AP614A - Antifungal sordan derivatives. - Google Patents

Antifungal sordan derivatives. Download PDF

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Publication number
AP614A
AP614A APAP/P/1996/000824A AP9600824A AP614A AP 614 A AP614 A AP 614A AP 9600824 A AP9600824 A AP 9600824A AP 614 A AP614 A AP 614A
Authority
AP
ARIPO
Prior art keywords
compound
group
formula
solution
methyl
Prior art date
Application number
APAP/P/1996/000824A
Other languages
English (en)
Other versions
AP9600824A0 (en
Inventor
Jose Radon Ruin Games
Jose Maria Bueno Calderon
Dorado Sivestre Garcia-Ochoa
Gabaldon Maria Teresa Fraile
Julia Castro Pichel
Roman Jose Fiandor
Viola Domingo Gargallo
Zurita Juan Carlos Cuevas
Diaz Jose Luis Lavandera
Sophie Huss
Original Assignee
Glaxo Wellcome Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94500175A external-priority patent/EP0711784A1/en
Priority claimed from EP94500173A external-priority patent/EP0712859A1/en
Application filed by Glaxo Wellcome Sa filed Critical Glaxo Wellcome Sa
Publication of AP9600824A0 publication Critical patent/AP9600824A0/xx
Application granted granted Critical
Publication of AP614A publication Critical patent/AP614A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
APAP/P/1996/000824A 1994-11-08 1995-11-06 Antifungal sordan derivatives. AP614A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94500175A EP0711784A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
EP94500173A EP0712859A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
PCT/EP1995/004331 WO1996014326A1 (en) 1994-11-08 1995-11-06 Antifungal sordaridin derivatives

Publications (2)

Publication Number Publication Date
AP9600824A0 AP9600824A0 (en) 1996-07-31
AP614A true AP614A (en) 1997-09-05

Family

ID=26137608

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1996/000824A AP614A (en) 1994-11-08 1995-11-06 Antifungal sordan derivatives.

Country Status (34)

Country Link
US (2) US5854280A (is)
EP (1) EP0753001B1 (is)
JP (1) JPH09508144A (is)
KR (1) KR100391401B1 (is)
CN (1) CN1056849C (is)
AP (1) AP614A (is)
AR (1) AR013815A1 (is)
AT (1) ATE184284T1 (is)
AU (1) AU704405B2 (is)
BG (1) BG62620B1 (is)
BR (1) BR9506473A (is)
CA (1) CA2179403A1 (is)
CO (1) CO4520226A1 (is)
CZ (1) CZ202796A3 (is)
DE (1) DE69512041T2 (is)
DK (1) DK0753001T3 (is)
EE (1) EE9600117A (is)
ES (1) ES2137549T3 (is)
FI (1) FI962773A7 (is)
GR (1) GR3031677T3 (is)
HU (1) HU218611B (is)
IL (1) IL115905A0 (is)
IS (1) IS4352A (is)
MX (1) MX9602563A (is)
NO (1) NO307092B1 (is)
NZ (1) NZ296091A (is)
OA (1) OA10303A (is)
PE (1) PE49696A1 (is)
RU (1) RU2152398C1 (is)
SI (1) SI0753001T1 (is)
SK (1) SK88496A3 (is)
TW (1) TW321644B (is)
WO (1) WO1996014326A1 (is)
ZA (1) ZA959362B (is)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177457B1 (en) * 1996-05-08 2001-01-23 Glaxo Wellcome S.A. Process for the preparation of indacene compound
US6436395B1 (en) 1996-09-18 2002-08-20 Merck & Co., Inc. Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) * 1996-10-07 2000-03-21 Merck & Co., Inc. Sordarin derivatives
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
EP1007031B1 (en) * 1997-08-22 2003-06-04 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US6136853A (en) * 1997-10-03 2000-10-24 Merck & Co., Inc. Sordarin derivatives
FI974385A0 (fi) 1997-12-01 1997-12-01 Xyrofin Oy Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) * 1998-04-14 2006-07-04 Zhenhua Yang Small molecule anticancer compounds and related production process
MA26628A1 (fr) * 1998-05-11 2004-12-20 Glaxo Wellcome Sa Morpholino ethers
ES2211191T3 (es) 1998-10-26 2004-07-01 MERCK & CO., INC. Producto de transformacion microbiana.
AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
WO2001034583A1 (en) * 1999-11-11 2001-05-17 Glaxo Wellcome Sa Antifungal sordaricin derivatives
WO2002022567A1 (en) * 2000-09-15 2002-03-21 Bristol-Myers Squibb Company Novel thio derivatives of sordarin as antifungal agents
CA2434302A1 (en) 2001-01-08 2002-08-15 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
WO2003007878A2 (en) 2001-07-18 2003-01-30 Merck & Co., Inc. Antifungal agents of sordarin derivatives
RU2223093C2 (ru) * 2001-11-19 2004-02-10 Открытое акционерное общество "Биосинтез" Фармацевтическая композиция для лечения грибковых заболеваний
JP2005516933A (ja) 2001-12-13 2005-06-09 ダウ グローバル テクノロジーズ インコーポレイティド 放射性医薬による骨髄炎の治療
JP2005519039A (ja) * 2001-12-14 2005-06-30 メルク　エンド　カムパニー　インコーポレーテッド 培養株の発酵産物から単離された新規ソルダリン誘導体及び抗真菌剤としての機能
RU2201230C1 (ru) * 2001-12-24 2003-03-27 Закрытое акционерное общество "Брынцалов-А" Лекарственное средство флузол, обладающее противогрибковым действием
RU2207842C1 (ru) * 2002-02-18 2003-07-10 Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Противогрибковое средство в виде мази и способ его получения
MXPA05007156A (es) * 2002-12-31 2005-09-21 Nektar Therapeutics Formulacion farmaceuticas aerosolizable para terapia para infecciones fungicas.
US9314524B2 (en) 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US8419948B2 (en) * 2009-11-22 2013-04-16 United Laboratories International, Llc Wastewater treatment
WO2012033427A1 (ru) * 2010-09-08 2012-03-15 Dalin Mikhail Viktorovich Способ лечения микотических инфекций и препарат для его осуществления
RU2630403C2 (ru) * 2016-02-25 2017-09-07 Жанна Владимировна Вараткова Абразивная масса для изготовления инструмента с высокими номерами структуры

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6240292A (ja) * 1985-08-14 1987-02-21 Sankyo Co Ltd 抗生物質ゾフイマリン
JPH06157582A (ja) * 1992-11-20 1994-06-03 Banyu Pharmaceut Co Ltd 抗真菌性物質ｂｅ−３１４０５

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH465771A (de) * 1965-12-06 1968-11-30 Sandoz Ag Verfahren zur Herstellung eines neuen Antibioticums
DE69724626T2 (de) * 1996-09-12 2004-07-29 Merck & Co., Inc. Fungizide kombinationstherapie

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6240292A (ja) * 1985-08-14 1987-02-21 Sankyo Co Ltd 抗生物質ゾフイマリン
JPH06157582A (ja) * 1992-11-20 1994-06-03 Banyu Pharmaceut Co Ltd 抗真菌性物質ｂｅ−３１４０５

Also Published As

Publication number Publication date
HU218611B (hu) 2000-10-28
CZ202796A3 (en) 1997-02-12
NO962856D0 (no) 1996-07-05
NO962856L (no) 1996-09-05
HU9601865D0 (en) 1996-11-28
NZ296091A (en) 1998-06-26
BG100699A (bg) 1997-02-28
AU3980995A (en) 1996-05-31
WO1996014326A1 (en) 1996-05-17
IL115905A0 (en) 1996-01-31
EP0753001A1 (en) 1997-01-15
JPH09508144A (ja) 1997-08-19
DE69512041D1 (de) 1999-10-14
CN1056849C (zh) 2000-09-27
NO307092B1 (no) 2000-02-07
IS4352A (is) 1996-06-10
ES2137549T3 (es) 1999-12-16
US5952334A (en) 1999-09-14
EP0753001B1 (en) 1999-09-08
PE49696A1 (es) 1996-12-05
FI962773L (fi) 1996-08-26
SK88496A3 (en) 1997-04-09
ZA959362B (en) 1996-05-08
CA2179403A1 (en) 1996-05-17
BR9506473A (pt) 1997-10-07
US5854280A (en) 1998-12-29
OA10303A (en) 1997-10-07
TW321644B (is) 1997-12-01
GR3031677T3 (en) 2000-02-29
MX9602563A (es) 1997-05-31
CN1143965A (zh) 1997-02-26
RU2152398C1 (ru) 2000-07-10
DK0753001T3 (da) 2000-05-08
AP9600824A0 (en) 1996-07-31
HUT76292A (en) 1997-07-28
AR013815A1 (es) 2001-01-31
FI962773A0 (fi) 1996-07-05
BG62620B1 (bg) 2000-03-31
AU704405B2 (en) 1999-04-22
CO4520226A1 (es) 1997-10-15
FI962773A7 (fi) 1996-08-26
DE69512041T2 (de) 2000-02-03
HK1004222A1 (en) 1998-11-20
KR100391401B1 (ko) 2003-12-31
SI0753001T1 (en) 1999-12-31
EE9600117A (et) 1997-04-15
ATE184284T1 (de) 1999-09-15

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