AR038235A1 - Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1 - Google Patents
Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1Info
- Publication number
- AR038235A1 AR038235A1 ARP030100227A ARP030100227A AR038235A1 AR 038235 A1 AR038235 A1 AR 038235A1 AR P030100227 A ARP030100227 A AR P030100227A AR P030100227 A ARP030100227 A AR P030100227A AR 038235 A1 AR038235 A1 AR 038235A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- independently selected
- hydroxy
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Estos compuestos son ligandos para el receptor ORL-1 y especialmente son antagonistas del citado receptor. Reivindicación 1: Un compuesto de la siguiente fórmula (1): o una sal o solvato farmacéuticamente aceptable del mismo, caracterizado porque R1 a R12 se seleccionan independientemente del grupo constituido por hidrógeno; halo; hidroxi; alquilo C1-6; alquilo C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; alquilo C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino, [alquil C1-6]NH-, [alquil C1-6]2N-, H2NC(=O)-, [alquil C1-6]NHC(=O)-, [alquil C1-6]2NC(=O)-, alcoxi C1-6 y un heterociclilo de cinco a seis miembros totalmente saturado que contiene de uno a dos heteroátomos independientemente seleccionados de nitrógeno y oxígeno; alcoxi C1-6; alcoxi C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; alcoxi C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino, [alquil C1-6]NH-, [alquil C1-6]2N-, H2NC(=O)-, [alquil C1-6]NHC(=O)- y [alquil C1-6]2NC(=O)-; amino; carboxi; [alcoxi C1-6]C(=O)-; H2NC(=O)-; [alquil C1-6]NHC(=O)-; [alquil C1-6]NHC(=O)- en el que el citado alquilo C1-6 está sustituido con un hidroxi; [alquil C1-6]2NC(=O)-, [alquil C1-6]2NC(=O)-, en el que uno o ambos de los alquilo C1-6 están sustituidos con un hidroxilo; arilo seleccionados de fenilo y naftilo; y un heterociclilo de cuatro a ocho miembros que contiene de uno a cuatro heteroátomos en el anillo independientemente seleccionados de nitrógeno, oxígeno y azufre; o de los grupos R1, R2, R3 y R4 tomados conjuntamente forman -CH2- o -(CH2)2-, y los dos grupos restantes se definen como anteriormente; X1 y X2 se seleccionan independientemente de CH2; CH-hidroxi; O; NH; S; C(=O); SO2 y [alquil C1-6]N; o X1 y X2 tomados conjuntamente forman CH=CH; R13 se selecciona del grupo constituido por hidrógeno; hidroxi; alquilo C1-6; alquilo C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; y alquilo C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino, [alquil C1-6]NH-, [alquil C1-6]2N-, H2NC(=O)-, [alquil C1-6]NHC(=O)-, [alquil C1-6]2NC(=O)-, alcoxi C1-6 y un heterociclilo de cinco a seis miembros totalmente saturado que contiene de uno a dos heteroátomos independientemente seleccionados de nitrógeno y oxígeno; o R12 y R13 tomados conjuntamente con los tres átomos de anillo del anillo de dihidroquinolina o tetrahidroquinolina que separa los citados sustituyentes forman un anillo de cinco a siete miembros que está parcial o totalmente insaturado, en el que el átomo de anillo no compartido con el anillo de dihidroquinolina o tetrahidroquinolina y adyacente al átomo de nitrógeno en el anillo de dihidroquinolina o tetrahidroquinolina es un átomo de carbono; los restantes uno a tres átomos de anillo no compartidos con el anillo de dihidroquinolina o tetrahidroquinolina son átomos de carbono, estando opcionalmente reemplazado uno de los citados átomos de carbono por un átomo de nitrógeno, oxígeno o azufre; y uno o dos de los átomos de carbono y nitrógeno no compartidos con el anillo de dihidroquinolina o tetrahidroquinolina están opcionalmente sustituidos con sustituyentes independientemente seleccionados de oxo; hidroxi; alquilo C1-6; alquilo C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; alquilo C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino [alquil C1-6]NH-, [alquil C1-6]2N-, -H2NC(=O)-, [alquil C1-6]NHC(=O)-, alcoxi C1-6 y un heterociclilo de cinco a seis miembros totalmente saturado que contiene de uno a dos heteroátomos independientemente seleccionados de nitrógeno y oxígeno; alcoxi C1-6; alcoxi C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; alcoxi C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino, [alquil C1-6]NH-, [alquil C1-6]2N-, H2NC(=O)-, [alquil C1-6NHC(=O)- y [alquil C1-6]2NC(=O)-, amino; ambos R14 y R15 son hidrógeno o tomados conjuntamente forman un grupo oxo y la línea de trazos representa un enlace sencillo o doble.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35243702P | 2002-01-28 | 2002-01-28 |
Publications (1)
Publication Number | Publication Date |
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AR038235A1 true AR038235A1 (es) | 2005-01-05 |
Family
ID=27663095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030100227A AR038235A1 (es) | 2002-01-28 | 2003-01-27 | Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1 |
Country Status (13)
Country | Link |
---|---|
US (1) | US6869960B2 (es) |
EP (1) | EP1470126A1 (es) |
JP (1) | JP2005519921A (es) |
AR (1) | AR038235A1 (es) |
BR (1) | BR0307268A (es) |
CA (1) | CA2466915A1 (es) |
GT (1) | GT200300014A (es) |
MX (1) | MXPA04007242A (es) |
PA (1) | PA8564201A1 (es) |
PE (1) | PE20030848A1 (es) |
TW (1) | TW200302725A (es) |
UY (1) | UY27623A1 (es) |
WO (1) | WO2003064425A1 (es) |
Families Citing this family (46)
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US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
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ITMI20031349A1 (it) * | 2003-07-01 | 2005-01-02 | Ufpeptides S R L | Antagonisti del recettore nop e loro usi terapeutici. |
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EP1726590A4 (en) * | 2004-03-05 | 2009-07-15 | Banyu Pharma Co Ltd | D RIV CYCLOALKANOPYRIDINE |
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CA2660974A1 (en) * | 2006-08-18 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
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US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
CN106336357A (zh) * | 2016-08-29 | 2017-01-18 | 启东东岳药业有限公司 | 2‑羟甲基丙烯酸甲酯的制备方法 |
CN110143918B (zh) * | 2019-06-19 | 2020-08-04 | 青岛农业大学 | 3,4-二氢-3-(2-羟基苯甲酰)-2(1h)-喹啉酮活性骨架及合成方法和应用 |
CN113264949B (zh) * | 2021-05-31 | 2022-04-05 | 西南大学 | 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用 |
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AU4562799A (en) | 1998-06-15 | 2000-01-05 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
ATE413175T1 (de) * | 2001-04-18 | 2008-11-15 | Euro Celtique Sa | Spiroinden- und spiroindan-verbindungen |
US20030078278A1 (en) * | 2001-06-26 | 2003-04-24 | Pfizer Inc. | Spiropiperidine compounds as ligands for ORL-1 receptor |
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2003
- 2003-01-16 MX MXPA04007242A patent/MXPA04007242A/es unknown
- 2003-01-16 BR BR0307268-1A patent/BR0307268A/pt not_active IP Right Cessation
- 2003-01-16 JP JP2003564048A patent/JP2005519921A/ja not_active Withdrawn
- 2003-01-16 EP EP20030700412 patent/EP1470126A1/en not_active Withdrawn
- 2003-01-16 CA CA002466915A patent/CA2466915A1/en not_active Abandoned
- 2003-01-16 WO PCT/IB2003/000203 patent/WO2003064425A1/en not_active Application Discontinuation
- 2003-01-23 US US10/349,760 patent/US6869960B2/en not_active Expired - Fee Related
- 2003-01-24 GT GT200300014A patent/GT200300014A/es unknown
- 2003-01-24 UY UY27623A patent/UY27623A1/es not_active Application Discontinuation
- 2003-01-24 PE PE2003000075A patent/PE20030848A1/es not_active Application Discontinuation
- 2003-01-27 AR ARP030100227A patent/AR038235A1/es not_active Application Discontinuation
- 2003-01-27 TW TW092101738A patent/TW200302725A/zh unknown
- 2003-01-28 PA PA20038564201A patent/PA8564201A1/es unknown
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MXPA04007242A (es) | 2004-10-29 |
TW200302725A (en) | 2003-08-16 |
PA8564201A1 (es) | 2003-12-10 |
CA2466915A1 (en) | 2003-08-07 |
UY27623A1 (es) | 2003-08-29 |
EP1470126A1 (en) | 2004-10-27 |
BR0307268A (pt) | 2004-12-14 |
US6869960B2 (en) | 2005-03-22 |
JP2005519921A (ja) | 2005-07-07 |
PE20030848A1 (es) | 2003-10-11 |
WO2003064425A1 (en) | 2003-08-07 |
US20030158219A1 (en) | 2003-08-21 |
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