AR023400A1 - Metodos para inducir la muerte de celulas cancerosas y la regresion de tumores - Google Patents
Metodos para inducir la muerte de celulas cancerosas y la regresion de tumoresInfo
- Publication number
- AR023400A1 AR023400A1 ARP000101576A ARP000101576A AR023400A1 AR 023400 A1 AR023400 A1 AR 023400A1 AR P000101576 A ARP000101576 A AR P000101576A AR P000101576 A ARP000101576 A AR P000101576A AR 023400 A1 AR023400 A1 AR 023400A1
- Authority
- AR
- Argentina
- Prior art keywords
- cancer cells
- methods
- induce death
- death
- regression
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Uso para tratar cáncer en un paciente que necesita dicho tratamiento, que comprende cantidades que son eficaces para inducir un nivel sinérgico de muertede las células cancerosas de (1) un inhibidor de FPT y (2) un inhibidor de vía de senalizacionRa s adicional para inducir regresion del tumor y muerte de lascélulas cancerosas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/289,255 US6316462B1 (en) | 1999-04-09 | 1999-04-09 | Methods of inducing cancer cell death and tumor regression |
Publications (1)
Publication Number | Publication Date |
---|---|
AR023400A1 true AR023400A1 (es) | 2002-09-04 |
Family
ID=23110723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000101576A AR023400A1 (es) | 1999-04-09 | 2000-04-06 | Metodos para inducir la muerte de celulas cancerosas y la regresion de tumores |
Country Status (24)
Country | Link |
---|---|
US (1) | US6316462B1 (es) |
EP (1) | EP1165078B1 (es) |
JP (1) | JP2003529540A (es) |
CN (1) | CN100421661C (es) |
AR (1) | AR023400A1 (es) |
AT (1) | ATE347360T1 (es) |
AU (1) | AU783177B2 (es) |
BR (1) | BR0009670A (es) |
CA (1) | CA2364675A1 (es) |
CY (1) | CY1107545T1 (es) |
DE (1) | DE60032226T2 (es) |
DK (1) | DK1165078T3 (es) |
ES (1) | ES2275505T3 (es) |
HK (1) | HK1038512B (es) |
HU (1) | HUP0200773A3 (es) |
MX (1) | MXPA01010211A (es) |
MY (1) | MY120841A (es) |
NO (1) | NO329133B1 (es) |
NZ (1) | NZ514628A (es) |
PE (1) | PE20010025A1 (es) |
PT (1) | PT1165078E (es) |
TW (1) | TWI255184B (es) |
WO (1) | WO2000061145A1 (es) |
ZA (1) | ZA200108258B (es) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
US20030060434A1 (en) * | 1997-02-18 | 2003-03-27 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
US20030064949A1 (en) * | 1998-02-17 | 2003-04-03 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
IL144144A0 (en) | 1999-01-13 | 2002-05-23 | Bayer Ag | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
US20030086924A1 (en) * | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
HU226742B1 (en) * | 1999-06-25 | 2009-08-28 | Genentech Inc | Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies |
US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
US20040013667A1 (en) * | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
JP2003525246A (ja) * | 2000-02-29 | 2003-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 白金化合物とのファルネシルタンパク質トランスフェラーゼ阻害剤の組み合わせ剤 |
DE10017480A1 (de) * | 2000-04-07 | 2001-10-11 | Transmit Technologietransfer | Verwendung von Substanzen, die als MEK Inhibitor wirken, zur Herstellung eines Arneimittels gegen DNA- und RNA-Viren |
WO2001083781A2 (en) * | 2000-04-28 | 2001-11-08 | Millennium Pharmaceuticals, Inc. | 14094, a novel human trypsin family member and uses thereof |
PL400669A1 (pl) | 2000-05-19 | 2012-11-05 | Genentech, Inc. | Genowa próba wykrywania odpowiedzi na antagoniste ErbB dla poprawienia prawdopodobienstwa i skutecznosci leczenia raka |
AU2002211427A1 (en) * | 2000-10-05 | 2002-04-15 | Whitehead Institute For Biomedical Research | Effects of combined administration of farnesyl transferase inhibitors and signal transduction inhibitors |
BR0114430A (pt) * | 2000-10-05 | 2004-01-06 | George Q Daley | Processos para a indução da morte de células cancerìgenas e para a regressão de tumor |
JP4458746B2 (ja) * | 2001-01-16 | 2010-04-28 | グラクソ グループ リミテッド | 癌の治療方法 |
EP1353924A1 (en) * | 2001-01-18 | 2003-10-22 | Schering Corporation | Synthesis of temozolomide and analogs |
NZ516873A (en) * | 2001-02-12 | 2003-11-28 | Warner Lambert Co | Compositions containing retinoids and erb inhibitors and their use in inhibiting retinoid skin damage |
US6703400B2 (en) | 2001-02-23 | 2004-03-09 | Schering Corporation | Methods for treating multidrug resistance |
CN1617755A (zh) * | 2001-11-30 | 2005-05-18 | 先灵公司 | 法尼基蛋白转移酶抑制剂和其它抗肿瘤剂联合使用在制备抗癌症的药物中的应用 |
WO2003047586A1 (en) * | 2001-12-03 | 2003-06-12 | Schering Corporation | Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer |
JP4636486B2 (ja) | 2002-02-11 | 2011-02-23 | バイエル、ファーマシューテイカルズ、コーポレイション | 脈管形成阻害活性を有するアリール尿素 |
WO2003090686A2 (en) | 2002-04-25 | 2003-11-06 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
US6984389B2 (en) * | 2002-04-25 | 2006-01-10 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
EP2316922B1 (en) * | 2002-05-24 | 2013-05-22 | Merck Sharp & Dohme Corp. | Neutralizing human anti-IGFR antibody |
WO2004041185A2 (en) * | 2002-10-31 | 2004-05-21 | University Of Rochester | Hyfroxyflutamide induced pathways related to androgen receptor negative prostate cancer cells |
US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
US8168568B1 (en) | 2003-03-10 | 2012-05-01 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Combinatorial therapy for protein signaling diseases |
WO2005016970A2 (en) * | 2003-05-01 | 2005-02-24 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
ES2305808T3 (es) | 2003-05-20 | 2008-11-01 | Bayer Healthcare Llc | Diarilureas con actividad inhibidora de quinasas. |
CL2004001834A1 (es) | 2003-07-23 | 2005-06-03 | Bayer Pharmaceuticals Corp | Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol |
US7326567B2 (en) | 2003-11-12 | 2008-02-05 | Schering Corporation | Plasmid system for multigene expression |
WO2005051392A1 (en) | 2003-11-20 | 2005-06-09 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use |
AR046639A1 (es) * | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
JP2007513967A (ja) * | 2003-12-11 | 2007-05-31 | セラヴァンス, インコーポレーテッド | 変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物 |
US20050232927A1 (en) * | 2004-02-03 | 2005-10-20 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
US20060205810A1 (en) * | 2004-11-24 | 2006-09-14 | Schering Corporation | Platinum therapeutic combinations |
MX2007006640A (es) * | 2004-12-03 | 2007-06-19 | Schering Corp | Biomarcadores para la preseleccion de pacientes para la terapia con anti-receptor 1 del factor de crecimiento similar a la insulina. |
KR20190110637A (ko) | 2005-01-21 | 2019-09-30 | 제넨테크, 인크. | Her 항체의 고정 용량 투여법 |
RU2404806C2 (ru) | 2005-02-23 | 2010-11-27 | Дженентек, Инк. | Продление времени до прогрессирования заболевания или продолжительности жизни у онкологических больных с применением ингибиторов димеризации her |
US7524831B2 (en) * | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
CN101222926B (zh) * | 2005-04-15 | 2013-07-17 | 默沙东公司 | 用于治疗或预防癌症的方法和组合物 |
CN109485727A (zh) * | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
EP1896505A2 (en) * | 2005-06-15 | 2008-03-12 | Schering Corporation | Anti-igf1r antibody formulations |
CN101613409B (zh) | 2005-06-17 | 2014-06-04 | 英克隆有限责任公司 | 抗-PDGFRα抗体 |
