (es)
CL (1) CL2008003333A1 (es)
EA (1) EA017287B1 (es)
FR (1) FR2923484B1 (es)
IL (1) IL205601A0 (es)
MA (1) MA31982B1 (es)
MX (1) MX2010005124A (es)
NZ (1) NZ585218A (es)
SG (1) SG186591A1 (es)
TW (1) TW200936592A (es)
UY (1) UY31460A1 (es)
WO (1) WO2009092912A1 (es)
ZA (1) ZA201003241B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN102174049A (zh) * 2011-03-11 2011-09-07 山东新华制药股份有限公司 一种盐酸纳洛酮成盐的制备工艺
ES2622342T3 (es) * 2012-02-08 2017-07-06 Mallinckrodt Llc Proceso en un solo recipiente para producir 6-hidroxilo nal-opiáceos
ES2846735T3 (es) 2013-03-15 2021-07-29 Johnson Matthey Plc Solvato metanólico de sulfato de morfina, procedimientos para hacer el mismo y las composiciones relacionadas y métodos de tratamiento del dolor
CN103408553B (zh) * 2013-08-20 2016-02-03 宜昌人福药业有限责任公司 一种氢吗啡酮酸式盐的精制工艺
CN104230945B (zh) * 2014-08-23 2016-05-18 成都天台山制药有限公司 盐酸纳洛酮的合成方法
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
CN110724155A (zh) * 2019-11-11 2020-01-24 北京华素制药股份有限公司 一种羟考酮羟醛二聚体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0421149D0 (en) 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
WO2006094672A1 (en) * 2005-03-04 2006-09-14 Euro-Celtique S.A. Method of reducing alpha, beta unsaturated ketones in opioid compositions
CN101346384B (zh) * 2005-11-22 2012-07-04 控制化学品公司 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法
EP1994034B1 (en) * 2006-03-02 2009-11-11 Mallinckrodt, Inc. Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
CN104761561A (zh) * 2006-12-04 2015-07-08 诺拉姆科有限公司 减少羟考酮碱中杂质的方法
US7906647B2 (en) * 2006-12-04 2011-03-15 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics

Also Published As

Publication number Publication date
MX2010005124A (es) 2010-05-27
JP2011503040A (ja) 2011-01-27
KR20100083815A (ko) 2010-07-22
NZ585218A (en) 2012-08-31
MA31982B1 (fr) 2011-01-03
IL205601A0 (en) 2010-11-30
US8455509B2 (en) 2013-06-04
EP2231673A1 (fr) 2010-09-29
ZA201003241B (en) 2011-08-31
BRPI0820300A2 (pt) 2015-05-19
EA017287B1 (ru) 2012-11-30
TW200936592A (en) 2009-09-01
FR2923484A1 (fr) 2009-05-15
US20100256176A1 (en) 2010-10-07
CA2705251A1 (fr) 2009-07-30
FR2923484B1 (fr) 2012-11-09
SG186591A1 (en) 2013-01-30
WO2009092912A1 (fr) 2009-07-30
EA201070589A1 (ru) 2010-10-29
CN101868462A (zh) 2010-10-20
AU2008348675A1 (en) 2009-07-30
AR069225A1 (es) 2010-01-06
CL2008003333A1 (es) 2010-03-05

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20140729