AR046510A1 - Composicion de un antagonista de vegf y un agente anti-proliferativo - Google Patents
Composicion de un antagonista de vegf y un agente anti-proliferativoInfo
- Publication number
- AR046510A1 AR046510A1 ARP040102585A ARP040102585A AR046510A1 AR 046510 A1 AR046510 A1 AR 046510A1 AR P040102585 A ARP040102585 A AR P040102585A AR P040102585 A ARP040102585 A AR P040102585A AR 046510 A1 AR046510 A1 AR 046510A1
- Authority
- AR
- Argentina
- Prior art keywords
- vegf
- proliferative agent
- composition
- agent
- vegf antagonist
- Prior art date
Links
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 title abstract 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 title abstract 6
- 230000001028 anti-proliverative effect Effects 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 abstract 5
- 239000005022 packaging material Substances 0.000 abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 abstract 2
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 abstract 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
- 210000003556 vascular endothelial cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49000203P | 2003-07-25 | 2003-07-25 | |
| US49397103P | 2003-08-08 | 2003-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046510A1 true AR046510A1 (es) | 2005-12-14 |
Family
ID=34118812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102585A AR046510A1 (es) | 2003-07-25 | 2004-07-21 | Composicion de un antagonista de vegf y un agente anti-proliferativo |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7354579B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1648428A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5355856B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101175990B1 (cg-RX-API-DMAC7.html) |
| AR (1) | AR046510A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004261165C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0412798A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2529742C (cg-RX-API-DMAC7.html) |
| IL (1) | IL172406A (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA05013642A (cg-RX-API-DMAC7.html) |
| MY (1) | MY149169A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20060924L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ544570A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2353353C2 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI351953B (cg-RX-API-DMAC7.html) |
| UY (1) | UY28438A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005011734A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (79)
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| US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| JP4303105B2 (ja) * | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
| US20100234570A1 (en) * | 2001-06-28 | 2010-09-16 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| CN1678634A (zh) * | 2002-06-28 | 2005-10-05 | 多曼蒂斯有限公司 | 免疫球蛋白单个变体抗原结合区及其特异性构建体 |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| CA2511910A1 (en) * | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| CA2519875C (en) * | 2003-06-06 | 2014-01-14 | Regeneron Pharmaceuticals, Inc. | Method of tumor regression with vegf inhibitors |
| FR2878749B1 (fr) * | 2004-12-03 | 2007-12-21 | Aventis Pharma Sa | Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives |
| EP1853298A2 (en) * | 2005-02-11 | 2007-11-14 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent |
| US20070166388A1 (en) * | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
| CN103169729A (zh) | 2005-02-18 | 2013-06-26 | 阿布拉科斯生物科学有限公司 | 治疗剂的组合和给予方式以及联合治疗 |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| CA3142945A1 (en) * | 2005-03-25 | 2006-10-05 | Regeneron Pharmaceuticals, Inc. | Histidine-buffered formulations of vegf antagonist |
| CA2632866A1 (en) * | 2005-12-01 | 2007-06-07 | Domantis Limited | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
| FR2895258B1 (fr) * | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | Combinaison comprenant de la combretastatine et des agents anticancereux |
| ES2828739T3 (es) | 2006-04-07 | 2021-05-27 | Aerpio Pharmaceuticals Inc | Anticuerpos que se unen a la proteína tirosina fosfatasa beta humana (HPTP-beta) y sus usos |
| US20080045589A1 (en) * | 2006-05-26 | 2008-02-21 | Susan Kelley | Drug Combinations with Substituted Diaryl Ureas for the Treatment of Cancer |
| CA2654510C (en) | 2006-06-16 | 2015-03-17 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| AU2008224929A1 (en) * | 2007-03-14 | 2008-09-18 | Mayo Foundation For Medical Education And Research | Treating skin cancer |
| CA2683801A1 (en) * | 2007-06-06 | 2008-12-11 | Domantis Limited | Polypeptides, antibody variable domains and antagonists |
| FR2918279B1 (fr) * | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan |
| LT5610B (lt) | 2007-12-17 | 2009-11-25 | Uab Baltec Cnc Technologies, , | Kompleksinė sveikatinimo ir sporto įrangos sistema ir jos įgyvendinimo būdas |
| ES2531322T3 (es) * | 2008-06-17 | 2015-03-13 | Wyeth Llc | Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina |
| WO2010005527A1 (en) | 2008-06-30 | 2010-01-14 | Angioblast Systems, Inc. | Treatment of eye diseases and excessive neovascularization using a combined therapy |
| EP3266453A1 (en) | 2008-07-03 | 2018-01-10 | Mayo Foundation for Medical Education and Research | Treating cancer |
| BRPI1006897A2 (pt) | 2009-07-06 | 2015-09-08 | Akebia Therapeutics Inc | compostos, composições e métodos de prevenção da metástase de células cancerosas. |
| TWI426920B (zh) * | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | 雙專一性、雙價抗-vegf/抗-ang-2抗體 |
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| KR20180023015A (ko) | 2011-01-13 | 2018-03-06 | 리제너론 파아마슈티컬스, 인크. | 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
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| JP2014516075A (ja) | 2011-06-06 | 2014-07-07 | シェブロン フィリップス ケミカル カンパニー エルピー | 癌治療のためのメタロセン化合物の使用 |
| MX363351B (es) | 2011-10-13 | 2019-03-20 | Aerpio Therapeutics Inc | Un agente de unión a hptp?-ecd para usarse en el tratamiento de síndrome de fuga vascular. |
| US10413606B2 (en) | 2012-10-01 | 2019-09-17 | Mayo Foundation For Medical Education And Research | Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies |
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| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
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| US10213513B2 (en) | 2014-06-16 | 2019-02-26 | Mayo Foundation For Medical Education And Research | Treating myelomas |
| WO2015200905A2 (en) | 2014-06-28 | 2015-12-30 | Oligasis, Llc | Dual pdgf/vegf antagonists |
| RS58957B1 (sr) | 2014-07-18 | 2019-08-30 | Sanofi Sa | Postupak za predviđanje ishoda tretmana sa afliberceptom kod pacijenta za kog se sumnja da boluje od raka |
| CN107073132B (zh) | 2014-10-06 | 2021-08-27 | 梅约医学教育与研究基金会 | 载体-抗体组合物及其制备和使用方法 |
| TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體-抗體組合物及其製造及使用方法 |
| CN113713101B (zh) | 2015-09-23 | 2023-07-28 | 视点制药公司 | 用tie-2的激活剂治疗眼内压的方法 |
| TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
| IL290457B2 (en) | 2015-12-30 | 2025-02-01 | Kodiak Sciences Inc | Antibodies and their conjugates |
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| CN109310756B (zh) * | 2016-05-13 | 2022-06-28 | 奥美药业有限公司 | 新型血管生成素2,vegf双特异性拮抗剂 |
| US11059885B2 (en) | 2016-05-13 | 2021-07-13 | Askgene Pharma Inc. | Angiopoietin 2, VEGF dual antagonists |
| CN109890419A (zh) | 2016-09-01 | 2019-06-14 | 梅约医学教育与研究基金会 | 用于治疗癌症的载体-pd-l1结合剂组合物 |
| CN109843336A (zh) | 2016-09-01 | 2019-06-04 | 梅约医学教育与研究基金会 | 用于靶向t细胞癌症的方法和组合物 |
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| CN109843924A (zh) | 2016-09-06 | 2019-06-04 | 梅约医学教育与研究基金会 | 治疗表达pd-l1的癌症的方法 |
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| WO2018160917A1 (en) | 2017-03-03 | 2018-09-07 | Janssen Biotech, Inc. | Co-therapy comprising a small molecule csf-1r inhibitor and an agonistic antibody that specifically binds cd40 for the treatment of cancer |
| KR20200093621A (ko) | 2017-11-30 | 2020-08-05 | 리제너론 파아마슈티컬스, 인크. | 혈관형성 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
| US11524053B2 (en) | 2018-01-26 | 2022-12-13 | The Regents Of The University Of California | Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents |
| CA3092588A1 (en) | 2018-03-02 | 2019-09-06 | Kodiak Sciences Inc. | Il-6 antibodies and fusion constructs and conjugates thereof |
| RS67656B1 (sr) | 2018-05-10 | 2026-02-27 | Regeneron Pharma | Formulacije koje sadrže visoke koncentracije fuzionog proteina vegf receptora |
| JP7564824B2 (ja) | 2019-04-29 | 2024-10-09 | アイポイント ファーマシューティカルズ, インコーポレイテッド | シュレム管を標的とするTie-2活性化物質 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN114867487A (zh) | 2019-11-25 | 2022-08-05 | 加利福尼亚大学董事会 | 用于眼内新生血管的长效vegf抑制剂 |
| MX2022013812A (es) | 2020-05-08 | 2022-12-15 | Regeneron Pharma | Trampas y mini-trampas de vegf y metodos para el tratamiento de trastornos oculares y cancer. |
| FI4185318T3 (fi) | 2021-05-17 | 2025-10-13 | Regeneron Pharma | Pitkäaikaisia, suuren annoksen VEGF-antagonistihoitoja angiogeenisten silmäsairauksien hoitoon |
| US20230295266A1 (en) | 2022-03-15 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Extended, High Dose VEGF Antagonist Regimens for Treatment of Angiogenic Eye Disorders |
| TW202400214A (zh) | 2022-03-15 | 2024-01-01 | 美商再生元醫藥公司 | 用於血管新生眼睛病症之治療之延長高劑量vegf拮抗劑方案 |
| CN121712520A (zh) | 2023-06-23 | 2026-03-20 | 瑞泽恩制药公司 | 用于治疗血管生成性眼病的延长的高剂量vegf拮抗剂方案 |
| WO2025217334A1 (en) | 2024-04-09 | 2025-10-16 | Regeneron Pharmaceuticals, Inc. | Low concentration vegf receptor fusion protein containing formulations |
| KR20260096819A (ko) | 2024-12-13 | 2026-06-24 | 리제너론 파아마슈티컬스, 인크. | 망막 정맥 폐쇄에 속발하는 혈관신생 눈 장애의 치료를 위한 연장된 고용량 vegf 길항제 레지먼 |
| WO2026148214A1 (en) | 2025-01-02 | 2026-07-09 | Regeneron Pharmaceuticals, Inc. | High concentration vegf receptor fusion protein containing buffer free formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
| US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| EP1179541B1 (en) * | 1999-04-28 | 2004-06-16 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting VEGF |
| CN101433715B (zh) * | 1999-06-08 | 2013-04-17 | 里珍纳龙药品有限公司 | 具有改善的药物动力学特性的修饰嵌合多肽 |
| CA2519875C (en) * | 2003-06-06 | 2014-01-14 | Regeneron Pharmaceuticals, Inc. | Method of tumor regression with vegf inhibitors |
-
2004
- 2004-07-21 AR ARP040102585A patent/AR046510A1/es unknown
- 2004-07-23 KR KR1020067000521A patent/KR101175990B1/ko not_active Expired - Lifetime
- 2004-07-23 MY MYPI20042968A patent/MY149169A/en unknown
- 2004-07-23 WO PCT/US2004/023815 patent/WO2005011734A2/en not_active Ceased
- 2004-07-23 TW TW093121978A patent/TWI351953B/zh not_active IP Right Cessation
- 2004-07-23 AU AU2004261165A patent/AU2004261165C1/en not_active Expired
- 2004-07-23 MX MXPA05013642A patent/MXPA05013642A/es not_active Application Discontinuation
- 2004-07-23 EP EP04779050A patent/EP1648428A2/en not_active Withdrawn
- 2004-07-23 RU RU2006105496/15A patent/RU2353353C2/ru active
- 2004-07-23 US US10/897,802 patent/US7354579B2/en not_active Expired - Lifetime
- 2004-07-23 CA CA2529742A patent/CA2529742C/en not_active Expired - Lifetime
- 2004-07-23 BR BRPI0412798-6A patent/BRPI0412798A/pt not_active Application Discontinuation
- 2004-07-23 JP JP2006521281A patent/JP5355856B2/ja not_active Expired - Lifetime
- 2004-07-23 NZ NZ544570A patent/NZ544570A/en not_active IP Right Cessation
- 2004-07-26 UY UY28438A patent/UY28438A1/es not_active Application Discontinuation
-
2005
- 2005-12-06 IL IL172406A patent/IL172406A/en not_active IP Right Cessation
-
2006
- 2006-02-24 NO NO20060924A patent/NO20060924L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060028654A (ko) | 2006-03-30 |
| MY149169A (en) | 2013-07-31 |
| US7354579B2 (en) | 2008-04-08 |
| AU2004261165C1 (en) | 2009-12-17 |
| JP5355856B2 (ja) | 2013-11-27 |
| TWI351953B (en) | 2011-11-11 |
| CA2529742A1 (en) | 2005-02-10 |
| CA2529742C (en) | 2012-09-18 |
| US20050032699A1 (en) | 2005-02-10 |
| AU2004261165B2 (en) | 2009-07-16 |
| WO2005011734A3 (en) | 2005-04-14 |
| UY28438A1 (es) | 2004-11-08 |
| EP1648428A2 (en) | 2006-04-26 |
| IL172406A0 (en) | 2006-04-10 |
| MXPA05013642A (es) | 2006-03-10 |
| BRPI0412798A (pt) | 2006-09-26 |
| JP2007500131A (ja) | 2007-01-11 |
| KR101175990B1 (ko) | 2012-08-23 |
| TW200524589A (en) | 2005-08-01 |
| AU2004261165A1 (en) | 2005-02-10 |
| NZ544570A (en) | 2008-08-29 |
| RU2006105496A (ru) | 2006-06-10 |
| IL172406A (en) | 2016-04-21 |
| WO2005011734A2 (en) | 2005-02-10 |
| RU2353353C2 (ru) | 2009-04-27 |
| NO20060924L (no) | 2006-04-25 |
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