AR047325A1 - Derivados de indano sustituidos y compuestos relacionados para el tratamiento de la esquizofrenia. composiciones farmaceuticas que los contienen. - Google Patents
Derivados de indano sustituidos y compuestos relacionados para el tratamiento de la esquizofrenia. composiciones farmaceuticas que los contienen.Info
- Publication number
- AR047325A1 AR047325A1 ARP040104547A ARP040104547A AR047325A1 AR 047325 A1 AR047325 A1 AR 047325A1 AR P040104547 A ARP040104547 A AR P040104547A AR P040104547 A ARP040104547 A AR P040104547A AR 047325 A1 AR047325 A1 AR 047325A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- fluorine atoms
- integer
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composiciones farmacéuticas que los contienen. Reivindicacion 1: Un compuesto de grupo de formulas (1), en el que J es S, SO, SO, CH2, O o NR10, en el que R10 es hidrogeno, alquilo C1-6, C(=O)alquilo(C1-6) o C(=O)O-alquilo(C1-6); M es CH o N; G es CH o N; m es un numero entero de uno a seis; X es O o NR3, en el que R3 se define tal como se define R10 anteriormente, C(=O), CHOH, CHOR3, CH(halo) o CHNR3R12, en el que R12 se define tal como se define R10 anteriormente; o X está ausente; R1 es hidrogeno, halogeno, ciano, alquilo C1-6 opcionalmente sustituido con uno a tres átomos de fluor o R1 forma un anillo heterocíclico con R10; R2 se define tal como R1 con la condicion de que R2 no puede formar un anillo heterocíclico cuando está presente R1; R4 y R5 son, independientemente, hidrogeno, halogeno, ciano, aminoalquilo C1-6, (alquil C1-6)aminoalquilo C1-6, di(alquil C1-6)aminoalquilo C1-6, hidroxialquilo C1-6, alcoxi C1-6 o (alcoxi C1-6)alquilo, en los que cada uno de los restos alcoxi y alquilo de los grupos R4 y R5 anteriores puede estar opcionalmente sustituido con uno a tres átomos de halo, preferiblemente con uno a tres átomos de fluor; R6, R7, R8 y R9, son, independientemente, hidrogeno o alquilo C1-6 opcionalmente sustituido con uno a tres átomos de fluor; Y, cuando R11 está presente, se selecciona de O, NR13, en el que R13 se define tal como se define R10 anteriormente o (CH2)w en el que w es un numero entero de uno o seis; o Y, cuando R11 está ausente, se selecciona de (=O), hidroxi, NR13R14 en el que R13 y R14 se definen tal como se define R10 anteriormente y (CH2)qCH3, en el que q es un numero entero de uno a cinco; n es un numero entero de uno a tres; z es un numero entero de uno a tres; y R11 es hidrogeno, -SO2-alquilo(C1-6), -SO2-arilo, arilo, arilalquilo C1-6, heteroarilo, heteroarilalquilo C1-6, heterociclilo, heterociclilalquilo C1-4, COR15, C(O)OR15 o C(O)NR15R16, en los que R15 y R16 se seleccionan independientemente de alquilo C1-6, arilo, heteroarilo, heteroarilalquilo C1-6, arilalquilo C1-6, heterociclilo y heterociclilalquilo C1-6; en los que dichos restos alquilo en dichos grupos R11 pueden estar opcionalmente sustituidos con uno a tres átomos de fluor y los restos arilo, heteroarilo y heterociclilo en dichos grupos R11 pueden estar opcionalmente sustituidos, con uno o más sustituyentes, preferiblemente de cero a dos sustituyentes, que se seleccionan independientemente de alquilo C1-6 opcionalmente sustituido con uno a tres átomos de fluor, alcoxi C1-6 opcionalmente sustituido con uno a tres átomos de fluor, ciano, nitro, halo, amino, (alquil C1-6)amino y di(alquil C1-6)amino; o R11 está ausente; con la condicion de que la suma de n más z no puede superar 3; y las sales farmacéuticamente aceptables de tales compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52785203P | 2003-12-08 | 2003-12-08 | |
| US53109603P | 2003-12-19 | 2003-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR047325A1 true AR047325A1 (es) | 2006-01-18 |
Family
ID=34811295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104547A AR047325A1 (es) | 2003-12-08 | 2004-12-06 | Derivados de indano sustituidos y compuestos relacionados para el tratamiento de la esquizofrenia. composiciones farmaceuticas que los contienen. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050282819A1 (es) |
| EP (1) | EP1697334A1 (es) |
| JP (1) | JP2007513197A (es) |
| AR (1) | AR047325A1 (es) |
| BR (1) | BRPI0416739A (es) |
| CA (1) | CA2548447A1 (es) |
| NL (1) | NL1027680C2 (es) |
| PA (1) | PA8619301A1 (es) |
| PE (1) | PE20050862A1 (es) |
| TW (1) | TW200524922A (es) |
| UY (1) | UY28656A1 (es) |
| WO (1) | WO2005056540A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20052216A1 (it) * | 2005-11-18 | 2007-05-19 | Dipharma Spa | Procedimento per la preparazione di ziprasidone |
| WO2007076601A1 (en) * | 2006-01-03 | 2007-07-12 | Clera Inc. | Imaging of d2high receptors using radiolabelled (-)- quinpirole and analogs thereof |
| TW200804347A (en) * | 2006-01-10 | 2008-01-16 | Janssen Pharmaceutica Nv | Urotensin II receptor antagonists |
| CN101448803A (zh) * | 2006-03-17 | 2009-06-03 | 阿斯利康(瑞典)有限公司 | 用作5-ht6调节剂的四氢萘 |
| AU2007281591A1 (en) | 2006-07-31 | 2008-02-07 | Janssen Pharmaceutica, N.V. | Urotensin II receptor antagonists |
| US9079896B2 (en) * | 2008-08-02 | 2015-07-14 | Janssen Pharmaceutica Nv | Urotensin II receptor antagonists |
| TW201040153A (en) | 2009-02-13 | 2010-11-16 | Sanofi Aventis | Novel substituted tetrahydronaphthalenes, process for preparation thereof and use thereof as medicaments |
| UY32442A (es) * | 2009-02-13 | 2010-09-30 | Sanofi Aventis | Nuevos indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento |
| CN104140421B (zh) * | 2013-05-08 | 2017-04-05 | 上海医药工业研究院 | 苯并异噻唑类化合物及在制备抗精神分裂症药物中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| US5350747A (en) * | 1989-07-07 | 1994-09-27 | Pfizer Inc | Heteroaryl piperazine antipsychotic agents |
| FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
| AU645681B2 (en) * | 1991-05-02 | 1994-01-20 | John Wyeth & Brother Limited | Piperazine derivatives |
| US6242450B1 (en) * | 1998-07-27 | 2001-06-05 | Eli Lilly And Company | 5-HT1F antagonists |
| KR100799134B1 (ko) * | 1999-05-24 | 2008-01-29 | 미츠비시 웰파마 가부시키가이샤 | 페녹시프로필아민 화합물 |
| WO2001017993A1 (en) * | 1999-09-09 | 2001-03-15 | EGIS Gyógyszergyár Rt. | Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient |
| KR20050057404A (ko) * | 2002-09-17 | 2005-06-16 | 워너-램버트 캄파니 엘엘씨 | 정신분열증 치료용 헤테로환 치환된 피페라진 |
| MXPA05002003A (es) * | 2002-09-26 | 2005-08-03 | Warner Lambert Co | Piperazinas sustituidas heterociclicas para el tratamiento de la esquizofrenia. |
-
2004
- 2004-11-26 CA CA002548447A patent/CA2548447A1/en not_active Abandoned
- 2004-11-26 BR BRPI0416739-2A patent/BRPI0416739A/pt not_active IP Right Cessation
- 2004-11-26 EP EP04799000A patent/EP1697334A1/en not_active Withdrawn
- 2004-11-26 WO PCT/IB2004/003898 patent/WO2005056540A1/en active Application Filing
- 2004-11-26 JP JP2006543635A patent/JP2007513197A/ja active Pending
- 2004-12-06 UY UY28656A patent/UY28656A1/es not_active Application Discontinuation
- 2004-12-06 PE PE2004001197A patent/PE20050862A1/es not_active Application Discontinuation
- 2004-12-06 AR ARP040104547A patent/AR047325A1/es unknown
- 2004-12-07 PA PA20048619301A patent/PA8619301A1/es unknown
- 2004-12-07 TW TW093137739A patent/TW200524922A/zh unknown
- 2004-12-07 NL NL1027680A patent/NL1027680C2/nl not_active IP Right Cessation
- 2004-12-08 US US11/007,486 patent/US20050282819A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NL1027680A1 (nl) | 2005-06-09 |
| TW200524922A (en) | 2005-08-01 |
| UY28656A1 (es) | 2005-07-29 |
| JP2007513197A (ja) | 2007-05-24 |
| BRPI0416739A (pt) | 2007-01-16 |
| NL1027680C2 (nl) | 2005-11-30 |
| US20050282819A1 (en) | 2005-12-22 |
| PA8619301A1 (es) | 2005-11-25 |
| CA2548447A1 (en) | 2005-06-23 |
| PE20050862A1 (es) | 2005-12-17 |
| WO2005056540A1 (en) | 2005-06-23 |
| EP1697334A1 (en) | 2006-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |