AR040504A1 - Compuestos de actividad antiparasitaria y medicamentos que los contienen - Google Patents

Compuestos de actividad antiparasitaria y medicamentos que los contienen

Info

Publication number
AR040504A1
AR040504A1 AR20030102593A ARP030102593A AR040504A1 AR 040504 A1 AR040504 A1 AR 040504A1 AR 20030102593 A AR20030102593 A AR 20030102593A AR P030102593 A ARP030102593 A AR P030102593A AR 040504 A1 AR040504 A1 AR 040504A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
oso2
heterocycle
nitrogen
Prior art date
Application number
AR20030102593A
Other languages
English (en)
Inventor
Henri Vial
Marie-Laure Ancelin
Francoise Escale
Valerie Vidal
Francoise Bressolle
Michele Calas
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Publication of AR040504A1 publication Critical patent/AR040504A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicación 1: Compuestos que presentan una actividad antiparasitaria, en especial antipalúdica caracterizados porque responden a la fórmula general (1) en la que: X representa un grupo de fórmula (2) donde: Z es un grupo -(CH2)m, con m = 8 a 21, n = 0 ó 1; e Y = R3; R1 y R1', idénticos o diferentes uno del otro, elegidos entre H, alquil, OH, O-alquil, O-aril, O-CO-alquil, O-CO-aril, OSO2-alquil, OSO2-aril, OSO2-heterociclo, O-CO-O(o S o NH)-alquil, O-CO-O(o S o NH)-aril, PO(O-alquil o O-aril)2, CO-O-CH2-aril, cicloalquil; R2 y R2', idénticos o diferentes uno del otro, elegidos entre H, alquil, CO-O-CH2-aril, CO-O-alquil, cicloalquil; R3 y R3', idénticos o diferentes uno del otro, representando H, alquil, CO-O-alquil, CO-O-aril, COO-CH(R)-O-CO-alquil, PO(O-alquil o O-aril u ONa)2, CO-O-CH(R)-aril; R siendo H o alquil; o bien R1 y R2 y/o R1' y R2', o R2 y R3 y/o R2' y R3', forman juntos un monoheterociclo con el o los átomos de nitrógeno a los que están unidos respectivamente, o aún, R2 y R3 y/o R2' y R3' pueden ser el mismo sustituido, doblemente unido al nitrógeno, ciclizado con, respectivamente, R1 o R1' para formar un heterociclo, llegado el caso sustituido por Ra, que es elegido entre H, alquil, alquil sustituido por 1, 2 ó 3 átomos de halógeno, aril, CO-O-alquil(o aril), -CO-OH, -CO-NH2, -CN, -CO-NH-alquil, ( o aril), -CO-N-(alquil)2, -CO-heterociclo nitrogenado y/o oxigenado, NH(H o alquil), N(alquil)2, heterociclo nitrogenado y/u oxigenado, -O-alquil(o aril), -O-CH2-aril, CH2N[H, (H, alquil), (dialquil), aril], -CH2-heterociclo nitrogenado y/u oxigenado, CH2-CO-OH, sea X = R4 y Y representa un grupo de fórmula (3) con n y Z tal como se definen anteriormente, R1 y R1', idénticos o diferentes uno del otro, elegidos entre H, alquil, OH, O-alquil, O-aril, O-CO-alquil, O-CO-aril, OSO2-alquil, OSO2-aril, OSO2-heterociclo, O-CO-O(o S o NH)-alquil, O-CO-O(o S o NH)-aril, PO(O-alquil o O-aril)2, CO-O-CH2-aril, cicloalquil; R4 y R4' representan un H, alquil o aril, estos pueden ser sustituidos por OH, O-alquil, O-aril, NH(H o alquil), heterociclo nitrogenado y/o oxigenado y R2 y R2', idénticos o diferentes uno del otro, elegidos entre H, alquil, CO-O-CH2-aril, CO-O-alquil cicloalquil; o R1 y R4 y/o R1' y R4' forman juntos un grupo -(CH2)p, p siendo un entero de 1 a 5, uno o varios átomos de hidrógeno pueden ser reemplazados por un alquil inferior, y R2 y R2' representando H , o bien R4 y R2 y/o R4' y R2' forman juntos un grupo -(CH2)p, uno o varios H pueden ser reemplazados por un alquil inferior, R1 y R1' representando H, y las sales farmacológicamente aceptables de estos compuestos.
AR20030102593A 2002-07-18 2003-07-18 Compuestos de actividad antiparasitaria y medicamentos que los contienen AR040504A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0209156A FR2842423B1 (fr) 2002-07-18 2002-07-18 Composes a activite anti-parasitaire et medicaments les renfermant

Publications (1)

Publication Number Publication Date
AR040504A1 true AR040504A1 (es) 2005-04-06

Family

ID=29797562

Family Applications (1)

Application Number Title Priority Date Filing Date
AR20030102593A AR040504A1 (es) 2002-07-18 2003-07-18 Compuestos de actividad antiparasitaria y medicamentos que los contienen

Country Status (17)

Country Link
US (1) US8012985B2 (es)
EP (5) EP2275100A3 (es)
JP (1) JP5063860B2 (es)
CN (2) CN102079729B (es)
AP (1) AP2098A (es)
AR (1) AR040504A1 (es)
AU (2) AU2003269035A1 (es)
BR (1) BR0312719A (es)
CA (1) CA2491989C (es)
FR (1) FR2842423B1 (es)
IL (1) IL166036A0 (es)
MX (1) MXPA05000751A (es)
OA (1) OA12888A (es)
PL (1) PL374308A1 (es)
TW (1) TW200412932A (es)
WO (1) WO2004009068A2 (es)
ZA (1) ZA200500250B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088441A1 (en) * 2010-12-23 2012-06-28 Alkermes, Inc. Multi- api loading prodrugs
FR3017240B1 (fr) * 2014-02-04 2016-01-29 Ncs Pyrotechnie Et Tech Sas Coupe-circuit pyrotechnique

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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CH214041A (fr) * 1938-04-14 1941-03-31 May & Baker Ltd Verfahren zur Herstellung von 4.4'-Diamidino-a, y-diphenoxypropan.
US2364075A (en) * 1942-10-15 1944-12-05 Du Pont Disinfectant compounds
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US3471509A (en) * 1965-06-17 1969-10-07 William J Mckillip Oxadiazoles
GB1197929A (en) * 1966-10-31 1970-07-08 Toyo Jozo Kk Process for the Manufacture of Substituted Bis-AmidinoCompounds
FR1542163A (fr) * 1966-10-31 1968-10-11 Toyo Jozo Kk Procédé de fabrication de composés bisamidino substitués et composés obtenus par le procédé précédent ou similaire
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JPS5748902A (en) * 1980-09-10 1982-03-20 Dainippon Ink & Chem Inc Agricultural and horticultural germicide
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US5654451B1 (en) * 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
EP0679153A4 (en) * 1993-01-14 1996-05-15 Magainin Pharma FINALLY MODIFIED AMINO ACIDS AND PEPTIDES.
EP0712844A4 (en) * 1994-06-06 1996-11-06 Green Cross Corp NOVEL CARBOXYLIC ACID COMPOUND WITH FUSED CORE OR SALT THEREOF, AND ITS USE IN MEDICINE
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US5874438A (en) * 1996-10-11 1999-02-23 Bayer Aktiengesellschaft 2,2'-bridged bis-2,4-diaminoquinazolines
EP0836851A1 (en) * 1996-10-21 1998-04-22 Virbac S.A. Amidine compounds for use in treating ecto or endo parasitic diseases and systemic parasite control compositions
JPH10237761A (ja) * 1997-02-21 1998-09-08 Lion Corp 柔軟仕上げ剤組成物
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Also Published As

Publication number Publication date
US20050176819A1 (en) 2005-08-11
EP2275100A2 (fr) 2011-01-19
EP1524972A2 (fr) 2005-04-27
EP2260841A2 (fr) 2010-12-15
EP2266555A2 (fr) 2010-12-29
CN102079729A (zh) 2011-06-01
AP2005003224A0 (en) 2005-03-31
AU2003269035A1 (en) 2004-02-09
MXPA05000751A (es) 2005-04-28
EP2260841A3 (fr) 2013-01-02
AU2009225272B2 (en) 2012-08-23
FR2842423B1 (fr) 2005-07-08
EP2275100A3 (fr) 2013-01-09
US8012985B2 (en) 2011-09-06
CN102079729B (zh) 2013-04-24
BR0312719A (pt) 2005-04-26
CN1668288A (zh) 2005-09-14
ZA200500250B (en) 2006-05-31
AU2009225272A1 (en) 2009-10-29
EP2260840A3 (fr) 2013-01-02
OA12888A (fr) 2006-10-13
CN1668288B (zh) 2013-07-17
PL374308A1 (en) 2005-10-03
FR2842423A1 (fr) 2004-01-23
TWI369979B (es) 2012-08-11
EP2266555A3 (fr) 2013-01-09
WO2004009068A2 (fr) 2004-01-29
CA2491989C (fr) 2012-03-20
EP2260840A2 (fr) 2010-12-15
JP5063860B2 (ja) 2012-10-31
AP2098A (en) 2010-02-02
IL166036A0 (en) 2006-01-15
TW200412932A (en) 2004-08-01
WO2004009068A3 (fr) 2004-08-12
JP2006504652A (ja) 2006-02-09
CA2491989A1 (fr) 2004-01-29

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