AR022203A1 - UN COMPUESTO, PROCESO PARA SU PREPARACIoN, COMPOSICIoN FARMACÉUTICA QUE LO COMPRENDE, Y UN PRODUCTO COMESTIBLE. - Google Patents

UN COMPUESTO, PROCESO PARA SU PREPARACIoN, COMPOSICIoN FARMACÉUTICA QUE LO COMPRENDE, Y UN PRODUCTO COMESTIBLE.

Info

Publication number
AR022203A1
AR022203A1 ARP000100028A ARP000100028A AR022203A1 AR 022203 A1 AR022203 A1 AR 022203A1 AR P000100028 A ARP000100028 A AR P000100028A AR P000100028 A ARP000100028 A AR P000100028A AR 022203 A1 AR022203 A1 AR 022203A1
Authority
AR
Argentina
Prior art keywords
heteroaryl
reduced
heteroarylalkyl
alkyl
arylalkyl
Prior art date
Application number
ARP000100028A
Other languages
English (en)
Original Assignee
Norgine Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norgine Bv filed Critical Norgine Bv
Publication of AR022203A1 publication Critical patent/AR022203A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

El uso de un compuesto que comprende a la formula (1) o su sal, éster, amida o sus prodrogas farmacéuticamente aceptable; que es para la fabricacion de unmedicamento para el tratamiento o prevencion de las condiciones que requieren la inhibicion de una enzima cuyo modo preferido de accion es catalizar lahidrolisis de una funcionalidad éster, donde en la formula (1): A es un anillo aromático o heteroaromático de 6 miembros; y R1 es un alquilo ramificado o noramificado (opcionalmente interrumpidopor uno más átomos de oxígeno), alquenilo, alquinilo, cicloalquilo, cicloalquenilo, arilo, arilalquilo, arilalquiloreducido, arilalquenilo, heteroarilo, heteroarilalquilo, heteroarilalquenilo, arilo reducido, heteroarilo reducido, heteroarilalquilo reducido o un derivadosustituido de cualquiera de los grupos anteriores, donde los sustituyentes son uno o más independientemente elegidos del grupo que consiste de halogeno,alquilo, alquilo halosustituido, arilo, arilalquilo, heterorarilo, heteroarilo reducido, heteroarilalquilo reducido, arilalcoxi, ciano, nitro, -C(O)R4, -CO2R4,-SOR4, -SO2R4, -NR6R7, -OR6, -SR6, -C(O)CX1X2NR6R7, -C(O)NR4R5, -C(O)N(OR5)R6, -NR6C(O)R4, -CR6(NH2)CO2R6, -NHCX1X2CO2R6, N(OH)C(O)NR6R7, -N(OH)C(O)R4,-NHC(O)NR6R7, -C(O)NHNR6R7, -C(O)N(OR5)R6, o un lípido o esteroide (natural o sintético) con la condicion de que cualquier sustituyente heteroátomo en R1 y/oR2 debe ser separado del átomo de nitrogeno exocíclico por al menos dos átomos de carbono (preferentemente, saturados), y R2 es hidrogeno o es un grupo comodefinimos arriba para R1; Y donde: R4 es hidrogeno, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, arilo, arilalquilo, heteroarilo,heteroarilalquilo, heteroarilo reducido, heteroarilalquiloreducido, -OR6, -NHCX1X2CO2R6 o -NR6R7; R5 es hidrogeno, alquilo alquenilo, alquinilo, cicloalquilo,cicloalquenilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, heteroarilo reducido o heteroarilalquilo reducido; y R6 y R7 son independientementehidrogeno, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, arilo, arilalquilo, heteroarilo, heteroarilo reducido, heteroarilalquilo,
ARP000100028A 1999-01-08 2000-01-05 UN COMPUESTO, PROCESO PARA SU PREPARACIoN, COMPOSICIoN FARMACÉUTICA QUE LO COMPRENDE, Y UN PRODUCTO COMESTIBLE. AR022203A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9900416.0A GB9900416D0 (en) 1999-01-08 1999-01-08 Inhibitors

Publications (1)

Publication Number Publication Date
AR022203A1 true AR022203A1 (es) 2002-09-04

Family

ID=10845777

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000100028A AR022203A1 (es) 1999-01-08 2000-01-05 UN COMPUESTO, PROCESO PARA SU PREPARACIoN, COMPOSICIoN FARMACÉUTICA QUE LO COMPRENDE, Y UN PRODUCTO COMESTIBLE.

Country Status (22)

Country Link
US (2) US6656934B2 (es)
EP (1) EP1144395B1 (es)
JP (1) JP2002534419A (es)
KR (1) KR100615914B1 (es)
CN (1) CN100480245C (es)
AR (1) AR022203A1 (es)
AT (1) ATE293610T1 (es)
AU (1) AU770342B2 (es)
CA (1) CA2359987C (es)
DE (1) DE60019556T2 (es)
DK (1) DK1144395T3 (es)
ES (1) ES2240051T3 (es)
GB (1) GB9900416D0 (es)
HK (1) HK1047284A1 (es)
HU (1) HUP0104909A3 (es)
MY (1) MY129247A (es)
NO (1) NO321058B1 (es)
NZ (1) NZ512739A (es)
PL (1) PL350412A1 (es)
PT (1) PT1144395E (es)
RU (1) RU2244711C2 (es)
WO (1) WO2000040569A1 (es)

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NO20013380L (no) 2001-09-07
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DE60019556D1 (de) 2005-05-25
NO321058B1 (no) 2006-03-06
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WO2000040569A1 (en) 2000-07-13
US20030191123A1 (en) 2003-10-09
PT1144395E (pt) 2005-08-31
AU1884500A (en) 2000-07-24
WO2000040569A9 (en) 2002-02-28
NO20013380D0 (no) 2001-07-06
AU770342B2 (en) 2004-02-19
US7776853B2 (en) 2010-08-17
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HUP0104909A2 (hu) 2002-04-29
RU2244711C2 (ru) 2005-01-20
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US6656934B2 (en) 2003-12-02
ATE293610T1 (de) 2005-05-15
CA2359987A1 (en) 2000-07-13
CN100480245C (zh) 2009-04-22
EP1144395A1 (en) 2001-10-17
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