AR005357A1 - Derivados de 14-o-carbamoil mutilina y sus sales utiles en el tratamiento de infecciones bacterianas, procedimiento para prepararlas, composicionesfarmaceuticas formuladas con dichos derivados y uso de los mismos para preparar dichas composiciones - Google Patents
Derivados de 14-o-carbamoil mutilina y sus sales utiles en el tratamiento de infecciones bacterianas, procedimiento para prepararlas, composicionesfarmaceuticas formuladas con dichos derivados y uso de los mismos para preparar dichas composicionesInfo
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- AR005357A1 AR005357A1 ARP970100026A ARP970100026A AR005357A1 AR 005357 A1 AR005357 A1 AR 005357A1 AR P970100026 A ARP970100026 A AR P970100026A AR P970100026 A ARP970100026 A AR P970100026A AR 005357 A1 AR005357 A1 AR 005357A1
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- optionally substituted
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- unsaturated
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- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- C07C271/36—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
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- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/20—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carbonic acid, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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Abstract
Se proponen compuestos de 14-O-carbamoil mutilina de fórmula (3) y sales derivadas farmacéuticamente aceptables de los mismos, donde; R1 es vino oetilo; R2 y R3 son grupos iguales o diferentes seleccionados entre hidrógeno; un grupohidrocarbona do C1 a C3 de cadena lineal o ramificada, saturado oinsaturado, opcionalmente sustituído; un grupo hidrocarbonado cíclio C3 a C6, saturado o insaturado opcionalmente sustituído; un grupo heterocíclicoopcionalmente sustituído; ungrupo arilo opcion almente sustituído; o conjuntamente forman un grupo cíclico opcionalmente sustituído de 3 a 8 átomosen el anillo, que contiene opcionalmente un heteroátomo adicional seleccionado entre N, O y S, y opcionalmentecondensado con un anillo hi drocarbonado, ungrupo heterocíclico o un grupo aromático; o R2 es uno de los grupos monovalentes anteriores y R3 es un grupo seleccionado entre SO2R4, COR6, OR4 yNR6R3, donde R4 se selecciona entre un grupohidrocarbonado C1 a C6 lineal o ramificado, saturado o insaturado, opcionalmente sustituído; un grupohidrocarbonado cíclico C3 a C6, saturado o insaturado, opcionalmente sustituído un grupo heterocíclico opcionalmente sustituído; un grupo ariloopcionalmentesustituído; un grup o alquilamino C1 a C6 opcionalmente sustituído y un grupo arilamino opcionalmente sustituído; R4 se selecciona entre hidrógeno; un grupohidrocarbonado C1 a C6 lineal o ramificado, saturado o insaturado, opcionalmente sustituído; un gr upo hidrocarbonado cíclico C3 a C6 saturado oinsaturado , opcionalmente sustituído ; un grupo heterocíclico opcionalmente sustituído; y un grupo arilo opcionalmente sustituído; R6 y R2 son gruposiguales odiferentes seleccionados entre hidrógeno; un grupo hidrocarbonado C1 a C6, lineal o ramificado, saturado o insaturado, opcionalmente sustituído
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GBGB9600048.4A GB9600048D0 (en) | 1996-01-03 | 1996-01-03 | Novel compounds |
GBGB9616305.0A GB9616305D0 (en) | 1996-08-02 | 1996-08-02 | Novel compounds |
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AR005357A1 true AR005357A1 (es) | 1999-04-28 |
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970100026A AR005357A1 (es) | 1996-01-03 | 1997-01-03 | Derivados de 14-o-carbamoil mutilina y sus sales utiles en el tratamiento de infecciones bacterianas, procedimiento para prepararlas, composicionesfarmaceuticas formuladas con dichos derivados y uso de los mismos para preparar dichas composiciones |
Country Status (26)
Country | Link |
---|---|
US (2) | US6020368A (es) |
EP (1) | EP0874809B1 (es) |
JP (1) | JP4163254B2 (es) |
KR (1) | KR19990076988A (es) |
CN (1) | CN1214039A (es) |
AP (1) | AP9801283A0 (es) |
AR (1) | AR005357A1 (es) |
AT (1) | ATE248143T1 (es) |
AU (1) | AU715229B2 (es) |
BG (1) | BG102600A (es) |
BR (1) | BR9612426A (es) |
CA (1) | CA2240467A1 (es) |
CZ (1) | CZ212498A3 (es) |
DE (1) | DE69629721T2 (es) |
EA (1) | EA199800525A1 (es) |
ES (1) | ES2205072T3 (es) |
HU (1) | HUP9900973A3 (es) |
IL (1) | IL124912A0 (es) |
MX (1) | MX9805416A (es) |
NO (1) | NO983074L (es) |
NZ (1) | NZ325837A (es) |
OA (1) | OA10708A (es) |
PL (1) | PL327737A1 (es) |
SK (1) | SK91098A3 (es) |
TR (1) | TR199801282T2 (es) |
WO (1) | WO1997025309A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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US6753006B1 (en) | 1993-02-22 | 2004-06-22 | American Bioscience, Inc. | Paclitaxel-containing formulations |
EP0874809B1 (en) * | 1996-01-03 | 2003-08-27 | SmithKline Beecham plc | Carbamoyloxy derivatives of mutiline and their use as antibacterials |
HUP0001741A3 (en) * | 1996-08-02 | 2000-11-28 | Smithkline Beecham Plc | Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use |
GB9719187D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | Compounds |
UY25225A1 (es) * | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
GB9817029D0 (en) * | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
WO2000037074A1 (en) * | 1998-12-18 | 2000-06-29 | Smithkline Beecham Plc | Mutilin 14-ester derivatives having antibacterial activity |
GB9912657D0 (en) * | 1999-06-01 | 1999-07-28 | Smithkline Beecham Plc | Novel compounds |
IL151887A0 (en) | 2000-04-04 | 2003-04-10 | Smithkline Beecham Plc | 2-hydroxy-mutilin carbamate derivatives for antibacterial use |
GB0018951D0 (en) * | 2000-08-03 | 2000-09-20 | Smithkline Beecham Plc | Novel compounds |
PE20020676A1 (es) * | 2000-09-13 | 2002-08-27 | Biochemie Gmbh | Compuestos de mutilina como antibacterianos |
GB0024811D0 (en) * | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
ATE343376T1 (de) * | 2002-03-20 | 2006-11-15 | Elan Pharma Int Ltd | Nanopartikelzusammensetzungen von angiogeneseinhibitoren |
US20080220075A1 (en) * | 2002-03-20 | 2008-09-11 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
GB0218578D0 (en) * | 2002-08-09 | 2002-09-18 | Glaxo Group Ltd | Novel method |
GB0308114D0 (en) * | 2003-04-08 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
JPWO2006070671A1 (ja) * | 2004-12-27 | 2008-06-12 | 杏林製薬株式会社 | 12位置換ムチリン誘導体 |
GB0504314D0 (en) | 2005-03-02 | 2005-04-06 | Glaxo Group Ltd | Novel polymorph |
US7696112B2 (en) | 2005-05-17 | 2010-04-13 | Milliken & Company | Non-woven material with barrier skin |
US7651964B2 (en) | 2005-08-17 | 2010-01-26 | Milliken & Company | Fiber-containing composite and method for making the same |
US7825050B2 (en) | 2006-12-22 | 2010-11-02 | Milliken & Company | VOC-absorbing nonwoven composites |
WO2008143343A1 (ja) | 2007-05-24 | 2008-11-27 | Kyorin Pharmaceutical Co., Ltd. | 14位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
TWM384453U (en) * | 2010-03-02 | 2010-07-11 | Winharbor Technology Co Ltd | Pull-resistant illuminating/heat generating structure capable of being charged in wireless manner |
CN102249982B (zh) * | 2010-05-18 | 2013-10-23 | 中国科学院上海药物研究所 | 新型截短侧耳素类化合物、其药物组合物及其制备方法和用途 |
WO2012006276A1 (en) | 2010-07-06 | 2012-01-12 | North Carolina State University | Inhibition of bacterial biofilms with aryl carbamates |
US9125408B2 (en) | 2010-09-01 | 2015-09-08 | North Carolina State University | Use of aryl carbamates in agriculture and other plant-related areas |
CA2844794C (en) | 2011-08-18 | 2018-02-20 | Nippon Shinyaku Co., Ltd. | Heterocyclic derivatives with mpges-1 inhibitory activity |
CZ307500B6 (cs) * | 2012-08-15 | 2018-10-24 | Zentiva, K.S. | Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty |
CN113563368A (zh) * | 2016-03-02 | 2021-10-29 | 比尔及梅琳达盖茨基金会 | 含硼小分子 |
US10611781B2 (en) * | 2016-03-02 | 2020-04-07 | Bill And Melinda Gates Foundation | Boron-containing small molecules |
US10874679B2 (en) * | 2016-03-02 | 2020-12-29 | Bill & Melinda Gates Foundation | Boron-containing small molecules |
CN106699690B (zh) * | 2016-12-07 | 2019-09-10 | 华南农业大学 | 一种具有酰基哌嗪基侧链的截短侧耳素衍生物及其制备方法和用途 |
TWI762573B (zh) | 2017-02-10 | 2022-05-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素之純化 |
CN111574395B (zh) * | 2020-06-18 | 2021-07-02 | 华南农业大学 | 一种具有酰胺侧链的截短侧耳素衍生物及制备与应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT301752B (de) * | 1969-07-21 | 1972-09-25 | Biochemie Gmbh | Verfahren zur Herstellung neuer Pleuromutilin-Derivate |
US3979423A (en) * | 1969-07-25 | 1976-09-07 | Biochemie Gesellschaft M.B.H. | 14-Desoxy-14-tosyloxyacetoxy-mutilin |
US3919290A (en) * | 1972-10-03 | 1975-11-11 | Sandoz Ltd | Substituted 14-desoxy-mutilins |
BE789629A (fr) * | 1971-10-05 | 1973-04-03 | Sandoz Sa | Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique |
CH627940A5 (de) * | 1976-12-23 | 1982-02-15 | Sandoz Ag | Kokzidiostatisches kombinationspraeparat. |
EP0013768B1 (en) * | 1979-01-12 | 1984-02-01 | Sandoz Ag | New pleuromutilin derivatives, their production and pharmaceutical compositions containing them |
EP0874809B1 (en) * | 1996-01-03 | 2003-08-27 | SmithKline Beecham plc | Carbamoyloxy derivatives of mutiline and their use as antibacterials |
-
1996
- 1996-12-19 EP EP96944684A patent/EP0874809B1/en not_active Expired - Lifetime
- 1996-12-19 JP JP52482697A patent/JP4163254B2/ja not_active Expired - Fee Related
- 1996-12-19 AP APAP/P/1998/001283A patent/AP9801283A0/en unknown
- 1996-12-19 CN CN96180177A patent/CN1214039A/zh active Pending
- 1996-12-19 ES ES96944684T patent/ES2205072T3/es not_active Expired - Lifetime
- 1996-12-19 SK SK910-98A patent/SK91098A3/sk unknown
- 1996-12-19 PL PL96327737A patent/PL327737A1/xx unknown
- 1996-12-19 AU AU13078/97A patent/AU715229B2/en not_active Ceased
- 1996-12-19 CA CA002240467A patent/CA2240467A1/en not_active Abandoned
- 1996-12-19 HU HU9900973A patent/HUP9900973A3/hu unknown
- 1996-12-19 TR TR1998/01282T patent/TR199801282T2/xx unknown
- 1996-12-19 KR KR1019980705118A patent/KR19990076988A/ko not_active Application Discontinuation
- 1996-12-19 EA EA199800525A patent/EA199800525A1/ru unknown
- 1996-12-19 AT AT96944684T patent/ATE248143T1/de not_active IP Right Cessation
- 1996-12-19 US US09/101,210 patent/US6020368A/en not_active Expired - Fee Related
- 1996-12-19 WO PCT/EP1996/005874 patent/WO1997025309A1/en not_active Application Discontinuation
- 1996-12-19 DE DE69629721T patent/DE69629721T2/de not_active Expired - Lifetime
- 1996-12-19 CZ CZ982124A patent/CZ212498A3/cs unknown
- 1996-12-19 BR BR9612426A patent/BR9612426A/pt unknown
- 1996-12-19 IL IL12491296A patent/IL124912A0/xx unknown
- 1996-12-19 NZ NZ325837A patent/NZ325837A/xx unknown
-
1997
- 1997-01-03 AR ARP970100026A patent/AR005357A1/es unknown
-
1998
- 1998-07-02 NO NO983074A patent/NO983074L/no not_active Application Discontinuation
- 1998-07-02 OA OA9800101A patent/OA10708A/en unknown
- 1998-07-02 MX MX9805416A patent/MX9805416A/es unknown
- 1998-07-03 BG BG102600A patent/BG102600A/xx unknown
-
1999
- 1999-12-21 US US09/467,695 patent/US6239175B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ325837A (en) | 1999-11-29 |
DE69629721D1 (de) | 2003-10-02 |
ATE248143T1 (de) | 2003-09-15 |
US6020368A (en) | 2000-02-01 |
BG102600A (en) | 1999-09-30 |
IL124912A0 (en) | 1999-01-26 |
HUP9900973A3 (en) | 2000-04-28 |
EP0874809B1 (en) | 2003-08-27 |
NO983074D0 (no) | 1998-07-02 |
OA10708A (en) | 2002-11-28 |
NO983074L (no) | 1998-08-31 |
KR19990076988A (ko) | 1999-10-25 |
WO1997025309A1 (en) | 1997-07-17 |
PL327737A1 (en) | 1998-12-21 |
MX9805416A (es) | 1998-10-31 |
US6239175B1 (en) | 2001-05-29 |
SK91098A3 (en) | 1999-02-11 |
AU1307897A (en) | 1997-08-01 |
DE69629721T2 (de) | 2004-06-09 |
EA199800525A1 (ru) | 1999-02-25 |
HUP9900973A2 (hu) | 1999-08-30 |
BR9612426A (pt) | 1999-07-13 |
AP9801283A0 (en) | 1998-09-30 |
JP4163254B2 (ja) | 2008-10-08 |
EP0874809A1 (en) | 1998-11-04 |
CZ212498A3 (cs) | 1998-12-16 |
CA2240467A1 (en) | 1997-07-17 |
AU715229B2 (en) | 2000-01-20 |
TR199801282T2 (xx) | 1998-12-21 |
ES2205072T3 (es) | 2004-05-01 |
CN1214039A (zh) | 1999-04-14 |
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