AU2835192A - New 3-sulfonylamino-2(1h)-quinolone compounds, process for preparing them and pharmaceutical compositions containing them - Google Patents
New 3-sulfonylamino-2(1h)-quinolone compounds, process for preparing them and pharmaceutical compositions containing themInfo
- Publication number
- AU2835192A AU2835192A AU28351/92A AU2835192A AU2835192A AU 2835192 A AU2835192 A AU 2835192A AU 28351/92 A AU28351/92 A AU 28351/92A AU 2835192 A AU2835192 A AU 2835192A AU 2835192 A AU2835192 A AU 2835192A
- Authority
- AU
- Australia
- Prior art keywords
- branched
- linear
- trihalomethyl
- unsubstituted
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SBRVYAOCKKOQDY-UHFFFAOYSA-N 3-(sulfonylamino)-1h-quinolin-2-one Chemical class C1=CC=C2C=C(N=S(=O)=O)C(=O)NC2=C1 SBRVYAOCKKOQDY-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006823 (C1-C6) acyl group Chemical group 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- JKFAIQOWCVVSKC-UHFFFAOYSA-N furazan Chemical group C=1C=NON=1 JKFAIQOWCVVSKC-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000005504 styryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Compounds of formula (I): <IMAGE> in which: X, Y, Z - which are identical or different, represent a hydrogen atom, a halogen atom or a nitro, cyano, azido, trihalomethyl, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, or amino (unsubstituted or substituted by a linear or branched (C1-C6)acyl group) group, - or else, when they are situated on two adjacent carbons, form, with the carbon atoms to which they are attached, a phenyl ring or a 5- or 6-membered heterocycle containing from 1 to 3 hetero atoms, preferably a 1,2,5-oxadiazole ring, R represents a linear or branched (C1-C6)alkyl, trihalomethyl, phenyl (unsubstituted or substituted by one or a number of halogen atoms or linear or branched (C1-C6)alkyl, trihalomethyl or linear or branched (C1-C6)alkoxy groups), 2-thienyl (unsubstituted or substituted by a halogen atom), naphthyl or styryl group, A represents a CH radical or a nitrogen atom. Medicaments.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9113977 | 1991-11-14 | ||
| FR9113977A FR2683818B1 (en) | 1991-11-14 | 1991-11-14 | NOVEL 3-SULFONYLAMINO-2- (1H) -QUINOLEINONE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2835192A true AU2835192A (en) | 1993-05-20 |
| AU651255B2 AU651255B2 (en) | 1994-07-14 |
Family
ID=9418879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU28351/92A Ceased AU651255B2 (en) | 1991-11-14 | 1992-11-13 | New 3-sulfonylamino-2(1H)-quinolone compounds, process for preparing them and pharmaceutical compositions containing them |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0542609B1 (en) |
| JP (1) | JPH06102650B2 (en) |
| AT (1) | ATE111082T1 (en) |
| AU (1) | AU651255B2 (en) |
| CA (1) | CA2082856A1 (en) |
| DE (1) | DE69200394T2 (en) |
| DK (1) | DK0542609T3 (en) |
| ES (1) | ES2064156T3 (en) |
| FR (1) | FR2683818B1 (en) |
| NZ (1) | NZ245127A (en) |
| ZA (1) | ZA928727B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7696246B2 (en) | 1999-08-27 | 2010-04-13 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2709489B1 (en) * | 1993-08-31 | 1995-10-20 | Adir | New derivatives of 2- (1H) -quinolineone, their preparation process and the pharmaceutical compositions containing them. |
| FR2750988B1 (en) * | 1996-07-11 | 1998-09-18 | Adir | NOVEL 2- (1H) -QUINOLEINONE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
| CA2549558C (en) | 1999-01-13 | 2010-08-31 | Bayer Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US20020065296A1 (en) | 1999-01-13 | 2002-05-30 | Bayer Corporation | Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors |
| JP2003508402A (en) | 1999-08-27 | 2003-03-04 | リガンド・ファーマシューティカルズ・インコーポレイテッド | Androgen receptor modulator compounds and methods |
| EP1212322A2 (en) | 1999-08-27 | 2002-06-12 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators |
| CO5200852A1 (en) | 1999-09-14 | 2002-09-27 | Lilly Co Eli | RXR MODULATORS WITH IMPROVED CEPTORS X PHARMACOLOGICAL PROFILE OF RETINOIDS |
| FR2805261A1 (en) * | 2000-02-18 | 2001-08-24 | Adir | NOVEL 6-AMINO OR 6-HYDRAZINOSULFONYL-3- QUINOLINYL PHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2805260A1 (en) * | 2000-02-18 | 2001-08-24 | Adir | NOVEL 6-SULFAMOYL-3-QUINOLINYL PHOSPHONIC ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| FR2805262A1 (en) * | 2000-02-18 | 2001-08-24 | Adir | NOVEL PHYPHONIC ARYL OR HETEROARYL QUINOLINYL ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| TWI298068B (en) * | 2000-06-21 | 2008-06-21 | Dainippon Sumitomo Pharma Co | Pharmaceutical composition for schizophrenia |
| DK1636585T3 (en) | 2003-05-20 | 2008-05-26 | Bayer Pharmaceuticals Corp | Diarylurines with kinase inhibitory activity |
| MXPA06001751A (en) | 2003-08-22 | 2006-05-12 | Ligand Pharm Inc | 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds. |
| US20090068146A1 (en) | 2005-10-31 | 2009-03-12 | Scott Wilhelm | Diaryl ureas and combinations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3066145A (en) * | 1962-02-07 | 1962-11-27 | American Home Prod | 3-amino-6-chloro-4-phenyl-2(1h)-quinolone |
| ATE147732T1 (en) * | 1989-03-08 | 1997-02-15 | Merck Sharp & Dohme | TETRAHYDROQUINOLINE DERIVATIVES USABLE IN NEURODEGENERATIVE DISEASES |
| GB9004288D0 (en) * | 1990-02-26 | 1990-04-18 | Almirall Lab | New 4(1h)quinoline derivatives |
-
1991
- 1991-11-14 FR FR9113977A patent/FR2683818B1/en not_active Expired - Fee Related
-
1992
- 1992-11-09 EP EP92403014A patent/EP0542609B1/en not_active Expired - Lifetime
- 1992-11-09 DK DK92403014.1T patent/DK0542609T3/en active
- 1992-11-09 ES ES92403014T patent/ES2064156T3/en not_active Expired - Lifetime
- 1992-11-09 AT AT92403014T patent/ATE111082T1/en active
- 1992-11-09 DE DE69200394T patent/DE69200394T2/en not_active Expired - Fee Related
- 1992-11-12 ZA ZA928727A patent/ZA928727B/en unknown
- 1992-11-13 CA CA002082856A patent/CA2082856A1/en not_active Abandoned
- 1992-11-13 NZ NZ24512792A patent/NZ245127A/en unknown
- 1992-11-13 AU AU28351/92A patent/AU651255B2/en not_active Ceased
- 1992-11-16 JP JP4305550A patent/JPH06102650B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7696246B2 (en) | 1999-08-27 | 2010-04-13 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06102650B2 (en) | 1994-12-14 |
| AU651255B2 (en) | 1994-07-14 |
| FR2683818A1 (en) | 1993-05-21 |
| ATE111082T1 (en) | 1994-09-15 |
| DK0542609T3 (en) | 1995-03-20 |
| NZ245127A (en) | 1994-07-26 |
| EP0542609B1 (en) | 1994-09-07 |
| CA2082856A1 (en) | 1993-05-15 |
| EP0542609A1 (en) | 1993-05-19 |
| DE69200394T2 (en) | 1995-04-27 |
| DE69200394D1 (en) | 1994-10-13 |
| ZA928727B (en) | 1993-05-10 |
| FR2683818B1 (en) | 1993-12-31 |
| JPH05221997A (en) | 1993-08-31 |
| ES2064156T3 (en) | 1995-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |