AR004254A1 - Inhibidores de trombina de ligadura no lenta, un procedimiento para la preparacion de dichos inhibidores, composiciones farmaceuticas que loscontienen y el uso de estos inhibidores de trombina como agentes antitromboticos - Google Patents
Inhibidores de trombina de ligadura no lenta, un procedimiento para la preparacion de dichos inhibidores, composiciones farmaceuticas que loscontienen y el uso de estos inhibidores de trombina como agentes antitromboticosInfo
- Publication number
- AR004254A1 AR004254A1 ARP960104997A ARP960104997A AR004254A1 AR 004254 A1 AR004254 A1 AR 004254A1 AR P960104997 A ARP960104997 A AR P960104997A AR P960104997 A ARP960104997 A AR P960104997A AR 004254 A1 AR004254 A1 AR 004254A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibitors
- alkyl
- cooh
- hydroxy
- antithrombotic agents
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 2
- 229960004676 antithrombotic agent Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 abstract 4
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 2-hydroxy-3-cyclohexyl-propionyl Chemical group 0.000 abstract 1
- 150000008574 D-amino acids Chemical class 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical class OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
- 239000003868 thrombin inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95202982 | 1995-11-03 | ||
| EP95203554 | 1995-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004254A1 true AR004254A1 (es) | 1998-11-04 |
Family
ID=26139759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104997A AR004254A1 (es) | 1995-11-03 | 1996-11-01 | Inhibidores de trombina de ligadura no lenta, un procedimiento para la preparacion de dichos inhibidores, composiciones farmaceuticas que loscontienen y el uso de estos inhibidores de trombina como agentes antitromboticos |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6432921B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP0858464B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH11515033A (cg-RX-API-DMAC7.html) |
| KR (1) | KR19990067219A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1202902A (cg-RX-API-DMAC7.html) |
| AR (1) | AR004254A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE239755T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU712940B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9611377A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2235586A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ133998A3 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69628027T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0858464T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2199302T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUP9900728A3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL119466A (cg-RX-API-DMAC7.html) |
| NO (1) | NO981965L (cg-RX-API-DMAC7.html) |
| PL (1) | PL326863A1 (cg-RX-API-DMAC7.html) |
| PT (1) | PT858464E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2178796C2 (cg-RX-API-DMAC7.html) |
| TR (1) | TR199800773T2 (cg-RX-API-DMAC7.html) |
| TW (1) | TW486459B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997017363A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121474A0 (en) * | 1996-08-23 | 1998-02-08 | Akzo Nobel Nv | Thrombin inhibitors |
| US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
| US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
| WO1998016523A2 (en) * | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6133256A (en) * | 1997-04-14 | 2000-10-17 | Cor Therapeutics Inc | Selective factor Xa inhibitors |
| US6369063B1 (en) | 1997-04-14 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| AU747531B2 (en) | 1997-04-14 | 2002-05-16 | Millennium Pharmaceuticals, Inc. | Selective factor Xa inhibitors |
| EP0977772A1 (en) | 1997-04-14 | 2000-02-09 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
| EP0884325A1 (en) * | 1997-04-24 | 1998-12-16 | Akzo Nobel N.V. | Thrombin inhibitors containing a peptidyl heterocycle |
| US5877156A (en) * | 1997-04-24 | 1999-03-02 | Akzo Nobel, N.V. | Thrombin inhibitors |
| TR199902692T2 (xx) * | 1997-05-02 | 2000-07-21 | Akzo Nobel N.V. | Serin proteaz inhibit�rleri. |
| US6214841B1 (en) | 1997-05-15 | 2001-04-10 | Eli Lilly And Company | Antithrombotic compound |
| US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
| US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| BR0007778A (pt) * | 1999-01-27 | 2002-06-04 | Ortho Mcneil Pharm Inc | Peptidila cetonas heterocìclicas úteis como inibidores de triptase |
| US6344450B1 (en) * | 1999-02-09 | 2002-02-05 | Bristol-Myers Squibb Company | Lactam compounds and their use as inhibitors of serine proteases and method |
| US7405210B2 (en) * | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
| ATE483708T1 (de) | 2004-03-08 | 2010-10-15 | Prosidion Ltd | Pyrrolopyridin-2-carbonsäurehydrazide als inhibitoren von glykogenphosphorylase |
| ATE480561T1 (de) | 2004-10-19 | 2010-09-15 | Lonza Ag | Verfahren zur festphasen-peptidsynthese |
| ATE424821T1 (de) | 2004-12-02 | 2009-03-15 | Prosidion Ltd | Pyrrolopyridin-2-karbonsäureamide |
| EP2027143A2 (en) | 2006-05-23 | 2009-02-25 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| CA2677487A1 (en) | 2007-02-09 | 2008-08-14 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| SG187271A1 (en) * | 2011-07-07 | 2013-02-28 | Agency Science Tech & Res | Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutic |
| EP3204352B1 (en) * | 2014-10-06 | 2020-07-01 | Cortexyme, Inc. | Inhibitors of lysine gingipain |
| EP3374352A4 (en) | 2015-11-09 | 2019-10-02 | Cortexyme, Inc. | GINGIPAINE ARGININE INHIBITORS |
| IL265389B1 (en) | 2016-09-16 | 2026-07-01 | Quince Therapeutics Inc | Ketone compounds lysine inhibitors gingerapine, preparations containing them and uses thereof |
| IL270789B2 (en) | 2017-05-25 | 2023-09-01 | Jw Pharmaceutical Corp | Process for the preparation of (5,3-dibromo-4-hydroxyphenyl) (3,2-dihydro-h4-pyrido]3,4-b [4,1] oxazine-4-yl)-methanone and its intermediate compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9110298D0 (en) * | 1991-05-13 | 1991-07-03 | Fujisawa Pharmaceutical Co | New peptide compound and a process for the preparation thereof |
| CN1175259A (zh) * | 1994-12-22 | 1998-03-04 | 生化制药有限公司 | 低分子量双环凝血酶抑制剂 |
| US5827860A (en) | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| US5523308A (en) | 1995-06-07 | 1996-06-04 | Costanzo; Michael J. | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| US5827866A (en) * | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
-
1996
- 1996-10-22 IL IL11946696A patent/IL119466A/xx not_active IP Right Cessation
- 1996-10-30 US US09/068,074 patent/US6432921B2/en not_active Expired - Fee Related
- 1996-10-30 ES ES96937337T patent/ES2199302T3/es not_active Expired - Lifetime
- 1996-10-30 CN CN96198628A patent/CN1202902A/zh active Pending
- 1996-10-30 HU HU9900728A patent/HUP9900728A3/hu unknown
- 1996-10-30 CA CA002235586A patent/CA2235586A1/en not_active Abandoned
- 1996-10-30 PT PT96937337T patent/PT858464E/pt unknown
- 1996-10-30 KR KR1019980703176A patent/KR19990067219A/ko not_active Ceased
- 1996-10-30 CZ CZ981339A patent/CZ133998A3/cs unknown
- 1996-10-30 BR BR9611377A patent/BR9611377A/pt unknown
- 1996-10-30 DE DE69628027T patent/DE69628027T2/de not_active Expired - Fee Related
- 1996-10-30 JP JP9517828A patent/JPH11515033A/ja not_active Ceased
- 1996-10-30 PL PL96326863A patent/PL326863A1/xx unknown
- 1996-10-30 EP EP96937337A patent/EP0858464B1/en not_active Expired - Lifetime
- 1996-10-30 RU RU98110641/04A patent/RU2178796C2/ru not_active IP Right Cessation
- 1996-10-30 TR TR1998/00773T patent/TR199800773T2/xx unknown
- 1996-10-30 AU AU74975/96A patent/AU712940B2/en not_active Ceased
- 1996-10-30 WO PCT/EP1996/004785 patent/WO1997017363A1/en not_active Ceased
- 1996-10-30 AT AT96937337T patent/ATE239755T1/de not_active IP Right Cessation
- 1996-10-30 DK DK96937337T patent/DK0858464T3/da active
- 1996-11-01 AR ARP960104997A patent/AR004254A1/es unknown
- 1996-11-04 TW TW085113438A patent/TW486459B/zh active
-
1998
- 1998-04-30 NO NO981965A patent/NO981965L/no not_active Application Discontinuation
-
2002
- 2002-01-04 US US10/039,737 patent/US20020142967A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9900728A3 (en) | 2000-12-28 |
| WO1997017363A1 (en) | 1997-05-15 |
| US6432921B2 (en) | 2002-08-13 |
| IL119466A (en) | 2001-08-26 |
| RU2178796C2 (ru) | 2002-01-27 |
| MX9803479A (es) | 1998-09-30 |
| TR199800773T2 (xx) | 1998-08-21 |
| AU712940B2 (en) | 1999-11-18 |
| PT858464E (pt) | 2003-08-29 |
| CZ133998A3 (cs) | 1998-09-16 |
| TW486459B (en) | 2002-05-11 |
| DE69628027T2 (de) | 2004-04-08 |
| DK0858464T3 (da) | 2003-08-25 |
| NO981965L (no) | 1998-06-30 |
| CN1202902A (zh) | 1998-12-23 |
| US20010007764A1 (en) | 2001-07-12 |
| BR9611377A (pt) | 1999-02-23 |
| HUP9900728A2 (hu) | 1999-08-30 |
| DE69628027D1 (en) | 2003-06-12 |
| NO981965D0 (no) | 1998-04-30 |
| KR19990067219A (ko) | 1999-08-16 |
| ATE239755T1 (de) | 2003-05-15 |
| PL326863A1 (en) | 1998-10-26 |
| US20020142967A1 (en) | 2002-10-03 |
| CA2235586A1 (en) | 1997-05-15 |
| EP0858464B1 (en) | 2003-05-07 |
| EP0858464A1 (en) | 1998-08-19 |
| AU7497596A (en) | 1997-05-29 |
| IL119466A0 (en) | 1997-01-10 |
| JPH11515033A (ja) | 1999-12-21 |
| ES2199302T3 (es) | 2004-02-16 |
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