MX2010005124A - Procedimiento de preparacion de compuestos morfinicos. - Google Patents

Procedimiento de preparacion de compuestos morfinicos.

Info

Publication number
MX2010005124A
MX2010005124A MX2010005124A MX2010005124A MX2010005124A MX 2010005124 A MX2010005124 A MX 2010005124A MX 2010005124 A MX2010005124 A MX 2010005124A MX 2010005124 A MX2010005124 A MX 2010005124A MX 2010005124 A MX2010005124 A MX 2010005124A
Authority
MX
Mexico
Prior art keywords
morphine
compound
preparation
compounds
unsaturated
Prior art date
Application number
MX2010005124A
Other languages
English (en)
Inventor
Alain Dlubala
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39099817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010005124(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2010005124A publication Critical patent/MX2010005124A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/02—Purification; Separation; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento de preparación de compuestos morfinicos con un contenido bajo en compuestos a-ß insaturados que comprende las etapas de:(i) poner en contacto el compuesto con una base de morfina crudo, a un pH por encima de 13 y en condiciones que permitan la reacción de adición de Michael del (s) compuesto (s) de a-ß insaturados (ii) la separación de compuestos morfina de la mezcla de reacción, y (iii) en su caso, separar el producto formado a partir de compuestos de morfina. Es una composición que comprende al menos el 99% en peso seco de compuestos morfina o una sal farmacéuticamente aceptable de la misma y un contenido de compuestos de a-ß-insaturados de menos de 100 ppm.
MX2010005124A 2007-11-09 2008-11-06 Procedimiento de preparacion de compuestos morfinicos. MX2010005124A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0758923A FR2923484B1 (fr) 2007-11-09 2007-11-09 Procede de preparation de composes morphiniques
US2194908P 2008-01-18 2008-01-18
PCT/FR2008/001558 WO2009092912A1 (fr) 2007-11-09 2008-11-06 Procede de preparation de composes morphiniques

Publications (1)

Publication Number Publication Date
MX2010005124A true MX2010005124A (es) 2010-05-27

Family

ID=39099817

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010005124A MX2010005124A (es) 2007-11-09 2008-11-06 Procedimiento de preparacion de compuestos morfinicos.

Country Status (21)

Country Link
US (1) US8455509B2 (es)
EP (1) EP2231673A1 (es)
JP (1) JP2011503040A (es)
KR (1) KR20100083815A (es)
CN (1) CN101868462A (es)
AR (1) AR069225A1 (es)
AU (1) AU2008348675A1 (es)
BR (1) BRPI0820300A2 (es)
CA (1) CA2705251A1 (es)
CL (1) CL2008003333A1 (es)
EA (1) EA017287B1 (es)
FR (1) FR2923484B1 (es)
IL (1) IL205601A0 (es)
MA (1) MA31982B1 (es)
MX (1) MX2010005124A (es)
NZ (1) NZ585218A (es)
SG (1) SG186591A1 (es)
TW (1) TW200936592A (es)
UY (1) UY31460A1 (es)
WO (1) WO2009092912A1 (es)
ZA (1) ZA201003241B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN102174049A (zh) * 2011-03-11 2011-09-07 山东新华制药股份有限公司 一种盐酸纳洛酮成盐的制备工艺
PL2812336T3 (pl) * 2012-02-08 2017-07-31 Mallinckrodt Llc Sposób wytwarzania 6-hydroksyIowej pochodnej opiatu nal w jednym naczyniu
EP2970320B1 (en) 2013-03-15 2020-10-28 Johnson Matthey Public Limited Company Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain
CN103408553B (zh) * 2013-08-20 2016-02-03 宜昌人福药业有限责任公司 一种氢吗啡酮酸式盐的精制工艺
CN104230945B (zh) * 2014-08-23 2016-05-18 成都天台山制药有限公司 盐酸纳洛酮的合成方法
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods
CN110724155A (zh) * 2019-11-11 2020-01-24 北京华素制药股份有限公司 一种羟考酮羟醛二聚体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0421149D0 (en) 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
EP1861405B1 (en) * 2005-03-04 2009-04-29 Euro-Celtique S.A. Method of reducing alpha, beta- unsaturated ketones in opioid compositions
WO2007062184A2 (en) * 2005-11-22 2007-05-31 Controlled Chemicals, Inc. Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions
JP5695296B2 (ja) * 2006-03-02 2015-04-01 マリンクロッド エルエルシー 低レベルのアルファ，ベータ−不飽和ケトン化合物を伴うモルフィナン−６−オン生成物の製造方法
CN101652370A (zh) * 2006-12-04 2010-02-17 诺拉姆科有限公司 制备14-羟基可待因酮水平减少的羟考酮的方法
CN101652369A (zh) * 2006-12-04 2010-02-17 诺拉姆科有限公司 减少羟考酮碱中杂质的方法
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics

Also Published As

Publication number Publication date
FR2923484A1 (fr) 2009-05-15
US20100256176A1 (en) 2010-10-07
CN101868462A (zh) 2010-10-20
EP2231673A1 (fr) 2010-09-29
TW200936592A (en) 2009-09-01
EA017287B1 (ru) 2012-11-30
FR2923484B1 (fr) 2012-11-09
NZ585218A (en) 2012-08-31
EA201070589A1 (ru) 2010-10-29
AU2008348675A1 (en) 2009-07-30
BRPI0820300A2 (pt) 2015-05-19
US8455509B2 (en) 2013-06-04
SG186591A1 (en) 2013-01-30
CL2008003333A1 (es) 2010-03-05
CA2705251A1 (fr) 2009-07-30
IL205601A0 (en) 2010-11-30
MA31982B1 (fr) 2011-01-03
UY31460A1 (es) 2009-07-17
AR069225A1 (es) 2010-01-06
KR20100083815A (ko) 2010-07-22
JP2011503040A (ja) 2011-01-27
ZA201003241B (en) 2011-08-31
WO2009092912A1 (fr) 2009-07-30

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