ATE111082T1 - 3-sulfonylamino-2-(1h)-chinolinone und deren 7- azaderivate als anregende aminosäuren antagonisten. - Google Patents

3-sulfonylamino-2-(1h)-chinolinone und deren 7- azaderivate als anregende aminosäuren antagonisten.

Info

Publication number
ATE111082T1
ATE111082T1 AT92403014T AT92403014T ATE111082T1 AT E111082 T1 ATE111082 T1 AT E111082T1 AT 92403014 T AT92403014 T AT 92403014T AT 92403014 T AT92403014 T AT 92403014T AT E111082 T1 ATE111082 T1 AT E111082T1
Authority
AT
Austria
Prior art keywords
branched
linear
trihalomethyl
unsubstituted
substituted
Prior art date
Application number
AT92403014T
Other languages
English (en)
Inventor
Alex Cordi
Patrice Desos
Jean Lepagnol
John Randle
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of ATE111082T1 publication Critical patent/ATE111082T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
AT92403014T 1991-11-14 1992-11-09 3-sulfonylamino-2-(1h)-chinolinone und deren 7- azaderivate als anregende aminosäuren antagonisten. ATE111082T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113977A FR2683818B1 (fr) 1991-11-14 1991-11-14 Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ATE111082T1 true ATE111082T1 (de) 1994-09-15

Family

ID=9418879

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92403014T ATE111082T1 (de) 1991-11-14 1992-11-09 3-sulfonylamino-2-(1h)-chinolinone und deren 7- azaderivate als anregende aminosäuren antagonisten.

Country Status (11)

Country Link
EP (1) EP0542609B1 (de)
JP (1) JPH06102650B2 (de)
AT (1) ATE111082T1 (de)
AU (1) AU651255B2 (de)
CA (1) CA2082856A1 (de)
DE (1) DE69200394T2 (de)
DK (1) DK0542609T3 (de)
ES (1) ES2064156T3 (de)
FR (1) FR2683818B1 (de)
NZ (1) NZ245127A (de)
ZA (1) ZA928727B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2709489B1 (fr) * 1993-08-31 1995-10-20 Adir Nouveaux dérivés de 2-(1H)-quinoléinone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2750988B1 (fr) * 1996-07-11 1998-09-18 Adir Nouveaux derives de 2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2298311B1 (de) 1999-01-13 2012-05-09 Bayer HealthCare LLC Omega-carboxyarylsubstituierte-Diphenyl-Harnstoffe als p38-Kinasehemmer
US20020065296A1 (en) 1999-01-13 2002-05-30 Bayer Corporation Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
SI1140840T1 (sl) 1999-01-13 2006-06-30 Bayer Pharmaceuticals Corp Omega-karboksiarilno substituirane difenil secnine kot inhibitorji raf kinaze
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
JP2003508397A (ja) 1999-08-27 2003-03-04 リガンド・ファーマシューティカルズ・インコーポレイテッド アンドロゲンレセプターモジュレーターとしての８−置換−６−トリフルオロメチル−９−ピリド［３，２−ｇ］キノリン化合物
TR200200507T2 (tr) * 1999-08-27 2002-10-21 Ligand Pharmaceuticals Inc Androjen reseptörü modülatör bileşikleri ve metotları
EP1216221A2 (de) 1999-09-14 2002-06-26 Ligand Pharmaceuticals Incorporated Rxr modulatoren mit verbessertem pharmakologischem profil
FR2805262A1 (fr) * 2000-02-18 2001-08-24 Adir Nouveaux derives d'acides aryle ou heteroaryle quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2805260A1 (fr) * 2000-02-18 2001-08-24 Adir Nouveaux derives d'acides 6-sulfamoyl-3-quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2805261A1 (fr) * 2000-02-18 2001-08-24 Adir Nouveaux derives d'acides 6-amino ou 6-hydrazinosulfonyl-3- quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TWI298068B (en) 2000-06-21 2008-06-21 Dainippon Sumitomo Pharma Co Pharmaceutical composition for schizophrenia
EP1636585B2 (de) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl-harnstoffe mit kinasehemmender wirkung
AU2004266160A1 (en) 2003-08-22 2005-03-03 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
EP1968589A2 (de) 2005-10-31 2008-09-17 Bayer Pharmaceuticals Corporation Kombinationen mit sorafenib und interferon zur behandlung von krebs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3066145A (en) * 1962-02-07 1962-11-27 American Home Prod 3-amino-6-chloro-4-phenyl-2(1h)-quinolone
EP0386839B1 (de) * 1989-03-08 1997-01-15 Merck Sharp & Dohme Ltd. Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten
GB9004288D0 (en) * 1990-02-26 1990-04-18 Almirall Lab New 4(1h)quinoline derivatives

Also Published As

Publication number Publication date
FR2683818B1 (fr) 1993-12-31
NZ245127A (en) 1994-07-26
JPH06102650B2 (ja) 1994-12-14
CA2082856A1 (fr) 1993-05-15
AU2835192A (en) 1993-05-20
ZA928727B (en) 1993-05-10
DK0542609T3 (da) 1995-03-20
AU651255B2 (en) 1994-07-14
DE69200394D1 (de) 1994-10-13
EP0542609B1 (de) 1994-09-07
FR2683818A1 (fr) 1993-05-21
DE69200394T2 (de) 1995-04-27
JPH05221997A (ja) 1993-08-31
EP0542609A1 (de) 1993-05-19
ES2064156T3 (es) 1995-01-16

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