AR036172A1 - 4-aminociclohexanoles sustituidos, medicamentos que los contienen, su uso para elaborar estos ultimos y proceso para la elaboracion de los mismos - Google Patents

4-aminociclohexanoles sustituidos, medicamentos que los contienen, su uso para elaborar estos ultimos y proceso para la elaboracion de los mismos

Info

Publication number
AR036172A1
AR036172A1 ARP020102649A ARP020102649A AR036172A1 AR 036172 A1 AR036172 A1 AR 036172A1 AR P020102649 A ARP020102649 A AR P020102649A AR P020102649 A ARP020102649 A AR P020102649A AR 036172 A1 AR036172 A1 AR 036172A1
Authority
AR
Argentina
Prior art keywords
substituted
unsubstituted
ch2r7
aryl
multiple form
Prior art date
Application number
ARP020102649A
Other languages
English (en)
Inventor
C Sundermann
H Hennies
W Englberger
S Wnendt
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR036172A1 publication Critical patent/AR036172A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

4-aminociclohexanoles sustituidos que tienen la fórmula general (1), en donde: R1 y R2 en forma independiente se seleccionan a partir de H; alquilo C1-8 o cicloalquilo C3-8, ya sea saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, y sea no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido mediante alquileno C1-3, ya sea no sustituido o sustituido en forma simple o múltiple; en donde ni R1 ni R2 pueden ser H, o los restos R1 y R2 en forma conjunta forman un ciclo y significan CH2CH2OCH2CH2, CH2CH2NR5CH2CH2 ó (CH2)3-6, con R5 seleccionado a partir de H; alquilo C1-8 o cicloalquilo C3-8, ya sea saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, ya sea no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8, o heteroarilo unido mediante alquileno C1-3, ya sea no sustituido o sustituido en forma simple o múltiple; R3 es seleccionado a partir de arilo o heteroarilo, ya sea no sustituido o sustituido en forma simple o múltiple; R4 se selecciona a partir de cicloalquilo C3-8, arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; -CHR6R7, -CHR6-CH2R7, -CHR6-CH2-CH2R7, -CHR6-CH2-CH2-CH2R7, -C(Y)R7, -C(Y)-CH2R7, -C(Y)-CH2-CH2R7 ó -C(Y)-CH2-CH2-CH2R7; ó -R8-L-R9; con Y = O, S ó H2; con R6 seleccionado a partir de H; alquilo C1-7, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; o C(O)O-alquilo C1-6, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; y con R7 seleccionado a partir de H; cicloalquilo C3-8, arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; con R8 seleccionado a partir de arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; con L seleccionado a partir de -C(O)-NH-, -NH-C(O)-, -C(O)-O-, -O-C(O)-, -O-, -S- ó -S(O)2-; y con R9 seleccionado a partir de arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; con la reserva que, (Factor de rechazo - Grupo 1) si R3 = fenilo, sustituido o no sustituido, y R4 = fenilo, sustituido o no sustituido, ó -CHR6R7, -CHR6-CH2R7, -CHR6-CH2-CH2R7, -CHR6-CH2-CH2-CH2R7, -C(Y)R7, -C(Y)-CH2R7, -C(Y)-CH2-CH2R7 ó -C(Y)-CH2-CH2-CH2R7 con Y = H2, R6 = H, alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple y/o R7 = H, cicloalquilo C3-8 o fenilo, ya sea sustituido o no sustituido, ni R1 ni R2 en forma independiente son alquilo C1-5; (Factor de rechazo - Grupo 2) si R3 = tiofenilo, sustituido o no sustituido, y R4 = -CH2-CH2-fenilo, los restos R1 y R2 no forman un ciclo ni significan (CH2)5; en la forma de su racemato; estereoisómeros puros, en especial enantiómeros y diastereómeros, o en la forma de mezclad de estereoisómeros, en especial de los enantiómeros y diasterómeros en una relación de mezcla arbitraria; en la forma producida o en la forma de sus ácidos o bases, como también de sus sales, en especial sales fisiológicamente tolerantes, o en la forma de sus solvatos, en especial de los hidratos. Medicamentos que comprenden al menos uno de los 4-aminociclohexanoles sustituidos de la fórmula general (1) y uso de estos últimos para elaborar dichos medicamentos. Proceso para elaborar los 4-aminociclohexanoles descriptos. Los compuestos de la fórmula general (1) son útiles para el tratamiento del dolor, estados de ansiedad, síndromes generados por o relacionados con el estrés, depresiones, epilepsia, mal de Alzheimer, demencia senil, disfunciones cognitivas generales y trastornos del aprendizaje.
ARP020102649A 2001-07-17 2002-07-15 4-aminociclohexanoles sustituidos, medicamentos que los contienen, su uso para elaborar estos ultimos y proceso para la elaboracion de los mismos AR036172A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10135636A DE10135636A1 (de) 2001-07-17 2001-07-17 Substituierte 4-Aminocyclohexanole

Publications (1)

Publication Number Publication Date
AR036172A1 true AR036172A1 (es) 2004-08-18

Family

ID=7692668

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020102649A AR036172A1 (es) 2001-07-17 2002-07-15 4-aminociclohexanoles sustituidos, medicamentos que los contienen, su uso para elaborar estos ultimos y proceso para la elaboracion de los mismos

Country Status (18)

Country Link
US (1) US7183436B2 (es)
EP (1) EP1406858B1 (es)
JP (1) JP4208139B2 (es)
AR (1) AR036172A1 (es)
AT (1) ATE435197T1 (es)
AU (1) AU2002321215B2 (es)
CA (1) CA2453901C (es)
CY (1) CY1109361T1 (es)
DE (2) DE10135636A1 (es)
DK (1) DK1406858T3 (es)
ES (1) ES2329017T3 (es)
HU (1) HU228911B1 (es)
MX (1) MXPA04000446A (es)
PE (1) PE20030325A1 (es)
PL (1) PL208676B1 (es)
PT (1) PT1406858E (es)
SI (1) SI1406858T1 (es)
WO (1) WO2003008370A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186310A1 (en) * 2001-06-22 2004-09-23 Kim Keun-Sik Process for preparation of cyclohexanol derivatives
PE20030320A1 (es) * 2001-07-17 2003-04-03 Gruenenthal Chemie Derivados sustituidos de 4-aminociclohexanol
DE10153346A1 (de) 2001-10-29 2004-04-22 Grünenthal GmbH Substituierte Indole
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
KR101608702B1 (ko) * 2007-06-05 2016-04-04 사노피 디(헤테로)아릴사이클로헥산 유도체, 이들의 제조방법, 이들의 용도 및 이들을 포함하는 약제학적 조성물
SI2271613T1 (sl) * 2008-03-27 2014-08-29 Grunenthal Gmbh Hidroksimetilcikloheksilamini
ES2375543T3 (es) 2008-03-27 2012-03-01 Grünenthal GmbH Derivados de espiro(5.5)undecano.
EP2260022B1 (de) 2008-03-27 2017-01-04 Grünenthal GmbH Substituierte cyclohexyldiamine
NZ600207A (en) 2008-03-27 2013-09-27 Gruenenthal Chemie Substituted 4-aminocyclohexane derivatives
SI2260042T1 (sl) 2008-03-27 2011-11-30 Gruenenthal Gmbh Substituirani spirociklični cikloheksanski derivati
CA2718209A1 (en) * 2008-03-27 2009-10-01 Gruenenthal Gmbh (hetero)aryl cyclohexane derivatives
HUE051642T2 (hu) * 2016-01-13 2021-03-01 Gruenenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-dekán származékok

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115589A (en) * 1977-05-17 1978-09-19 The Upjohn Company Compounds, compositions and method of use
US4366172A (en) * 1977-09-29 1982-12-28 The Upjohn Company 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use
US4212878A (en) * 1978-01-26 1980-07-15 The Upjohn Company Phenylacetamide derivative analgesics
US4346101A (en) * 1980-12-08 1982-08-24 The Upjohn Company Benzamide derivative analgesics
DE3924304A1 (de) * 1989-07-22 1991-01-31 Bayer Ag Neue fluorierte cyclohexanderivate, verfahren und zwischenprodukte zu deren herstellung und die verwendung der neuen fluorierten cyclohexanderivate als fungizide und zwischenprodukte
US5304479A (en) * 1991-12-06 1994-04-19 Diagnostic Reagents, Inc. Phencyclidine compounds and assays for its determination
US5239110A (en) * 1992-12-30 1993-08-24 Sterling Winthrop, Inc. Phenylcyclohexanol derivatives as agents for treating CNS disorders
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
DE19963175A1 (de) * 1999-12-27 2001-07-12 Gruenenthal Gmbh Verwendung von substituierten 4-Amino-1-phenylbutan-2-ol-Verbindungen als Arzneimittel

Also Published As

Publication number Publication date
DK1406858T3 (da) 2009-11-23
ATE435197T1 (de) 2009-07-15
ES2329017T3 (es) 2009-11-20
PL208676B1 (pl) 2011-05-31
DE50213651D1 (de) 2009-08-13
PE20030325A1 (es) 2003-04-03
CY1109361T1 (el) 2014-07-02
PL368050A1 (en) 2005-03-21
EP1406858B1 (de) 2009-07-01
JP4208139B2 (ja) 2009-01-14
CA2453901A1 (en) 2003-01-30
PT1406858E (pt) 2009-09-21
MXPA04000446A (es) 2004-03-18
JP2004534858A (ja) 2004-11-18
EP1406858A1 (de) 2004-04-14
HU228911B1 (en) 2013-06-28
CA2453901C (en) 2011-05-24
SI1406858T1 (sl) 2009-12-31
US7183436B2 (en) 2007-02-27
DE10135636A1 (de) 2003-02-06
AU2002321215B2 (en) 2007-08-02
WO2003008370A1 (de) 2003-01-30
HUP0401082A2 (hu) 2004-08-30
HUP0401082A3 (en) 2011-07-28
US20040236104A1 (en) 2004-11-25

Similar Documents

Publication Publication Date Title
AR036172A1 (es) 4-aminociclohexanoles sustituidos, medicamentos que los contienen, su uso para elaborar estos ultimos y proceso para la elaboracion de los mismos
RU2434865C2 (ru) Аналоги тетрагидрохинолина в качестве мускариновых агонистов
ES2632430T3 (es) Compuestos de imidazopirrolidinona
AR041941A1 (es) Derivado de 1-aminociclohexano sustituidos en la posicion 4 utilizado como receptor orl1
AR045255A1 (es) Derivados de 1,2 benzodiazol
AR074358A1 (es) Derivados de pirazina como inhibidores de la fosfodiesterasa 10
JP2005527593A5 (es)
AR074966A1 (es) Compuestos amino-heterociclicos
AR074529A2 (es) Derivados de ciclohexano espirociclicos
AR043466A1 (es) Proceso de un solo paso para la preparacion de derivados anticonvulsivos
AR035617A1 (es) Compuestos derivados de fenetanolamina, combinaciones y formulaciones farmaceuticas de los mismos, proceso para su preparacion, su uso en la preparacion de medicamentos para el tratamiento o profilaxis de una condicion clinica para la cual se indica un agonista beta2 adreno-receptor e intermediarios
PE20020221A1 (es) CARBAMATOS AZABICICLICOS COMO AGONISTAS DEL RECEPTOR DE ACETILCOLINA NICOTINICO alfa 7
AR063331A1 (es) Derivados de biaril eter urea y composiciones farmaceuticas
AR051802A1 (es) Heterociclos antagonistas de mchr1
AR057681A1 (es) Moduladores de interleuquina-1 y factor-alfa de necrosis tumoral; sintesis y metodos de uso de dichos moduladores
AR074184A1 (es) Compuestos de 7-azaspiro[3.5]nonano-7-carboxamida, composiciones farmaceuticas que los comprenden y su uso en la fabricacion de medicamentos para el tratamiento de afecciones mediadas por la inhibicion de faah
CO6260069A2 (es) Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de la leucotrieno a4 hidrolasa
AR040489A1 (es) Compuestos derivados de 3-fenil-propionamido, 3-fenil-acrilamido y 3-fenil-propinamido, su uso para la elaboracion de medicamentos, un proceso para elaborar los compuestos y medicamentos que los contienen
AR050798A1 (es) Derivados de difenil eter utiles para el tratamiento en terapia
AR074409A1 (es) Derivados de arilciclohexileteres de 5,6-dihidro-4h-2,3,5,10-b-tetraaza-benzo[e]azuleno, composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos en disfunciones sexuales y trastornos del snc, entre otras patologias.
AR071054A1 (es) Compuestos para usar en la formacion de imagenes el diagnostico y/o el tratamiento de enfermedades del sistema nervioso central o de tumores, metodos de preparacion, composiciones farmaceuticas, usos y metodos de deteccion de monoamina oxidasa.
AR042002A1 (es) Benzoxazinonas sustituidas, proceso de obtencion y usos para tratamiento de enfermedades del sistema nervioso central.
AR057525A1 (es) Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion
WO2007017264A3 (en) Pyrrolopyridinederivatives as modulators of the cannabinoid receptor for the treatment of immune and inflammatory disorders
AR040253A1 (es) Fluorobenzamidas, procesos de preparacion y medicamento

Legal Events

Date Code Title Description
FB Suspension of granting procedure