DE69200394D1 - 3-Sulfonylamino-2-(1H)-Chinolinone und deren 7-Azaderivate als anregende Aminosäuren Antagonisten. - Google Patents

3-Sulfonylamino-2-(1H)-Chinolinone und deren 7-Azaderivate als anregende Aminosäuren Antagonisten.

Info

Publication number
DE69200394D1
DE69200394D1 DE69200394T DE69200394T DE69200394D1 DE 69200394 D1 DE69200394 D1 DE 69200394D1 DE 69200394 T DE69200394 T DE 69200394T DE 69200394 T DE69200394 T DE 69200394T DE 69200394 D1 DE69200394 D1 DE 69200394D1
Authority
DE
Germany
Prior art keywords
branched
linear
trihalomethyl
unsubstituted
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69200394T
Other languages
English (en)
Other versions
DE69200394T2 (de
Inventor
Alex Cordi
Patrice Desos
Jean Lepagnol
John Randle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of DE69200394D1 publication Critical patent/DE69200394D1/de
Publication of DE69200394T2 publication Critical patent/DE69200394T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DE69200394T 1991-11-14 1992-11-09 3-Sulfonylamino-2-(1H)-Chinolinone und deren 7-Azaderivate als anregende Aminosäuren Antagonisten. Expired - Fee Related DE69200394T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113977A FR2683818B1 (fr) 1991-11-14 1991-11-14 Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
DE69200394D1 true DE69200394D1 (de) 1994-10-13
DE69200394T2 DE69200394T2 (de) 1995-04-27

Family

ID=9418879

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69200394T Expired - Fee Related DE69200394T2 (de) 1991-11-14 1992-11-09 3-Sulfonylamino-2-(1H)-Chinolinone und deren 7-Azaderivate als anregende Aminosäuren Antagonisten.

Country Status (11)

Country Link
EP (1) EP0542609B1 (de)
JP (1) JPH06102650B2 (de)
AT (1) ATE111082T1 (de)
AU (1) AU651255B2 (de)
CA (1) CA2082856A1 (de)
DE (1) DE69200394T2 (de)
DK (1) DK0542609T3 (de)
ES (1) ES2064156T3 (de)
FR (1) FR2683818B1 (de)
NZ (1) NZ245127A (de)
ZA (1) ZA928727B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2709489B1 (fr) * 1993-08-31 1995-10-20 Adir Nouveaux dérivés de 2-(1H)-quinoléinone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2750988B1 (fr) * 1996-07-11 1998-09-18 Adir Nouveaux derives de 2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20020065296A1 (en) 1999-01-13 2002-05-30 Bayer Corporation Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
EP1690853B1 (de) 1999-01-13 2010-03-10 Bayer HealthCare LLC Verwendung von Omega-Carboxyaryl-substituierten Diphenylharnstoffen als raf-Kinase-Inhibitoren
EP1158985B1 (de) 1999-01-13 2011-12-28 Bayer HealthCare LLC GAMMA CARBOXYARYLSUBSTITUIERTE DIPHENYLHARNSTOFFVERBINDUNGEN ALS p38 KINASEHEMMER
EP1212330B1 (de) 1999-08-27 2006-04-19 Ligand Pharmaceuticals Incorporated Androgenrezeptor-modulatorverbindungen und verfahren
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
EP1212322A2 (de) 1999-08-27 2002-06-12 Ligand Pharmaceuticals Incorporated 8-substituierte-6-trifluoromethyl-9-pyrido[3,2-g]chiolinverbindungen als androgen rezeptormodulatoren
EP1216221A2 (de) 1999-09-14 2002-06-26 Ligand Pharmaceuticals Incorporated Rxr modulatoren mit verbessertem pharmakologischem profil
FR2805262A1 (fr) * 2000-02-18 2001-08-24 Adir Nouveaux derives d'acides aryle ou heteroaryle quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2805260A1 (fr) * 2000-02-18 2001-08-24 Adir Nouveaux derives d'acides 6-sulfamoyl-3-quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2805261A1 (fr) * 2000-02-18 2001-08-24 Adir Nouveaux derives d'acides 6-amino ou 6-hydrazinosulfonyl-3- quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TWI298068B (en) * 2000-06-21 2008-06-21 Dainippon Sumitomo Pharma Co Pharmaceutical composition for schizophrenia
PL1636585T3 (pl) 2003-05-20 2008-10-31 Bayer Healthcare Llc Diarylowe pochodne mocznika inhibowane kinazą
CA2536349A1 (en) 2003-08-22 2005-03-03 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
WO2007053574A2 (en) 2005-10-31 2007-05-10 Bayer Pharmaceuticals Corporation Combinations comprising sorafenib and interferon for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3066145A (en) * 1962-02-07 1962-11-27 American Home Prod 3-amino-6-chloro-4-phenyl-2(1h)-quinolone
IL93610A0 (en) * 1989-03-08 1990-12-23 Merck Sharp & Dohme Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them
GB9004288D0 (en) * 1990-02-26 1990-04-18 Almirall Lab New 4(1h)quinoline derivatives

Also Published As

Publication number Publication date
DK0542609T3 (da) 1995-03-20
AU2835192A (en) 1993-05-20
ES2064156T3 (es) 1995-01-16
DE69200394T2 (de) 1995-04-27
FR2683818A1 (fr) 1993-05-21
JPH06102650B2 (ja) 1994-12-14
FR2683818B1 (fr) 1993-12-31
EP0542609B1 (de) 1994-09-07
CA2082856A1 (fr) 1993-05-15
ZA928727B (en) 1993-05-10
AU651255B2 (en) 1994-07-14
EP0542609A1 (de) 1993-05-19
JPH05221997A (ja) 1993-08-31
ATE111082T1 (de) 1994-09-15
NZ245127A (en) 1994-07-26

Similar Documents

Publication Publication Date Title
DE69200394T2 (de) 3-Sulfonylamino-2-(1H)-Chinolinone und deren 7-Azaderivate als anregende Aminosäuren Antagonisten.
NO923528D0 (no) Benzyliden-karbamoyl-pyrrolidonanaloger
ES2137915T3 (es) Derivados de tiazolidindiona sustituida.
FI950016A (fi) Heterosykliset yhdisteet lääkeaineena
ES2081120T3 (es) Procedimiento para la preparacion de derivados de la bacatina iii y la desacetil-10 bacatina iii.
ES8605511A1 (es) Un procedimiento para la preparacion de derivados de tiazol,2, 4, disustituidos.
DE69216509D1 (de) Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
MX170732B (es) Composicion de derivados de succinimida y su uso
ATE69605T1 (de) Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide.
FR2709489B1 (fr) Nouveaux dérivés de 2-(1H)-quinoléinone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FI933468A (fi) Tetrahydronaftalenderivat, framstaellning av dessa och terapeutisk anvaendning av dessa
DE69204859T2 (de) Substituierte Pyridinsulfonamide oder deren Salze, Verfahren zur Herstellung und diese enthaltende Herbizide.
PT90815A (pt) Processo de preparacao de derivados da fenotiazina
SE8200320L (sv) Nya derivat av spiro-1 isobensofuraner och spiro-1 isobensotiofener, derasframstellningssett och terapeutiska anvendning
ATE44741T1 (de) 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee