AP690A - Immunomodulators based on a polypeptide other than human interleukin 10. - Google Patents
Immunomodulators based on a polypeptide other than human interleukin 10. Download PDFInfo
- Publication number
- AP690A AP690A APAP/P/1997/000962A AP9700962A AP690A AP 690 A AP690 A AP 690A AP 9700962 A AP9700962 A AP 9700962A AP 690 A AP690 A AP 690A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK80094 | 1994-07-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9700962A0 AP9700962A0 (en) | 1997-04-30 |
| AP690A true AP690A (en) | 1998-10-16 |
Family
ID=8097707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1997/000962A AP690A (en) | 1994-07-05 | 1995-06-07 | Immunomodulators based on a polypeptide other than human interleukin 10. |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US6159937A (hu) |
| EP (2) | EP0769054B1 (hu) |
| JP (1) | JPH10502249A (hu) |
| CN (1) | CN1216992C (hu) |
| AP (1) | AP690A (hu) |
| AT (1) | ATE195003T1 (hu) |
| AU (1) | AU686816B2 (hu) |
| BR (1) | BR9508243A (hu) |
| CA (1) | CA2194444C (hu) |
| CZ (1) | CZ1497A3 (hu) |
| DE (1) | DE69518156T2 (hu) |
| DK (1) | DK0769054T3 (hu) |
| EE (1) | EE03451B1 (hu) |
| ES (1) | ES2148525T3 (hu) |
| FI (1) | FI970009A (hu) |
| GR (1) | GR3034628T3 (hu) |
| HK (1) | HK1012416A1 (hu) |
| HU (1) | HU220344B (hu) |
| MX (1) | MX9606537A (hu) |
| NO (1) | NO970020L (hu) |
| NZ (1) | NZ287406A (hu) |
| PL (1) | PL181042B1 (hu) |
| PT (1) | PT769054E (hu) |
| RO (1) | RO118758B1 (hu) |
| RU (1) | RU2218348C2 (hu) |
| SK (1) | SK283096B6 (hu) |
| UA (1) | UA57702C2 (hu) |
| WO (1) | WO1996001318A1 (hu) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9403526D0 (sv) | 1994-10-14 | 1994-10-14 | Astra Ab | New Peptides |
| SE9501067D0 (sv) | 1995-03-24 | 1995-03-24 | Astra Ab | New peptides |
| WO1997026278A1 (en) * | 1996-01-18 | 1997-07-24 | Steeno Research Group A/S | Synthetic il-10 analogues |
| US20030124125A1 (en) * | 1996-04-05 | 2003-07-03 | South Alabama Medical Science Foundation | Oncofetal antigen specific T-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10 |
| AU721943B2 (en) * | 1996-05-02 | 2000-07-20 | Schering Corporation | Method for treating or preventing ischemia-reperfusion injury |
| FR2748938B1 (fr) * | 1996-05-22 | 1998-07-31 | Pasteur Institut | Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih |
| SE9603468D0 (sv) * | 1996-09-23 | 1996-09-23 | Astra Ab | New compounds |
| SE9603463D0 (sv) * | 1996-09-23 | 1996-09-23 | Astra Ab | New compounds |
| US6086868A (en) * | 1997-04-30 | 2000-07-11 | Schering Corporation | Method for treating or preventing ischemia-reperfusion injury |
| AU9449398A (en) * | 1997-10-10 | 1999-05-03 | Imperial College Innovations Ltd. | Use of csaidtm compounds for the management of uterine contractions |
| CA2356010A1 (en) * | 1998-12-22 | 2000-06-29 | Schering Corporation | Treatment of hepatitis c virus infections with interleukin-10 |
| ATE292177T1 (de) * | 1999-05-25 | 2005-04-15 | Canji Inc | Gentherapy von lungenkrankheiten |
| CA2429769C (en) * | 2000-12-07 | 2016-04-26 | Board Of Regents, The University Of Texas System | Methods of treatment involving human mda-7 |
| WO2002057283A1 (en) * | 2001-01-19 | 2002-07-25 | Baylor College Of Medecine | Methods and compositions in breast cancer diagnosis and therapeutics |
| US20040086896A1 (en) * | 2001-04-19 | 2004-05-06 | Julie Carman | Polynucleotides and polypeptides associated with the NF-kB pathway |
| KR20040105710A (ko) * | 2002-02-11 | 2004-12-16 | 아르키온 라이프 사이언씨즈 엘엘씨 | 정제된 사이토킨 억제인자 |
| AU2003228267A1 (en) * | 2002-03-05 | 2003-09-22 | Board Of Regents, The University Of Texas System | Methods of enhancing immune induction involving mda-7 |
| EP1444989A1 (en) * | 2003-02-07 | 2004-08-11 | Giorgio Dr. Stassi | Sensitizing cells for apoptosis by selectively blocking cytokines |
| ES2387275T3 (es) * | 2003-05-15 | 2012-09-19 | Genentech, Inc. | Métodos y composiciones para la prevención y el tratamiento de la sepsis |
| US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| US20050164244A1 (en) * | 2003-10-23 | 2005-07-28 | David Glass | Methods of determining juvenile arthritis classification |
| CA2548220A1 (en) * | 2003-12-01 | 2005-09-09 | Introgen Therapeutics, Inc. | Use of mda-7 to inhibit infection by pathogenic organisms |
| US8034773B2 (en) * | 2004-02-05 | 2011-10-11 | Arizona Biomedical Research Commission | Immunostimulatory compositions and uses thereof |
| US20070281041A1 (en) * | 2004-03-02 | 2007-12-06 | Introgen Therapeutics, Inc. | Compositions and Methods Involving MDA-7 for the Treatment of Cancer |
| WO2006063028A2 (en) * | 2004-12-07 | 2006-06-15 | The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Immunostimulatory compositions and uses thereof |
| GB0500643D0 (en) * | 2005-01-13 | 2005-02-23 | Renovo Ltd | Medicaments |
| CN101166539B (zh) * | 2005-02-08 | 2012-01-04 | 得克萨斯大学体系董事会 | 用于治疗癌症的涉及mda-7的组合物和方法 |
| US20100028296A1 (en) * | 2005-05-02 | 2010-02-04 | Chavez Raymond A | Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease |
| US8114964B2 (en) * | 2005-05-19 | 2012-02-14 | Centocor, Inc. | Anti-MCP-1 antibodies, compositions, methods and uses |
| DK2816118T3 (en) | 2005-05-31 | 2018-12-03 | Univ Colorado Regents | Methods for delivery of genes |
| CN101529253A (zh) * | 2006-06-21 | 2009-09-09 | 阿珀吉尼科斯有限公司 | Il-4和/或il-10细胞因子在人癌症中的差异表达 |
| AU2007271349A1 (en) * | 2006-07-06 | 2008-01-10 | Apogenix Gmbh | Human IL-4 muteins in combination with chemotherapeutics or pro-apoptotic agents in cancer therapy |
| US7838497B2 (en) * | 2006-12-13 | 2010-11-23 | Susavion Biosciences, Inc. | Pro-angiogenic peptides |
| USRE46425E1 (en) | 2006-12-13 | 2017-06-06 | Susavion Biosciences, Inc. | Pro-angiogenic peptides and uses thereof |
| US8460697B2 (en) * | 2006-12-13 | 2013-06-11 | Susavion Biosciences, Inc. | Pro-angiogenic peptides and uses thereof |
| CN101391103B (zh) * | 2008-07-31 | 2013-07-24 | 张可 | 一种预防和治疗艾滋病病毒感染的药物组合物 |
| WO2010022227A1 (en) * | 2008-08-20 | 2010-02-25 | Schering Corporation | Methods for monitoring il-10 therapy |
| WO2011047097A2 (en) * | 2009-10-13 | 2011-04-21 | Sigalov Alexander B | Inhibition of trem receptor signaling with peptide variants |
| US9359405B2 (en) * | 2011-03-14 | 2016-06-07 | Phlogo Aps | Antagonists of the interleukin-1 receptor |
| RS60583B1 (sr) | 2012-02-13 | 2020-08-31 | Agency Science Tech & Res | Ljudska monoklonalna antitela koja vrše neutralizaciju il-ss |
| PL3369435T3 (pl) | 2013-07-18 | 2020-04-30 | Xalud Therapeutics, Inc. | Kompozycja do leczenia choroby zapalnej stawów |
| JP6140566B2 (ja) * | 2013-07-31 | 2017-05-31 | アイシン・エィ・ダブリュ株式会社 | コイル装着方法及びコイル装着治具 |
| CN105944086B (zh) * | 2016-06-13 | 2017-08-25 | 浙江生创精准医疗科技有限公司 | Il‑8单独或与其他细胞因子联合在治疗肝纤维化中的用途 |
| EP4252629A3 (en) | 2016-12-07 | 2023-12-27 | Biora Therapeutics, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3054156A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist |
| EP3883634A1 (en) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| JP7315968B2 (ja) * | 2019-01-31 | 2023-07-27 | 積水メディカル株式会社 | 生物学的試料中の遊離ａｉｍの免疫学的分析方法及び対象におけるｎａｓｈの検出方法 |
| EP4309722A2 (en) | 2019-12-13 | 2024-01-24 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991000349A1 (en) * | 1989-06-28 | 1991-01-10 | Schering Corporation | Cytokine synthesis inhibitory factor, antagonists thereof, and methods of using same |
Family Cites Families (5)
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| JPH07502019A (ja) * | 1991-08-06 | 1995-03-02 | シェリング・コーポレーション | 内毒素または超抗原に誘導された毒性を治療するインターロイキン−１０類似体またはアンタゴニストの使用 |
| CA2131524A1 (en) * | 1992-03-04 | 1993-09-16 | Maria-Grazia Roncarolo | Use of interleukin-10 to suppress graft-vs.-host disease |
| CA2085291A1 (en) * | 1992-07-30 | 1994-01-31 | Martin L. Breitman | Novel receptor tyrosine kinase |
| JP3494647B2 (ja) * | 1992-08-20 | 2004-02-09 | シェリング・コーポレーション | Ｉｌ−４および／またはｉｌ−１０ならびにそれらに対する抗体の新規な用途 |
| ZA945434B (en) * | 1993-07-26 | 1995-01-23 | Schering Corp | Agonists and antagonists of human interleukin-10 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991000349A1 (en) * | 1989-06-28 | 1991-01-10 | Schering Corporation | Cytokine synthesis inhibitory factor, antagonists thereof, and methods of using same |
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