IL126860A0 - Inhibitors of the production of s-cd23 and secretion of tnf - Google Patents

Inhibitors of the production of s-cd23 and secretion of tnf

Info

Publication number
IL126860A0
IL126860A0 IL12686097A IL12686097A IL126860A0 IL 126860 A0 IL126860 A0 IL 126860A0 IL 12686097 A IL12686097 A IL 12686097A IL 12686097 A IL12686097 A IL 12686097A IL 126860 A0 IL126860 A0 IL 126860A0
Authority
IL
Israel
Prior art keywords
tnf
secretion
inhibitors
production
Prior art date
Application number
IL12686097A
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of IL126860A0 publication Critical patent/IL126860A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
IL12686097A 1996-05-10 1997-05-06 Inhibitors of the production of s-cd23 and secretion of tnf IL126860A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9609794.4A GB9609794D0 (en) 1996-05-10 1996-05-10 Novel compounds
PCT/EP1997/002433 WO1997043249A1 (en) 1996-05-10 1997-05-06 INHIBITORS OF THE PRODUCTION OF s-CD23 AND THE SECRETION OF TNF

Publications (1)

Publication Number Publication Date
IL126860A0 true IL126860A0 (en) 1999-09-22

Family

ID=10793494

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12686097A IL126860A0 (en) 1996-05-10 1997-05-06 Inhibitors of the production of s-cd23 and secretion of tnf

Country Status (21)

Country Link
US (1) US6235753B1 (en)
EP (1) EP0918747B1 (en)
JP (1) JP2000510473A (en)
KR (1) KR20000010892A (en)
AR (1) AR007060A1 (en)
AT (1) ATE246673T1 (en)
AU (1) AU2897397A (en)
BR (1) BR9709450A (en)
CA (1) CA2253590A1 (en)
CO (1) CO4990945A1 (en)
CZ (1) CZ363198A3 (en)
DE (1) DE69723984T2 (en)
ES (1) ES2205218T3 (en)
GB (1) GB9609794D0 (en)
IL (1) IL126860A0 (en)
NO (1) NO985214L (en)
NZ (1) NZ332628A (en)
PL (1) PL329855A1 (en)
TR (1) TR199802271T2 (en)
WO (1) WO1997043249A1 (en)
ZA (1) ZA973964B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020082200A1 (en) * 1994-07-13 2002-06-27 Smithkline Beecham P.1.C. Use of inhibitors of human S-CD23
US6548084B2 (en) 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
ATE286892T1 (en) 1997-11-12 2005-01-15 Darwin Discovery Ltd HYDROXAM AND CARBOXYLIC ACID DERIVATIVES WITH MMP AND TNF INHIBITING ACTIVITY
GB9813451D0 (en) * 1998-06-22 1998-08-19 Smithkline Beecham Plc Novel compounds
GB9922825D0 (en) * 1999-09-25 1999-11-24 Smithkline Beecham Biolog Medical use
KR20020070285A (en) 1999-11-23 2002-09-05 메틸진, 인크. Inhibitors of histone deacetylase
GB9930754D0 (en) * 1999-12-29 2000-02-16 Smithkline Beecham Plc Novel compounds
EP1599449A2 (en) 2003-02-25 2005-11-30 TopoTarget UK Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
GB0818907D0 (en) * 2008-10-15 2008-11-19 Isis Innovation Histone lysine demethylase inhibitors
EP2435402B1 (en) 2009-05-28 2016-04-13 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
AR076707A1 (en) * 2009-05-28 2011-06-29 Novartis Ag AMINO-PROPIONIC DERIVATIVES REPLACED AS NEPRILISINE INHIBITORS
EP2860195A1 (en) 2009-12-01 2015-04-15 Boston Medical Center Corporation Treatment of IgE-mediated disease
AU2014216417B2 (en) 2013-02-14 2016-05-12 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
PT2956464T (en) 2013-02-14 2018-07-04 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
TW201625569A (en) * 2014-11-19 2016-07-16 艾克泰聯製藥有限公司 Antibacterial benzothiazole derivatives
AU2019352741A1 (en) 2018-10-04 2021-05-06 Assistance Publique-Hôpitaux De Paris (Aphp) EGFR inhibitors for treating keratodermas

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds
DE69502378T2 (en) * 1994-01-20 1998-10-01 British Biotech Pharm METALOPROTEINAS INHIBITORS
GB9414157D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Medical use
US5562917A (en) 1994-12-23 1996-10-08 Pentech Pharmaceuticals, Inc. Transdermal administration of apomorphine
DE19506492C2 (en) 1995-02-24 2003-05-08 Focke & Co Device for storing cigarettes or the like
US5570079A (en) 1995-04-24 1996-10-29 Dockery; Devan Home security system for detecting an intrusion into a monitored area by an infrared detector

Also Published As

Publication number Publication date
DE69723984T2 (en) 2004-06-09
CA2253590A1 (en) 1997-11-20
NZ332628A (en) 2000-06-23
ZA973964B (en) 1998-11-09
CZ363198A3 (en) 1999-06-16
EP0918747A1 (en) 1999-06-02
TR199802271T2 (en) 2000-08-21
GB9609794D0 (en) 1996-07-17
ES2205218T3 (en) 2004-05-01
DE69723984D1 (en) 2003-09-11
JP2000510473A (en) 2000-08-15
CO4990945A1 (en) 2000-12-26
WO1997043249A1 (en) 1997-11-20
US6235753B1 (en) 2001-05-22
NO985214D0 (en) 1998-11-09
NO985214L (en) 1998-12-01
AR007060A1 (en) 1999-10-13
PL329855A1 (en) 1999-04-12
KR20000010892A (en) 2000-02-25
AU2897397A (en) 1997-12-05
ATE246673T1 (en) 2003-08-15
EP0918747B1 (en) 2003-08-06
BR9709450A (en) 1999-08-10

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