AR028818A1 - Pirido-tieno-diazepinas, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que las contienen y compuestos intermediarios utilizados en dicho procedimiento - Google Patents
Pirido-tieno-diazepinas, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que las contienen y compuestos intermediarios utilizados en dicho procedimientoInfo
- Publication number
- AR028818A1 AR028818A1 ARP000101597A ARP000101597A AR028818A1 AR 028818 A1 AR028818 A1 AR 028818A1 AR P000101597 A ARP000101597 A AR P000101597A AR P000101597 A ARP000101597 A AR P000101597A AR 028818 A1 AR028818 A1 AR 028818A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- optionally substituted
- hydrogen atom
- lower alkyl
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Nuevas pirido - tieno - diazepinas, procedimiento para su preparacion, medicamentos y composiciones farmacéuticas que las contienen y productos intermedios utilizados en dicho procedimiento. Estas diazepinas son particularmente utiles para tratar los estados patologicos o las enfermedades en las cuales intervienen uno o más receptores de la somatostatina. Las referidas pirido - tieno - diazepinas responden a la formula (1) en forma racémica, enantiomérica o diastereomérica o mezclas de las mismas. En la cual R1 representa un átomo de hidrogeno o un radical de la formula R'1 - NH - C (Y)-; R'1 representa un radical arilo o héteroarilo, estando los radicales arilo y héteroarilo, opcionalmente sustituídos; R2 representa un radical alquilo inferior, un radical trifluormetilo o un radical fenilo, opcionalmente sustituído; X e Y, independientemente entre si, representan O o S; R3a representa un átomo de hidrogeno, un radical alquilo inferior, hidroxi o un radical de la siguiente formula: -OC (O) R'3a; R'3a representa un radical alquilo que contiene C1-10 opcionalmente sustituído; R3b representa un átomo de hidrogeno o un radical alquilo inferior, R4 representa un radical de la siguiente formula: -(CH2)n-CHR'R4R''4, n representa los numeros enteros 0, 1, 2, 3, 4, 5 o 6; R'4 y R4'' representan, independientemente entre sí, un átomo de hidrogeno, un radical alquilo inferior, cicloalquilo, cicloalquilo inferior alquilo, arilo, arialquilo inferior, héteroarilo, héteroarilalquilo inferior, arilcarbonilo o adamantilo, estando dichos radicales, opcionalmente sustituídos; A---B representa -C=N- o -C-N(R5)-; R5 representa un átomo de hidrogeno, un radical alquilo inferior, alquenilo inferior, o un radical de la formula -C(O) -)CH2) p-R'5; R'5 representa un átomo de hidrogeno, un radical amino, alquil inferior amino, di (alquilo inferior) amino, cicloalquilo, héterociclo alquilo guanidilo opcionalmente sustituído por nitro o ciano, arilo opcionalmente sustituído, héteroarilo o un radical de la formula -NH-C (O)- (CH2) c - NH - C (O) - (CH2) d - NH2; p representa los numeros enteros 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 o 10; c y d representan, independientemente entre sí, los numeros enteros 0, 1, 2 o 3; o una sal de estos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9904440A FR2791980B1 (fr) | 1999-04-09 | 1999-04-09 | Pyrido-thieno-diazepines, leur procede de preparation, et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR028818A1 true AR028818A1 (es) | 2003-05-28 |
Family
ID=9544211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000101597A AR028818A1 (es) | 1999-04-09 | 2000-04-07 | Pirido-tieno-diazepinas, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que las contienen y compuestos intermediarios utilizados en dicho procedimiento |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6777408B1 (es) |
| EP (1) | EP1171444B1 (es) |
| JP (1) | JP4681737B2 (es) |
| AR (1) | AR028818A1 (es) |
| AT (1) | ATE244246T1 (es) |
| AU (1) | AU3825700A (es) |
| CA (1) | CA2369725C (es) |
| CZ (1) | CZ302455B6 (es) |
| DE (1) | DE60003662T2 (es) |
| DK (1) | DK1171444T3 (es) |
| ES (1) | ES2202091T3 (es) |
| FR (1) | FR2791980B1 (es) |
| HU (1) | HUP0200928A3 (es) |
| MY (1) | MY120085A (es) |
| NO (1) | NO20014803L (es) |
| PL (1) | PL207639B1 (es) |
| PT (1) | PT1171444E (es) |
| RU (1) | RU2245883C2 (es) |
| TW (1) | TW513433B (es) |
| WO (1) | WO2000061587A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002359359A1 (en) | 2001-12-28 | 2003-07-24 | Somatocor Pharmaceuticals, Inc. | Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands |
| AU2007325315A1 (en) * | 2006-11-28 | 2008-06-05 | Kalypsys Inc | Heterocyclic modulators of TGR5 |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| HUE043441T2 (hu) | 2014-06-20 | 2019-08-28 | Constellation Pharmaceuticals Inc | 2-((4S)-6-(4-klórfenil)-l-metil-4H-benzo[c]izoxazolo[4,5-e]azepin-4-il)acetamid kristályos formái |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3435974A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| NL9000627A (nl) * | 1990-03-29 | 1991-10-16 | Scras | Werkwijze ter bereiding van nieuwe thienotriazolo-diazepines. |
| JP3239364B2 (ja) * | 1991-10-11 | 2001-12-17 | ウェルファイド株式会社 | 骨粗鬆症治療薬およびジアゼピン化合物 |
| CA2144985A1 (en) * | 1992-09-18 | 1994-03-31 | Minoru Moriwaki | Thienodiazepine compounds and their pharmaceutical use |
| EP0661284A1 (en) * | 1992-09-18 | 1995-07-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienodiazepine compound and medicinal use thereof |
| DE19636769A1 (de) * | 1996-09-10 | 1998-03-12 | Basf Ag | 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| CZ20004640A3 (cs) * | 1999-06-15 | 2001-06-13 | Sod Conseils Rech Applic | Nové diazepiny, kompozice s jejich obsahem a léčivo pro léčení patologických stavů nebo onemocnění při kterých působí receptory somatostatinu |
-
1999
- 1999-04-09 FR FR9904440A patent/FR2791980B1/fr not_active Expired - Fee Related
-
2000
- 2000-04-07 AR ARP000101597A patent/AR028818A1/es active IP Right Grant
- 2000-04-07 DE DE60003662T patent/DE60003662T2/de not_active Expired - Lifetime
- 2000-04-07 US US09/958,168 patent/US6777408B1/en not_active Expired - Fee Related
- 2000-04-07 CA CA2369725A patent/CA2369725C/fr not_active Expired - Fee Related
- 2000-04-07 RU RU2001130147/04A patent/RU2245883C2/ru not_active IP Right Cessation
- 2000-04-07 ES ES00917149T patent/ES2202091T3/es not_active Expired - Lifetime
- 2000-04-07 JP JP2000610858A patent/JP4681737B2/ja not_active Expired - Fee Related
- 2000-04-07 HU HU0200928A patent/HUP0200928A3/hu unknown
- 2000-04-07 CZ CZ20013572A patent/CZ302455B6/cs not_active IP Right Cessation
- 2000-04-07 PL PL350902A patent/PL207639B1/pl unknown
- 2000-04-07 DK DK00917149T patent/DK1171444T3/da active
- 2000-04-07 WO PCT/FR2000/000881 patent/WO2000061587A1/fr active IP Right Grant
- 2000-04-07 EP EP00917149A patent/EP1171444B1/fr not_active Expired - Lifetime
- 2000-04-07 PT PT00917149T patent/PT1171444E/pt unknown
- 2000-04-07 AU AU38257/00A patent/AU3825700A/en not_active Abandoned
- 2000-04-07 AT AT00917149T patent/ATE244246T1/de active
- 2000-04-08 MY MYPI20001477A patent/MY120085A/en unknown
- 2000-04-08 TW TW089106560A patent/TW513433B/zh not_active IP Right Cessation
-
2001
- 2001-10-03 NO NO20014803A patent/NO20014803L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2202091T3 (es) | 2004-04-01 |
| MY120085A (en) | 2005-08-30 |
| CA2369725C (fr) | 2011-05-31 |
| DE60003662T2 (de) | 2004-06-09 |
| EP1171444B1 (fr) | 2003-07-02 |
| DE60003662D1 (de) | 2003-08-07 |
| PL207639B1 (pl) | 2011-01-31 |
| JP2002541260A (ja) | 2002-12-03 |
| AU3825700A (en) | 2000-11-14 |
| JP4681737B2 (ja) | 2011-05-11 |
| DK1171444T3 (da) | 2003-10-27 |
| WO2000061587A1 (fr) | 2000-10-19 |
| CZ302455B6 (cs) | 2011-06-01 |
| HUP0200928A3 (en) | 2004-07-28 |
| NO20014803L (no) | 2001-10-04 |
| FR2791980A1 (fr) | 2000-10-13 |
| NO20014803D0 (no) | 2001-10-03 |
| FR2791980B1 (fr) | 2001-07-06 |
| PT1171444E (pt) | 2003-11-28 |
| HUP0200928A2 (hu) | 2002-07-29 |
| ATE244246T1 (de) | 2003-07-15 |
| RU2245883C2 (ru) | 2005-02-10 |
| PL350902A1 (en) | 2003-02-10 |
| TW513433B (en) | 2002-12-11 |
| CA2369725A1 (fr) | 2000-10-19 |
| EP1171444A1 (fr) | 2002-01-16 |
| US6777408B1 (en) | 2004-08-17 |
| CZ20013572A3 (cs) | 2002-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |