AR043848A1 - Procedimiento para preparar la fenilamida del acido 5-(4- fluorofenil)-1-[2-((2r,4r)-4-hidroxi-6-oxo-tetrahidropiran-2- il) etil]-2-isopropil-4-fenil-1h-pirrol-3-carboxilico e intermediarios de sintesis. - Google Patents

Procedimiento para preparar la fenilamida del acido 5-(4- fluorofenil)-1-[2-((2r,4r)-4-hidroxi-6-oxo-tetrahidropiran-2- il) etil]-2-isopropil-4-fenil-1h-pirrol-3-carboxilico e intermediarios de sintesis.

Info

Publication number
AR043848A1
AR043848A1 ARP040101212A ARP040101212A AR043848A1 AR 043848 A1 AR043848 A1 AR 043848A1 AR P040101212 A ARP040101212 A AR P040101212A AR P040101212 A ARP040101212 A AR P040101212A AR 043848 A1 AR043848 A1 AR 043848A1
Authority
AR
Argentina
Prior art keywords
formula
compound
tetrahidropiran
fluorophenil
carboxilico
Prior art date
Application number
ARP040101212A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33159855&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR043848(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR043848A1 publication Critical patent/AR043848A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Reivindicación 1: Un procedimiento para preparar un compuesto de fórmula (1) comprendiendo (a) poner en contacto en un disolvente opcionalmente en presencia de un ácido de Lewis un compuesto de fórmula (2) con en compuesto de fórmula (7), en la que M es SiCl3, SiMe3, B(OH)2, CuLi, MgBr, ZnBr, InBr, SnBr3, en los que R3 es alquilo C1-6, para proporcionar un compuesto de fórmula (3); (b) convertir el compuesto de fórmula (3) en un éster de acriloilo de fórmula (4) en presencia de una base usando el compuesto de fórmula (8), en la que X es Cl, Br, I, o el compuesto de fórmula (9), y R es H, alquilo (C1-6), o fenilo, o un equivalente de éster activado con acriloilo; (c) poner en contacto en un disolvente el éster de acriloilo (4) con un catalizador para proporcionar 5,6-dihidropiran-2-ona (5); (d) convertir el compuesto de fórmula (5) a un compuesto de fórmula (6) mediante la adición 1,4 facial selectiva de alcohol alilico o bencílico; y (e) eliminar el resto alilo o bencilo en el compuesto de fórmula (6) mediante hidrogenólisis para proporcionar un compuesto de fórmula (1).
ARP040101212A 2003-04-14 2004-04-12 Procedimiento para preparar la fenilamida del acido 5-(4- fluorofenil)-1-[2-((2r,4r)-4-hidroxi-6-oxo-tetrahidropiran-2- il) etil]-2-isopropil-4-fenil-1h-pirrol-3-carboxilico e intermediarios de sintesis. AR043848A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46261303P 2003-04-14 2003-04-14

Publications (1)

Publication Number Publication Date
AR043848A1 true AR043848A1 (es) 2005-08-17

Family

ID=33159855

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101212A AR043848A1 (es) 2003-04-14 2004-04-12 Procedimiento para preparar la fenilamida del acido 5-(4- fluorofenil)-1-[2-((2r,4r)-4-hidroxi-6-oxo-tetrahidropiran-2- il) etil]-2-isopropil-4-fenil-1h-pirrol-3-carboxilico e intermediarios de sintesis.

Country Status (16)

Country Link
US (1) US20060205804A1 (es)
EP (1) EP1615883A1 (es)
JP (1) JP2006523670A (es)
KR (1) KR100780984B1 (es)
CN (1) CN1774421A (es)
AR (1) AR043848A1 (es)
AU (1) AU2004228463A1 (es)
BR (1) BRPI0409333A (es)
CA (1) CA2521903A1 (es)
CL (1) CL2004000777A1 (es)
MX (1) MXPA05011013A (es)
RS (1) RS20050760A (es)
RU (1) RU2337905C2 (es)
TW (2) TW200920745A (es)
WO (1) WO2004089894A1 (es)
ZA (1) ZA200507174B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0412786A (pt) * 2003-07-25 2006-09-26 Avecia Pharmaceuticals Ltd processo para a preparação de um composto, e, composto
GB0514612D0 (en) * 2005-07-15 2005-08-24 Sasol Technology Uk Ltd The use of a phosphorus containing ligand and a cyclic organic ligand in a metathesis catalyst
US9334266B2 (en) 2009-09-04 2016-05-10 The University Of Toledo Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby
JP5184565B2 (ja) * 2010-03-10 2013-04-17 独立行政法人科学技術振興機構 水系溶媒中での含窒素化合物の製造方法
CN101892276B (zh) * 2010-06-12 2012-11-21 郝志艳 一种阿托伐他汀钙化合物及其新方法
CN104356118B (zh) * 2014-10-17 2017-03-22 上海应用技术学院 多取代吡咯类他汀内酯脱水化合物及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5097045A (en) * 1989-02-01 1992-03-17 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5216174A (en) * 1988-02-22 1993-06-01 Warner-Lambert Co. Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5124482A (en) * 1988-02-22 1992-06-23 Warner-Lambert Company Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
US5149837A (en) * 1988-02-22 1992-09-22 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5245047A (en) * 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5248793A (en) * 1990-10-17 1993-09-28 Warner-Lambert Company Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
HRP960313B1 (en) * 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
PT1148049E (pt) * 1995-07-17 2005-02-28 Warner Lambert Co Formas cristalinas de hemi-sal de calcio do acido [r-(r*,r*)]-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil)-1h-pirrole-1-heptanoico (atorvastatina)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
CN1093126C (zh) * 1996-07-29 2002-10-23 沃尼尔·朗伯公司 合成被保护的(s)－3,4－二羟基丁酸酯的改进方法
US6476235B2 (en) * 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
RU2279430C2 (ru) * 2002-08-06 2006-07-10 Уорнер-Ламберт Компани Ллс Способ получения фениламида 5-(4-фторфенил)-1-[2-(2r,4r)-4-гидрокси-6-оксотетрагидропиран-2-ил)этил]-2-изопропил-4-фенил-1h-пиррол-3-карбоновой кислоты

Also Published As

Publication number Publication date
RU2337905C2 (ru) 2008-11-10
TW200426149A (en) 2004-12-01
KR20050110042A (ko) 2005-11-22
BRPI0409333A (pt) 2006-04-25
KR100780984B1 (ko) 2007-11-29
CN1774421A (zh) 2006-05-17
RS20050760A (sr) 2008-04-04
RU2005131853A (ru) 2006-03-10
WO2004089894A1 (en) 2004-10-21
TW200920745A (en) 2009-05-16
ZA200507174B (en) 2006-10-25
AU2004228463A1 (en) 2004-10-21
MXPA05011013A (es) 2005-12-12
JP2006523670A (ja) 2006-10-19
US20060205804A1 (en) 2006-09-14
EP1615883A1 (en) 2006-01-18
CL2004000777A1 (es) 2005-03-04
WO2004089894A8 (en) 2005-12-01
CA2521903A1 (en) 2004-10-21

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