AR023678A1 - Benzotieno[3,2-c]piridinas como antagonistas de alfa2, proceso para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de un medicamento. - Google Patents
Benzotieno[3,2-c]piridinas como antagonistas de alfa2, proceso para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de un medicamento.Info
- Publication number
- AR023678A1 AR023678A1 ARP990105039A ARP990105039A AR023678A1 AR 023678 A1 AR023678 A1 AR 023678A1 AR P990105039 A ARP990105039 A AR P990105039A AR P990105039 A ARP990105039 A AR P990105039A AR 023678 A1 AR023678 A1 AR 023678A1
- Authority
- AR
- Argentina
- Prior art keywords
- manufacture
- pharmaceutical compositions
- piridinas
- benzotiene
- anfagist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se refiere a benzotieno[3,2-c]piridinas tricíclicas como antagonistas de alfa 2 que comprenden los compuestos de la formula (1), las formas de N-oxido, lassales de adicion farmacéuticamente aceptables y las formas estereoquímicamente isoméricas delo s mismos, donde cada R1 es independientemente hidrogeno,halogeno, alquilo C1-6, nitro, hidroxi o alquiloxi C1-4; Alk es alcanodiilo C1-6; n es 1 o 2 ; p es 0, 1 o 2; D es un heterociclo con contenido de nitrogenomono, bi- o tricíclico, conactividad antagonista del adrenorreceptor alfa2 central. También se relaciona con un proceso de preparacion , composicionesfarmacéuticas que los comprenden y el uso de los mismos para la manufactura de un medicamento utiles para el tratamiento yprofilaxis de la depresion, lostrastornos cognoscitivos, la enfermedad de Parkinson, la diabetes Mellitus, disfuncion sexual y la impotencia , la presion intraocular elevada y lasenfermedades relacionadas con perturbaciones de la enterocinesia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203363 | 1998-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023678A1 true AR023678A1 (es) | 2002-09-04 |
Family
ID=8234188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105039A AR023678A1 (es) | 1998-10-06 | 1999-10-05 | Benzotieno[3,2-c]piridinas como antagonistas de alfa2, proceso para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de un medicamento. |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6426350B1 (es) |
| EP (1) | EP1117667B1 (es) |
| JP (1) | JP4580555B2 (es) |
| KR (1) | KR20010071828A (es) |
| CN (1) | CN1158287C (es) |
| AR (1) | AR023678A1 (es) |
| AT (1) | ATE363485T1 (es) |
| AU (1) | AU760226B2 (es) |
| BG (1) | BG64625B1 (es) |
| BR (1) | BR9913110A (es) |
| CA (1) | CA2346084C (es) |
| CZ (1) | CZ20011103A3 (es) |
| DE (1) | DE69936219T2 (es) |
| EE (1) | EE04835B1 (es) |
| ES (1) | ES2288025T3 (es) |
| HK (1) | HK1039113A1 (es) |
| HU (1) | HUP0103612A3 (es) |
| ID (1) | ID28280A (es) |
| IL (2) | IL142442A0 (es) |
| NO (1) | NO20011309D0 (es) |
| NZ (1) | NZ509911A (es) |
| PL (1) | PL347184A1 (es) |
| RU (1) | RU2222542C2 (es) |
| SK (1) | SK4312001A3 (es) |
| TR (1) | TR200100954T2 (es) |
| TW (1) | TWI251595B (es) |
| UA (1) | UA70334C2 (es) |
| WO (1) | WO2000020422A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1482964B1 (en) * | 2002-03-08 | 2011-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of egfr transactivation inhibitors in human cancer |
| EP1490338B1 (en) * | 2002-04-03 | 2011-08-24 | Orion Corporation | Use of an alfa2-adrenoreceptor antagonist for cns-related diseases |
| JP4816453B2 (ja) | 2004-04-12 | 2011-11-16 | 大正製薬株式会社 | 環状アミン化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3752820A (en) | 1972-03-20 | 1973-08-14 | Colgate Palmolive Co | Substituted-1,2,3,4-tetrahydrobenzothieno(3,2-c)pyridine derivatives |
| FR2570701B1 (fr) * | 1984-09-27 | 1987-05-22 | Synthelabo | Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique |
| US4686226A (en) | 1985-09-03 | 1987-08-11 | Merck & Co., Inc. | Substituted benzo[b]furo- and benzo[b]thieno quinolizines |
| EP0339959A3 (en) * | 1988-04-27 | 1991-03-20 | Glaxo Group Limited | Lactam derivatives |
| US5100891A (en) * | 1991-01-18 | 1992-03-31 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds |
| ATE247114T1 (de) * | 1994-09-12 | 2003-08-15 | Lilly Co Eli | Serotonergische modulatoren |
| JP3274579B2 (ja) * | 1995-01-12 | 2002-04-15 | 住友製薬株式会社 | 脳血管障害に伴う精神症候治療剤 |
| UA52681C2 (uk) | 1997-04-08 | 2003-01-15 | Янссен Фармацевтика Н.В. | Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі |
-
1999
- 1999-01-10 UA UA2001031998A patent/UA70334C2/uk unknown
- 1999-10-01 EP EP99947469A patent/EP1117667B1/en not_active Expired - Lifetime
- 1999-10-01 NZ NZ509911A patent/NZ509911A/xx unknown
- 1999-10-01 EE EEP200100206A patent/EE04835B1/xx not_active IP Right Cessation
- 1999-10-01 DE DE69936219T patent/DE69936219T2/de not_active Expired - Lifetime
- 1999-10-01 WO PCT/EP1999/007418 patent/WO2000020422A1/en active IP Right Grant
- 1999-10-01 TW TW088116899A patent/TWI251595B/zh not_active IP Right Cessation
- 1999-10-01 TR TR2001/00954T patent/TR200100954T2/xx unknown
- 1999-10-01 JP JP2000574534A patent/JP4580555B2/ja not_active Expired - Fee Related
- 1999-10-01 US US09/806,432 patent/US6426350B1/en not_active Expired - Lifetime
- 1999-10-01 ES ES99947469T patent/ES2288025T3/es not_active Expired - Lifetime
- 1999-10-01 RU RU2001111753/04A patent/RU2222542C2/ru not_active IP Right Cessation
- 1999-10-01 BR BR9913110-2A patent/BR9913110A/pt not_active Application Discontinuation
- 1999-10-01 PL PL99347184A patent/PL347184A1/xx not_active Application Discontinuation
- 1999-10-01 SK SK431-2001A patent/SK4312001A3/sk unknown
- 1999-10-01 CN CNB998116777A patent/CN1158287C/zh not_active Expired - Fee Related
- 1999-10-01 CZ CZ20011103A patent/CZ20011103A3/cs unknown
- 1999-10-01 IL IL14244299A patent/IL142442A0/xx active IP Right Grant
- 1999-10-01 HU HU0103612A patent/HUP0103612A3/hu unknown
- 1999-10-01 CA CA2346084A patent/CA2346084C/en not_active Expired - Fee Related
- 1999-10-01 ID IDW20010781A patent/ID28280A/id unknown
- 1999-10-01 AU AU60899/99A patent/AU760226B2/en not_active Ceased
- 1999-10-01 KR KR1020017000400A patent/KR20010071828A/ko active Search and Examination
- 1999-10-01 AT AT99947469T patent/ATE363485T1/de not_active IP Right Cessation
- 1999-10-05 AR ARP990105039A patent/AR023678A1/es active IP Right Grant
-
2001
- 2001-03-12 BG BG105331A patent/BG64625B1/bg unknown
- 2001-03-15 NO NO20011309A patent/NO20011309D0/no not_active Application Discontinuation
- 2001-04-04 IL IL142442A patent/IL142442A/en not_active IP Right Cessation
- 2001-12-15 HK HK01108819A patent/HK1039113A1/xx not_active IP Right Cessation
-
2002
- 2002-04-16 US US10/123,338 patent/US6774129B2/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |