AR046285A1 - Inhibidores de glutamina fructuosa - 6 - fosfato amidotransferasa (gfat) - Google Patents
Inhibidores de glutamina fructuosa - 6 - fosfato amidotransferasa (gfat)Info
- Publication number
- AR046285A1 AR046285A1 ARP040103726A ARP040103726A AR046285A1 AR 046285 A1 AR046285 A1 AR 046285A1 AR P040103726 A ARP040103726 A AR P040103726A AR P040103726 A ARP040103726 A AR P040103726A AR 046285 A1 AR046285 A1 AR 046285A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- ring
- heterocyclic ring
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de la presente poseen utilidad para el tratamiento de diabetes mellitus de tipo 2. Reivindicación 1: Un compuesto de fórmula (1) donde R1 es -COOH, -alquilo inferior-COOH, -alcohol inferior, -CH2OCH3, -CH2NH2, -CH2NHSO2R7, -C(=O)R8, - CNHCH2CH2-R8, -C(=NH)-R8,-(CH2)nNHC(=O)R9, -(CH2)mC(=O)N(R11)(R12), -C(=NH)-R13, o -(CH2)n-R14, R2 es como se muestra en los compuestos de fórmulas (2) o (3) en donde X es -CH o -N; R3, R4, R5, y R6 están cada uno seleccionados del grupo que consiste de -H, -alquilo inferior, -N(CH3)2, -N(CH3)CH2CH3, -N(CH2CH3)CH2CH3, halo, -O-alqueno inferior, -alcoxilo inferior, -O-alcohol inferior, y -O(CH2)n-cicloalquilo, o donde R5 y R6 son sustituyentes en los átomos de C del anillo adyacente, opcionalmente R5 y R6junto a los átomos de C a los que están unidos forman un anillo carbocíclico de 5 o 6 miembros saturado; R7 es -CF3, -alquilo inferior, -CH2Cl, -CH2CF3, o -R8; R8 es un anillo heterocíclico de 5 o 6 miembros saturado sustituido o sin sustituir que contiene un heteroátomo que está seleccionado de N, O, y S en donde el anillo sustituido es el anillo heterocíclico sustituido con -OH o -fenilo; R9 es -alquilo inferior, -alcoxilo inferior, o -(CH2)nR10, R10 es un anillo heterocíclico de 5 o 6 miembros saturado o insaturado que contiene uno o dos heteroátomos que están seleccionados de N y O; R11 es -H, o -CH3; R12 es -H, -alquilo inferior, -C:::N, -OH, -alcoxilo inferior, o -CH2COOCH2CH3; 13 es -alcoxilo inferior, -NH2 o -N-alquilo inferior; R14 es un anillo heterocíclico saturado o insaturado de 5 miembros sustituido o sin sustituir que contiene de 1 a 4 heteroátomos en donde los heteroátomos se seleccionan de N, O y S, en donde el anillo sustituido es el anillo heterocíclico que está sustituido en uno o dos C del anillo con =O, o sustituido en un N del anillo con -alcohol inferior o -alquilo inferior; m es 0, 1 o 2; n es 0 o 1; o una sal o éster farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51195403P | 2003-10-16 | 2003-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046285A1 true AR046285A1 (es) | 2005-11-30 |
Family
ID=34520042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103726A AR046285A1 (es) | 2003-10-16 | 2004-10-14 | Inhibidores de glutamina fructuosa - 6 - fosfato amidotransferasa (gfat) |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7037924B2 (es) |
| EP (1) | EP1675845A2 (es) |
| JP (1) | JP2007508338A (es) |
| KR (1) | KR100919723B1 (es) |
| CN (1) | CN100445280C (es) |
| AR (1) | AR046285A1 (es) |
| AU (1) | AU2004283822B2 (es) |
| BR (1) | BRPI0415497A (es) |
| CA (1) | CA2541690A1 (es) |
| MX (1) | MXPA06004116A (es) |
| RU (1) | RU2355686C2 (es) |
| TW (1) | TW200517111A (es) |
| WO (1) | WO2005040150A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090325944A1 (en) * | 2006-04-12 | 2009-12-31 | Suzanne Walker Kahne | Methods and Compositions for Modulating Glycosylation |
| WO2008156676A1 (en) | 2007-06-15 | 2008-12-24 | President And Fellows Of Harvard College | Methods and compositions for detecting and modulating o-glycosylation |
| EP2438046A4 (en) | 2009-06-01 | 2013-04-17 | Harvard College | O-GLCNAC TRANSFERASE INHIBITORS AND USES THEREOF |
| US9573911B2 (en) | 2011-07-06 | 2017-02-21 | President And Fellows Of Harvard College | Diphosphate mimetics and uses thereof |
| RU2543374C2 (ru) * | 2013-05-30 | 2015-02-27 | государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ПГФА Минздрава России) | Амид 2-(3-метил-6-метокси-7-этокси-3,4-дигидроизохинолил-1)-этановой кислоты гидрохлорид, проявляющий антигельминтное действие |
| CN114645070B (zh) * | 2022-02-28 | 2022-12-20 | 北京焉支山科技有限公司 | 一种己糖-6-磷酸组合物的制备方法及其在化妆品中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2199462A1 (en) | 1972-09-21 | 1974-04-12 | Bruneau & Cie Lab | Papaveraldime oxime ethers and esters - analgesics and antiinflammatories prepd by treatment of papaveraldime oxime with an alkyl or acyl halide |
| US4042697A (en) * | 1972-10-19 | 1977-08-16 | Allen & Hanburys Limited | Isoquinolium compounds for treating diabetes |
| GB1407685A (en) * | 1972-10-19 | 1975-09-24 | Allen & Hanburys Ltd | Isoquinolinium compounds |
| JPS63310813A (ja) | 1987-06-12 | 1988-12-19 | Keikichi Sugiyama | 毛髪用組成物 |
| ES2172376B1 (es) * | 2000-01-28 | 2003-11-16 | Servier Lab | Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
-
2004
- 2004-10-07 CA CA002541690A patent/CA2541690A1/en not_active Abandoned
- 2004-10-07 AU AU2004283822A patent/AU2004283822B2/en not_active Ceased
- 2004-10-07 BR BRPI0415497-5A patent/BRPI0415497A/pt not_active IP Right Cessation
- 2004-10-07 JP JP2006534646A patent/JP2007508338A/ja active Pending
- 2004-10-07 RU RU2006116463/04A patent/RU2355686C2/ru not_active IP Right Cessation
- 2004-10-07 EP EP04765869A patent/EP1675845A2/en not_active Withdrawn
- 2004-10-07 MX MXPA06004116A patent/MXPA06004116A/es active IP Right Grant
- 2004-10-07 CN CNB2004800298354A patent/CN100445280C/zh not_active Expired - Fee Related
- 2004-10-07 WO PCT/EP2004/011206 patent/WO2005040150A2/en active Application Filing
- 2004-10-12 US US10/961,906 patent/US7037924B2/en not_active Expired - Fee Related
- 2004-10-13 TW TW093131033A patent/TW200517111A/zh unknown
- 2004-10-14 AR ARP040103726A patent/AR046285A1/es not_active Application Discontinuation
-
2006
- 2006-04-14 KR KR1020067007203A patent/KR100919723B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2541690A1 (en) | 2005-05-06 |
| AU2004283822B2 (en) | 2008-11-13 |
| EP1675845A2 (en) | 2006-07-05 |
| BRPI0415497A (pt) | 2006-12-26 |
| MXPA06004116A (es) | 2006-07-05 |
| RU2006116463A (ru) | 2007-11-27 |
| AU2004283822A1 (en) | 2005-05-06 |
| TW200517111A (en) | 2005-06-01 |
| US20050113407A1 (en) | 2005-05-26 |
| KR100919723B1 (ko) | 2009-09-29 |
| WO2005040150A3 (en) | 2005-06-16 |
| WO2005040150A2 (en) | 2005-05-06 |
| KR20060083221A (ko) | 2006-07-20 |
| RU2355686C2 (ru) | 2009-05-20 |
| JP2007508338A (ja) | 2007-04-05 |
| CN1867559A (zh) | 2006-11-22 |
| US7037924B2 (en) | 2006-05-02 |
| CN100445280C (zh) | 2008-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |