AP3430A - Novel pyridazine compound and use thereof - Google Patents

Novel pyridazine compound and use thereof

Info

Publication number
AP3430A
AP3430A AP2008004717A AP2008004717A AP3430A AP 3430 A AP3430 A AP 3430A AP 2008004717 A AP2008004717 A AP 2008004717A AP 2008004717 A AP2008004717 A AP 2008004717A AP 3430 A AP3430 A AP 3430A
Authority
AP
ARIPO
Prior art keywords
pyridazine compound
novel pyridazine
novel
compound
pyridazine
Prior art date
Application number
AP2008004717A
Other languages
English (en)
Other versions
AP2008004717A0 (en
Inventor
Vahid Zia
Terrence C Dahl
Winston C Tse
Original Assignee
Gileas Sciences Inc
Ku Leuven Res And Dev
Puerstinger Gerhard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gileas Sciences Inc, Ku Leuven Res And Dev, Puerstinger Gerhard filed Critical Gileas Sciences Inc
Publication of AP2008004717A0 publication Critical patent/AP2008004717A0/xx
Application granted granted Critical
Publication of AP3430A publication Critical patent/AP3430A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AP2008004717A 2006-07-07 2007-07-06 Novel pyridazine compound and use thereof AP3430A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81928906P 2006-07-07 2006-07-07
US83240306P 2006-07-21 2006-07-21
US83276906P 2006-07-24 2006-07-24
PCT/US2007/015553 WO2008005519A2 (en) 2006-07-07 2007-07-06 Novel pyridazine compound and use thereof

Publications (2)

Publication Number Publication Date
AP2008004717A0 AP2008004717A0 (en) 2008-12-31
AP3430A true AP3430A (en) 2015-09-30

Family

ID=38814329

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2008004717A AP3430A (en) 2006-07-07 2007-07-06 Novel pyridazine compound and use thereof

Country Status (28)

Country Link
US (3) US7754720B2 (ja)
EP (1) EP2038275B1 (ja)
JP (1) JP4958974B2 (ja)
KR (1) KR101143596B1 (ja)
CN (1) CN102617571B (ja)
AP (1) AP3430A (ja)
AR (1) AR061969A1 (ja)
AT (1) ATE454384T1 (ja)
AU (1) AU2007269614B2 (ja)
CA (1) CA2656415C (ja)
CY (1) CY1112107T1 (ja)
DE (1) DE602007004220D1 (ja)
DK (1) DK2038275T3 (ja)
EA (1) EA019452B1 (ja)
ES (1) ES2339298T3 (ja)
HK (1) HK1123803A1 (ja)
HR (2) HRP20090078A2 (ja)
IL (1) IL195528A (ja)
MX (1) MX2009000235A (ja)
NO (1) NO20090595L (ja)
NZ (1) NZ574312A (ja)
PL (1) PL2038275T3 (ja)
PT (1) PT2038275E (ja)
RS (1) RS51336B (ja)
SG (1) SG175604A1 (ja)
SI (1) SI2038275T1 (ja)
TW (1) TWI360549B (ja)
WO (1) WO2008005519A2 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215293D0 (en) * 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US20050222198A1 (en) * 2003-12-22 2005-10-06 K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
ES2324794T3 (es) * 2004-12-21 2009-08-14 Gilead Sciences Inc Imidazo(4,5-c)pyridine componente y metodo de tratamiento antiviral.
PT2038275E (pt) 2006-07-07 2010-04-08 Puerstinger Gerhard Novo composto de piridazina e sua utilização
US8263612B2 (en) 2006-12-14 2012-09-11 Gilead Sciences, Inc. Viral inhibitors
UA99466C2 (en) * 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
GB0809314D0 (en) * 2008-05-22 2008-07-02 Summit Corp Plc Compounds for treating muscular dystrophy
TW201113279A (en) 2009-06-23 2011-04-16 Gilead Sciences Inc Pharmaceutical compositions useful for treating HCV
TW201111381A (en) * 2009-06-23 2011-04-01 Gilead Sciences Inc Pharmaceutical combinations useful for treating HCV
WO2010151488A1 (en) 2009-06-23 2010-12-29 Gilead Sciences, Inc. Combination of boceprevir with 5- ( { 6- [2, 4- bis (trifluoromethyl) phenyl] pyridazin-3 -yl } methyl) -2- (2 -fluorophenyl) -5h- imidazo [4, 5-c] pyridine for the treatment of hcv
CN102596201A (zh) 2009-10-30 2012-07-18 贝林格尔.英格海姆国际有限公司 包含BI201335、干扰素α和利巴韦林的HCV组合治疗的用药方案
CN102753173A (zh) * 2009-12-18 2012-10-24 贝林格尔.英格海姆国际有限公司 Hcv组合疗法
CA2797872A1 (en) 2010-05-21 2011-11-24 Gilead Sciences, Inc. Heterocyclic flaviviridae virus inhibitors
UY33445A (es) * 2010-06-10 2012-01-31 Gilead Sciences Inc Un régimen de dosificación, métodos para tratar el virus de la hepatitis c, composición farmacéutica, compuesta, compuestos anti-hcv y kit
TW201701876A (zh) * 2010-12-20 2017-01-16 吉李德科學股份有限公司 治療ｃ型肝炎病毒（ｈｃｖ）之方法
CA3024230C (en) 2011-04-28 2022-10-18 Oncopeptides Ab Lyophilized preparation of cytotoxic dipeptides
ME03009B (me) 2011-09-16 2018-10-20 Gilead Pharmasset Llc Metode za lecenje hcv-a
MX365205B (es) * 2012-10-26 2019-05-27 Oncopeptides Ab Preparaciones liofilizadas de melfalán flufenamida.
JP2015508418A (ja) 2013-01-31 2015-03-19 ギリアド ファーマセット エルエルシー ２種の抗ウイルス化合物のコンビナトリアル製剤
HRP20211456T1 (hr) 2014-12-26 2021-12-24 Emory University Protuvirusni derivati n4-hidroksicitidina
JP6804790B1 (ja) 2017-12-07 2020-12-23 エモリー ユニバーシティー Ｎ４−ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072253A2 (en) * 2003-02-07 2004-08-26 The Trustees Of Columbia University In The City Of New York Human excitatory amino acid transporter-2 gene promoter and uses thereof
WO2005063744A2 (en) * 2003-12-22 2005-07-14 K.U. Leuven Research & Development IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2191978A (en) * 1935-10-10 1940-02-27 Ig Farbenindustrie Ag Quaternary nitrogen compounds and process of preparing them
US2411662A (en) * 1943-05-13 1946-11-26 Geigy Ag J R Imino-di-fatty acid amide
US2548863A (en) * 1946-05-29 1951-04-17 Wyeth Corp Substituted glycinamides
US2516674A (en) * 1948-10-29 1950-07-25 Wyeth Corp Substituted glycinamide
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
SU813921A1 (ru) 1979-10-26 1986-12-23 Институт физико-органической химии и углехимии АН УССР Стирильные производные имидазо(4,5- @ )пиридиний иодида,обладающие фунгицидной активностью
SU851940A1 (ru) 1980-03-20 1988-04-30 Институт физико-органической химии и углехимии АН УССР Четвертичные соли имидазо @ 4,5-с @ пиридини ,обладающие антимикробной и фунгистатической активностью
SU860463A1 (ru) 1980-04-09 1998-05-27 Институт физико-органической химии и углехимии АН Украинской ССР Производные 4-амино-1,3-диметилимидазо [4,5-с] пиридин-2-она, обладающие акарицидным действием
SU1048742A1 (ru) 1981-03-30 1986-12-23 Институт физико-органической химии и углехимии АН УССР 2,4-Дистирилпроизводные имидазо-(4,5- @ )пиридини ,обладающие бактериостатической и фунгистатической активностью
US4358387A (en) * 1981-08-10 1982-11-09 Texaco Inc. Cylinder lubricating oil composition
CA1183847A (en) 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5137896A (en) * 1981-10-01 1992-08-11 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)benzamide derivatives
FR2527608B1 (fr) * 1982-05-28 1986-10-10 Sandoz Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments
US4692443A (en) * 1983-10-17 1987-09-08 Eli Lilly And Company 3-bicyclicpyridinium-methyl cephalosporins
ZA847926B (en) 1983-10-17 1986-05-28 Lilly Co Eli 3-bicyclicpyridinium-methyl cephalosporins
GB8501542D0 (en) 1985-01-22 1985-02-20 Erba Farmitalia 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives
GB8530602D0 (en) 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds
EP0232937B1 (en) 1986-02-03 1992-08-19 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
US4804658A (en) * 1986-09-15 1989-02-14 G. D. Searle & Co. Imidazopyridine derivatives and pharmaceutical compositions
NZ225447A (en) 1987-07-20 1991-12-23 Merck & Co Inc Piperazinyl derivatives of purine and purine isosteres and pharmaceutical compositions
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US4914108A (en) * 1988-03-14 1990-04-03 G. D. Searle & Co. 5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US5227384A (en) * 1988-03-14 1993-07-13 G. D. Searle & Co. 5-substituted [4,5-c] imidazopyridines and pharmaceutical use thereof
US5302601A (en) * 1988-03-14 1994-04-12 G. D. Searle & Co. 5-substituted imidazo[4,5-c]pyridines
US5019581A (en) 1988-03-14 1991-05-28 G. D. Searle & Co. 5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US5332744A (en) * 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
US4988707A (en) * 1989-09-13 1991-01-29 G. D. Searle & Co. Pharmacologically active phenylalkanoyl substituted imidazo (4,5-C) pyridines
US4990518A (en) * 1989-09-13 1991-02-05 G. D. Searle & Co. Pharmacologically active heteroaryl substituted imidazo (4,5-c) pyridines
FR2663332B1 (fr) 1990-06-15 1997-11-07 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus.
US5011832A (en) * 1990-06-26 1991-04-30 Merck & Co., Inc. 2-biphenyl-carbapenem antibacterial agents
JPH04327587A (ja) 1991-04-26 1992-11-17 Asahi Chem Ind Co Ltd ６’−ｃ−アルキル−３−デアザネプラノシンａ誘導体、その製造法およびその用途
GB9116056D0 (en) * 1991-07-24 1991-09-11 British Bio Technology Compounds
US5587372A (en) * 1991-12-12 1996-12-24 Roussel Uclaf Cephalosporins
GB9202792D0 (en) 1992-02-11 1992-03-25 British Bio Technology Compounds
DE4211474A1 (de) 1992-04-06 1993-10-07 Merck Patent Gmbh Imidazopyridine
US5208242A (en) * 1992-08-26 1993-05-04 G. D. Searle & Co. 5-substituted-4-phenyl-5H-imidazo[4,5-c]pyridine derivatives
DE4230464A1 (de) 1992-09-11 1994-03-17 Merck Patent Gmbh Imidazolderivate
DE4236026A1 (de) * 1992-10-24 1994-04-28 Merck Patent Gmbh Imidazopyridine
JP3115455B2 (ja) 1992-12-18 2000-12-04 明治製菓株式会社 新規セファロスポリン誘導体
US5374638A (en) * 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
DE4309969A1 (de) 1993-03-26 1994-09-29 Bayer Ag Substituierte heteroanellierte Imidazole
DE4318813A1 (de) * 1993-06-07 1994-12-08 Merck Patent Gmbh Imidazopyridine
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5563143A (en) 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
US5585492A (en) * 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US6506876B1 (en) * 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5872136A (en) * 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5883105A (en) * 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5859035A (en) * 1996-04-03 1999-01-12 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5939557A (en) * 1996-04-03 1999-08-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5874452A (en) * 1996-04-03 1999-02-23 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5854265A (en) * 1996-04-03 1998-12-29 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5880140A (en) * 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
EP1035123B1 (en) * 1997-11-28 2003-08-20 Sumitomo Pharmaceuticals Company, Limited Novel heterocyclic compounds
DE19845153A1 (de) * 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
EP1142895B1 (en) * 1999-01-08 2006-07-05 Chisso Corporation Borane derivatives and organic electroluminescents
DE19900471A1 (de) 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
CA2373073A1 (en) * 1999-05-07 2000-11-16 Takeda Chemical Industries, Ltd. Cyclic compounds and uses thereof
US6844367B1 (en) * 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
CN1167680C (zh) 1999-12-27 2004-09-22 日本烟草产业株式会社 稠环化合物及其药物用途
US6770666B2 (en) * 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
CA2401778C (en) * 2000-02-29 2010-12-21 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
EP1132381A1 (en) 2000-03-08 2001-09-12 Cermol S.A. Ester derivatives of dimethylpropionic acid and pharmaceutical compositions containing them
US6448281B1 (en) * 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
JP4331944B2 (ja) 2001-04-17 2009-09-16 大日本住友製薬株式会社 新規アデニン誘導体
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
US20030073836A1 (en) * 2001-07-05 2003-04-17 Boehringer Ingelheim Pharma Kg Heteroarylcarboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
US7294457B2 (en) * 2001-08-07 2007-11-13 Boehringer Ingelheim (Canada) Ltd. Direct binding assay for identifying inhibitors of HCV polymerase
DE10140246A1 (de) * 2001-08-09 2003-03-06 Forsch Pigmente Und Lacke E V Verfahren zur Behandlung von Oberflächen von Substraten
WO2003026587A2 (en) * 2001-09-26 2003-04-03 Bristol-Myers Squibb Company Compounds useful for treating hepatitus c virus
AU2003205570A1 (en) 2002-01-10 2003-07-24 Boehringer Ingelheim Pharma Gmbh And Co. Kg Combination of mtp inhibitors or apob secretion inhibitors with fibrates for use as drugs
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
EP2308878A3 (de) 2002-08-21 2011-10-26 Boehringer Ingelheim Pharma GmbH & Co. KG 8-[3-Amino-Piperidin-1-YL] -Xanthine, deren Herstellung und deren Verwendung als Arzneimittel
JP4619786B2 (ja) * 2002-08-29 2011-01-26 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 炎症性、アレルギー性及び増殖性疾患の治療において糖質コルチコイドミメティックスとして使用するための３−（スルホンアミドエチル）−インドール誘導体
AU2003269850A1 (en) 2002-10-08 2004-05-04 Novo Nordisk A/S Hemisuccinate salts of heterocyclic dpp-iv inhibitors
AU2003294249A1 (en) 2002-11-08 2004-06-03 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
WO2004054974A2 (en) 2002-12-13 2004-07-01 Smithkline Beecham Corporation Piperidine derivatives as ccr5 antagonists
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
DE602004022633D1 (de) 2003-01-30 2009-10-01 Boehringer Ingelheim Pharma 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
CN1771050A (zh) * 2003-02-07 2006-05-10 益安药业 丙型肝炎丝氨酸蛋白酶的大环抑制剂
US7566707B2 (en) * 2003-06-18 2009-07-28 Boehringer Ingelheim International Gmbh Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
BRPI0416283A (pt) * 2003-11-05 2007-01-23 Hoffmann La Roche compostos, processo para a fabricação de compostos, composição farmacêutica, método para o tratamento e/ou prevenção de doenças que são moduladas por agonistas de ppar(delta) e/ou ppar(alfa) e uso destes compostos
JP5014129B2 (ja) * 2004-07-27 2012-08-29 ギリアード サイエンシーズ， インコーポレイテッド イミダゾ［４，５−ｄ］ピリミジン、それらの使用および調製方法
WO2006029966A1 (en) 2004-09-13 2006-03-23 Ciba Specialty Chemicals Holding Inc. Alkylaminoacetamide lubricant additives
ES2324794T3 (es) * 2004-12-21 2009-08-14 Gilead Sciences Inc Imidazo(4,5-c)pyridine componente y metodo de tratamiento antiviral.
WO2007063744A1 (ja) * 2005-11-30 2007-06-07 Fujifilm Corporation 平版刷版の後露光方法、後露光装置、露光装置、露光用器具、現像方法、及び現像装置
CN101004515A (zh) * 2006-01-21 2007-07-25 鸿富锦精密工业（深圳）有限公司 直下式背光模组
PT2038275E (pt) 2006-07-07 2010-04-08 Puerstinger Gerhard Novo composto de piridazina e sua utilização
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
GB0718575D0 (en) * 2007-09-24 2007-10-31 Angeletti P Ist Richerche Bio Nucleoside derivatives as inhibitors of viral polymerases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072253A2 (en) * 2003-02-07 2004-08-26 The Trustees Of Columbia University In The City Of New York Human excitatory amino acid transporter-2 gene promoter and uses thereof
WO2005063744A2 (en) * 2003-12-22 2005-07-14 K.U. Leuven Research & Development IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT

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