AR003132A1 - Derivados de n-hetero aril piridinsulfonamidas; composiciones farmaceuticas que los contienen; proceso para su preparacion y el uso de los mismos en la produccion de un medicamento - Google Patents
Derivados de n-hetero aril piridinsulfonamidas; composiciones farmaceuticas que los contienen; proceso para su preparacion y el uso de los mismos en la produccion de un medicamentoInfo
- Publication number
- AR003132A1 AR003132A1 ARP960102899A AR10289996A AR003132A1 AR 003132 A1 AR003132 A1 AR 003132A1 AR P960102899 A ARP960102899 A AR P960102899A AR 10289996 A AR10289996 A AR 10289996A AR 003132 A1 AR003132 A1 AR 003132A1
- Authority
- AR
- Argentina
- Prior art keywords
- nitrogen
- substituted
- alkoxy
- alkyl
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se relaciona con compuestos farmacéuticamente útiles de la fórmula (I), en los que A, A2, A3, A4, B1 m, A, W, X, Y, Z y R1 adoptancualquiera de los siguientes significados. Uno entre A1, A2, A3 y A4 es nitrógeno y elre sto son CH, un grupo fenilo no sustituido o sustituido con 1,2 ó 3 sustituyentes seleccionados independientemente entre alquilo (C1-C6) no sustituido o sustituido con amino, hidroxi, carboxi, alcoxicarbonilo,alquilcarboniloxi, carbamoilo,carbamoil oxi, halógeno, alcoxi, sulfinilo, sulfonilo, cicloalquilo (C3-C8), fenilo; alcoxi, alquiltio; alquenilo (C2-C6);alquinilo (C2-C6); cicloalquilo todos sin sustituir o sustituidos; fenilo; fenoxi; mercapto; ciano; nitro; carbonilosustituido o no; benzoilo; sulfamoilosolo o sustituido, ureido, un grupo heterocíclico de 6 miembros que contiene 1, 2 ó 3 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno yazufre y un grupo -NRaRb en el cual Ra y Rb estánseleccionados e ntre hidrógeno alquilo (C1-C6) solo o sustituido o en conjunto el grupo -NRaRb completa unanillo 1-pirrolidinilo, 2-oxo-1-pirrolidinilo, 1-piperidinilo, 2-oxo-1- piperidinilo, morfolino o tiomorfolino; B1 es un sustituyenteoptativo en unátom o de carbono de A1, A2, A3 ó A4 seleccionado entre alquilo (C1-C4), halógeno y alcoxi (C1-C4); m es cero, 1, 2, ó 3; el anillo que contiene W, X,Yy Z y que contiene sustituyente R1 está seleccionado entre: (a) un anillo enel que W es nitróge no; X es CH; Y es nitrógeno; y Z es CRy, donde Ry es hidrógeno,halógeno, alquilo (C1-C4),alcoxi (C1-C4) o trifluorometoxi, (b) anillo donde W es CRz en el cual Rz es hidrógeno, halógeno, alquilo (C1-C4), alcoxi (C1-C4)otrifluorometoxi; X es nitróge no; Y es nitrógeno; y Z es CH; (c)un anillo en el cual W y X son ambos nitrógeno; y Y es CH; y Z es CRx, en el cual Rx es
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9511507.7A GB9511507D0 (en) | 1995-06-07 | 1995-06-07 | Heterocyclic compounds |
GBGB9519666.3A GB9519666D0 (en) | 1995-09-27 | 1995-09-27 | Heterocyclic derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AR003132A1 true AR003132A1 (es) | 1998-07-08 |
Family
ID=26307176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960102899A AR003132A1 (es) | 1995-06-07 | 1996-06-04 | Derivados de n-hetero aril piridinsulfonamidas; composiciones farmaceuticas que los contienen; proceso para su preparacion y el uso de los mismos en la produccion de un medicamento |
Country Status (32)
Country | Link |
---|---|
US (3) | US5866568A (es) |
EP (1) | EP0832082B1 (es) |
JP (1) | JP3193058B2 (es) |
KR (1) | KR100451523B1 (es) |
CN (1) | CN1097051C (es) |
AR (1) | AR003132A1 (es) |
AT (1) | ATE209200T1 (es) |
AU (1) | AU715041B2 (es) |
BR (1) | BR9608611A (es) |
CA (1) | CA2219742C (es) |
CZ (1) | CZ289387B6 (es) |
DE (1) | DE69617236T2 (es) |
DK (1) | DK0832082T3 (es) |
EG (1) | EG25227A (es) |
ES (1) | ES2168487T3 (es) |
GE (1) | GEP20053470B (es) |
HK (1) | HK1005801A1 (es) |
HR (1) | HRP960272B1 (es) |
HU (1) | HUP9802300A3 (es) |
IL (1) | IL122464A (es) |
MX (1) | MX9709521A (es) |
MY (1) | MY114926A (es) |
NO (1) | NO314503B1 (es) |
NZ (1) | NZ308619A (es) |
PL (1) | PL187897B1 (es) |
PT (1) | PT832082E (es) |
RU (1) | RU2172738C2 (es) |
SK (1) | SK282338B6 (es) |
TR (1) | TR199701502T1 (es) |
TW (1) | TW340845B (es) |
UA (1) | UA58494C2 (es) |
WO (1) | WO1996040681A1 (es) |
Families Citing this family (50)
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US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5780473A (en) * | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
JPH09124620A (ja) | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
SG87051A1 (en) | 1996-02-20 | 2002-03-19 | Bristol Myers Squibb Co | Process for preparing biphenyl isoxazole sulfonamide intermediates |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
GB9614804D0 (en) * | 1996-07-15 | 1996-09-04 | Chiroscience Ltd | Resolution process |
TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
WO1998033781A1 (en) * | 1997-01-30 | 1998-08-06 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
GB9704762D0 (en) | 1997-03-07 | 1997-04-23 | Zeneca Ltd | Chemical process |
TR200101905T2 (tr) | 1997-04-28 | 2002-06-21 | Texas Biotechnology Corporation | Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler. |
US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
JP2002540088A (ja) | 1999-03-19 | 2002-11-26 | ブリストル−マイヤーズ スクイブ カンパニー | ビフェニルイソキサゾール・スルホンアミド化合物の製造法 |
US6448239B1 (en) * | 1999-06-03 | 2002-09-10 | Trustees Of Princeton University | Peroxynitrite decomposition catalysts and methods of use thereof |
DK1533311T3 (da) | 1999-12-31 | 2007-09-17 | Encysive Pharmaceuticals Inc | Sulfonamider og derivater deraf, der modulerer aktiviteten af endothelin |
US6639082B2 (en) | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6858592B2 (en) | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
GB0219660D0 (en) * | 2002-08-23 | 2002-10-02 | Astrazeneca Ab | Therapeutic use |
GB0223854D0 (en) * | 2002-10-12 | 2002-11-20 | Astrazeneca Ab | Therapeutic treatment |
US7169805B2 (en) * | 2003-05-28 | 2007-01-30 | Nicox S.A. | Captopril derivatives |
GB0320806D0 (en) * | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
GB0403744D0 (en) * | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
KR100839512B1 (ko) * | 2004-07-02 | 2008-06-19 | 주식회사 코오롱 | 설파제를 디아조화체로 하는 산성 항균 염료 및 그를이용한 항균 섬유 |
WO2006053250A2 (en) | 2004-11-12 | 2006-05-18 | Trustees Of Tufts College | Lipase inhibitors |
US20070054325A1 (en) * | 2005-04-14 | 2007-03-08 | Reglia | Materials and methods for screening modulators of neural regeneration |
GB0514743D0 (en) * | 2005-07-19 | 2005-08-24 | Astrazeneca Ab | Salt |
US7939637B2 (en) | 2005-12-13 | 2011-05-10 | Medimmune Limited | Insulin-like growth factor antibodies and uses thereof |
CN101437818A (zh) * | 2006-03-03 | 2009-05-20 | 托伦特药物有限公司 | At1和eta受体的新的双重作用受体拮抗剂(dara) |
KR20080111137A (ko) * | 2006-04-13 | 2008-12-22 | 액테리온 파마슈티칼 리미티드 | 초기 단계 특발성 폐 섬유증을 위한 엔도텔린 수용체 대항제 |
EP2094663B1 (en) * | 2006-09-21 | 2011-01-26 | Piramal Life Sciences Limited | Pyridine derivatives for the treatment of metabolic disorders related to insulin resistance or hyperglycemia |
CL2008000191A1 (es) | 2007-01-25 | 2008-08-22 | Astrazeneca Ab | Compuestos derivados de 4-amino-cinnotina-3-carboxamida; inhibidores de csf-1r quinasa; su proceso de preparacion; y su uso para tratar el cancer. |
NZ581606A (en) | 2007-05-03 | 2012-06-29 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
ATE536893T1 (de) | 2007-10-12 | 2011-12-15 | Astrazeneca Ab | Zibotentan zusammensetzung mit mannitol und mikrokristalliner zellulose |
RS57591B1 (sr) | 2008-06-19 | 2018-11-30 | Takeda Pharmaceuticals Co | Heterociklično jedinjenje i njegova upotreba |
PL2394999T3 (pl) * | 2009-02-06 | 2014-06-30 | Nippon Shinyaku Co Ltd | Pochodna aminopirazyny i lek |
CN102491973A (zh) * | 2011-12-15 | 2012-06-13 | 南京友杰医药科技有限公司 | Zd-4054的合成方法 |
US20230227477A1 (en) * | 2020-06-25 | 2023-07-20 | Wake Forest University Health Sciences | Compounds for sensing reactive oxygen species and methods for using the same |
KR20230038234A (ko) | 2020-07-10 | 2023-03-17 | 아스트라제네카 아베 | 만성 신장 질환 치료를 위한 지보텐탄 및 다파글리플로진의 조합 |
AU2022297082B2 (en) * | 2021-06-22 | 2024-04-18 | Alchemedicine, Inc. | Compound, endothelin A receptor antagonist and pharmaceutical composition |
