ATE204263T1 - Biologisch aktive amine - Google Patents

Biologisch aktive amine

Info

Publication number
ATE204263T1
ATE204263T1 AT92902511T AT92902511T ATE204263T1 AT E204263 T1 ATE204263 T1 AT E204263T1 AT 92902511 T AT92902511 T AT 92902511T AT 92902511 T AT92902511 T AT 92902511T AT E204263 T1 ATE204263 T1 AT E204263T1
Authority
AT
Austria
Prior art keywords
group
biologically active
represent hydrogen
active amine
phenylmethyne
Prior art date
Application number
AT92902511T
Other languages
English (en)
Inventor
Roger Charles Brown
Covert
John Dixon
Francis Ince
David Rayuls Cheshire
Roger Victor Bonnert
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909025178A external-priority patent/GB9025178D0/en
Priority claimed from GB909025180A external-priority patent/GB9025180D0/en
Priority claimed from GB909025176A external-priority patent/GB9025176D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE204263T1 publication Critical patent/ATE204263T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT92902511T 1990-11-20 1991-11-19 Biologisch aktive amine ATE204263T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB909025178A GB9025178D0 (en) 1990-11-20 1990-11-20 Compounds
GB909025180A GB9025180D0 (en) 1990-11-20 1990-11-20 Compounds
GB909025176A GB9025176D0 (en) 1990-11-20 1990-11-20 Compounds
PCT/GB1991/002042 WO1992008708A1 (en) 1990-11-20 1991-11-19 Biologically active amines

Publications (1)

Publication Number Publication Date
ATE204263T1 true ATE204263T1 (de) 2001-09-15

Family

ID=27265379

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92902511T ATE204263T1 (de) 1990-11-20 1991-11-19 Biologisch aktive amine

Country Status (11)

Country Link
EP (1) EP0558677B1 (de)
JP (2) JPH06502635A (de)
AT (1) ATE204263T1 (de)
AU (1) AU8912891A (de)
DE (1) DE69132689T2 (de)
DK (1) DK0558677T3 (de)
ES (1) ES2163396T3 (de)
IE (1) IE914003A1 (de)
PT (1) PT99563B (de)
SG (1) SG47947A1 (de)
WO (1) WO1992008708A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211172D0 (en) * 1992-05-27 1992-07-08 Fisons Plc Compounds
GB9210632D0 (en) * 1992-05-19 1992-07-01 Fisons Plc Compounds
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
GB9526511D0 (en) * 1995-12-23 1996-02-28 Astra Pharma Prod Pharmaceutically active compounds
US5990144A (en) * 1997-02-18 1999-11-23 American Home Products Corporation 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one dopamine autoreceptor agonists
HUP0001262A3 (en) * 1997-02-18 2002-04-29 American Home Products Corp Ma 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one deriatives, their preparation and their use as dopamine autoreceptor (d2) agonists
TW200508197A (en) * 2003-03-31 2005-03-01 Ucb Sa Indolone-acetamide derivatives, processes for preparing them and their uses
ES2329586T3 (es) 2003-11-21 2009-11-27 Theravance, Inc. Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino.
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
GB0704000D0 (en) * 2007-03-01 2007-04-11 Astrazeneca Ab Salts 670
WO2009154557A1 (en) 2008-06-18 2009-12-23 Astrazeneca Ab Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
GB8426200D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
US4554287A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones
AU4945185A (en) * 1984-11-08 1986-05-15 Syntex (U.S.A.) Inc. Dialkyl aminoethylaniline derivatives
DE3728695A1 (de) * 1987-08-25 1989-03-09 Schering Ag Neue benzimidazol-derivate

Also Published As

Publication number Publication date
JP2000290240A (ja) 2000-10-17
SG47947A1 (en) 1998-04-17
DE69132689D1 (de) 2001-09-20
ES2163396T3 (es) 2002-02-01
DK0558677T3 (da) 2001-11-12
JPH06502635A (ja) 1994-03-24
EP0558677B1 (de) 2001-08-16
WO1992008708A1 (en) 1992-05-29
IE914003A1 (en) 1992-05-20
PT99563A (pt) 1992-10-30
AU8912891A (en) 1992-06-11
PT99563B (pt) 1999-04-30
DE69132689T2 (de) 2002-06-27
EP0558677A1 (de) 1993-09-08

Similar Documents

Publication Publication Date Title
DE3365772D1 (en) 1,4-dihydropyridines, process for their preparation and their application as pharmaceutical preparations
ATE204263T1 (de) Biologisch aktive amine
ATE124405T1 (de) 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel.
NO996108L (no) 9-oksinerytromycinderivater
ATE150462T1 (de) Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung
EA200100983A1 (ru) Производные 13-метилэритромицина
FI943142A0 (fi) Amidi- ja ureajohdannaiset, joilla on veren korkeita kolesteroliarvoja vastustava vaikutus, niiden valmistus ja terapeuttiset käytöt
DK0734383T3 (da) Cykliske amidderivater som neurokinin-A-antagonister
DZ1694A1 (fr) "n-(2-Aminoethyl)-benzothialozones".
ATE211729T1 (de) Therapeutisch wirksame verbindungen
DK0587088T3 (da) Substituerede cyclohexan-derivater, fremgangsmåde til deres fremstilling og anvendelsen af forbindelserne til behandling af sygdomme
ATE201671T1 (de) Chinolon und acridinon derivate zur behandlung der harninkontinenz
PT992509E (pt) Novos derivados macrolidos
ATE170852T1 (de) Benzolsulfonamid-derivate zur behandlung der blaseninstabilität
NO961000L (no) Piperidinderivater, fremgangsmåte for fremstilling derav og medikament og preparat inneholdende slike
DE59409595D1 (de) Anellierte dihydropyridine und deren verwendung für die herstellung von pharmazeutischen zubereitungen
MX9804828A (es) Benzotiazolona etanaminas biologicamente activas.
DE3564684D1 (en) Tetrahydrothienopyridines, process for their preparation and their pharmaceutical application
PT861250E (pt) Derivados de amidina e de isotioureia como inibidores de oxido nitrico sintase
DE69330601D1 (de) Serotoninergische ergolin derivate
BR8400549A (pt) Derivados e sais inertes de hidroxido de aminopiridinios e processos de preparacao;e composicao farmaceutica
ATE144510T1 (de) N-(isochinolein-5-yl)-sulfonyl azazykloalkane, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
IT1241988B (it) 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono
PT782574E (pt) Carboxamidas biciclicas como antagonistas 5-ht1a
IT1241927B (it) 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee