AR019066A1 - Heliomicina, fragmentos de acidos nucleicos codificantes de la heliomicina y composiciones farmaceuticas que la contienen - Google Patents

Heliomicina, fragmentos de acidos nucleicos codificantes de la heliomicina y composiciones farmaceuticas que la contienen

Info

Publication number
AR019066A1
AR019066A1 ARP990101719A ARP990101719A AR019066A1 AR 019066 A1 AR019066 A1 AR 019066A1 AR P990101719 A ARP990101719 A AR P990101719A AR P990101719 A ARP990101719 A AR P990101719A AR 019066 A1 AR019066 A1 AR 019066A1
Authority
AR
Argentina
Prior art keywords
amino acids
heliomycin
cys
peptide moiety
nucleic acid
Prior art date
Application number
ARP990101719A
Other languages
English (en)
Original Assignee
Rhone Poulenc Agrochimie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Agrochimie filed Critical Rhone Poulenc Agrochimie
Publication of AR019066A1 publication Critical patent/AR019066A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Abstract

Se trata de péptidos ricos en cisteína que comprenden la secuencia siguiente: Xaa-Cys-Xab-Cys-Xac-Cys-Xad-Cys-Xae-Cys-Xaf-Cys-Xag, en la que: Xaa es -NH2 oun resto peptídico que comprende de 1 a 10 aminoácidos, preferiblemente de 1 a 6 aminoácidos; Xab es un resto peptídico que comprende de 1 a 10 aminoácidos,preferiblemente 10; Xac es un resto peptídico de 3 aminoácidos; Xad es un resto peptídico que comprende de 1 a 9 aminoácidos, preferiblemente 9; Xae es unresto peptídico que comprende de 1a 7 aminoácidos, preferiblemente 7; Xaf es un resto peptídico de 1 aminoácido; y Xag es -OH o un resto peptídico quecomprende de 1 a 5 aminoácidos, preferiblemente 1 o 2 aminoácidos. Dicho compuesto Heliomicina es de aplicacion como medicamento parael tratamiento deinfecciones fungicas. También es util para la transformacion de células vegetales y plantas transformadas a la que les confiere resistencia a las enfermedades,en particular a las de orígen fungico. También se proponen los objetos mencionados en el título de la presente.
ARP990101719A 1998-04-15 1999-04-14 Heliomicina, fragmentos de acidos nucleicos codificantes de la heliomicina y composiciones farmaceuticas que la contienen AR019066A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804933A FR2777568B1 (fr) 1998-04-15 1998-04-15 Gene codant pour l'heliomicine, proteine obtenue, vecteur le contenant, organismes transformes obtenus et procede de preparation

Publications (1)

Publication Number Publication Date
AR019066A1 true AR019066A1 (es) 2001-12-26

Family

ID=9525455

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101719A AR019066A1 (es) 1998-04-15 1999-04-14 Heliomicina, fragmentos de acidos nucleicos codificantes de la heliomicina y composiciones farmaceuticas que la contienen

Country Status (24)

Country Link
US (1) US6916782B1 (es)
EP (1) EP1071767B1 (es)
JP (1) JP2002511260A (es)
KR (1) KR20010042735A (es)
CN (1) CN1305526A (es)
AR (1) AR019066A1 (es)
AT (1) ATE366811T1 (es)
AU (1) AU754856B2 (es)
BR (1) BR9909745A (es)
CA (1) CA2325658A1 (es)
CY (1) CY1106926T1 (es)
CZ (1) CZ297645B6 (es)
DE (1) DE69936514T2 (es)
DK (1) DK1071767T3 (es)
ES (1) ES2291021T3 (es)
FR (1) FR2777568B1 (es)
HU (1) HU225803B1 (es)
IL (1) IL139011A0 (es)
NO (1) NO20005173L (es)
PL (1) PL198979B1 (es)
PT (1) PT1071767E (es)
TR (1) TR200002989T2 (es)
WO (1) WO1999053053A1 (es)
ZA (1) ZA200006567B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2810993B1 (fr) * 2000-06-29 2002-08-23 Rhobio Peptides antimicrobiens de la famille des defensines, polynucleotides codant ces peptides, vecteurs et organismes transformes les contenant
FR2811665B1 (fr) * 2000-07-13 2002-10-18 Entomed S A Peptides antifongiques et/ou antibacteriens, leurs preparations et les compositions les contenant
FR2811666B1 (fr) * 2000-07-13 2005-04-01 Entomed S A Peptides antifongiques et/ou antibacteriens, leurs preparations et les compositions les contenant
US6891085B2 (en) 2001-04-20 2005-05-10 Pioneer Hi-Bred International, Inc. Nucleic acid encoding the FUS6 antimicrobial polypeptide of Agrotis ipsilon and its use to enhance disease resistance in a plant
BR0214302A (pt) * 2001-11-20 2004-10-26 Novozymes As Polipeptìdeo que tem atividade antimicrobiana, polinucleotìdeo, construção de ácido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, método para produzir um polipeptìdeo comosição antimicrobiana, método para matar ou inibir o crescimento de células microbianas, composição detergente, uso de um polipeptìdeo antimicrobiano planta transgênica, parte da planta ou célula da planta, aditivo para ração animal, composição de ração animal
FR2844142B1 (fr) 2002-09-11 2007-08-17 Bayer Cropscience Sa Plantes transformees a biosynthese de prenylquinones amelioree
FR2848571A1 (fr) * 2002-12-12 2004-06-18 Bayer Cropscience Sa Cassette d'expression codant pour une hydroxy-phenyl pyruvate dioxygenase et plantes contenant un tel gene tolerantes aux herbicides
FR2848570B1 (fr) 2002-12-12 2005-04-01 Bayer Cropscience Sa Cassette d'expression codant pour une 5-enol pyruvylshikimate-3-phosphate synthase (epsps) et plantes tolerantes aux herbicides la contenant
EP1814996A2 (en) 2004-11-19 2007-08-08 Novozymes A/S Polypeptides having antimicrobial activity and polynucleotides encoding same
US7485619B2 (en) * 2005-01-31 2009-02-03 Yeon Sook KIM Antimicrobial agent
CN101142231A (zh) 2005-03-16 2008-03-12 诺维信公司 在丝状真菌中重组表达防卫素
AR052947A1 (es) 2005-03-18 2007-04-11 Novozymes As Polipeptidos que tienen actividad antimicrobiana y polinucleotidos que codifican para los mismos
US7130534B1 (en) * 2005-04-21 2006-10-31 Agilent Technologies, Inc. Gas chromatograph having a radiant oven for analytical devices
US9057073B2 (en) 2007-01-11 2015-06-16 Bayer Cropscience N.V. Differential expression of subgenome specific alleles in cotton and uses thereof
WO2008101847A1 (en) 2007-02-23 2008-08-28 Novozymes A/S Method for producing an antifungal peptide in a filamentous fungal host cell
AR074941A1 (es) 2009-01-07 2011-02-23 Bayer Cropscience Sa Plantas transplastomicas exentas de marcador de seleccion
AR080105A1 (es) 2010-02-02 2012-03-14 Bayer Cropscience Ag Transformacion de soja usando inhibidores de hidrofenil piruvato dioxigenasa (hppd) como agentes de seleccion
WO2011104284A1 (en) 2010-02-25 2011-09-01 Novozymes A/S Polypeptides having antimicrobial activity
CN103517986B (zh) 2011-01-26 2016-12-07 诺维信公司 具有纤维二糖水解酶活性的多肽及编码该多肽的多核苷酸
WO2013096603A2 (en) 2011-12-20 2013-06-27 Novozymes, Inc. Cellobiohydrolase variants and polynucleotides encoding same
AU2018304493B2 (en) 2017-07-17 2022-07-28 Linnane Pharma Ab Peptides with antibiotic potential against Mycobacterium tuberculosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU350364A1 (ru) * 1971-03-17 1973-10-19 Институт изысканию новых антибиотиков АМН СССР Продуцент гелиомицина
ZA885916B (en) * 1987-09-15 1989-04-26 Gen Hospital Corp Pathogenesis-related proteins in plants
CA2030779A1 (en) * 1989-04-11 1990-10-12 Huw M. Davies Use of animal-derived anti-microbial peptides for control of plant pathogens
FR2695392B1 (fr) * 1992-09-04 1994-10-14 Centre Nat Rech Scient Peptides possédant notamment des propriétés antibactériennes, leur procédé d'obtention, et leurs applications biologiques.
FR2700338B1 (fr) * 1993-01-11 1995-03-31 Transgene Sa Nouvelle séquence pro permettant la secrétion de protéines hétérologues à partir d'une cellule de levure.
FR2725992A1 (fr) * 1994-10-25 1996-04-26 Rhone Poulenc Agrochimie Peptide antifongique
FR2745004B1 (fr) * 1996-02-16 1998-03-27 Rhone Poulenc Agrochimie Peptide antibacterien et antifongique
FR2766207B1 (fr) * 1997-07-11 2000-12-08 Rhone Poulenc Agrochimie Gene chimere codant pour la drosomycine, vecteur le contenant pour la transformation des cellules vegetales et plantes transformees obtenues resistantes aux maladies

Also Published As

Publication number Publication date
KR20010042735A (ko) 2001-05-25
DE69936514D1 (de) 2007-08-23
FR2777568A1 (fr) 1999-10-22
CA2325658A1 (fr) 1999-10-21
FR2777568B1 (fr) 2002-10-31
HUP0102302A3 (en) 2003-03-28
AU3152599A (en) 1999-11-01
NO20005173L (no) 2000-12-15
HUP0102302A2 (hu) 2001-09-28
CZ20003785A3 (cs) 2001-03-14
CZ297645B6 (cs) 2007-02-21
DK1071767T3 (da) 2007-11-05
EP1071767B1 (fr) 2007-07-11
BR9909745A (pt) 2000-12-26
IL139011A0 (en) 2001-11-25
ZA200006567B (en) 2002-01-14
EP1071767A1 (fr) 2001-01-31
JP2002511260A (ja) 2002-04-16
ATE366811T1 (de) 2007-08-15
US6916782B1 (en) 2005-07-12
CY1106926T1 (el) 2012-09-26
CN1305526A (zh) 2001-07-25
NO20005173D0 (no) 2000-10-13
HU225803B1 (en) 2007-09-28
DE69936514T2 (de) 2008-03-20
TR200002989T2 (tr) 2000-12-21
PL345243A1 (en) 2001-12-03
AU754856B2 (en) 2002-11-28
PT1071767E (pt) 2007-10-23
ES2291021T3 (es) 2008-02-16
WO1999053053A1 (fr) 1999-10-21
PL198979B1 (pl) 2008-08-29

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