AR035257A1 - Compuestos de bencenosulfonamida, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen - Google Patents
Compuestos de bencenosulfonamida, un procedimiento para su preparacion y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR035257A1 AR035257A1 ARP020102609A ARP020102609A AR035257A1 AR 035257 A1 AR035257 A1 AR 035257A1 AR P020102609 A ARP020102609 A AR P020102609A AR P020102609 A ARP020102609 A AR P020102609A AR 035257 A1 AR035257 A1 AR 035257A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- groups
- alkyl
- denotes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Compuestos de fórmula (1) en la cual: G representa un grupo tal como la fórmula (2) en donde R1 y R2 representan independientemente un átomo de hidrógeno o un grupo alquilo, cicloalquilo, arilo opcionalmente sustituido, arilalquilo opcionalmente sustituido, cicloalquilalquilo, heteroarilo opcionalmente sustituido o heteroarilalquilo opcionalmente sustituido, o R1 y R2 junto con el átomo de nitrógeno forman un grupo heterocicloalquilo de fórmula (3) que tiene 5 a 7 miembros del anillo, en donde Y representa un átomo de nitrógeno, un átomo de oxígeno o un grupo CH2 y R6 representa un átomo de hidrógeno o un grupo alquilo, cicloalquilo, cicloalquilalquilo, arilo opcionalmente sustituido, arilalquilo opcionalmente sustituido, arilcarbonilo opcionalmente sustituido, arilcarbonilalquilo opcionalmente sustituido, diarilalquilo opcionalmente sustituido, diarilalquenilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroarilalquilo opcionalmente sustituido, heteroarilcarbonilo opcionalmente sustituido o heteroarilcarbonilalquilo opcionalmente sustituido; R3 representa un átomo de hidrógeno o un grupo alquilo o fenilo opcionalmente sustituido; Ra representa un grupo hidroxi, alcoxi, ariloxi opcionalmente sustituido, arilalquiloxi opcionalmente sustituido, amino, alquilamino, dialquilamino, arilamino opcionalmente sustituido o arilalquilamino opcionalmente sustituido; Rb y Rc, que pueden ser iguales o diferentes, representan cada uno un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo, un grupo alcoxi, un grupo hidroxi o un grupo trihaloalquilo; m es un número entero de 0 a 1 inclusive; n y q son números enteros iguales o diferentes de 0 a 6 inclusive; p y r son números enteros iguales o diferentes de 1 a 6 inclusive, sus enantiómeros y diastereoisómeros y también sales de adición de los mismos con un ácido o una base farmacéuticamente aceptables, en donde: el término "alquilo" denota una cadena lineal o ramificada que tiene de C1-6, el término "alcoxi" denota un grupo alquilo-oxi lineal o ramificado que tiene de C1-6, el término "trihaloalquilo" denota una cadena de carbono que tiene de C1-3 y de 1 a 3 átomos de halógeno iguales o diferentes, el término "alquenilo" denota una cadena que tiene de C2-6 y que contiene de 1 a 3 enlaces dobles, el término "cicloalquilo" denota un grupo cíclico saturado que tiene de C3-8, el término "arilo" denota un grupo fenilo o naftilo, el término "heteroarilo" denota un grupo monocíclico aromático, o un grupo bicíclico en el cual por lo menos uno de los anillos es aromático, que tiene de 5 a 11 miembros del anillo y de 1 a 5 heteroátomos seleccionados entre nitrógeno, oxígeno o azufre, los términos "diarilalquilo" y "diarilalquenilo" denotan, respectivamente, grupos alquilo y alquenilo, como se definieron en la presente más arriba, sustituidos por dos grupos arilo iguales o diferentes, como se definieron en la presente más arriba, el término "sustituido" con respecto a fenilo, arilo, arilalquilo, arilcarbonilo, arilcarbonilalquilo, diarilalquilo, diarilalquenilo, heteroarilo, heteroarilalquilo, heteroarilcarbonilo, heteroarilcarbonilalquilo, arilamino y arilalquilamino denota que los grupos en cuestión son sustituidos en la parte aromática por uno o dos sustituyentes iguales o diferentes seleccionados entre átomos de halógeno y grupos alquilo, grupos alcoxi, grupos hidroxi, grupos ciano, grupos nitro, grupos amino (opcionalmente sustituidos por uno o dos grupos alquilo) y grupos C(O)Rd, representando Rd un grupo seleccionado entre hidroxi, alcoxi y amino, en donde los grupos heteroarilo y heteroarilalquilo también pueden ser sustituidos por un grupo oxo en la parte no aromática del heteroarilo. Un procedimiento para preparar los compuestos de fórmula (1), y composiciones farmacéuticas que los comprenden. Los compuestos de fórmula (1) tienen una nueva estructura que les da un carácter antagonista del receptor de TXA2 y antagonista del receptor serotoninérgico 5HT2. Especialmente son útiles para el tratamiento de las enfermedades cardiovasculares aterotrombóticas, tales como infarto de miocardio, angina pectoris, accidentes vasculares cerebrales, enfermedad de Raynaud, y también asma y broncoespasmos, así como también migrana y enfermedades venosas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0109339A FR2827280B1 (fr) | 2001-07-13 | 2001-07-13 | Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035257A1 true AR035257A1 (es) | 2004-05-05 |
Family
ID=8865462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102609A AR035257A1 (es) | 2001-07-13 | 2002-07-12 | Compuestos de bencenosulfonamida, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6541471B1 (es) |
| EP (1) | EP1275641B1 (es) |
| JP (1) | JP3770858B2 (es) |
| KR (1) | KR100503157B1 (es) |
| CN (1) | CN1186318C (es) |
| AR (1) | AR035257A1 (es) |
| AT (1) | ATE286877T1 (es) |
| AU (1) | AU2002300092B2 (es) |
| BR (1) | BR0202685A (es) |
| CA (1) | CA2393995C (es) |
| DE (1) | DE60202554T2 (es) |
| DK (1) | DK1275641T3 (es) |
| EA (1) | EA005376B1 (es) |
| ES (1) | ES2234994T3 (es) |
| FR (1) | FR2827280B1 (es) |
| HK (1) | HK1050675A1 (es) |
| HU (1) | HUP0202284A3 (es) |
| MX (1) | MXPA02006853A (es) |
| NO (1) | NO20023390L (es) |
| NZ (1) | NZ520141A (es) |
| PL (1) | PL355009A1 (es) |
| PT (1) | PT1275641E (es) |
| SI (1) | SI1275641T1 (es) |
| ZA (1) | ZA200205597B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106083546A (zh) * | 2016-06-20 | 2016-11-09 | 上海引盛生物科技有限公司 | 一种3,5‑二溴苯甲醛的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02304022A (ja) * | 1989-05-18 | 1990-12-17 | Mitsubishi Kasei Corp | セロトニン拮抗剤 |
| US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| ATE167473T1 (de) * | 1990-08-20 | 1998-07-15 | Eisai Co Ltd | Sulfonamid-derivate |
| TW219358B (es) * | 1991-12-20 | 1994-01-21 | Hokuriku Pharmaceutical | |
| GB9220137D0 (en) * | 1992-09-23 | 1992-11-04 | Pfizer Ltd | Therapeutic agents |
| JPH0753505A (ja) * | 1992-10-01 | 1995-02-28 | Hokuriku Seiyaku Co Ltd | ベンゼンスルホンアミド誘導体及びその用途 |
| FR2760235B1 (fr) * | 1997-02-28 | 1999-04-09 | Adir | Nouveaux derives de benzenesulfonylamine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2001
- 2001-07-13 FR FR0109339A patent/FR2827280B1/fr not_active Expired - Fee Related
-
2002
- 2002-07-11 EP EP02291747A patent/EP1275641B1/fr not_active Expired - Lifetime
- 2002-07-11 AT AT02291747T patent/ATE286877T1/de not_active IP Right Cessation
- 2002-07-11 DK DK02291747T patent/DK1275641T3/da active
- 2002-07-11 PT PT02291747T patent/PT1275641E/pt unknown
- 2002-07-11 SI SI200230073T patent/SI1275641T1/xx unknown
- 2002-07-11 ES ES02291747T patent/ES2234994T3/es not_active Expired - Lifetime
- 2002-07-11 PL PL02355009A patent/PL355009A1/xx not_active Application Discontinuation
- 2002-07-11 MX MXPA02006853A patent/MXPA02006853A/es active IP Right Grant
- 2002-07-11 DE DE60202554T patent/DE60202554T2/de not_active Expired - Fee Related
- 2002-07-12 JP JP2002203408A patent/JP3770858B2/ja not_active Expired - Fee Related
- 2002-07-12 AR ARP020102609A patent/AR035257A1/es not_active Application Discontinuation
- 2002-07-12 NO NO20023390A patent/NO20023390L/no not_active Application Discontinuation
- 2002-07-12 EA EA200200666A patent/EA005376B1/ru not_active IP Right Cessation
- 2002-07-12 HU HU0202284A patent/HUP0202284A3/hu unknown
- 2002-07-12 BR BR0202685-6A patent/BR0202685A/pt not_active IP Right Cessation
- 2002-07-12 US US10/195,018 patent/US6541471B1/en not_active Expired - Fee Related
- 2002-07-12 AU AU2002300092A patent/AU2002300092B2/en not_active Ceased
- 2002-07-12 ZA ZA200205597A patent/ZA200205597B/xx unknown
- 2002-07-12 NZ NZ520141A patent/NZ520141A/en unknown
- 2002-07-13 KR KR10-2002-0040946A patent/KR100503157B1/ko not_active IP Right Cessation
- 2002-07-15 CN CNB021241627A patent/CN1186318C/zh not_active Expired - Fee Related
- 2002-07-15 CA CA002393995A patent/CA2393995C/fr not_active Expired - Fee Related
-
2003
- 2003-04-17 HK HK03102799A patent/HK1050675A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |