AR004122A1 - Procedimiento para la preparacion de un compuesto de dihaloazolopirimidinas y un procedimiento para la preparacion de un intermediario de dicho procedimiento - Google Patents

Procedimiento para la preparacion de un compuesto de dihaloazolopirimidinas y un procedimiento para la preparacion de un intermediario de dicho procedimiento

Info

Publication number
AR004122A1
AR004122A1 ARP960104928A ARP960104928A AR004122A1 AR 004122 A1 AR004122 A1 AR 004122A1 AR P960104928 A ARP960104928 A AR P960104928A AR P960104928 A ARP960104928 A AR P960104928A AR 004122 A1 AR004122 A1 AR 004122A1
Authority
AR
Argentina
Prior art keywords
procedure
preparation
dihaloazolopirimidines
intermediary
compound
Prior art date
Application number
ARP960104928A
Other languages
English (en)
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of AR004122A1 publication Critical patent/AR004122A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento efectivo y eficiente para la preparación de una dihaloazopirimidina que tiene la fórmula estructural (I), donde R, X, X1,Y y Z tienen los significados indicados en la memoria descriptiva. En este procedimiento, sehac e reaccionar un éster de ácido malónico con unaheterociclilamina para formar una sal intermediaria que opcionalmente puede acidificarse para formar una dihidroxiazolopirimidina; la sal o ladihidroxiazolopirimidina son luego halogenadas.También s e incluyeica un procedimiento para la preparación de un intermediario en dicho proceso.
ARP960104928A 1995-10-27 1996-10-25 Procedimiento para la preparacion de un compuesto de dihaloazolopirimidinas y un procedimiento para la preparacion de un intermediario de dicho procedimiento AR004122A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US802295P 1995-10-27 1995-10-27

Publications (1)

Publication Number Publication Date
AR004122A1 true AR004122A1 (es) 1998-09-30

Family

ID=21729405

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960104928A AR004122A1 (es) 1995-10-27 1996-10-25 Procedimiento para la preparacion de un compuesto de dihaloazolopirimidinas y un procedimiento para la preparacion de un intermediario de dicho procedimiento

Country Status (22)

Country Link
US (1) US5808066A (es)
EP (1) EP0770615B1 (es)
JP (1) JP4018182B2 (es)
KR (1) KR100443182B1 (es)
AR (1) AR004122A1 (es)
AT (1) ATE243211T1 (es)
BR (1) BR9605258A (es)
CA (1) CA2188905C (es)
DE (1) DE69628712T2 (es)
DK (1) DK0770615T3 (es)
ES (1) ES2202419T3 (es)
HU (1) HU217773B (es)
IL (1) IL119496A (es)
MX (1) MX9604882A (es)
PT (1) PT770615E (es)
RU (1) RU2147584C1 (es)
SG (1) SG55239A1 (es)
SI (1) SI0770615T1 (es)
SK (1) SK284071B6 (es)
TR (1) TR199600792A2 (es)
UA (1) UA48132C2 (es)
ZA (1) ZA968957B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
EP1054888B1 (en) * 1998-02-11 2003-11-26 Basf Aktiengesellschaft Fungicidal 7-alkyl-triazolopyrimidines
US6117865A (en) * 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6380202B1 (en) * 1998-09-25 2002-04-30 Basf Aktiengesellschaft Fungicidal fluoro-substituted 7-heterocyclyl-triazolopyrimidines
US6156925A (en) * 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
US7683071B2 (en) * 2000-07-26 2010-03-23 Taro Pharmaceuticals Industries Ltd. Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
US6756379B2 (en) * 2001-07-26 2004-06-29 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents
US6939873B2 (en) * 2000-07-26 2005-09-06 Taro Pharmaceuticals Industries Limited Non-sedating barbituric acid derivatives
DE10063115A1 (de) * 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
JP2002249492A (ja) * 2000-12-22 2002-09-06 Nippon Bayer Agrochem Co Ltd トリアゾロピリミジン類
DE10121101A1 (de) * 2001-04-27 2002-10-31 Bayer Ag Triazolopyrimidine
KR100619216B1 (ko) 2001-07-05 2006-09-08 바스프 악티엔게젤샤프트 살진균성 트리아졸로피리미딘, 이의 제조방법 및 유해진균 방제를 위한 이의 용도 및 상기 화합물을 포함하는조성물
EP1412356A1 (en) 2001-07-18 2004-04-28 Basf Aktiengesellschaft Substituted 6-(2-methoxyphenyl)triazolopyrimidines as fungicides
DK1414302T3 (da) 2001-07-26 2007-06-18 Basf Ag 7-aminotriazolopyrimidiner til bekæmpelse af skadelige svampe
DE60220296T2 (de) 2001-09-04 2008-01-17 Sumitomo Chemical Co., Ltd. IMIDAZO(1,2-a)PYRIMIDINE UND DIESE ENTHALTENDE FUNGIZIDZUSAMMENSETZUNGEN
EP1490372B1 (de) 2002-03-21 2008-01-16 Basf Aktiengesellschaft Fungizide triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
CA2505335C (en) * 2002-12-11 2013-09-10 Daniel Aaron Moros Method of treating movement disorders using barbituric acid derivatives
DK1684763T3 (da) * 2003-09-24 2008-09-01 Wyeth Corp 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
DE602004004295T8 (de) * 2003-09-24 2007-09-20 Wyeth Holdings Corp. 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
TW200533670A (en) * 2003-12-19 2005-10-16 Basf Ag 6-(aminocarbonylphenyl)triazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
DE102004007076A1 (de) * 2004-02-13 2005-08-25 Bayer Cropscience Ag Imidazolopyrimidine
ES2347664T3 (es) * 2004-03-10 2010-11-03 Basf Se 5,6-dialquil-7-aminotriazolopirimidinas, el procedimiento para su obtencion y su utilizacion para combatir hongos perjudiciales, asi como los productos que las contienen.
KR20060130720A (ko) * 2004-03-10 2006-12-19 바스프 악티엔게젤샤프트 5,6-디알킬-7-아미노-트리아졸로피리미딘, 그의 제조 방법,그의 병원성 진균류 방제를 위한 용도 및 상기 화합물을포함하는 제제
PE20060020A1 (es) * 2004-03-30 2006-03-10 Basf Ag 5-6-cicloalquil-7-amino-triazolopirimidinas para combatir hongos fitopatogenos y procedimientos para su obtencion
CA2572797A1 (en) * 2004-07-02 2006-01-12 Daniella Gutman A process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid
WO2006092411A1 (de) * 2005-03-01 2006-09-08 Basf Aktiengesellschaft 5,6-dialkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
TW200640928A (en) * 2005-03-01 2006-12-01 Basf Ag 5,6-Dialkyl-7-aminoazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
EP1856121A1 (de) * 2005-03-01 2007-11-21 Basf Aktiengesellschaft 5,6-dialkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
TW200643022A (en) * 2005-03-02 2006-12-16 Basf Ag 2-substituted 7-aminoazolopyrimidines, processes for their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
JP2008532979A (ja) * 2005-03-10 2008-08-21 ビーエーエスエフ ソシエタス・ヨーロピア 有害菌類を防除するための４−アミノピリミジン類の使用、新規の４−アミノピリミジン類、それらを調製する方法およびそれらを含む組成物
US20080146839A1 (en) * 2005-03-18 2008-06-19 Basf Aktiengesellschaft Method for Producing 5-Halo-2,4,6-Trifluoroisophthalic Acid
CN101208289A (zh) * 2005-06-27 2008-06-25 巴斯福股份公司 生产取代的苯基丙二酸酯中间体化合物的方法及其在生产5,7-二羟基-6-(2,4,6-三氟苯基)[1,2,4]三唑并[1,5-a]嘧啶中的用途
US20080200675A1 (en) * 2005-06-27 2008-08-21 Basf Aktiengesellschaft Method for Production of Substituted Phenylmalonate Esters, Novel Phenylmalonate Esters and Use Thereof
EP2081576A4 (en) * 2006-11-14 2010-06-30 Taro Pharmaceuticals North Ame METHOD FOR IMPROVING BIOAVAILABILITY FOR NON-EDMING BARBITURATES
CN101583613A (zh) * 2007-01-11 2009-11-18 巴斯夫欧洲公司 生产芳基取代的稠合嘧啶的方法
US8343977B2 (en) * 2009-12-30 2013-01-01 Arqule, Inc. Substituted triazolo-pyrimidine compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907799A (en) * 1971-08-16 1975-09-23 Icn Pharmaceuticals Xanthine oxidase inhibitors
JPS5962593A (ja) * 1982-09-30 1984-04-10 Ss Pharmaceut Co Ltd ３―置換―５，７―ジクロルトリアゾロピリミジン誘導体
DE3522463A1 (de) * 1985-06-22 1987-01-02 Bayer Ag Herbizide mittel
US4910306A (en) * 1987-11-09 1990-03-20 The Dow Chemical Company Preparation of substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonanilides
US4892945A (en) * 1987-12-21 1990-01-09 Ciba-Geigy Corporation Isoindoline pigments containing at least one triazolopyrimidone radical
US5006656A (en) * 1990-02-26 1991-04-09 Dowelanco Preparation of 5,7-dihydroxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonanilides
US5177206A (en) * 1991-10-08 1993-01-05 Dowelanco Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides
TW224044B (es) * 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
IL108731A (en) * 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
CA2171003C (en) * 1993-10-18 2005-12-13 James W. Ringer Process for preparing n-(2,6-dichloro-3-methylphenyl)-5-7-dihalo[1,2,4]triazolo[1,5a]pyrimidine-2-sulfonamide by cyclization and halo-dehydroxylation

Also Published As

Publication number Publication date
US5808066A (en) 1998-09-15
SI0770615T1 (en) 2003-12-31
EP0770615B1 (en) 2003-06-18
KR100443182B1 (ko) 2005-04-19
JP4018182B2 (ja) 2007-12-05
ATE243211T1 (de) 2003-07-15
JPH09124651A (ja) 1997-05-13
UA48132C2 (uk) 2002-08-15
SG55239A1 (en) 1998-12-21
MX9604882A (es) 1997-04-30
EP0770615A1 (en) 1997-05-02
ES2202419T3 (es) 2004-04-01
HUP9602957A3 (en) 1998-01-28
CA2188905A1 (en) 1997-04-28
BR9605258A (pt) 1998-07-21
HUP9602957A2 (en) 1997-06-30
RU2147584C1 (ru) 2000-04-20
TR199600792A2 (tr) 1997-05-21
ZA968957B (en) 1998-04-24
DE69628712D1 (de) 2003-07-24
IL119496A (en) 2001-07-24
HU217773B (hu) 2000-04-28
HU9602957D0 (en) 1996-12-30
IL119496A0 (en) 1997-01-10
DK0770615T3 (da) 2003-07-14
SK137796A3 (en) 1997-05-07
KR970021081A (ko) 1997-05-28
DE69628712T2 (de) 2004-04-29
SK284071B6 (sk) 2004-09-08
CA2188905C (en) 2005-12-06
PT770615E (pt) 2003-10-31

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