HUP0001294A2 - Proteáz inhibitor hatású (heterociklil-karbonil)-hidrazid-származékok, eljárás előállításukra és alkalmazásuk - Google Patents
Proteáz inhibitor hatású (heterociklil-karbonil)-hidrazid-származékok, eljárás előállításukra és alkalmazásukInfo
- Publication number
- HUP0001294A2 HUP0001294A2 HU0001294A HUP0001294A HUP0001294A2 HU P0001294 A2 HUP0001294 A2 HU P0001294A2 HU 0001294 A HU0001294 A HU 0001294A HU P0001294 A HUP0001294 A HU P0001294A HU P0001294 A2 HUP0001294 A2 HU P0001294A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- group
- het
- nitrogen
- heterocycleketo
- Prior art date
Links
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány proteázinhibitor-tulajdonsággal rendelkező (I) általánosképletű vegyületekre - amelyek képletében L alkil-, Ar-(0-6 szénatomos alkil)-, Het-(0-6 szénatomos alkil)-, -CH(R4)NR5R6, -CH(R4)Ar, -CH(R4)OAr' vagy -NR4R7 csoport; W karbonil- vagy szulfonilcsoport; X, Y és Z nitrogén-, oxigén-, kénatom vagy CR10 általános képletűcsoport, azzal a megkötéssel, hogy X, Y és Z közül legalább kettőjelentése heteroatom, valamint X, Y és Z közül legalább egy jelentésenitrogénatom, vagy X, Y és Z egyikének jelentése C=N, C=C vagy N=Nképletű csoport, és a másik kettő jelentése CR10 általános képletűcsoport vagy nitrogénatom, azzal a megkötéssel, hogy X, Y és Z közüllegalább kettő nitrogénatom; -egyes vagy kettős kötés az öttagú heterociklusos csoportban; R', R1, R2, R5, R8, R9, R10 és R12 hidrogénatom, alkil-, alkenil-, Ar-(0-6 szénatomos alkil)- vagy Het-(0-6 szénatomos alkil)-csoport; R3 alkil-, Ar, Het, -CH(R11)Ar, -CH(R11)OAr, -NR11, R12, -CH(R11)NR12R13 vagy csoport - és gyógyászatilag elfogadható sóira,hidrátjaira vagy szolvátjaira vonatkozik. A találmány szerintivegyületek és az ezeket hatóanyagként tartalmazó gyógyszerkészítményekkülönösen csont- és porcvesztéses betegségek kezelésére alkalmasak. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4506797P | 1997-04-29 | 1997-04-29 | |
| PCT/US1998/008740 WO1998048799A1 (en) | 1997-04-29 | 1998-04-29 | Protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001294A2 true HUP0001294A2 (hu) | 2001-04-28 |
| HUP0001294A3 HUP0001294A3 (en) | 2001-06-28 |
Family
ID=21935831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001294A HUP0001294A3 (en) | 1997-04-29 | 1998-04-29 | Heterocycleketo hydrazide derivatives having protease inhibitor activity, process for their preparation and their use |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1019046A4 (hu) |
| JP (1) | JP2002504097A (hu) |
| KR (1) | KR20010020391A (hu) |
| CN (1) | CN1261276A (hu) |
| AR (1) | AR012622A1 (hu) |
| AU (1) | AU7365198A (hu) |
| BR (1) | BR9809333A (hu) |
| CA (1) | CA2287989A1 (hu) |
| CO (1) | CO4940477A1 (hu) |
| HU (1) | HUP0001294A3 (hu) |
| IL (1) | IL132629A0 (hu) |
| MA (1) | MA26487A1 (hu) |
| NO (1) | NO995268L (hu) |
| PE (1) | PE69099A1 (hu) |
| PL (1) | PL337725A1 (hu) |
| TR (1) | TR199902703T2 (hu) |
| WO (1) | WO1998048799A1 (hu) |
| ZA (1) | ZA983522B (hu) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR017219A1 (es) | 1997-12-19 | 2001-08-22 | Smithkline Beecham Corp | Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento |
| US6100282A (en) * | 1998-01-02 | 2000-08-08 | Hoffman-La Roche Inc. | Thiazole derivatives |
| MA26618A1 (fr) * | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| DE69914357T2 (de) | 1998-11-04 | 2004-11-11 | Smithkline Beecham Corp. | Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine |
| CO5150165A1 (es) * | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| WO2001034599A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| WO2001034600A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| EP1229914A4 (en) | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
| US6797720B2 (en) | 1999-12-03 | 2004-09-28 | Ono Pharmaceutical Co., Ltd. | 1,3,4-oxadiazoline derivative and an agent comprising its derivative as active ingredient |
| WO2001040204A1 (fr) * | 1999-12-03 | 2001-06-07 | Ono Pharmaceutical Co., Ltd. | Derives de 1.3.4-oxadiazoline et medicaments contenant ces derives utiles comme ingredients actifs |
| NZ520588A (en) | 2000-03-21 | 2004-06-25 | Smithkline Beecham Corp | Protease inhibitors |
| WO2003062192A1 (en) | 2002-01-17 | 2003-07-31 | Smithkline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors |
| DE60227008D1 (de) * | 2002-07-04 | 2008-07-17 | Aventis Pharma Sa | Neue thiophenacylhydrazinoderivate, verfahren zu deren herstellung, deren verwendung als arzneimittel, pharmazeutische zusammensetzungen und neue anwendungen |
| KR100962972B1 (ko) | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-페닐피페리딘-3-온 유도체 및 그의 제조방법 |
| WO2011015524A2 (en) * | 2009-08-03 | 2011-02-10 | Bayer Cropscience Ag | Fungicide heterocycles derivatives |
| KR20150046259A (ko) * | 2012-08-23 | 2015-04-29 | 앨리오스 바이오파마 인크. | 파라믹소바이러스 바이러스성 감염의 치료용 화합물 |
| CN105636936B (zh) | 2013-08-21 | 2022-04-05 | 詹森生物制药有限公司 | 抗病毒化合物 |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA199800353A1 (ru) * | 1995-10-30 | 1998-12-24 | Смитклайн Бичам Корпорейшн | Ингибиторы протеаз |
-
1998
- 1998-04-24 MA MA25047A patent/MA26487A1/fr unknown
- 1998-04-27 PE PE1998000320A patent/PE69099A1/es not_active Application Discontinuation
- 1998-04-28 ZA ZA983522A patent/ZA983522B/xx unknown
- 1998-04-29 EP EP98920926A patent/EP1019046A4/en not_active Withdrawn
- 1998-04-29 CA CA002287989A patent/CA2287989A1/en not_active Abandoned
- 1998-04-29 TR TR1999/02703T patent/TR199902703T2/xx unknown
- 1998-04-29 CO CO98023491A patent/CO4940477A1/es unknown
- 1998-04-29 BR BR9809333-9A patent/BR9809333A/pt not_active IP Right Cessation
- 1998-04-29 IL IL13262998A patent/IL132629A0/xx unknown
- 1998-04-29 KR KR1019997010013A patent/KR20010020391A/ko not_active Application Discontinuation
- 1998-04-29 HU HU0001294A patent/HUP0001294A3/hu unknown
- 1998-04-29 JP JP54738998A patent/JP2002504097A/ja active Pending
- 1998-04-29 WO PCT/US1998/008740 patent/WO1998048799A1/en not_active Application Discontinuation
- 1998-04-29 AR ARP980101999A patent/AR012622A1/es unknown
- 1998-04-29 AU AU73651/98A patent/AU7365198A/en not_active Abandoned
- 1998-04-29 PL PL98337725A patent/PL337725A1/xx unknown
- 1998-04-29 CN CN98806641A patent/CN1261276A/zh active Pending
-
1999
- 1999-10-28 NO NO995268A patent/NO995268L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2287989A1 (en) | 1998-11-05 |
| PL337725A1 (en) | 2000-08-28 |
| CO4940477A1 (es) | 2000-07-24 |
| HUP0001294A3 (en) | 2001-06-28 |
| EP1019046A1 (en) | 2000-07-19 |
| IL132629A0 (en) | 2001-03-19 |
| EP1019046A4 (en) | 2002-11-27 |
| WO1998048799A1 (en) | 1998-11-05 |
| PE69099A1 (es) | 1999-09-26 |
| ZA983522B (en) | 1998-10-29 |
| NO995268L (no) | 1999-11-15 |
| KR20010020391A (ko) | 2001-03-15 |
| NO995268D0 (no) | 1999-10-28 |
| JP2002504097A (ja) | 2002-02-05 |
| AU7365198A (en) | 1998-11-24 |
| TR199902703T2 (xx) | 2000-02-21 |
| BR9809333A (pt) | 2000-07-04 |
| MA26487A1 (fr) | 2004-12-20 |
| CN1261276A (zh) | 2000-07-26 |
| AR012622A1 (es) | 2000-11-08 |
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