AR036007A1 - Compuesto del acido 2-[(2's)-(2'-amino)-propionil]amino-biciclo[3.1.0]hexano-2,6-dicarboxilico, sal farmaceuticamente aceptable del mismo, formulacion farmaceutica que lo comprende, proceso para preparar dicho compuesto, metodo para afectar los receptores de glutamato metabotropicos unidos-camp en u - Google Patents

Compuesto del acido 2-[(2's)-(2'-amino)-propionil]amino-biciclo[3.1.0]hexano-2,6-dicarboxilico, sal farmaceuticamente aceptable del mismo, formulacion farmaceutica que lo comprende, proceso para preparar dicho compuesto, metodo para afectar los receptores de glutamato metabotropicos unidos-camp en u

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Publication number
AR036007A1
AR036007A1 ARP020100085A ARP020100085A AR036007A1 AR 036007 A1 AR036007 A1 AR 036007A1 AR P020100085 A ARP020100085 A AR P020100085A AR P020100085 A ARP020100085 A AR P020100085A AR 036007 A1 AR036007 A1 AR 036007A1
Authority
AR
Argentina
Prior art keywords
compound
pharmaceutically acceptable
amino
acceptable salt
formula
Prior art date
Application number
ARP020100085A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01500263A external-priority patent/EP1310480A1/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR036007A1 publication Critical patent/AR036007A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Psychology (AREA)
  • Emergency Medicine (AREA)
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  • Oncology (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

Un compuesto del ácido 2-[(2'S)-(2'-amino)-propionil]amino-biciclo[3.1.0]hexano-2,6-dicarboxílico que tiene la fórmula (1), en donde: R13, R14, y R17 son hidrógeno; o una sal farmacéuticamente aceptable de las mismas. Dicha sal farmacéuticamente aceptable es una sal de adición-ácida hecha con un ácido que proporciona un anión farmacéuticamente aceptable o, para un compuesto que contiene una fracción acídica, que es una sal hecha con una base que proporciona un anión farmacéuticamente aceptable. Formulación farmacéutica que comprende en asociación con un vehículo farmacéuticamente aceptable, un diluyente o un excipiente, un compuesto de la fórmula (1), o una sal farmacéuticamente aceptable del mismo. Proceso para preparar el compuesto de la fórmula (1) y compuesto intermediario de utilidad en dicho proceso. Método para afectar los receptores de glutamato metabotrópicos unidos-cAMP mediante la administración a un paciente que requiera neuro transmisión aminoácido excitante modulado, una cantidad farmacéuticamente efectiva del compuesto de fórmula (1). Uso de un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, para la fabricación de un medicamento para tratar un desorden neurológico o psiquiátrico, donde el desorden neurológico es un déficit cerebral subsecuente a un by-pass e injerto cardíaco, isquemia cerebral, trauma de la médula espinal, trauma de la cabeza, la enfermedad de Alzheimer, la enfermedad de Corea de Huntington, la esclerosis lateral amiotrópica, la demencia inducida por SIDA, la hipoxia perinatal, el dano neuronal hipoglucémico, el dano ocular y la retinopatía, los desordenes cognitivos y la enfermedad de Parkinson droga-inducida e idiopática; los espasmos musculares, la migrana, la incontinencia urinaria, la tolerancia, el rechazo y el abandono de la droga; el dejar de fumar, los vómitos, el edema cerebral, el dolor crónico, los desórdenes del sueno, las convulsiones. el síndrome de Tourette, el desorden del déficit de atención o la disquinesia tardía.
ARP020100085A 2001-01-11 2002-01-11 Compuesto del acido 2-[(2's)-(2'-amino)-propionil]amino-biciclo[3.1.0]hexano-2,6-dicarboxilico, sal farmaceuticamente aceptable del mismo, formulacion farmaceutica que lo comprende, proceso para preparar dicho compuesto, metodo para afectar los receptores de glutamato metabotropicos unidos-camp en u AR036007A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP01500007 2001-01-11
EP01500206 2001-08-02
US32978601P 2001-10-16 2001-10-16
EP01500263A EP1310480A1 (en) 2001-11-07 2001-11-07 Prodrugs of excitatory amino acids

Publications (1)

Publication Number Publication Date
AR036007A1 true AR036007A1 (es) 2004-08-04

Family

ID=27440162

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020100085A AR036007A1 (es) 2001-01-11 2002-01-11 Compuesto del acido 2-[(2's)-(2'-amino)-propionil]amino-biciclo[3.1.0]hexano-2,6-dicarboxilico, sal farmaceuticamente aceptable del mismo, formulacion farmaceutica que lo comprende, proceso para preparar dicho compuesto, metodo para afectar los receptores de glutamato metabotropicos unidos-camp en u

Country Status (24)

Country Link
US (1) US7256217B2 (es)
EP (1) EP1368304B1 (es)
JP (1) JP4064237B2 (es)
KR (1) KR20030090622A (es)
CN (1) CN1267407C (es)
AR (1) AR036007A1 (es)
AT (1) ATE356111T1 (es)
AU (1) AU2002228737B2 (es)
BR (1) BR0116770A (es)
CA (1) CA2433667C (es)
CZ (1) CZ303490B6 (es)
DE (1) DE60127182T2 (es)
DZ (1) DZ3461A1 (es)
ES (1) ES2282315T3 (es)
HU (1) HUP0400620A3 (es)
IL (1) IL156364A0 (es)
MX (1) MXPA03006186A (es)
NO (1) NO20033166L (es)
NZ (1) NZ526050A (es)
PE (1) PE20020829A1 (es)
PL (1) PL208413B1 (es)
SK (1) SK287934B6 (es)
SV (1) SV2003000836A (es)
WO (1) WO2002055481A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0311558A (pt) 2002-06-11 2007-04-27 Lilly Co Eli composto ou sal farmaceuticamente aceitável do mesmo, processo para preparar o mesmo, métodos para afetar os receptores de glutamato metabotrópicos ligados a camp, para administrar uma quantidade eficaz de um composto e para tratar um distúrbio neurológico e psiquiátrico em um paciente, e, formulação farmacêutica
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia
AR079343A1 (es) * 2009-12-21 2012-01-18 Lilly Co Eli Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico
EA023553B1 (ru) 2011-06-17 2016-06-30 Эли Лилли Энд Компани Агонисты рецептора mglu2
AR089718A1 (es) 2012-02-01 2014-09-10 Lilly Co Eli AGONISTAS DE mGlu2/3
JP7349449B2 (ja) 2018-04-17 2023-09-22 バイエル・アクチエンゲゼルシヤフト 酸－不安定性ケトン保護官能基を有するｎ－アシルアミノ酸のエステルを調製するための方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661184A (en) * 1994-08-12 1997-08-26 Eli Lilly And Company Psychiatric agents
PL182285B1 (pl) * 1994-08-12 2001-12-31 Lilly Co Eli Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL
AU3364995A (en) * 1994-08-12 1996-03-07 Eli Lilly And Company Composition and method for treating anxiety
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
AU734812B2 (en) 1998-01-28 2001-06-21 Taisho Pharmaceutical Co., Ltd. Fluorine-containing amino acid derivatives
GB9815542D0 (en) 1998-07-17 1998-09-16 Lilly Co Eli Bicyclohexane derivatives
US6528499B1 (en) 2000-04-27 2003-03-04 Georgetown University Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
WO2002055485A1 (en) 2001-01-11 2002-07-18 Eli Lilly And Company Prodrugs of excitatory amino acids
WO2003006489A2 (en) 2001-07-09 2003-01-23 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1463713A1 (en) 2001-11-23 2004-10-06 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1458671A1 (en) 2001-12-21 2004-09-22 Eli Lilly And Company Prodrugs of excitatory amino acids

Also Published As

Publication number Publication date
DE60127182T2 (de) 2007-11-22
SK287934B6 (sk) 2012-05-03
IL156364A0 (en) 2004-01-04
ES2282315T3 (es) 2007-10-16
US7256217B2 (en) 2007-08-14
PL361669A1 (en) 2004-10-04
ATE356111T1 (de) 2007-03-15
DZ3461A1 (fr) 2002-07-18
WO2002055481A8 (en) 2003-10-02
NO20033166D0 (no) 2003-07-10
CZ20031916A3 (en) 2004-03-17
US20040121962A1 (en) 2004-06-24
HUP0400620A3 (en) 2012-09-28
CN1267407C (zh) 2006-08-02
KR20030090622A (ko) 2003-11-28
SV2003000836A (es) 2003-01-13
EP1368304A1 (en) 2003-12-10
CN1486298A (zh) 2004-03-31
MXPA03006186A (es) 2004-02-13
AU2002228737B2 (en) 2007-01-04
PE20020829A1 (es) 2002-09-21
JP4064237B2 (ja) 2008-03-19
EP1368304B1 (en) 2007-03-07
JP2004524292A (ja) 2004-08-12
CZ303490B6 (cs) 2012-10-17
BR0116770A (pt) 2003-12-23
CA2433667A1 (en) 2002-07-18
NO20033166L (no) 2003-09-09
DE60127182D1 (de) 2007-04-19
PL208413B1 (pl) 2011-04-29
WO2002055481A1 (en) 2002-07-18
NZ526050A (en) 2005-03-24
CA2433667C (en) 2011-06-14
SK8262003A3 (en) 2004-01-08
HUP0400620A2 (hu) 2004-12-28

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