US20240058331A1 (en) | 2022-08-12 | 2024-02-22 | Astrazeneca Ab | Combination therapies for treatment of cirrhosis with portal hypertension |
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JPH0655708B2 (ja) * | 1985-05-13 | 1994-07-27 | 三井東圧化学株式会社 | スルホンアミド系化合物及び農業用殺菌剤 |
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US5571821A (en) * | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
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CA2121724A1 (en) * | 1993-04-21 | 1994-10-22 | Toshifumi Watanabe | Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction |
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GB9504854D0 (en) * | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
GB9409618D0 (en) * | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
DE4426346A1 (de) * | 1994-07-25 | 1996-02-01 | Basf Ag | Herbizide Pyrazinderivate |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
GB2295616A (en) * | 1994-12-01 | 1996-06-05 | Zeneca Ltd | N-Diazine-benzenesulphonamide derivatives as endothelin receptor antagonists |
CZ299246B6 (cs) * | 1995-04-04 | 2008-05-28 | Encysive Pharmaceuticals Inc. | Sulfonamid, farmaceutická kompozice s jeho obsahem a jeho použití pro výrobu léciva |
-
1996
- 1996-03-06 UA UA98010043A patent/UA58494C2/uk unknown
- 1996-06-03 CN CN96196149A patent/CN1097051C/zh not_active Expired - Fee Related
- 1996-06-03 KR KR1019970708807A patent/KR100451523B1/ko not_active IP Right Cessation
- 1996-06-03 PL PL96324660A patent/PL187897B1/pl not_active IP Right Cessation
- 1996-06-03 EP EP96919941A patent/EP0832082B1/en not_active Expired - Lifetime
- 1996-06-03 WO PCT/GB1996/001295 patent/WO1996040681A1/en active IP Right Grant
- 1996-06-03 AU AU58403/96A patent/AU715041B2/en not_active Ceased
- 1996-06-03 CZ CZ19973887A patent/CZ289387B6/cs not_active IP Right Cessation
- 1996-06-03 IL IL12246496A patent/IL122464A/en not_active IP Right Cessation
- 1996-06-03 ES ES96919941T patent/ES2168487T3/es not_active Expired - Lifetime
- 1996-06-03 MX MX9709521A patent/MX9709521A/es unknown
- 1996-06-03 SK SK1680-97A patent/SK282338B6/sk not_active IP Right Cessation
- 1996-06-03 NZ NZ308619A patent/NZ308619A/xx not_active IP Right Cessation
- 1996-06-03 RU RU98100054/04A patent/RU2172738C2/ru not_active IP Right Cessation
- 1996-06-03 DK DK96919941T patent/DK0832082T3/da active
- 1996-06-03 AT AT96919941T patent/ATE209200T1/de active
- 1996-06-03 PT PT96919941T patent/PT832082E/pt unknown
- 1996-06-03 CA CA002219742A patent/CA2219742C/en not_active Expired - Fee Related
- 1996-06-03 DE DE69617236T patent/DE69617236T2/de not_active Expired - Lifetime
- 1996-06-03 BR BR9608611A patent/BR9608611A/pt not_active IP Right Cessation
- 1996-06-03 JP JP50020997A patent/JP3193058B2/ja not_active Expired - Fee Related
- 1996-06-03 HU HU9802300A patent/HUP9802300A3/hu unknown
- 1996-06-03 TR TR97/01502T patent/TR199701502T1/xx unknown
- 1996-06-04 AR ARP960102899A patent/AR003132A1/es active IP Right Grant
- 1996-06-04 TW TW085106632A patent/TW340845B/zh not_active IP Right Cessation
- 1996-06-04 US US08/658,969 patent/US5866568A/en not_active Expired - Lifetime
- 1996-06-04 MY MYPI96002166A patent/MY114926A/en unknown
- 1996-06-06 HR HR960272A patent/HRP960272B1/xx not_active IP Right Cessation
- 1996-06-06 EG EG50996A patent/EG25227A/xx active
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1997
- 1997-12-05 NO NO19975700A patent/NO314503B1/no not_active IP Right Cessation
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1998
- 1998-06-06 HK HK98105010A patent/HK1005801A1/xx not_active IP Right Cessation
- 1998-12-14 US US09/211,483 patent/US6060475A/en not_active Expired - Lifetime
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2000
- 2000-02-15 US US09/504,364 patent/US6258817B1/en not_active Expired - Lifetime
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2004
- 2004-07-19 GE GE5624A patent/GEP20053470B/en unknown
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