AP3396A - Methods of creating and screening DNA-encoded libraries - Google Patents

Methods of creating and screening DNA-encoded libraries

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Publication number
AP3396A
AP3396A AP2011005847A AP2011005847A AP3396A AP 3396 A AP3396 A AP 3396A AP 2011005847 A AP2011005847 A AP 2011005847A AP 2011005847 A AP2011005847 A AP 2011005847A AP 3396 A AP3396 A AP 3396A
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AP
ARIPO
Prior art keywords
creating
methods
screening dna
encoded libraries
libraries
Prior art date
Application number
AP2011005847A
Other languages
English (en)
Other versions
AP2011005847A0 (en
Inventor
Richard Wagner
Original Assignee
Chem Inc X
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42562099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3396(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chem Inc X filed Critical Chem Inc X
Publication of AP2011005847A0 publication Critical patent/AP2011005847A0/xx
Application granted granted Critical
Publication of AP3396A publication Critical patent/AP3396A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AP2011005847A 2009-02-13 2010-02-16 Methods of creating and screening DNA-encoded libraries AP3396A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15250809P 2009-02-13 2009-02-13
PCT/US2010/024314 WO2010094036A1 (fr) 2009-02-13 2010-02-16 Methodes de creation et de criblage de bibliotheques de codage adn

Publications (2)

Publication Number Publication Date
AP2011005847A0 AP2011005847A0 (en) 2011-08-31
AP3396A true AP3396A (en) 2015-08-31

Family

ID=42562099

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2011005847A AP3396A (en) 2009-02-13 2010-02-16 Methods of creating and screening DNA-encoded libraries

Country Status (17)

Country Link
US (3) US9359601B2 (fr)
EP (3) EP2396459B1 (fr)
JP (6) JP5770641B2 (fr)
KR (4) KR101789216B1 (fr)
CN (2) CN107916456B (fr)
AP (1) AP3396A (fr)
BR (1) BRPI1008429A2 (fr)
CA (2) CA2752543A1 (fr)
DK (2) DK2396459T3 (fr)
EA (4) EA035311B1 (fr)
ES (2) ES2842527T3 (fr)
HK (2) HK1243467A1 (fr)
IL (3) IL214399B (fr)
MX (1) MX2011008563A (fr)
NZ (2) NZ611886A (fr)
SG (3) SG173627A1 (fr)
WO (1) WO2010094036A1 (fr)

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AP3396A (en) 2009-02-13 2015-08-31 Chem Inc X Methods of creating and screening DNA-encoded libraries
EP3540059A1 (fr) 2010-04-16 2019-09-18 Nuevolution A/S Complexes bifonctionnels et procédés de fabrication et d'utilisation de tels complexes
SG11201400374TA (en) * 2011-09-07 2014-09-26 Chem Inc X Methods for tagging dna-encoded libraries
EP2872680B1 (fr) * 2012-07-13 2018-04-04 X-Chem, Inc. Banques encodées par l'adn possédant des liaisons oligonucléotidiques codantes ne pouvant être lues par les polymérases
EP3000898B1 (fr) 2013-05-21 2020-11-18 Hitgen Inc. Procédé de capture de cibles de médicaments
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
GB201404552D0 (en) * 2014-03-14 2014-04-30 Philochem Ag Purification of dna-conjugate products
EP3218479A1 (fr) 2014-11-11 2017-09-20 Nanocore ApS Procédé d'identification de molécules présentant des caractéristiques souhaitées
NL2013857B1 (en) 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
WO2016165621A1 (fr) * 2015-04-14 2016-10-20 成都先导药物开发有限公司 Procédé de synthèse en phase solide de bibliothèque chimique codée par adn
EP3472376A4 (fr) * 2016-06-16 2019-12-18 Richard Edward Watts Synthèse combinatoire dirigée et enregistrée d'oligonucléotides de molécules de sondes codées
CN107130300A (zh) * 2016-10-08 2017-09-05 深圳劲宇生物科技有限公司 一种dna编码分子库的合成方法及dna模板
US11667951B2 (en) 2016-10-24 2023-06-06 Geneinfosec, Inc. Concealing information present within nucleic acids
AU2017357638B2 (en) * 2016-11-08 2023-11-16 Nanna Therapeutics Limited Tagless encoded chemical library
CN108149325A (zh) * 2016-12-02 2018-06-12 杭州阿诺生物医药科技股份有限公司 Dna编码动态分子库的合成与筛选方法
US20200149034A1 (en) * 2017-03-17 2020-05-14 Hitgen Ltd. Methods and Compositions for Synthesis of Encoded Libraries
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
CN108070009B (zh) * 2017-12-12 2021-04-13 上海药明康德新药开发有限公司 一种制备dna编码化合物文库的方法及起始头片段化合物和制得的dna编码化合物
CN110658163A (zh) * 2018-06-29 2020-01-07 成都先导药物开发股份有限公司 一种合成dna编码化合物中的反应监测方法
WO2020015683A1 (fr) * 2018-07-18 2020-01-23 Shanghaitech University Marquage indépendant de la fonctionnalité de composés organiques
CN109338477A (zh) * 2018-10-25 2019-02-15 深圳劲宇生物科技有限公司 基于环形模板的dna编码分子库及其合成方法和应用
US11634835B2 (en) 2019-01-22 2023-04-25 Vipergen Aps Method for screening of an in vitro display library within a cell
CN111675744B (zh) * 2019-03-11 2022-01-04 成都先导药物开发股份有限公司 一种可溶于有机溶剂的dna编码化合物及其中间体化合物
WO2020212439A1 (fr) 2019-04-16 2020-10-22 F. Hoffmann-La Roche Ag Dosage cellulaire de criblage de petites molécules utilisant des billes modifiées
CN112143783B (zh) * 2019-06-27 2024-09-24 成都先导药物开发股份有限公司 一种可识别混合物对复杂生物体系的鉴别方法
KR102376443B1 (ko) 2020-02-26 2022-03-17 포항공과대학교 산학협력단 나노구조체, 나노구조체를 포함하는 바이오센서, 및 스크리닝 방법
JP7548305B2 (ja) 2020-05-25 2024-09-10 日産化学株式会社 切断可能なｄｎａコード化ライブラリ
JPWO2023095841A1 (fr) * 2021-11-24 2023-06-01
WO2023108090A2 (fr) * 2021-12-09 2023-06-15 University Of Florida Research Foundation, Incorporated Plateforme faisant appel à des banques de petites molécules codées par adn et une sélection d'arn pour concevoir de petites molécules qui ciblent l'arn
CN114989229A (zh) * 2022-03-25 2022-09-02 康龙化成(宁波)科技发展有限公司 一种寡聚核酸-吡唑类化合物及其合成方法
JP7204026B1 (ja) 2022-03-31 2023-01-13 大阪ガスケミカル株式会社 不織布及びその製造方法、それを用いた有機溶剤回収方法、並びに有機溶剤回収装置
CN114920791B (zh) * 2022-04-28 2024-06-18 康龙化成(宁波)科技发展有限公司 一种寡聚核酸-琥珀酰亚胺化合物的合成方法
WO2024069235A2 (fr) 2022-09-30 2024-04-04 Sixfold Bioscience Ltd. Compositions contenant des oligonucléotides ayant des applications théranostiques

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