AR007060A1 - Inhibidores de la formacion de la cd23 humana soluble, el uso de los mismos una composicion farmaceutica que los comprende, un metodo para preparar dichosinhibidores y compuestos intermediarios - Google Patents
Inhibidores de la formacion de la cd23 humana soluble, el uso de los mismos una composicion farmaceutica que los comprende, un metodo para preparar dichosinhibidores y compuestos intermediariosInfo
- Publication number
- AR007060A1 AR007060A1 ARP970101926A ARP970101926A AR007060A1 AR 007060 A1 AR007060 A1 AR 007060A1 AR P970101926 A ARP970101926 A AR P970101926A AR P970101926 A ARP970101926 A AR P970101926A AR 007060 A1 AR007060 A1 AR 007060A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- inhibitors
- aryl
- alkenyl
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Inhibidores de la formación de CD23 humana soluble de la fórmula (I) en la que : R es hidroxi, hidrógeno, alquilo, alquenilo, alquinilo o arilo; R1 esarilmetilo o heterociclilmetilo; R2 es alquilo, alquenilo, arilo cicloalquilo o cicloalquenilo; yR 3 es hidrógeno, alquilo, alquenilo, alquinilo o arilo con lacondición de que: si R1 es fenilmetilo o naftilmetilo, en que el grupo fenilo o naftilo está sin sustituir o sustituido hasta con cinco sustituyentesseleccionados del grupo que consisteen halógeno, alquilo (C1-6) aril-alquilo (C1-6), alcoxi (C1-6)m alcoxi (C1-6)-alquilo (C1-6), halo-alquilo (C1-6),hidroxi, nitro, amino, mono- y di-N-alquil (C1-6)-amino, acilamino, aciloxi carboxi, sales de carboxi, ésteres de carboxi,carbamoíl o, mono y di-N-alquil(C1-6)-carbamoílo, alcoxi (C1-6)-carbonilo, ariloxi-carbonilo, ureído, guanidino, sulfonilamino, aminosulfonilo, alquil(C1-6)-tio, alquil(C1-6)-sulfinilo, alquilo (C1-6)-sulfonilo, heterociclilo,heterociclilalquilo (C1- 6), y una cadena alquileno (C3-5) que enlaza a dos átomos de carbono de anillosadyacentes para formar un anillo carbocíclico; entonces R es hidróxi; son útiles en el tratamiento de trastornos mediados por s-CD23. Sedescribe ademásel uso de los mismos, una compocisión farmacéutica que los contiene, un método para la preparación de dichos inhibidores, un compuesto de fórmula (II) y uncompuesto de fórmula (IV).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9609794.4A GB9609794D0 (en) | 1996-05-10 | 1996-05-10 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR007060A1 true AR007060A1 (es) | 1999-10-13 |
Family
ID=10793494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970101926A AR007060A1 (es) | 1996-05-10 | 1997-05-08 | Inhibidores de la formacion de la cd23 humana soluble, el uso de los mismos una composicion farmaceutica que los comprende, un metodo para preparar dichosinhibidores y compuestos intermediarios |
Country Status (21)
Country | Link |
---|---|
US (1) | US6235753B1 (es) |
EP (1) | EP0918747B1 (es) |
JP (1) | JP2000510473A (es) |
KR (1) | KR20000010892A (es) |
AR (1) | AR007060A1 (es) |
AT (1) | ATE246673T1 (es) |
AU (1) | AU2897397A (es) |
BR (1) | BR9709450A (es) |
CA (1) | CA2253590A1 (es) |
CO (1) | CO4990945A1 (es) |
CZ (1) | CZ363198A3 (es) |
DE (1) | DE69723984T2 (es) |
ES (1) | ES2205218T3 (es) |
GB (1) | GB9609794D0 (es) |
IL (1) | IL126860A0 (es) |
NO (1) | NO985214L (es) |
NZ (1) | NZ332628A (es) |
PL (1) | PL329855A1 (es) |
TR (1) | TR199802271T2 (es) |
WO (1) | WO1997043249A1 (es) |
ZA (1) | ZA973964B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020082200A1 (en) * | 1994-07-13 | 2002-06-27 | Smithkline Beecham P.1.C. | Use of inhibitors of human S-CD23 |
US6548084B2 (en) | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
AUPO721997A0 (en) * | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
CA2308361A1 (en) | 1997-11-12 | 1999-05-20 | Andrew Douglas Baxter | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
GB9813451D0 (en) * | 1998-06-22 | 1998-08-19 | Smithkline Beecham Plc | Novel compounds |
GB9922825D0 (en) * | 1999-09-25 | 1999-11-24 | Smithkline Beecham Biolog | Medical use |
WO2001038322A1 (en) | 1999-11-23 | 2001-05-31 | Methylgene, Inc. | Inhibitors of histone deacetylase |
GB9930754D0 (en) * | 1999-12-29 | 2000-02-16 | Smithkline Beecham Plc | Novel compounds |
JP4790594B2 (ja) * | 2003-02-25 | 2011-10-12 | トポターゲット ユーケー リミテッド | Hdacインヒビターとしての、二環式ヘテロアリール基を含むヒドロキサム酸化合物 |
GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
MX2011012627A (es) | 2009-05-28 | 2011-12-14 | Novartis Ag | Derivados aminobutiricos sustituidos como inhibidores de nepralisina. |
EP2594557B1 (en) * | 2009-05-28 | 2016-08-10 | Novartis AG | Substituted aminopropionic derivatives as neprilysin inhibitors |
EP2860195A1 (en) | 2009-12-01 | 2015-04-15 | Boston Medical Center Corporation | Treatment of IgE-mediated disease |
EA026989B1 (ru) | 2013-02-14 | 2017-06-30 | Новартис Аг | Производные замещенной бисфенилбутановой кислоты в качестве ингибиторов nep с улучшенной in vivo эффективностью |
CN105073762B (zh) | 2013-02-14 | 2017-03-08 | 诺华股份有限公司 | 作为nep(中性内肽酶)抑制剂的取代的联苯丁酰膦酸衍生物 |
TW201625569A (zh) * | 2014-11-19 | 2016-07-16 | 艾克泰聯製藥有限公司 | 抗菌性苯并噻唑衍生物 |
AU2019352741A1 (en) | 2018-10-04 | 2021-05-06 | Assistance Publique-Hôpitaux De Paris (Aphp) | EGFR inhibitors for treating keratodermas |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9215665D0 (en) | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
DK0822186T3 (da) * | 1994-01-20 | 2000-06-26 | British Biotech Pharm | L-tert-leucin-2-pyridylamid |
GB9414157D0 (en) * | 1994-07-13 | 1994-08-31 | Smithkline Beecham Plc | Medical use |
US5562917A (en) | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
DE19506492C2 (de) | 1995-02-24 | 2003-05-08 | Focke & Co | Einrichtung zum Speichern von Zigaretten oder dergleichen |
US5570079A (en) | 1995-04-24 | 1996-10-29 | Dockery; Devan | Home security system for detecting an intrusion into a monitored area by an infrared detector |
-
1996
- 1996-05-10 GB GBGB9609794.4A patent/GB9609794D0/en active Pending
-
1997
- 1997-05-06 DE DE69723984T patent/DE69723984T2/de not_active Expired - Fee Related
- 1997-05-06 TR TR1998/02271T patent/TR199802271T2/xx unknown
- 1997-05-06 ES ES97923064T patent/ES2205218T3/es not_active Expired - Lifetime
- 1997-05-06 IL IL12686097A patent/IL126860A0/xx unknown
- 1997-05-06 AU AU28973/97A patent/AU2897397A/en not_active Abandoned
- 1997-05-06 EP EP97923064A patent/EP0918747B1/en not_active Expired - Lifetime
- 1997-05-06 PL PL97329855A patent/PL329855A1/xx unknown
- 1997-05-06 KR KR1019980709039A patent/KR20000010892A/ko not_active Application Discontinuation
- 1997-05-06 NZ NZ332628A patent/NZ332628A/en unknown
- 1997-05-06 AT AT97923064T patent/ATE246673T1/de not_active IP Right Cessation
- 1997-05-06 BR BR9709450A patent/BR9709450A/pt not_active Application Discontinuation
- 1997-05-06 CA CA002253590A patent/CA2253590A1/en not_active Abandoned
- 1997-05-06 JP JP09540514A patent/JP2000510473A/ja not_active Ceased
- 1997-05-06 US US09/180,547 patent/US6235753B1/en not_active Expired - Fee Related
- 1997-05-06 WO PCT/EP1997/002433 patent/WO1997043249A1/en not_active Application Discontinuation
- 1997-05-06 CZ CZ983631A patent/CZ363198A3/cs unknown
- 1997-05-08 ZA ZA973964A patent/ZA973964B/xx unknown
- 1997-05-08 AR ARP970101926A patent/AR007060A1/es not_active Application Discontinuation
- 1997-05-09 CO CO97025078A patent/CO4990945A1/es unknown
-
1998
- 1998-11-09 NO NO985214A patent/NO985214L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ZA973964B (en) | 1998-11-09 |
CO4990945A1 (es) | 2000-12-26 |
TR199802271T2 (xx) | 2000-08-21 |
US6235753B1 (en) | 2001-05-22 |
IL126860A0 (en) | 1999-09-22 |
ES2205218T3 (es) | 2004-05-01 |
CA2253590A1 (en) | 1997-11-20 |
JP2000510473A (ja) | 2000-08-15 |
WO1997043249A1 (en) | 1997-11-20 |
GB9609794D0 (en) | 1996-07-17 |
NZ332628A (en) | 2000-06-23 |
DE69723984D1 (de) | 2003-09-11 |
NO985214L (no) | 1998-12-01 |
BR9709450A (pt) | 1999-08-10 |
ATE246673T1 (de) | 2003-08-15 |
DE69723984T2 (de) | 2004-06-09 |
PL329855A1 (en) | 1999-04-12 |
KR20000010892A (ko) | 2000-02-25 |
CZ363198A3 (cs) | 1999-06-16 |
AU2897397A (en) | 1997-12-05 |
EP0918747B1 (en) | 2003-08-06 |
NO985214D0 (no) | 1998-11-09 |
EP0918747A1 (en) | 1999-06-02 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |