AR057681A1 - Moduladores de interleuquina-1 y factor-alfa de necrosis tumoral; sintesis y metodos de uso de dichos moduladores - Google Patents

Moduladores de interleuquina-1 y factor-alfa de necrosis tumoral; sintesis y metodos de uso de dichos moduladores

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Publication number
AR057681A1
AR057681A1 ARP060103177A ARP060103177A AR057681A1 AR 057681 A1 AR057681 A1 AR 057681A1 AR P060103177 A ARP060103177 A AR P060103177A AR P060103177 A ARP060103177 A AR P060103177A AR 057681 A1 AR057681 A1 AR 057681A1
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AR
Argentina
Prior art keywords
substituted
alkenyl
alkyls
halogen
hydrogen
Prior art date
Application number
ARP060103177A
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English (en)
Inventor
Michael A Palladino
Emmanuel A Theodorakis
Venkat Rami Reddy Macherla
Ta-Hsiang Chao
Young Ger Suh
Original Assignee
Nereus Pharmaceuticals Inc
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Publication date
Application filed by Nereus Pharmaceuticals Inc filed Critical Nereus Pharmaceuticals Inc
Publication of AR057681A1 publication Critical patent/AR057681A1/es

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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/557—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings having unsaturation outside the rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/04—Antibacterial agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
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    • C07C2603/86—Ring systems containing bridged rings containing four rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

Reivindicacion 1: Un compuesto caracterizado porque responde a la siguiente estructura química (1): (IIBB) en donde: R2 se selecciona entre el grupo formado por hidrogeno, un halogeno, COOH, ácidos C1-12 carboxílicos, haluros de C1-12 acilo, residuos C1-12 acilo, C1-12 ésteres, C1-12 amidas secundarias, (C1-12)(C1-12) amidas terciarias, (C1-12) amidas cíclicas, C1-12) aminas, C1-12 alcoholes, (C1-12)(C1-12) éteres, C1-12 alquilos, C1-12 alquilos sustituidos, C2-12 alquenilos, C2-12 alquenilos sustituidos, y C5-12 arilos; R17 se selecciona entre C5-12 alquilos cíclicos; C5-12 alquenilos cíclicos; C5-12 alquilos cíclicos sustituidos, C5-12 alquenilos cíclicos sustituidos; fenilo y C5-12 arilos; R9 se selecciona entre hidrogeno,un halogeno, C1-12 alquilo, C1-12 alquilos sustituidos, C2-12 alquenilo, C2-12 alquenilo sustituido, C2-12 alquinilo, C1-12 alcohol, C1-12 acilo, y C5-12 arilo; R3-R5, R7, R8 y R11-R13 se seleccionan cada uno por separado entre hidrogeno, un halogeno, C1-12 alquilo, C1-12 alquilos sustituidos, C2-12 alquenilo, C2-12 alquenilo sustituido, C2-12 alquinilo, y C5-12 arilo; R6 se selecciona entre hidrogeno, un halogeno, C1-12 alquilo, C1-12 alquilos sustituidos, C2-12 alquenilo, C2-12 alquenilo sustituido, y C2-12 alquinilo; R10 se selecciona ente hidrogeno, un halogeno, CH2, C1-6 alquilo, C1-6 alquilo sustituido, C2-6 alquenilo, C2-6 alquenilo sustituido, C1-12 alcohol, y C5-12 arilo; R14 y R15 se seleccionan por separado entre hidrogeno, un halogeno CH2, C1-6 alquilo, C1-6 alquilo sustituido, C2-6 alquenilo, C2-6 alquenilo sustituido, C1-6 alcohol, y C5-6 arilo; y R16 se selecciona entre el grupo formado por un hidrogeno, un halogeno, COOH, ácidos C1-12 carboxílicos, haluros de C1-C12 acilo, residuos C1-12 acilo, C1-12 ésteres, C1-12 amidas secundarias, (C1-12)(C1-12) amidas terciarias, (C1-12) amidas cíclicas, (C1-12) aminas, C1-12 alcoholes, (C1-12)(C1-12) éteres, C1-12 alquilos, C1-12 alquilos sustituidos, C2- 12 alquenilos, C2-12 alquenilos sustituidos, y C5-12 arilos; en donde el compuesto incluye los ésteres prodroga de los compuestos precedentes, y sus sales de adicion ácida. Que son utiles como moduladores de Interleuquina-1 y Factor-alfa de Necrosis Tumoral, y por lo tanto son utiles en el tratamiento de diversas enfermedades, donde los grupos R se definen en las reivindicaciones.
ARP060103177A 2005-07-21 2006-07-21 Moduladores de interleuquina-1 y factor-alfa de necrosis tumoral; sintesis y metodos de uso de dichos moduladores AR057681A1 (es)

Applications Claiming Priority (5)

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US70193205P 2005-07-21 2005-07-21
US73467905P 2005-11-07 2005-11-07
US73459005P 2005-11-07 2005-11-07
US74954205P 2005-12-12 2005-12-12
US78522306P 2006-03-22 2006-03-22

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AR057681A1 true AR057681A1 (es) 2007-12-12

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US (3) US7893299B2 (es)
EP (2) EP2311795A3 (es)
JP (1) JP2009505954A (es)
KR (1) KR20080035650A (es)
AR (1) AR057681A1 (es)
AT (1) ATE556046T1 (es)
AU (1) AU2006276274B2 (es)
CA (1) CA2613366A1 (es)
IL (1) IL188353A0 (es)
TW (1) TW200744992A (es)
WO (1) WO2007015757A2 (es)

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BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
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EP2785351A4 (en) * 2011-11-29 2015-05-27 Reveragen Biopharma Inc NON-HORMONAL STEROID MODULATORS OF NF-KB FOR THE TREATMENT OF DISEASES
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US7893299B2 (en) 2011-02-22
AU2006276274B2 (en) 2012-03-29
TW200744992A (en) 2007-12-16
EP1912932A2 (en) 2008-04-23
EP1912932B1 (en) 2012-05-02
US20120238634A1 (en) 2012-09-20
WO2007015757A3 (en) 2007-06-21
EP2311795A2 (en) 2011-04-20
JP2009505954A (ja) 2009-02-12
CA2613366A1 (en) 2007-02-08
EP2311795A3 (en) 2011-12-28
ATE556046T1 (de) 2012-05-15
AU2006276274A1 (en) 2007-02-08
WO2007015757A2 (en) 2007-02-08
US20110160309A1 (en) 2011-06-30
US20080064753A1 (en) 2008-03-13
KR20080035650A (ko) 2008-04-23
US8133915B2 (en) 2012-03-13
IL188353A0 (en) 2008-04-13

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