PE20030325A1 - 4-aminociclohexanoles sustituidos con afinidad por el receptor opiaceo orl1 - Google Patents

4-aminociclohexanoles sustituidos con afinidad por el receptor opiaceo orl1

Info

Publication number
PE20030325A1
PE20030325A1 PE2002000625A PE2002000625A PE20030325A1 PE 20030325 A1 PE20030325 A1 PE 20030325A1 PE 2002000625 A PE2002000625 A PE 2002000625A PE 2002000625 A PE2002000625 A PE 2002000625A PE 20030325 A1 PE20030325 A1 PE 20030325A1
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PE
Peru
Prior art keywords
heteroaryl
aryl
cycloalkyl
dimethylamino
alkyl
Prior art date
Application number
PE2002000625A
Other languages
English (en)
Inventor
Werner Englberger
Stephan Wnendt
Bernd Sundermann
Hagen-Heinrich Hennies
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20030325A1 publication Critical patent/PE20030325A1/es

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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
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    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
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Abstract

SE REFIERE A 4 AMINOCICLOHEXANOLES DE FORMULA I DONDE R1 Y R2 SON H, ALQUILO C1-C8, CICLOALQUILO C3-C8, ARILO, HETEROARILO, ARILO-CICLOALQUILO C3-C8, HETEROARILO-ALQUILENO C1-C3, R1 Y R2 NO SON H A LA VEZ O JUNTOS FORMAN CICLO, CH2CH2OCH2CH2, CH2CH2NR5CH2CH2, (CH2)(3-6); R5 ES H, ALQUILO C1-C8-CICLOALQUILO C3-C8, ARILO, HETEROARILO, ARILO-CICLOALQUILO C3-C8, ENTRE OTROS; R3 ES ARILO, HETEROARILO; R4 ES CICLOALQUILO C3-C8, ARILO, HETEROARILO, CHR6R7, CHR6, CH2R7, R8-L-R9, ENTRE OTROS; R6 ES H, ALQUILO C1-C7, COO-ALQUILO C1-C6; R7 ES H, CICLOALQUILO C3-C8, ARILO, HETEROARILO; R8 ES ARILO, HETEROARILO; L ES CONH, NHCO, COO, OCO, O, S, SO2; R9 ES ARILO, HETEROARILO; EXCEPTO CUANDO R3 ES FENILO; R4 ES FENILO, CHR6R7, CHR6(CH2)2R7, CHR6CH2CH2CH2R7, ENTRE OTROS; SON COMPUESTOS PREFERIDOS 4-DIMETILAMINO-1-FENETILO-4-FENILCICLOHEXANOL; 4-(4-CLOROFENIL)-4-DIMETILAMINO-1-FENETILOCICLOHEXANOL; 4-(4-BROMOFENIL)-4-DIMETILAMINO-1-FENETILOCICLOHEXANOL; 4-DIMETILAMINO-1-(1-METILO-1H-INDOL-2-IL)-4-FENILCICLOHEXANOL, ENTRE OTROS. TAMBIEN SE REFIERE A UN MEDICAMENTO QUE CONTIENE ADEMAS MORFINA, HEXOBARBITAL, HALOTAN. LOS COMPUESTOS TIENEN AFINIDAD CON EL RECEPTOR ORL1 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DOLOR, ANSIEDAD, EPILEPSIA, ALZHEIMER, DEMENCIA SENIL, DISFUNCIONES COGNITIVAS, TRASTORNOS DEL APRENDIZAJE
PE2002000625A 2001-07-17 2002-07-12 4-aminociclohexanoles sustituidos con afinidad por el receptor opiaceo orl1 PE20030325A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10135636A DE10135636A1 (de) 2001-07-17 2001-07-17 Substituierte 4-Aminocyclohexanole

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PE20030325A1 true PE20030325A1 (es) 2003-04-03

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US (1) US7183436B2 (es)
EP (1) EP1406858B1 (es)
JP (1) JP4208139B2 (es)
AR (1) AR036172A1 (es)
AT (1) ATE435197T1 (es)
AU (1) AU2002321215B2 (es)
CA (1) CA2453901C (es)
CY (1) CY1109361T1 (es)
DE (2) DE10135636A1 (es)
DK (1) DK1406858T3 (es)
ES (1) ES2329017T3 (es)
HU (1) HU228911B1 (es)
MX (1) MXPA04000446A (es)
PE (1) PE20030325A1 (es)
PL (1) PL208676B1 (es)
PT (1) PT1406858E (es)
SI (1) SI1406858T1 (es)
WO (1) WO2003008370A1 (es)

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US20040186310A1 (en) * 2001-06-22 2004-09-23 Kim Keun-Sik Process for preparation of cyclohexanol derivatives
PE20030320A1 (es) * 2001-07-17 2003-04-03 Gruenenthal Chemie Derivados sustituidos de 4-aminociclohexanol
DE10153346A1 (de) 2001-10-29 2004-04-22 Grünenthal GmbH Substituierte Indole
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
KR101608702B1 (ko) * 2007-06-05 2016-04-04 사노피 디(헤테로)아릴사이클로헥산 유도체, 이들의 제조방법, 이들의 용도 및 이들을 포함하는 약제학적 조성물
SI2271613T1 (sl) * 2008-03-27 2014-08-29 Grunenthal Gmbh Hidroksimetilcikloheksilamini
ES2375543T3 (es) 2008-03-27 2012-03-01 Grünenthal GmbH Derivados de espiro(5.5)undecano.
EP2260022B1 (de) 2008-03-27 2017-01-04 Grünenthal GmbH Substituierte cyclohexyldiamine
NZ600207A (en) 2008-03-27 2013-09-27 Gruenenthal Chemie Substituted 4-aminocyclohexane derivatives
SI2260042T1 (sl) 2008-03-27 2011-11-30 Gruenenthal Gmbh Substituirani spirociklični cikloheksanski derivati
CA2718209A1 (en) * 2008-03-27 2009-10-01 Gruenenthal Gmbh (hetero)aryl cyclohexane derivatives
HUE051642T2 (hu) * 2016-01-13 2021-03-01 Gruenenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-dekán származékok

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US4115589A (en) * 1977-05-17 1978-09-19 The Upjohn Company Compounds, compositions and method of use
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US4212878A (en) * 1978-01-26 1980-07-15 The Upjohn Company Phenylacetamide derivative analgesics
US4346101A (en) * 1980-12-08 1982-08-24 The Upjohn Company Benzamide derivative analgesics
DE3924304A1 (de) * 1989-07-22 1991-01-31 Bayer Ag Neue fluorierte cyclohexanderivate, verfahren und zwischenprodukte zu deren herstellung und die verwendung der neuen fluorierten cyclohexanderivate als fungizide und zwischenprodukte
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DK1406858T3 (da) 2009-11-23
ATE435197T1 (de) 2009-07-15
ES2329017T3 (es) 2009-11-20
PL208676B1 (pl) 2011-05-31
DE50213651D1 (de) 2009-08-13
CY1109361T1 (el) 2014-07-02
PL368050A1 (en) 2005-03-21
EP1406858B1 (de) 2009-07-01
JP4208139B2 (ja) 2009-01-14
CA2453901A1 (en) 2003-01-30
PT1406858E (pt) 2009-09-21
MXPA04000446A (es) 2004-03-18
JP2004534858A (ja) 2004-11-18
EP1406858A1 (de) 2004-04-14
HU228911B1 (en) 2013-06-28
CA2453901C (en) 2011-05-24
SI1406858T1 (sl) 2009-12-31
US7183436B2 (en) 2007-02-27
DE10135636A1 (de) 2003-02-06
AU2002321215B2 (en) 2007-08-02
WO2003008370A1 (de) 2003-01-30
HUP0401082A2 (hu) 2004-08-30
HUP0401082A3 (en) 2011-07-28
US20040236104A1 (en) 2004-11-25
AR036172A1 (es) 2004-08-18

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