AR041292A1 - Pirazolopiridinas como inhibidores de quinasa dependientes de ciclina - Google Patents
Pirazolopiridinas como inhibidores de quinasa dependientes de ciclinaInfo
- Publication number
- AR041292A1 AR041292A1 ARP030103374A ARP030103374A AR041292A1 AR 041292 A1 AR041292 A1 AR 041292A1 AR P030103374 A ARP030103374 A AR P030103374A AR P030103374 A ARP030103374 A AR P030103374A AR 041292 A1 AR041292 A1 AR 041292A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- alkyl
- cycloalkyl
- nr5r6
- heteroaryl
- Prior art date
Links
- 230000001419 dependent effect Effects 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 23
- 125000003118 aryl group Chemical group 0.000 abstract 23
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 22
- 125000000623 heterocyclic group Chemical group 0.000 abstract 17
- 125000001072 heteroaryl group Chemical group 0.000 abstract 15
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 12
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 12
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 11
- 229910052736 halogen Inorganic materials 0.000 abstract 10
- 150000002367 halogens Chemical class 0.000 abstract 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 9
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 7
- 101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 229910006069 SO3H Inorganic materials 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 108091007914 CDKs Proteins 0.000 abstract 1
- 125000004946 alkenylalkyl group Chemical group 0.000 abstract 1
- -1 alkylalkyl Chemical group 0.000 abstract 1
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 abstract 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000006872 improvement Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- DVUBDHRTVYLIPA-UHFFFAOYSA-N pyrazolo[1,5-a]pyridine Chemical class C1=CC=CN2N=CC=C21 DVUBDHRTVYLIPA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41213802P | 2002-09-19 | 2002-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041292A1 true AR041292A1 (es) | 2005-05-11 |
Family
ID=32030811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030103374A AR041292A1 (es) | 2002-09-19 | 2003-09-17 | Pirazolopiridinas como inhibidores de quinasa dependientes de ciclina |
Country Status (18)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1386922B1 (en) * | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereof, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| ATE350383T1 (de) | 2002-08-23 | 2007-01-15 | Sloan Kettering Inst Cancer | Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen |
| CA2576159A1 (en) * | 2004-08-27 | 2006-03-02 | Cyclacel Limited | Purine and pyrimidine cdk inhibitors and their use for the treatment of autoimmune diseases |
| PL1859793T3 (pl) * | 2005-02-28 | 2011-09-30 | Eisai R&D Man Co Ltd | Nowe połączone zastosowanie związku sulfonamidowego w leczeniu choroby nowotworowej |
| JP5106098B2 (ja) * | 2005-02-28 | 2012-12-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の抗癌剤との新規併用 |
| US7304074B2 (en) * | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| US7417053B2 (en) | 2005-04-07 | 2008-08-26 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof |
| CA2603457A1 (en) * | 2005-04-07 | 2006-10-19 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof |
| CA2621983A1 (en) | 2005-09-09 | 2007-03-22 | Schering Corporation | Azafused cyclin dependent kinase inhibitors |
| CA2670636A1 (en) * | 2006-11-27 | 2008-06-05 | H. Lundbeck A/S | Heteroaryl amide derivatives |
| KR20090031122A (ko) * | 2007-09-21 | 2009-03-25 | 주식회사 중외제약 | 인다졸 골격을 함유하는 화합물, 이의 제조방법 및 상기화합물을 함유하는 약제학적 조성물 |
| FR2940284B1 (fr) * | 2008-12-19 | 2011-02-18 | Sanofi Aventis | Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| CN107427521B (zh) * | 2015-03-27 | 2021-08-03 | 达纳-法伯癌症研究所股份有限公司 | 细胞周期蛋白依赖性激酶的抑制剂 |
| CN108700594B (zh) | 2015-11-18 | 2021-06-29 | 建新公司 | 多囊性肾病的生物标志物及其用途 |
| US10968215B2 (en) * | 2016-09-07 | 2021-04-06 | Shanghai Haihe Pharmaceutical Co., Ltd. | Pyrido five-element aromatic ring compound, preparation method therefor and use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066147C (zh) * | 1995-11-01 | 2001-05-23 | 诺瓦提斯公司 | 嘌呤衍生物及其制备方法 |
| EP1043998B1 (en) | 1997-12-13 | 2007-03-07 | Bristol-Myers Squibb Company | USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS |
| SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
| FR2801308B1 (fr) * | 1999-11-19 | 2003-05-09 | Oreal | COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES |
| DE60141889D1 (de) * | 2000-02-03 | 2010-06-02 | Eisai R&D Man Co Ltd | Inhibitoren der integrinexpression |
| JP2004516297A (ja) * | 2000-12-20 | 2004-06-03 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・（エス．セー．エール．アー．エス） | サイクリン依存性キナーゼ（ｃｄｋ）及びグリコーゲンシンターゼキナーゼ−３（ｇｓｋ−３）の阻害剤 |
| CZ20032398A3 (cs) * | 2001-03-08 | 2004-02-18 | Astrazeneca Ab | Nové použití derivátů 6-karboxamidoimidazo [1,2-a] pyridinu |
| CN1202896C (zh) * | 2002-02-07 | 2005-05-25 | 北京燕化高新技术股份有限公司 | 空气分离时纯化空气的方法 |
-
2003
- 2003-09-17 KR KR1020057004435A patent/KR20050072090A/ko not_active Abandoned
- 2003-09-17 MY MYPI20033535A patent/MY136840A/en unknown
- 2003-09-17 AT AT03752559T patent/ATE382048T1/de not_active IP Right Cessation
- 2003-09-17 AR ARP030103374A patent/AR041292A1/es active IP Right Grant
- 2003-09-17 ES ES03752559T patent/ES2297203T3/es not_active Expired - Lifetime
- 2003-09-17 CA CA2499593A patent/CA2499593C/en not_active Expired - Fee Related
- 2003-09-17 JP JP2004538405A patent/JP4845380B2/ja not_active Expired - Fee Related
- 2003-09-17 AU AU2003270846A patent/AU2003270846B2/en not_active Ceased
- 2003-09-17 MX MXPA05003059A patent/MXPA05003059A/es active IP Right Grant
- 2003-09-17 WO PCT/US2003/029841 patent/WO2004026872A1/en not_active Ceased
- 2003-09-17 NZ NZ538595A patent/NZ538595A/en not_active IP Right Cessation
- 2003-09-17 US US10/664,337 patent/US7151104B2/en not_active Expired - Lifetime
- 2003-09-17 CN CNB038220113A patent/CN100475812C/zh not_active Expired - Fee Related
- 2003-09-17 TW TW092125613A patent/TWI283243B/zh not_active IP Right Cessation
- 2003-09-17 DE DE60318321T patent/DE60318321T2/de not_active Expired - Lifetime
- 2003-09-17 EP EP03752559A patent/EP1539750B1/en not_active Expired - Lifetime
-
2005
- 2005-03-15 IL IL167432A patent/IL167432A/en not_active IP Right Cessation
- 2005-03-17 ZA ZA200502271A patent/ZA200502271B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004026872A1 (en) | 2004-04-01 |
| ES2297203T3 (es) | 2008-05-01 |
| CA2499593A1 (en) | 2004-04-01 |
| ZA200502271B (en) | 2005-09-19 |
| NZ538595A (en) | 2006-04-28 |
| DE60318321T2 (de) | 2008-12-11 |
| MXPA05003059A (es) | 2005-05-27 |
| EP1539750B1 (en) | 2007-12-26 |
| TWI283243B (en) | 2007-07-01 |
| JP2006503060A (ja) | 2006-01-26 |
| CA2499593C (en) | 2011-08-16 |
| ATE382048T1 (de) | 2008-01-15 |
| US7151104B2 (en) | 2006-12-19 |
| JP4845380B2 (ja) | 2011-12-28 |
| EP1539750A1 (en) | 2005-06-15 |
| TW200409775A (en) | 2004-06-16 |
| CN1681816A (zh) | 2005-10-12 |
| MY136840A (en) | 2008-11-28 |
| IL167432A (en) | 2010-05-17 |
| AU2003270846B2 (en) | 2006-11-23 |
| CN100475812C (zh) | 2009-04-08 |
| KR20050072090A (ko) | 2005-07-08 |
| DE60318321D1 (en) | 2008-02-07 |
| HK1071758A1 (en) | 2005-07-29 |
| US20040097516A1 (en) | 2004-05-20 |
| AU2003270846A1 (en) | 2004-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |