AP2301A - Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids. - Google Patents

Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids.

Info

Publication number
AP2301A
AP2301A AP2006003764A AP2006003764A AP2301A AP 2301 A AP2301 A AP 2301A AP 2006003764 A AP2006003764 A AP 2006003764A AP 2006003764 A AP2006003764 A AP 2006003764A AP 2301 A AP2301 A AP 2301A
Authority
AP
ARIPO
Prior art keywords
carboxylic acids
aliphatic dinitriles
cyano carboxylic
bioconversion
stereoselective
Prior art date
Application number
AP2006003764A
Other languages
English (en)
Other versions
AP2006003764A0 (en
Inventor
Michael P Burns
Justin Kaine Weaver
John Wing Wong
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2006003764A0 publication Critical patent/AP2006003764A0/xx
Application granted granted Critical
Publication of AP2301A publication Critical patent/AP2301A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/207497—Molecular oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AP2006003764A 2004-04-14 2005-04-01 Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids. AP2301A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56213304P 2004-04-14 2004-04-14
PCT/IB2005/000873 WO2005100580A1 (en) 2004-04-14 2005-04-01 Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids

Publications (2)

Publication Number Publication Date
AP2006003764A0 AP2006003764A0 (en) 2006-10-31
AP2301A true AP2301A (en) 2011-10-31

Family

ID=34962755

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2006003764A AP2301A (en) 2004-04-14 2005-04-01 Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids.

Country Status (43)

Country Link
US (2) US7727749B2 (de)
EP (1) EP1745136B1 (de)
JP (1) JP4051082B2 (de)
KR (1) KR100887777B1 (de)
CN (1) CN1942587B (de)
AP (1) AP2301A (de)
AR (1) AR048690A1 (de)
AT (1) ATE445019T1 (de)
AU (1) AU2005233371B2 (de)
BR (1) BRPI0509908A (de)
CA (1) CA2563307C (de)
CR (2) CR8686A (de)
CY (1) CY1109556T1 (de)
DE (1) DE602005017027D1 (de)
DK (1) DK1745136T3 (de)
DO (1) DOP2005000055A (de)
EA (1) EA010305B1 (de)
EC (1) ECSP066917A (de)
ES (1) ES2331140T3 (de)
GE (1) GEP20084530B (de)
GT (1) GT200500086A (de)
HN (1) HN2005000162A (de)
HR (1) HRP20090562T1 (de)
IL (1) IL177918A (de)
MA (1) MA28536B1 (de)
ME (1) ME01107B (de)
MY (1) MY144296A (de)
NL (1) NL1028762C2 (de)
NO (1) NO335624B1 (de)
NZ (1) NZ549698A (de)
PA (1) PA8629801A1 (de)
PE (1) PE20060252A1 (de)
PL (1) PL1745136T3 (de)
PT (1) PT1745136E (de)
RS (1) RS50994B (de)
SI (1) SI1745136T1 (de)
SV (1) SV2005002085A (de)
TN (1) TNSN06329A1 (de)
TW (1) TWI304095B (de)
UA (1) UA82292C2 (de)
UY (1) UY28851A1 (de)
WO (1) WO2005100580A1 (de)
ZA (1) ZA200607476B (de)

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KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
AT412092B (de) * 2003-02-27 2004-09-27 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung chiraler alpha-hydroxycarbonsäuren durch enzymatische hydrolyse von chiralen cyanhydrinen
MX2007012396A (es) 2005-04-06 2007-11-20 Teva Pharma Formas cristalinas de pregabalina.
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
KR20070118305A (ko) 2005-05-10 2007-12-14 테바 파마슈티컬 인더스트리즈 리미티드 3-카르바모일메틸-5-메틸 헥산산의 광학 분할
JP2008505980A (ja) 2005-05-10 2008-02-28 テバ ファーマシューティカル インダストリーズ リミティド イソブチルグルタル酸を有さないプレガバリン及びその調製方法
WO2006122258A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Method for the preparation of pregabalin and salts thereof
US7446220B2 (en) 2005-09-19 2008-11-04 Teva Pharmaceutical Industries Ltd. Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
US20070141684A1 (en) * 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
EP2019817A2 (de) 2006-05-24 2009-02-04 Teva Pharmaceutical Industries Ltd. Verfahren zur erzeugung von r-(+)-3-(carbamoyl-methyl)-5-methylhexansäure und ihren salzen
BRPI0702897A2 (pt) * 2006-05-31 2011-03-15 Teva Pharmaceutical Ind Ltda processo para preparar um intermediário de pregabalina
EP1881077A1 (de) * 2006-07-19 2008-01-23 Solvay Organics GmbH Verfahren zur Herstellung von fluorhaltigen alpha-Hydroxycarbonsäuren
KR101036536B1 (ko) 2007-03-22 2011-05-24 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성
WO2009087650A2 (en) * 2007-10-15 2009-07-16 V.B. Medicare Pvt. Ltd. A novel process for synthesis of pregabalin from substituted cyclopropane intermediate and a process for enzymatic resolution of racemic pregabalin
SI2294207T1 (sl) 2008-05-21 2013-01-31 Sandoz Ag Postopek za stereoselektivno encimatsko hidrolizo estra 5-metil-3-nitrometil-heksanojske kisline
WO2011011630A2 (en) 2009-07-23 2011-01-27 Codexis, Inc. Nitrilase biocatalysts
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8604062B2 (en) * 2011-10-20 2013-12-10 Hoffman-La Roche Inc. Process for the preparation of isoxazolyl-methoxy nicotinic acids
CA2888877C (en) * 2012-11-07 2021-07-27 Hikal Limited A process for the preparation of pregabalin
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
CN105017072B (zh) * 2015-06-30 2017-10-03 河北诚信有限责任公司 异丁基琥珀腈的合成方法
CN105176955B (zh) 2015-08-27 2018-11-02 浙江工业大学 来源于高山南芥的腈水解酶、基因、载体、工程菌及其应用
CN108424900B (zh) * 2018-02-09 2020-11-03 浙江工业大学 一种腈水解酶突变体及其构建方法和应用
CN114164197B (zh) * 2020-01-13 2023-08-18 浙江工业大学 一种热稳定性和活力提高的腈水解酶突变体及其应用
CN113651717B (zh) * 2021-08-05 2024-08-30 浙江工业大学 一种光学纯异丁基丁二腈的消旋方法
CN116041214B (zh) * 2022-11-15 2025-04-22 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

Citations (3)

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Publication number Priority date Publication date Assignee Title
US5593871A (en) * 1990-09-20 1997-01-14 E. I. Du Pont De Nemours And Company Process for the preparation of enantiometric 2-alkanoic acid amides from nitriles
US6046353A (en) * 1995-06-07 2000-04-04 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
WO2002095045A2 (fr) * 2001-05-21 2002-11-28 Adisseo France S.A.S. Procede de preparation d'acides carboxyliques aliphatiques par hydrolyse enzymatique de composes nitriles aliphatiques

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JP3218133B2 (ja) * 1993-02-03 2001-10-15 三菱レイヨン株式会社 フェニル基を有する光学活性α−ヒドロキシカルボン酸の製造法
US5858736A (en) 1996-05-17 1999-01-12 E. I. Du Pont De Nemours And Company Preparation of lactams from aliphatic α,ω-dinitriles
DE69834204T2 (de) 1997-10-27 2007-03-29 Warner-Lambert Co. Llc Zyklische aminosäuren und deren derivate als arzneimittel
US6642398B2 (en) 1999-06-10 2003-11-04 Warner-Lambert Company Mono-and disubstituted 3-propyl gamma-aminobutyric acids
US6551804B2 (en) 1999-07-12 2003-04-22 E. I. Du Pont De Nemours And Company Process for preparing 4-cyanopentanoic acid
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
PT1250311E (pt) 2000-01-27 2004-07-30 Warner Lambert Co Sintese assimetrica de pregabalina
CA2528388A1 (en) * 2003-06-19 2004-12-23 Pfizer Products Inc. Biocatalytic preparation of 1-cyanocyclohexaneacetic acid

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US5593871A (en) * 1990-09-20 1997-01-14 E. I. Du Pont De Nemours And Company Process for the preparation of enantiometric 2-alkanoic acid amides from nitriles
US6046353A (en) * 1995-06-07 2000-04-04 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
WO2002095045A2 (fr) * 2001-05-21 2002-11-28 Adisseo France S.A.S. Procede de preparation d'acides carboxyliques aliphatiques par hydrolyse enzymatique de composes nitriles aliphatiques

Non-Patent Citations (1)

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Title
GAVAGAN J.E. ET AL.: "Chemoenzymic Production of Lactams from Aliphatic alpha,omega-Dinitriles" JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 63, no. 14, 1998, pages 4792-4801 *

Also Published As

Publication number Publication date
HN2005000162A (es) 2007-11-16
NZ549698A (en) 2009-10-30
CR20110356A (es) 2011-07-21
GEP20084530B (en) 2008-11-10
CN1942587A (zh) 2007-04-04
PT1745136E (pt) 2009-11-26
NO335624B1 (no) 2015-01-12
RS50994B (sr) 2010-10-31
HRP20090562T1 (hr) 2009-11-30
ECSP066917A (es) 2006-12-20
EA200601574A1 (ru) 2007-04-27
EP1745136A1 (de) 2007-01-24
UA82292C2 (uk) 2008-03-25
PL1745136T3 (pl) 2010-02-26
SV2005002085A (es) 2005-12-13
DE602005017027D1 (de) 2009-11-19
CA2563307C (en) 2011-02-08
US20070196905A1 (en) 2007-08-23
TWI304095B (en) 2008-12-11
DOP2005000055A (es) 2005-12-15
ATE445019T1 (de) 2009-10-15
PE20060252A1 (es) 2006-04-01
AP2006003764A0 (en) 2006-10-31
EA010305B1 (ru) 2008-08-29
NL1028762A1 (nl) 2005-10-17
TW200533756A (en) 2005-10-16
AR048690A1 (es) 2006-05-17
US20100204503A1 (en) 2010-08-12
BRPI0509908A (pt) 2007-09-18
JP4051082B2 (ja) 2008-02-20
AU2005233371A1 (en) 2005-10-27
AU2005233371B2 (en) 2007-12-20
IL177918A (en) 2013-11-28
DK1745136T3 (da) 2009-11-30
ES2331140T3 (es) 2009-12-22
SI1745136T1 (sl) 2009-12-31
EP1745136B1 (de) 2009-10-07
JP2007532125A (ja) 2007-11-15
HK1105215A1 (zh) 2008-02-06
NO20065181L (no) 2006-11-10
PA8629801A1 (es) 2005-11-25
IL177918A0 (en) 2006-12-31
GT200500086A (es) 2006-01-10
TNSN06329A1 (fr) 2008-02-22
UY28851A1 (es) 2005-11-30
CY1109556T1 (el) 2014-08-13
MA28536B1 (fr) 2007-04-03
KR100887777B1 (ko) 2009-03-09
WO2005100580A1 (en) 2005-10-27
ZA200607476B (en) 2008-05-28
CN1942587B (zh) 2010-05-05
US7727749B2 (en) 2010-06-01
MY144296A (en) 2011-08-29
NL1028762C2 (nl) 2006-07-25
ME01107B (me) 2012-12-20
CR8686A (es) 2006-11-21
CA2563307A1 (en) 2005-10-27
US8304252B2 (en) 2012-11-06
KR20070020009A (ko) 2007-02-16

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