AR021867A1 - UN COMPUESTO DERIVADO DE 4-ARILQUINOLIN-2-ONA-3-SUSTITUIDOS, COMPOSICIoN FARMACCUTICA QUE LO CONTIENE Y USO PARA PREPARAR UNA COMPOSICIoN FARMACEUTICA DEL MISMO - Google Patents
UN COMPUESTO DERIVADO DE 4-ARILQUINOLIN-2-ONA-3-SUSTITUIDOS, COMPOSICIoN FARMACCUTICA QUE LO CONTIENE Y USO PARA PREPARAR UNA COMPOSICIoN FARMACEUTICA DEL MISMOInfo
- Publication number
- AR021867A1 AR021867A1 ARP990106137A ARP990106137A AR021867A1 AR 021867 A1 AR021867 A1 AR 021867A1 AR P990106137 A ARP990106137 A AR P990106137A AR P990106137 A ARP990106137 A AR P990106137A AR 021867 A1 AR021867 A1 AR 021867A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- pharmaccutic
- arilquinolin
- ona
- substitutes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Se revelan derivados de 4-arilquinolin-2-ona 3-substituidos, que tienen la formula general (1) en la cual R y R1 son cada uno, de manera independiente,hidrogeno o metilo, R2, R3 y R4, son cada uno, de manera independiente, hidrogeno, halogeno, nitroo trifluorometilo, con la condicion de que R2, R3 y R4 nosean todos hidrogeno; R5 es bromo, cloro o nitro; R6 es hidrogeno o fluoro; n es un numero entero de 0 a 6; m es un numero entero igual a 0 o 1; y R7 es CH3,-CRR1OH, -CHO, -C=NOH, -COCH3 oaril o opcionalmente substituido por uno o dos substituyentes seleccionados del grupo que consiste en halogeno, hidroxi, metoxi,amino, acetilamino y trifluorometilo; o una sal farmacéuticamente aceptable, no toxica, del mismo. Dichos compuestos sonmodula dores de los canales de K+activados por el calcio, de gran conductancia, y son utiles en el tratamiento de transtornos que son sensibles a la apertura de los canales de potasio. Sedescriben también las composiciones farmacéuticas quecontienen dichos compuestos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11107998P | 1998-12-04 | 1998-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR021867A1 true AR021867A1 (es) | 2002-08-07 |
Family
ID=22336494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990106137A AR021867A1 (es) | 1998-12-04 | 1999-12-02 | UN COMPUESTO DERIVADO DE 4-ARILQUINOLIN-2-ONA-3-SUSTITUIDOS, COMPOSICIoN FARMACCUTICA QUE LO CONTIENE Y USO PARA PREPARAR UNA COMPOSICIoN FARMACEUTICA DEL MISMO |
Country Status (28)
Country | Link |
---|---|
US (1) | US6184231B1 (es) |
EP (1) | EP1133474B1 (es) |
JP (1) | JP2002531549A (es) |
KR (1) | KR100641254B1 (es) |
CN (1) | CN1129582C (es) |
AR (1) | AR021867A1 (es) |
AT (1) | ATE354569T1 (es) |
AU (1) | AU755202B2 (es) |
BR (1) | BR9915744A (es) |
CO (1) | CO5150159A1 (es) |
CZ (1) | CZ20011965A3 (es) |
DE (1) | DE69935245T2 (es) |
DK (1) | DK1133474T3 (es) |
ES (1) | ES2281975T3 (es) |
HU (1) | HUP0201613A3 (es) |
ID (1) | ID28959A (es) |
IL (1) | IL142457A (es) |
MY (1) | MY115935A (es) |
NO (1) | NO318897B1 (es) |
NZ (1) | NZ510987A (es) |
PE (1) | PE20001327A1 (es) |
PL (1) | PL196955B1 (es) |
PT (1) | PT1133474E (es) |
RU (1) | RU2240998C2 (es) |
TR (1) | TR200101339T2 (es) |
TW (1) | TW495504B (es) |
WO (1) | WO2000034244A1 (es) |
ZA (1) | ZA200104455B (es) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02001207A (es) * | 1999-08-03 | 2002-07-30 | Abbott Lab | Abridores de canal de potasio. |
US6436944B1 (en) * | 1999-09-30 | 2002-08-20 | Pfizer Inc. | Combination effective for the treatment of impotence |
TW562799B (en) * | 1999-12-01 | 2003-11-21 | Bristol Myers Squibb Co | Preparation of 3-substituted-4-arylquinolin-2-one derivatives |
WO2002030868A1 (en) * | 2000-10-13 | 2002-04-18 | Bristol-Myers Squibb Company | Selective maxi-k- potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof |
US6831102B2 (en) * | 2001-12-07 | 2004-12-14 | Bristol-Myers Squibb Company | Phenyl naphthol ligands for thyroid hormone receptor |
WO2003051878A1 (en) * | 2001-12-14 | 2003-06-26 | Merck Frosst Canada & Co. | Quinolinones as prostaglandin receptor ligands |
US6747048B2 (en) | 2002-05-08 | 2004-06-08 | Bristol-Myers Squibb Company | Pyridine-based thyroid receptor ligands |
US7405234B2 (en) * | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
US7632858B2 (en) * | 2002-11-15 | 2009-12-15 | Bristol-Myers Squibb Company | Open chain prolyl urea-related modulators of androgen receptor function |
US6939968B2 (en) * | 2002-12-23 | 2005-09-06 | Bristol-Myers Squibb Company | Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives |
TW200504021A (en) * | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
EP1587783A4 (en) * | 2003-01-24 | 2006-11-08 | Bristol Myers Squibb Co | CYCLOALKYL-CONTAINING ANILID LIGANDS FOR THE THYROID RECEPTOR |
DE602004028907D1 (de) | 2003-02-06 | 2010-10-14 | Bristol Myers Squibb Co | Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis |
US7557143B2 (en) * | 2003-04-18 | 2009-07-07 | Bristol-Myers Squibb Company | Thyroid receptor ligands |
UA81668C2 (en) | 2003-05-01 | 2008-01-25 | Бристол-Майерс Сквибб Компани | Normal;heading 1;heading 2;ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS |
EP1644335A4 (en) | 2003-07-11 | 2008-06-04 | Bristol Myers Squibb Co | TETRAHYDROQUINOLINE DERIVATIVES COMPRISING MODULATORS OF CANNABINOID RECEPTORS |
AU2004259755A1 (en) * | 2003-07-22 | 2005-02-03 | Janssen Pharmaceutica, N.V. | Quinolinone derivatives as inhibitors of c-fms kinase |
CN1856307A (zh) * | 2003-09-23 | 2006-11-01 | 默克公司 | 喹啉钾通道抑制剂 |
WO2005030792A2 (en) | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Quinoline potassium channel inhibitors |
EP1670460B1 (en) | 2003-10-10 | 2014-11-26 | Bristol-Myers Squibb Company | Pyrazole derivatives as cannabinoid receptor modulators |
US7179920B2 (en) * | 2003-10-14 | 2007-02-20 | Bristol-Myers Squibb Company | 3-thia-4-arylquinolin-2-one derivatives |
US7145013B2 (en) * | 2003-10-14 | 2006-12-05 | Bristol-Myers Squibb Company | 3-thia-4-arylquinolin-2-one derivatives |
US7002015B2 (en) * | 2003-10-14 | 2006-02-21 | Bristol-Myers Squibb Company | 3-Thia-4-arylquinolin-2-one derivatives as smooth muscle relaxants |
US7151180B2 (en) * | 2003-10-14 | 2006-12-19 | Bristol-Myers Squibb Company | Potassium channel modulators |
US7049309B2 (en) * | 2003-10-14 | 2006-05-23 | Bristol-Myers Squibb Company | 3-Thia-4-arylquinolin-2-one potassium channel modulators |
US7132542B2 (en) | 2003-10-14 | 2006-11-07 | Bristol-Myers Squibb Company | Compounds for the treatment of male erectile dysfunction |
JP2007518686A (ja) * | 2003-10-17 | 2007-07-12 | 田辺製薬株式会社 | 高コンダクタンス型カルシウム感受性kチャネル開口薬 |
BRPI0416143A (pt) * | 2003-11-07 | 2007-01-02 | Chiron Corp | sais farmaceuticamente aceitáveis de compostos de quinolinona tendo propriedades farmacêuticas aperfeiçoadas |
US7256208B2 (en) * | 2003-11-13 | 2007-08-14 | Bristol-Myers Squibb Company | Monocyclic N-Aryl hydantoin modulators of androgen receptor function |
US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
US20050182105A1 (en) * | 2004-02-04 | 2005-08-18 | Nirschl Alexandra A. | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function |
US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
US7388027B2 (en) * | 2004-03-04 | 2008-06-17 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
US7253167B2 (en) * | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
US8143425B2 (en) * | 2004-10-12 | 2012-03-27 | Bristol-Myers Squibb Company | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
EP1652521A1 (en) * | 2004-10-20 | 2006-05-03 | Laboratorios Del Dr. Esteve, S.A. | Pharmaceutical composition of sildenafil and a large conductance Ca(2+) activated K+ channels activator |
EP1676573A1 (en) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Phamaceutical composition comprising a 2,5-dihydroxybenzenesulfonic-compound, a potassium ion channel modulator and a phosphodiesterase type 5 inhibitor |
WO2006076568A2 (en) | 2005-01-12 | 2006-07-20 | Bristol-Myers Squibb Company | Thiazolopyridines as cannabinoid receptor modulators |
US7368458B2 (en) * | 2005-01-12 | 2008-05-06 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
WO2006076598A2 (en) * | 2005-01-12 | 2006-07-20 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
US20060160850A1 (en) * | 2005-01-18 | 2006-07-20 | Chongqing Sun | Bicyclic heterocycles as cannabinoid receptor modulators |
US20060178388A1 (en) * | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
ES2319461T3 (es) * | 2005-02-10 | 2009-05-07 | Bristol-Myers Squibb Company | Dihidroquinazolinonas como moduladores de 5ht. |
US7790895B2 (en) * | 2005-02-24 | 2010-09-07 | Janssen Pharmaceutica Nv | Quinoline derivatives as potassium ion channel openers |
US7452892B2 (en) * | 2005-06-17 | 2008-11-18 | Bristol-Myers Squibb Company | Triazolopyrimidine cannabinoid receptor 1 antagonists |
US7572808B2 (en) * | 2005-06-17 | 2009-08-11 | Bristol-Myers Squibb Company | Triazolopyridine cannabinoid receptor 1 antagonists |
US20060287342A1 (en) * | 2005-06-17 | 2006-12-21 | Mikkilineni Amarendra B | Triazolopyrimidine heterocycles as cannabinoid receptor modulators |
US7632837B2 (en) * | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
US7317012B2 (en) * | 2005-06-17 | 2008-01-08 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoind-1 receptor modulators |
US20070027178A1 (en) * | 2005-07-28 | 2007-02-01 | Bristol-Myers Squibb Company | Substituted tetrahydro-1H-pyrido[4,3-b]indoles as serotonin receptors agonists and antagonists |
US7473784B2 (en) | 2005-08-01 | 2009-01-06 | Bristol-Myers Squibb Company | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
EP1757290A1 (en) * | 2005-08-16 | 2007-02-28 | Zentaris GmbH | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors |
US7795436B2 (en) * | 2005-08-24 | 2010-09-14 | Bristol-Myers Squibb Company | Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
US7939545B2 (en) * | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
KR20080091949A (ko) * | 2007-04-10 | 2008-10-15 | 에스케이케미칼주식회사 | 락톤형 피리딘 화합물을 포함하는 허혈성 질환의 예방 및치료용 약학조성물 |
JP5366269B2 (ja) | 2007-09-14 | 2013-12-11 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 1,3−二置換4−(アリル−x−フェニル)−1h−ピリジン−2−オン |
KR101520086B1 (ko) | 2007-09-14 | 2015-05-14 | 얀센 파마슈티칼스 인코포레이티드 | 1´,3´-이치환된-4-페닐-3,4,5,6-테트라히드로-2h,1´h-[1,4´]비피리디닐-2´-온 |
EP2220046B1 (en) | 2007-11-16 | 2014-06-18 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
EP2103602A1 (en) | 2008-03-17 | 2009-09-23 | AEterna Zentaris GmbH | Novel 1,2,4-triazole derivatives and process of manufacturing thereof |
JP5277256B2 (ja) | 2008-04-09 | 2013-08-28 | 田辺三菱製薬株式会社 | maxi−Kチャネル開口薬としてのピリミジン、ピリジン及びトリアジン誘導体 |
AU2009289784B2 (en) | 2008-09-02 | 2012-03-22 | Addex Pharma S.A. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
WO2010065799A2 (en) | 2008-12-04 | 2010-06-10 | Palatin Technologies, Inc. | Amine substituted piperidine melanocortin receptor-specific compounds |
WO2010065801A1 (en) | 2008-12-04 | 2010-06-10 | Palatin Technologies, Inc. | Amine substituted piperazine melanocortin receptor-specific compounds |
WO2010065802A2 (en) | 2008-12-04 | 2010-06-10 | Palatin Technologies, Inc. | Substituted pyrrolidine or imidazolidine melanocortin receptor-specific compounds |
SG10201402250TA (en) | 2009-05-12 | 2014-07-30 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
DE102010028362A1 (de) * | 2010-04-29 | 2011-11-03 | Bayer Schering Pharma Aktiengesellschaft | Herstellverfahren |
EP2431035A1 (en) | 2010-09-16 | 2012-03-21 | Æterna Zentaris GmbH | Novel Triazole Derivatives with Improved Receptor Activity and Bioavailability Properties as Ghrelin Antagonists of Growth Hormone Secretagogue Receptors |
ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
US9012448B2 (en) | 2010-11-08 | 2015-04-21 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
CN109999033B (zh) | 2014-01-21 | 2022-12-23 | 詹森药业有限公司 | 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途 |
DK3096790T3 (da) | 2014-01-21 | 2019-10-07 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
TWI698438B (zh) * | 2015-03-13 | 2020-07-11 | 德商4Sc製藥公司 | Kv1.3抑制劑及其醫學應用 |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
WO2018136918A1 (en) | 2017-01-23 | 2018-07-26 | Cadent Therapeutics, Inc. | Methods for the treatment of tremors by positive modulation of sk channels |
US11548867B2 (en) * | 2017-07-19 | 2023-01-10 | Idea Ya Biosciences, Inc. | Amido compounds as AhR modulators |
CN117229206A (zh) * | 2023-09-18 | 2023-12-15 | 延安大学 | 一种碱催化合成多取代2-喹啉酮类化合物的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5200422A (en) | 1990-09-24 | 1993-04-06 | Neurosearch A/S | Benzimidazole derivatives, their preparation and use |
NZ239540A (en) | 1990-09-24 | 1993-11-25 | Neurosearch As | 1-phenyl benzimidazole derivatives and medicaments |
US5234947A (en) | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
US5565472A (en) | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
US5565483A (en) | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
TW504504B (en) | 1996-11-26 | 2002-10-01 | Bristol Myers Squibb Co | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators |
AU742452B2 (en) | 1997-08-28 | 2002-01-03 | Bristol-Myers Squibb Company | 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators |
-
1999
- 1999-12-01 PT PT99960636T patent/PT1133474E/pt unknown
- 1999-12-01 DE DE69935245T patent/DE69935245T2/de not_active Expired - Lifetime
- 1999-12-01 CZ CZ20011965A patent/CZ20011965A3/cs unknown
- 1999-12-01 RU RU2001115714/04A patent/RU2240998C2/ru not_active IP Right Cessation
- 1999-12-01 ES ES99960636T patent/ES2281975T3/es not_active Expired - Lifetime
- 1999-12-01 AT AT99960636T patent/ATE354569T1/de not_active IP Right Cessation
- 1999-12-01 CO CO99075316A patent/CO5150159A1/es unknown
- 1999-12-01 JP JP2000586692A patent/JP2002531549A/ja active Pending
- 1999-12-01 TR TR2001/01339T patent/TR200101339T2/xx unknown
- 1999-12-01 CN CN99813902A patent/CN1129582C/zh not_active Expired - Fee Related
- 1999-12-01 HU HU0201613A patent/HUP0201613A3/hu unknown
- 1999-12-01 EP EP99960636A patent/EP1133474B1/en not_active Expired - Lifetime
- 1999-12-01 KR KR1020017006938A patent/KR100641254B1/ko not_active IP Right Cessation
- 1999-12-01 NZ NZ510987A patent/NZ510987A/xx not_active IP Right Cessation
- 1999-12-01 ID IDW00200101184A patent/ID28959A/id unknown
- 1999-12-01 BR BR9915744-6A patent/BR9915744A/pt not_active Application Discontinuation
- 1999-12-01 WO PCT/US1999/028428 patent/WO2000034244A1/en active IP Right Grant
- 1999-12-01 PL PL348039A patent/PL196955B1/pl not_active IP Right Cessation
- 1999-12-01 US US09/452,523 patent/US6184231B1/en not_active Expired - Fee Related
- 1999-12-01 DK DK99960636T patent/DK1133474T3/da active
- 1999-12-01 AU AU17491/00A patent/AU755202B2/en not_active Ceased
- 1999-12-02 AR ARP990106137A patent/AR021867A1/es active IP Right Grant
- 1999-12-02 TW TW088121090A patent/TW495504B/zh not_active IP Right Cessation
- 1999-12-03 MY MYPI99005251A patent/MY115935A/en unknown
- 1999-12-03 PE PE1999001208A patent/PE20001327A1/es not_active Application Discontinuation
-
2001
- 2001-04-04 IL IL142457A patent/IL142457A/en not_active IP Right Cessation
- 2001-05-30 ZA ZA200104455A patent/ZA200104455B/en unknown
- 2001-06-01 NO NO20012739A patent/NO318897B1/no not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR021867A1 (es) | UN COMPUESTO DERIVADO DE 4-ARILQUINOLIN-2-ONA-3-SUSTITUIDOS, COMPOSICIoN FARMACCUTICA QUE LO CONTIENE Y USO PARA PREPARAR UNA COMPOSICIoN FARMACEUTICA DEL MISMO | |
ATE184598T1 (de) | Enniatine und enniatinderivate zur bekämpfung von endoparasiten | |
YU14495A (sh) | Jedinjenja koja su prolekovi antagonista morfolin tahikininskih receptora i njihove farmaceutske kompozicije | |
DK0711280T3 (da) | Perhydroisoindolderivater, fremstilling af disse forbindelser og farmaceutiske præparater indeholdende disse forbindelser | |
PE108898A1 (es) | Derivados 6,5-heterobiciclicos sustituidos | |
NO972324D0 (no) | Orale blandinger inneholdende Ondansetron | |
ES2144192T3 (es) | Nuevos derivados de 1-fenil-2-dimetil-amino-metil-ciclohexan-1-ol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
ES2167375T3 (es) | Derivados flavonoides y bioflavonoides, sus composiciones farmaceuticas, su actividad ansiolitica. | |
ES2175350T3 (es) | Compuestos triciclicos que tienen afinidad de union a receptores de melatonina, su produccion y uso. | |
AR027608A1 (es) | Derivados de azetidina, su preparacion y las composiciones farmaceuticas que los contienen | |
CO4910163A1 (es) | Prevencion de la perdida y restauracion de la masa osea por determinados agonistas de prostaglandinas | |
ATE2667T1 (de) | Antidepressiv wirkende derivate des trans-4phenyl-1,2,3,4-tetrahydro-1-naphthalin-amins und pharmazeutische zusammensetzungen daraus. | |
SE8302693L (sv) | Heterocykliska foreningar | |
AR028948A1 (es) | Compuestos novedosos | |
ES2012809B3 (es) | Derivados del taxol, su preparacion y composiciones farmaceuticas que los contienen. | |
ATE113604T1 (de) | Mometason-furoate-monohydrat, verfahren zu seiner herstellung und das enthaltende pharmazeutische zusammensetzungen. | |
NO2005003I2 (no) | Hydroksysubstituerte azetidinonforbindelser som kan anvendes som hypokolesterolemiske midler, farmasoytiske preparater som omfatter slike forbindelser, provesett som omfatter slike preparater, samt anvendelse av forbindelsene til fremstilling av medikamentet | |
EA200300323A1 (ru) | ПРОИЗВОДНЫЕ ГУАНИДИНОБЕНЗАМИДА (ВАРИАНТЫ), КОМПОЗИЦИЯ (ВАРИАНТЫ), СПОСОБ ЛЕЧЕНИЯ ОПОСРЕДОВАННОГО mc4-r ЗАБОЛЕВАНИЯ (ВАРИАНТЫ) | |
NO943002L (no) | Fosfono-oksymetyletere av taxanderivater | |
DE69725825D1 (de) | 5-HT1F-Agonisten | |
BG104930A (en) | 2-phenyl-1-[2-(-aminoethoxy)-benzyl]-indole in combination with estrogens | |
DK1056454T3 (da) | Anvendelse af makrolidforbindelser til behandling af glaukom | |
DK0556329T3 (da) | Substituerede piperaziner som midler til behandling af centralnervesystemet | |
HUP0103203A2 (hu) | Azaadamantánszármazékok és ezeket tartalmazó gyógyszerkészítmények | |
AR010306A1 (es) | Compuesto derivado de 4-aril-3-hidroxiquinolin-2-ona, composicion farmaceutica que lo comprende y su uso. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |