AP542A - Bicyclic Fibrinogen antagonists - Google Patents

Bicyclic Fibrinogen antagonists Download PDF

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Publication number
AP542A
AP542A APAP/P/1995/000710A AP9500710A AP542A AP 542 A AP542 A AP 542A AP 9500710 A AP9500710 A AP 9500710A AP 542 A AP542 A AP 542A
Authority
AP
ARIPO
Prior art keywords
mmol
methyl
tetrahydro
oxo
compound
Prior art date
Application number
APAP/P/1995/000710A
Other languages
English (en)
Other versions
AP9500710A0 (en
Inventor
William Edward Bondinell
James Francis Callahan
William Francis Huffman
Richard Mccullock Keenan
Ku Thomas Wen Fu
Kenneth Allen Newlander
James Martin Samanen
Irene Nijole Uzinkas
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AP9500710A0 publication Critical patent/AP9500710A0/xx
Application granted granted Critical
Publication of AP542A publication Critical patent/AP542A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
APAP/P/1995/000710A 1994-01-07 1995-01-06 Bicyclic Fibrinogen antagonists AP542A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17901194A 1994-01-07 1994-01-07

Publications (2)

Publication Number Publication Date
AP9500710A0 AP9500710A0 (en) 1995-01-31
AP542A true AP542A (en) 1996-10-01

Family

ID=22654859

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1995/000710A AP542A (en) 1994-01-07 1995-01-06 Bicyclic Fibrinogen antagonists

Country Status (26)

Country Link
US (1) US6117866A (de)
EP (1) EP0738150B1 (de)
JP (1) JPH09508620A (de)
KR (1) KR100388772B1 (de)
CN (1) CN1117569C (de)
AP (1) AP542A (de)
AT (1) ATE238993T1 (de)
AU (1) AU699186B2 (de)
BG (2) BG62844B1 (de)
BR (1) BR9506499A (de)
CZ (1) CZ292323B6 (de)
DE (1) DE69530571T2 (de)
DK (1) DK0738150T3 (de)
ES (1) ES2197914T3 (de)
HU (1) HUT76282A (de)
IL (1) IL112243A (de)
MA (1) MA23420A1 (de)
NO (1) NO962859L (de)
NZ (1) NZ279394A (de)
OA (1) OA10368A (de)
PT (1) PT738150E (de)
SG (1) SG64884A1 (de)
SK (1) SK86996A3 (de)
TW (1) TW420682B (de)
WO (1) WO1995018619A1 (de)
ZA (1) ZA9545B (de)

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US6458784B1 (en) * 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
EP0762882A4 (de) * 1994-06-29 2002-09-11 Smithkline Beecham Corp Vibronectin-rezeptor-antagonisten
JPH10504825A (ja) * 1994-08-22 1998-05-12 スミスクライン・ビーチャム・コーポレイション 二環式化合物
DE19516483A1 (de) * 1995-05-05 1996-11-07 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
ZA9610853B (en) * 1995-12-29 1998-04-06 Smithkline Beecham Corp Processes and intermediates for preparing pharmaceuticals.
PL332006A1 (en) * 1996-09-03 1999-08-16 Smithkline Beecham Corp Crystalline pharmaceutic product
EP0964928A1 (de) * 1996-12-27 1999-12-22 Smithkline Beecham Plc Enzymatische auflösung von benzodiazepin essigsäure estern mit einer lipase
EP1044980A1 (de) * 1997-12-09 2000-10-18 Ihara Chemical Industry Co., Ltd. Verfahren zur herstellung von toluolderivaten
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
EP1140864A2 (de) 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Pharmazeutische zusammensetzungen, vitronectinrezeptor antagonisten enthaltend
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
GB9908662D0 (en) * 1999-04-15 1999-06-09 Smithkline Beecham Plc Novel process for preparing benzodiazepines
CO5180550A1 (es) * 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
ATE285821T1 (de) 1999-10-08 2005-01-15 Affinium Pharm Inc Fab i inhibitoren
SE9904377D0 (sv) * 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
US6964974B2 (en) * 2000-09-08 2005-11-15 Hoffmann-La Roche Inc. 2,3-oxidosqualene-lanosterol cyclase inhibitors
CA2444597A1 (en) 2001-04-06 2002-10-06 Affinium Pharmaceuticals, Inc. Fab i inhibitors
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
EP1443963B1 (de) 2001-10-22 2014-05-21 The Scripps Research Institute Antikörper-targeting-verbindungen
WO2004036181A2 (en) * 2002-10-17 2004-04-29 The Trustees Of The University Of Pennsylvania Method of treating neurological diseases and disorders
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625333A1 (de) 2003-05-21 2006-02-15 Alexza Pharmaceuticals, Inc. Unabhängige heizeinheit und diese benutzende medikamentenabgabevorrichtung
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
EP1677783A2 (de) 2003-10-08 2006-07-12 Nicholas Piramal India Limited Fibrinogen-rezeptor-antagonisten und ihre verwendung
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (de) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosolverabreichungsvorrichtung mit Schlag gezündete Heizeinheit
WO2007048127A2 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
EP2687533B1 (de) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamidderivate als FAB-I-Hemmer
WO2008098374A1 (en) 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
EP2121088B1 (de) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Erhitzungseinheit zur verwendung in einer arzneimittelabgabevorrichtung
EP2395992A2 (de) 2009-02-10 2011-12-21 The Scripps Research Institute Chemisch programmierte impfung
SI2861608T1 (sl) 2012-06-19 2019-08-30 Debiopharm International Sa Derivati predzdravila (E)-N-metil-N-((3-metilbenzofuran-2-IL)metil)- 3-(7-okso-5,6,7,8-tetrahidro-1 ,8-nafthiridin-3-il)akrilamid
BR122023021456A2 (pt) 2016-02-26 2024-02-20 Debiopharm International S.A. Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica
EP3746138B1 (de) 2018-02-02 2025-12-10 Alexza Pharmaceuticals, Inc. Elektrische kondensationsaerosolvorrichtung
WO2019210308A1 (en) * 2018-04-27 2019-10-31 Arrowhead Pharmaceuticals, Inc. Integrin targeting ligands and uses thereof
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CN113939306B (zh) 2019-06-14 2024-07-19 德彪药业国际股份公司 用于治疗涉及生物膜的细菌感染的药物及其用途

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EP0045451A2 (de) * 1980-07-31 1982-02-10 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Benzodiazepin-Derivate, Zwischenprodukte und Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
US5241065A (en) * 1992-02-25 1993-08-31 Schering Corporation 2,3,4,5-tetrahydro-1h-3-benzazepines having anti-psychotic activity

Also Published As

Publication number Publication date
PT738150E (pt) 2003-08-29
OA10368A (en) 2001-11-15
IL112243A0 (en) 1995-03-30
CN1117569C (zh) 2003-08-13
MA23420A1 (fr) 1995-10-01
DE69530571D1 (de) 2003-06-05
CN1143323A (zh) 1997-02-19
AP9500710A0 (en) 1995-01-31
IL112243A (en) 1999-12-31
CZ198196A3 (en) 1997-06-11
SK86996A3 (en) 1997-02-05
NZ279394A (en) 1998-05-27
ES2197914T3 (es) 2004-01-16
DE69530571T2 (de) 2004-03-04
HU9601849D0 (en) 1996-09-30
HK1014668A1 (en) 1999-09-30
BG100698A (bg) 1997-02-28
WO1995018619A1 (en) 1995-07-13
TW420682B (en) 2001-02-01
HUT76282A (en) 1997-07-28
AU1600195A (en) 1995-08-01
SG64884A1 (en) 1999-05-25
BG62844B1 (bg) 2000-09-29
ATE238993T1 (de) 2003-05-15
CZ292323B6 (cs) 2003-09-17
NO962859D0 (no) 1996-07-05
BR9506499A (pt) 1997-09-09
EP0738150A1 (de) 1996-10-23
KR100388772B1 (ko) 2003-11-20
EP0738150A4 (de) 1997-03-19
WO1995018619A9 (en) 2004-10-21
BG102863A (en) 1999-05-31
US6117866A (en) 2000-09-12
JPH09508620A (ja) 1997-09-02
EP0738150B1 (de) 2003-05-02
AU699186B2 (en) 1998-11-26
ZA9545B (en) 1996-01-23
DK0738150T3 (da) 2003-08-25
NO962859L (no) 1996-09-05

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