US8101799B2 (en) | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
US9095581B2 (en) | 2005-07-21 | 2015-08-04 | Ardea Biosciences, Inc. | Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof |
CA2617056A1 (en) | 2005-07-29 | 2007-02-08 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase |
UA95945C2 (ru) * | 2006-02-03 | 2011-09-26 | Имклоун Ллк | Способ лечения рака предстательной железы, который включает проведение терапии депривацией андрогенов в комбинации с введением imc-а12 |
US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
ES2427924T3 (es) * | 2006-06-30 | 2013-11-04 | Merck Sharp & Dohme Corp. | Biomarcador IGFBP2 |
EP2076259A2 (en) * | 2006-10-25 | 2009-07-08 | Schering Corporation | Methods of treating ovarian cancer |
PE20090681A1 (es) | 2007-03-02 | 2009-06-10 | Genentech Inc | Prediccion de respuesta a un inhibidor her |
JP2010526809A (ja) | 2007-05-08 | 2010-08-05 | シェーリング コーポレイション | テモゾロミドを含む静脈内処方物を用いる治療方法 |
US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
WO2008154249A2 (en) | 2007-06-08 | 2008-12-18 | Genentech, Inc. | Gene expression markers of tumor resistance to her2 inhibitor treatment |
JP5479337B2 (ja) * | 2007-07-30 | 2014-04-23 | アルディア バイオサイエンス,インク. | Mek阻害剤およびrafキナーゼ阻害剤の組み合わせ、ならびにその使用 |
WO2009145852A1 (en) * | 2008-04-17 | 2009-12-03 | Concert Pharmaceuticals, Inc. | Tricyclic benzo[5,6]cyclohepta[1,2-b]pyridine derivatives and uses thereof |
BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
JP2012506380A (ja) * | 2008-10-21 | 2012-03-15 | エンゾン ファーマシューティカルズ,インコーポレーテッド | 7−エチル−10−ヒドロキシカンプトテシンのマルチアーム型ポリマーコンジュゲートによる神経芽腫の治療 |
TW201544123A (zh) | 2009-03-20 | 2015-12-01 | Genentech Inc | 抗-her抗體 |
CA2761280A1 (en) | 2009-05-29 | 2010-12-02 | F. Hoffmann-La Roche Ag | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
US9556249B2 (en) | 2010-02-18 | 2017-01-31 | Genentech, Inc. | Neuregulin antagonists and use thereof in treating cancer |
WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
WO2012069466A1 (en) | 2010-11-24 | 2012-05-31 | Novartis Ag | Multispecific molecules |
JP5766296B2 (ja) | 2010-12-23 | 2015-08-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用 |
CN103890007A (zh) | 2011-08-17 | 2014-06-25 | 霍夫曼-拉罗奇有限公司 | 神经调节蛋白抗体及其用途 |
WO2013063229A1 (en) | 2011-10-25 | 2013-05-02 | The Regents Of The University Of Michigan | Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells |
WO2013081645A2 (en) | 2011-11-30 | 2013-06-06 | Genentech, Inc. | Erbb3 mutations in cancer |
WO2013083810A1 (en) | 2011-12-09 | 2013-06-13 | F. Hoffmann-La Roche Ag | Identification of non-responders to her2 inhibitors |
RU2014136886A (ru) | 2012-03-27 | 2016-05-20 | Дженентек, Инк. | Диагностика и виды лечения, связанные с ингибиторами her3 |
WO2013166043A1 (en) | 2012-05-02 | 2013-11-07 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
MX363188B (es) | 2012-11-30 | 2019-03-13 | Hoffmann La Roche | Identificación de pacientes con necesidad de coterapia del inhibidor de pd-l1. |
AU2015249225B2 (en) * | 2014-04-25 | 2019-11-07 | Memorial Sloan-Kettering Cancer Center | Treatment of H-Ras-driven tumors |
US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
EP3454863A1 (en) | 2016-05-10 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations therapies for the treatment of cancer |
US20240058321A1 (en) | 2021-11-02 | 2024-02-22 | Semmelweis Egyetem | Farnesyl-transferase inhibitors and kras inhibitors for treating kras mutant cancers |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2546577B2 (de) | 1975-10-17 | 1981-04-02 | Sandoz-Patent-GmbH, 7850 Lörrach | Feste Stoffe aus Polyvinylpyrrolidon und Ergotalkaloiden |
EP0214092A1 (en) | 1985-08-08 | 1987-03-11 | Ciba-Geigy Ag | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
US4764378A (en) | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
US4826853A (en) | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
US5089496A (en) | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
EP0341860B1 (en) | 1988-04-28 | 1994-07-13 | Schering Corporation | Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use |
US5393890A (en) | 1988-06-02 | 1995-02-28 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
DE3830353A1 (de) | 1988-09-07 | 1990-03-15 | Basf Ag | Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen |
US5416091A (en) | 1990-12-18 | 1995-05-16 | Burroughs Wellcome Co. | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance |
CZ236294A3 (en) | 1992-03-27 | 1995-07-12 | Schering Corp | Bridge bis-aryl carbinol derivatives, preparations based thereon and their use |
US5512293A (en) | 1992-07-23 | 1996-04-30 | Alza Corporation | Oral sustained release drug delivery device |
FR2698560B1 (fr) | 1992-11-30 | 1995-02-03 | Virbac Laboratoires | Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications. |
US5719148A (en) | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
IL111258A0 (en) | 1993-10-15 | 1994-12-29 | Schering Corp | Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
US5721236A (en) | 1993-10-15 | 1998-02-24 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
IL111235A (en) | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
US5661152A (en) | 1993-10-15 | 1997-08-26 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5464840A (en) | 1993-12-06 | 1995-11-07 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5523095A (en) | 1993-12-15 | 1996-06-04 | Eastman Chemical Company | Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends |
CN1093758C (zh) | 1994-12-19 | 2002-11-06 | 第一制药株式会社 | 缓释粒状制剂及其制备方法 |
US5700806A (en) | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5684013A (en) | 1995-03-24 | 1997-11-04 | Schering Corporation | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
IL117798A (en) | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
US5712280A (en) | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
EP0856315B1 (en) | 1995-08-09 | 2005-08-24 | Banyu Pharmaceutical Co., Ltd. | Protein-farnesyltransferase inhibitors in combination with hmgcoa-reductase-inhibitors for the treatment of aids |
US5874442A (en) | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
AR005152A1 (es) | 1995-12-22 | 1999-04-14 | Schering Corp | Amidas tricíclicas útiles para la inhibición de la función de la proteina-g, sus sales , una composición farmacéutica que las contienen y el uso de las mismas para la fabricación de un medicamento para el tratamiento de enfermedades proliferativas |
WO1997036587A1 (en) | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | A method of treating cancer |
WO1997038697A1 (en) | 1996-04-15 | 1997-10-23 | The Trustees Of The University Of Pennsylvania | Sensitization of cells to radiation and chemotherapy |
CA2251955A1 (en) | 1996-04-18 | 1997-10-23 | Nancy E. Kohl | A method of treating cancer |
EP0934270A1 (en) | 1996-05-30 | 1999-08-11 | Merck & Co., Inc. | A method of treating cancer |
DE69730241T2 (de) | 1996-06-28 | 2005-08-11 | Schering Corp. | Feste lösung eines fungizids mit erhöhter bioverfügbarkeit |
US5972381A (en) | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
US6040305A (en) | 1996-09-13 | 2000-03-21 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
US5861395A (en) | 1996-09-13 | 1999-01-19 | Schering Corporation | Compounds useful for inhibition of farnesyl proteins transferase |
US5985879A (en) | 1996-09-13 | 1999-11-16 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
US5958890A (en) | 1996-09-13 | 1999-09-28 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5965570A (en) | 1996-09-13 | 1999-10-12 | Schering Corporation | Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase |
TR199901275T2 (xx) | 1996-09-13 | 1999-09-21 | Schering Corporation | Farnezil protein transferaz inhibisyonu i�in yararl� bile�ikler. |
US6030982A (en) | 1996-09-13 | 2000-02-29 | Schering Corporationm | Compounds useful for inhibition of farnesyl protein transferase |
US5945429A (en) | 1996-09-13 | 1999-08-31 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
US6071907A (en) | 1996-09-13 | 2000-06-06 | Schering Corporation | Tricyclic compounds useful as FPT inhibitors |
ATE361668T1 (de) | 1997-02-18 | 2007-06-15 | Canji Inc | Kombinierte tumor suppressor-gen-therapie und chemotherapie bei der neoplasmabehandlung |
GB9801231D0 (en) | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
US5925639A (en) | 1997-06-17 | 1999-07-20 | Schering Corporation | Keto amide derivatives useful as farnesyl protein transferase inhibitors |
US5939416A (en) | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
US5852034A (en) | 1997-06-17 | 1998-12-22 | Schering Corporation | Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors |
US5877177A (en) | 1997-06-17 | 1999-03-02 | Schering Corporation | Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5958940A (en) | 1997-09-11 | 1999-09-28 | Schering Corporation | Tricyclic compounds useful as inhibitors of farnesyl-protein transferase |
ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
HU229052B1 (en) | 1997-12-22 | 2013-07-29 | Merck Sharp & Dohme | Molecular dispersion composition with enhanced bioavailability |
-
1999
- 1999-04-09 US US09/289,255 patent/US6316462B1/en not_active Expired - Fee Related
-
2000
- 2000-04-06 PT PT00921765T patent/PT1165078E/pt unknown
- 2000-04-06 WO PCT/US2000/009124 patent/WO2000061145A1/en active IP Right Grant
- 2000-04-06 EP EP00921765A patent/EP1165078B1/en not_active Expired - Lifetime
- 2000-04-06 HU HU0200773A patent/HUP0200773A3/hu unknown
- 2000-04-06 DK DK00921765T patent/DK1165078T3/da active
- 2000-04-06 AT AT00921765T patent/ATE347360T1/de not_active IP Right Cessation
- 2000-04-06 CN CNB008085293A patent/CN100421661C/zh not_active Expired - Fee Related
- 2000-04-06 JP JP2000610478A patent/JP2003529540A/ja active Pending
- 2000-04-06 DE DE60032226T patent/DE60032226T2/de not_active Expired - Lifetime
- 2000-04-06 TW TW089106323A patent/TWI255184B/zh not_active IP Right Cessation
- 2000-04-06 AR ARP000101576A patent/AR023400A1/es unknown
- 2000-04-06 CA CA002364675A patent/CA2364675A1/en not_active Abandoned
- 2000-04-06 NZ NZ514628A patent/NZ514628A/xx not_active IP Right Cessation
- 2000-04-06 BR BR0009670-9A patent/BR0009670A/pt not_active IP Right Cessation
- 2000-04-06 MX MXPA01010211A patent/MXPA01010211A/es active IP Right Grant
- 2000-04-06 AU AU42041/00A patent/AU783177B2/en not_active Ceased
- 2000-04-06 ES ES00921765T patent/ES2275505T3/es not_active Expired - Lifetime
- 2000-04-07 MY MYPI20001455A patent/MY120841A/en unknown
- 2000-04-07 PE PE2000000317A patent/PE20010025A1/es not_active Application Discontinuation
-
2001
- 2001-10-08 NO NO20014897A patent/NO329133B1/no not_active IP Right Cessation
- 2001-10-08 ZA ZA200108258A patent/ZA200108258B/xx unknown
-
2002
- 2002-01-09 HK HK02100132.7A patent/HK1038512B/zh not_active IP Right Cessation
-
2007
- 2007-03-01 CY CY20071100296T patent/CY1107545T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HK1038512B (zh) | 2007-04-27 |
ATE347360T1 (de) | 2006-12-15 |
ES2275505T3 (es) | 2007-06-16 |
CY1107545T1 (el) | 2013-03-13 |
DE60032226D1 (de) | 2007-01-18 |
BR0009670A (pt) | 2002-01-15 |
EP1165078A1 (en) | 2002-01-02 |
JP2003529540A (ja) | 2003-10-07 |
AU4204100A (en) | 2000-11-14 |
EP1165078B1 (en) | 2006-12-06 |
DK1165078T3 (da) | 2007-04-16 |
MY120841A (en) | 2005-11-30 |
PE20010025A1 (es) | 2001-02-05 |
AU783177B2 (en) | 2005-09-29 |
CN1364084A (zh) | 2002-08-14 |
MXPA01010211A (es) | 2002-09-18 |
PT1165078E (pt) | 2007-02-28 |
CA2364675A1 (en) | 2000-10-19 |
ZA200108258B (en) | 2003-03-26 |
WO2000061145A1 (en) | 2000-10-19 |
NO329133B1 (no) | 2010-08-30 |
DE60032226T2 (de) | 2007-10-11 |
US6316462B1 (en) | 2001-11-13 |
HUP0200773A2 (hu) | 2002-07-29 |
TWI255184B (en) | 2006-05-21 |
HUP0200773A3 (en) | 2003-04-28 |
HK1038512A1 (en) | 2002-03-22 |
NO20014897D0 (no) | 2001-10-08 |
NO20014897L (no) | 2001-12-10 |
CN100421661C (zh) | 2008-10-01 |
NZ514628A (en) | 2004-01-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR023400A1 (es) | Metodos para inducir la muerte de celulas cancerosas y la regresion de tumores | |
ECSP045407A (es) | Benzazoles sustituidos y el uso del mismo como inhibidores de quinasa raf | |
ES2191192T3 (es) | Tienopirimidinas. | |
AR054094A1 (es) | Tratamientos de cancer | |
ATE339957T1 (de) | Verwendung von egfr tyrosine kinase hemmern zur behandlung von brustkrebs | |
BRPI0409919A (pt) | combinações para o tratamento de doenças envolvendo proliferação, migração ou apoptose celular de células de células de mieloma, ou angiogênese | |
IL138979A0 (en) | Use of cannabinoids as anti-inflammatory agents | |
EA200200990A1 (ru) | Ингибиторы фосфатидилинозитол-3-киназы дельта человека | |
PT933995E (pt) | Metodo para tratamento de lesao endotelial | |
ATE372341T1 (de) | Inhibitoren von mitotischem kinesin | |
BG101284A (en) | Compounds and methods for cancer treatment | |
ES2154693T3 (es) | Combinacion de sustancias inductoras de necrosis con sustancias que son activadas por necrosis, para la terapia selectiva de tumores y enfermedades inflamatorias. | |
BR112022020817A2 (pt) | Inibidores de kif18a para tratamento de doenças neoplásicas | |
EA200600921A1 (ru) | Способы и композиции с применением талидомида для лечения и менеджмента рака и других заболеваний | |
BR0010702A (pt) | Novas quinonas como terapias de doenças | |
BR0315942A (pt) | Tratamento de doenças e condições mediadas pelo aumento de fosforilação | |
PA8578001A1 (es) | Combinaciones terapeuticas de inhibidores de quinasa de erb b y terapias antineoplasicas | |
ES2185323T3 (es) | Utilizacion de eritropoietina en el tratamiento del mieloma multiple. | |
ES2164899T3 (es) | Uso de alcaloides de la clase lamellarina en metodos de tratamiento. | |
NZ524936A (en) | Methods of inducing cancer cell death and tumor regression using a FTP inhibitor and a tyrosine kinase inhibitor | |
ATE327973T1 (de) | Polyamin-analoge als cytotoxische wirkstoffe | |
TR200101693T2 (tr) | Lemfotoksin (LT) sentezlenme yolunun inhibitörleri kullanılarak foliküler lemfomaların tedavisi. | |
DK0841912T3 (da) | 2-Aminocarbonyl-1,2-bis-(methylsulfonyl)-1-(substituerede)-hydraziner med antitumor-virkning | |
PT971710E (pt) | Utilizacao de queleritrina e radiacao para terapia de tumores | |
AR015956A1 (es) | Composiciones de citoquinas oromucosales y usos de las mismas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |