FR2199462A1 - Papaveraldime oxime ethers and esters - analgesics and antiinflammatories prepd by treatment of papaveraldime oxime with an alkyl or acyl halide - Google Patents

Papaveraldime oxime ethers and esters - analgesics and antiinflammatories prepd by treatment of papaveraldime oxime with an alkyl or acyl halide

Info

Publication number
FR2199462A1
FR2199462A1 FR7233534A FR7233534A FR2199462A1 FR 2199462 A1 FR2199462 A1 FR 2199462A1 FR 7233534 A FR7233534 A FR 7233534A FR 7233534 A FR7233534 A FR 7233534A FR 2199462 A1 FR2199462 A1 FR 2199462A1
Authority
FR
France
Prior art keywords
papaveraldime
oxime
antiinflammatories
prepd
analgesics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7233534A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bruneau et Cie Laboratoires
Original Assignee
Bruneau et Cie Laboratoires
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bruneau et Cie Laboratoires filed Critical Bruneau et Cie Laboratoires
Priority to FR7233534A priority Critical patent/FR2199462A1/en
Publication of FR2199462A1 publication Critical patent/FR2199462A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds. are of formula (I): where R = (A) aliphatic or aminoaliphatic gp., or (b) carboxy aliphatic, carboxyacylaliphatic or carboxyaromatic gp. opt. amidated. The aliphatic gps. may be satd. or unsatd., straight or branched, cyclic or heterocyclic. In an example, papaveraldime was converted to its oxime with NH2OH.HCl in ethanolic KOH and 36.8 g. of this oxime was added to 2.3 g. Na in 250 ml. ethanol, refluxed for 30 mins., then 14.85 g. 2-diethylaminoethyl chloride added. After refluxing for 3 hrs. the mixt. was evapd., the basic material extracted into HCl and then basified. The base was converted to the dihydrochloride, which was obtd. in 70% yield, m.pt. 175 degrees C.
FR7233534A 1972-09-21 1972-09-21 Papaveraldime oxime ethers and esters - analgesics and antiinflammatories prepd by treatment of papaveraldime oxime with an alkyl or acyl halide Withdrawn FR2199462A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7233534A FR2199462A1 (en) 1972-09-21 1972-09-21 Papaveraldime oxime ethers and esters - analgesics and antiinflammatories prepd by treatment of papaveraldime oxime with an alkyl or acyl halide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7233534A FR2199462A1 (en) 1972-09-21 1972-09-21 Papaveraldime oxime ethers and esters - analgesics and antiinflammatories prepd by treatment of papaveraldime oxime with an alkyl or acyl halide

Publications (1)

Publication Number Publication Date
FR2199462A1 true FR2199462A1 (en) 1974-04-12

Family

ID=9104610

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7233534A Withdrawn FR2199462A1 (en) 1972-09-21 1972-09-21 Papaveraldime oxime ethers and esters - analgesics and antiinflammatories prepd by treatment of papaveraldime oxime with an alkyl or acyl halide

Country Status (1)

Country Link
FR (1) FR2199462A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7037924B2 (en) 2003-10-16 2006-05-02 Hoffmann-La Roche Inc. Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors
US7067529B2 (en) 2003-05-19 2006-06-27 Hoffmann-La Roche Inc. Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067529B2 (en) 2003-05-19 2006-06-27 Hoffmann-La Roche Inc. Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors
US7037924B2 (en) 2003-10-16 2006-05-02 Hoffmann-La Roche Inc. Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors

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Legal Events

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