AP2006003716A0 - Methods for making 3-O-protected morphines and 3-O-protected morphinone dienol carboxylates - Google Patents

Methods for making 3-O-protected morphines and 3-O-protected morphinone dienol carboxylates

Info

Publication number
AP2006003716A0
AP2006003716A0 AP2006003716A AP2006003716A AP2006003716A0 AP 2006003716 A0 AP2006003716 A0 AP 2006003716A0 AP 2006003716 A AP2006003716 A AP 2006003716A AP 2006003716 A AP2006003716 A AP 2006003716A AP 2006003716 A0 AP2006003716 A0 AP 2006003716A0
Authority
AP
ARIPO
Prior art keywords
protected
morphines
making
methods
morphinone dienol
Prior art date
Application number
AP2006003716A
Other languages
English (en)
Inventor
Andreas Stumpf
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2006003716(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of AP2006003716A0 publication Critical patent/AP2006003716A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
AP2006003716A 2004-02-06 2005-02-04 Methods for making 3-O-protected morphines and 3-O-protected morphinone dienol carboxylates AP2006003716A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54271104P 2004-02-06 2004-02-06
PCT/US2005/003390 WO2005077957A2 (en) 2004-02-06 2005-02-04 Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates

Publications (1)

Publication Number Publication Date
AP2006003716A0 true AP2006003716A0 (en) 2006-08-31

Family

ID=34860329

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2006003716A AP2006003716A0 (en) 2004-02-06 2005-02-04 Methods for making 3-O-protected morphines and 3-O-protected morphinone dienol carboxylates

Country Status (34)

Country Link
US (6) US8003793B2 (no)
EP (3) EP1711502B1 (no)
JP (1) JP4963968B2 (no)
KR (4) KR20070108956A (no)
CN (1) CN1918168B (no)
AP (1) AP2006003716A0 (no)
AT (2) ATE451374T1 (no)
AU (1) AU2005212258B2 (no)
BR (1) BRPI0506607B8 (no)
CA (2) CA2555215C (no)
CR (1) CR8590A (no)
CY (2) CY1108506T1 (no)
DE (2) DE602005009321D1 (no)
DK (2) DK1864987T3 (no)
EA (2) EA012905B1 (no)
EC (1) ECSP066824A (no)
ES (2) ES2313299T3 (no)
GE (1) GEP20084454B (no)
HK (2) HK1103071A1 (no)
HR (2) HRP20080618T3 (no)
IL (2) IL177281A (no)
MA (1) MA28346A1 (no)
MX (1) MXPA06008931A (no)
NO (2) NO20063989L (no)
NZ (2) NZ548786A (no)
PL (2) PL1864987T3 (no)
PT (2) PT1711502E (no)
RS (2) RS50663B (no)
SG (1) SG150500A1 (no)
SI (2) SI1864987T1 (no)
TN (1) TNSN06248A1 (no)
UA (2) UA88646C2 (no)
WO (1) WO2005077957A2 (no)
ZA (1) ZA200606252B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1864987T3 (da) 2004-02-06 2010-04-12 Euro Celtique Sa Fremgangsmåder til fremstilling af 3-O-beskyttede morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater
EP2099764B1 (en) * 2006-09-20 2011-07-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
WO2008109156A2 (en) * 2007-03-06 2008-09-12 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
PL2285780T3 (pl) 2008-05-27 2016-02-29 SpecGx LLC Sposoby i związki do wytwarzania normorfinanów
EP2331508B1 (en) * 2008-09-03 2014-11-12 Mallinckrodt LLC Substituted berbines and processes for their synthesis
MX344846B (es) 2010-05-10 2017-01-10 Euro-Celtique S A * Combinacion de granulos cargados activos con activos adicionales.
JP5838199B2 (ja) 2010-05-10 2016-01-06 ユーロ−セルティーク エス．エイ． 活性剤を含まない顆粒およびその顆粒を含む錠剤の製造
SE1251371A1 (sv) 2010-05-10 2012-12-27 Euro Celtique Sa Farmaceutiska kompositioner innefattande hydromorfon och naloxon
DE112014005175T5 (de) 2013-11-13 2016-07-21 Euro-Celtique S.A. Hydromorphon und Naloxon für die Behandlung von Schmerzen und Opioid-Darm-Dysfunktions-Syndrom
EP3357898B1 (en) 2015-09-30 2020-11-25 FUJIFILM Wako Pure Chemical Corporation Method for producing organic compound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) * 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
DE902257C (de) 1951-07-17 1954-01-21 Knoll Ag Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons
GB1495271A (en) * 1974-04-10 1977-12-14 Macfarlan Smith Ltd Dehydrohalogenation of codeinone derivatives
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
SE9003665D0 (sv) * 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
US5821374A (en) * 1995-11-21 1998-10-13 Hoffmann-La Roche Inc. Process for the oxidation of alcohols
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US6596877B2 (en) * 2001-10-17 2003-07-22 Novartis Ag Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
DK1864987T3 (da) 2004-02-06 2010-04-12 Euro Celtique Sa Fremgangsmåder til fremstilling af 3-O-beskyttede morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater

Also Published As

Publication number Publication date
PT1711502E (pt) 2008-11-20
US20150239898A1 (en) 2015-08-27
UA88646C2 (uk) 2009-11-10
IL177281A0 (en) 2006-12-10
EP2194059A2 (en) 2010-06-09
US20140171643A1 (en) 2014-06-19
NZ565355A (en) 2008-09-26
GEP20084454B (en) 2008-08-10
KR20070026401A (ko) 2007-03-08
EP2194059A3 (en) 2010-09-22
CY1109838T1 (el) 2014-09-10
WO2005077957A2 (en) 2005-08-25
US9670218B2 (en) 2017-06-06
HRP20100123T1 (hr) 2010-04-30
NO20063989L (no) 2006-10-31
CR8590A (es) 2007-07-19
KR20090089486A (ko) 2009-08-21
US8975257B2 (en) 2015-03-10
BRPI0506607A (pt) 2007-05-02
HRP20080618T3 (en) 2009-01-31
AU2005212258B2 (en) 2008-05-22
KR20070117701A (ko) 2007-12-12
CY1108506T1 (el) 2014-04-09
US8198444B2 (en) 2012-06-12
NO20150276L (no) 2006-10-31
DE602005018265D1 (de) 2010-01-21
JP4963968B2 (ja) 2012-06-27
DK1864987T3 (da) 2010-04-12
KR100921696B1 (ko) 2009-10-15
WO2005077957A3 (en) 2006-05-04
ECSP066824A (es) 2006-12-29
RS51317B (sr) 2010-12-31
BRPI0506607B1 (pt) 2018-01-16
EA200601394A1 (ru) 2006-12-29
US20080146804A1 (en) 2008-06-19
BRPI0506607B8 (pt) 2021-05-25
US20170233400A1 (en) 2017-08-17
CA2808199A1 (en) 2005-08-25
ES2338054T3 (es) 2010-05-03
DK1711502T3 (da) 2008-12-01
ATE406372T1 (de) 2008-09-15
IL205596A (en) 2011-11-30
DE602005009321D1 (de) 2008-10-09
PL1864987T3 (pl) 2010-05-31
EP1864987B1 (en) 2009-12-09
KR101011460B1 (ko) 2011-01-28
SI1864987T1 (sl) 2010-04-30
ZA200606252B (en) 2007-11-28
CN1918168A (zh) 2007-02-21
SI1711502T1 (sl) 2009-02-28
EP1864987A3 (en) 2008-02-20
US20120225902A1 (en) 2012-09-06
MA28346A1 (fr) 2006-12-01
HK1119160A1 (en) 2009-02-27
EA200801811A1 (ru) 2008-12-30
CA2555215C (en) 2013-05-21
CA2808199C (en) 2015-10-27
EP1711502A2 (en) 2006-10-18
NZ548786A (en) 2008-08-29
US20120022259A1 (en) 2012-01-26
US8685996B2 (en) 2014-04-01
ES2313299T3 (es) 2009-03-01
UA87833C2 (uk) 2009-08-25
JP2007520563A (ja) 2007-07-26
ATE451374T1 (de) 2009-12-15
EA012905B1 (ru) 2010-02-26
HK1103071A1 (en) 2007-12-14
SG150500A1 (en) 2009-03-30
KR20070108956A (ko) 2007-11-13
EA016062B1 (ru) 2012-01-30
RS50663B (sr) 2010-06-30
US8003793B2 (en) 2011-08-23
EP1864987A2 (en) 2007-12-12
PL1711502T3 (pl) 2009-02-27
CN1918168B (zh) 2011-04-27
MXPA06008931A (es) 2007-01-26
KR100921695B1 (ko) 2009-10-15
PT1864987E (pt) 2010-03-09
NO339083B1 (no) 2016-11-14
EP1711502B1 (en) 2008-08-27
TNSN06248A1 (fr) 2007-12-03
IL177281A (en) 2012-02-29
CA2555215A1 (en) 2005-08-25
AU2005212258A1 (en) 2005-08-25

Similar Documents

Publication Publication Date Title
AP2006003716A0 (en) Methods for making 3-O-protected morphines and 3-O-protected morphinone dienol carboxylates
IL180125A0 (en) Methods for producing biodiesel
EP1766753A4 (en) VEHICLE INTERFACE
IL176767A0 (en) Production method
PL1713760T3 (pl) Sposób wytwarzania dinitryli
PL383328A1 (pl) Sposób wytwarzania sewofluranu
EP1767491A4 (en) METHOD FOR PRODUCING NANOSTRUCTURE AND NANOSTRUCTURE
EP1757441A4 (en) MULTILAYER STRUCTURE AND METHOD FOR PRODUCING THE SAME
EP1731218A4 (en) PROCESS FOR DECOMPOSING POLYCARBONATE
GB0402639D0 (en) Method
EP1790668A4 (en) PROCESS FOR PRODUCING WATER ABSORBING RESIN
EP1754593A4 (en) METHOD AND DEVICE FOR FORMING A WOLST
EP1820630A4 (en) PROCESS FOR PRODUCING TIRE
IL183241A0 (en) Method for purifying tacrolimus
EP1767338A4 (en) APPARATUS FOR MANUFACTURING BRIQUETTES
GB0411607D0 (en) Recondenser interface
GB0408887D0 (en) Manufacturing method
EP1799252A4 (en) ANTIBODY PRODUCTION PROCESS
EG24430A (en) Beverage production method
TWI315261B (en) Method for transferring-printing
GB0519893D0 (en) Method of inspecting a vehicle
PL370959A1 (pl) Sposób otrzymywania adsorbentu
PL371146A1 (pl) Sposób wytwarzania propylofenoli
GB0418901D0 (en) Synthetic method
GB0412921D0 (en) Manufacturing method