JP2005522441A - クロピドグレル塩酸塩の多形体及び抗トロンビン化合物としての使用 - Google Patents

クロピドグレル塩酸塩の多形体及び抗トロンビン化合物としての使用 Download PDF

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Publication number
JP2005522441A
JP2005522441A JP2003566010A JP2003566010A JP2005522441A JP 2005522441 A JP2005522441 A JP 2005522441A JP 2003566010 A JP2003566010 A JP 2003566010A JP 2003566010 A JP2003566010 A JP 2003566010A JP 2005522441 A JP2005522441 A JP 2005522441A
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JP
Japan
Prior art keywords
thieno
chlorophenyl
dihydro
methyl
pyridin
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Pending
Application number
JP2003566010A
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English (en)
Japanese (ja)
Inventor
コータイ ナヂ ペーター
バルコーツイ ヨージェフ
シミグ ヂュラ
セント キラーリイ ジュジャ
グレゴル タマーシュ
ファルカシュ ベーラ
ヴェレツケイネー ドナート ヂェルヂィ
ナヂ カールマーン
コェルトゥヴェーリェスイ ヂュラーネー
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Egis Pharmaceuticals PLC
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Egis Pharmaceuticals PLC
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Filing date
Publication date
Application filed by Egis Pharmaceuticals PLC filed Critical Egis Pharmaceuticals PLC
Publication of JP2005522441A publication Critical patent/JP2005522441A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
JP2003566010A 2002-02-06 2002-12-20 クロピドグレル塩酸塩の多形体及び抗トロンビン化合物としての使用 Pending JP2005522441A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0200438A HUP0200438A3 (en) 2002-02-06 2002-02-06 Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
PCT/HU2002/000157 WO2003066637A1 (en) 2002-02-06 2002-12-20 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds

Publications (1)

Publication Number Publication Date
JP2005522441A true JP2005522441A (ja) 2005-07-28

Family

ID=89980128

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003566010A Pending JP2005522441A (ja) 2002-02-06 2002-12-20 クロピドグレル塩酸塩の多形体及び抗トロンビン化合物としての使用

Country Status (15)

Country Link
US (1) US20050113406A1 (WO2010069979A1)
EP (1) EP1474427A1 (WO2010069979A1)
JP (1) JP2005522441A (WO2010069979A1)
KR (1) KR20040079987A (WO2010069979A1)
AU (1) AU2002353251A1 (WO2010069979A1)
BG (1) BG108868A (WO2010069979A1)
CZ (1) CZ2004901A3 (WO2010069979A1)
EA (1) EA007119B1 (WO2010069979A1)
HR (1) HRP20040741A2 (WO2010069979A1)
HU (1) HUP0200438A3 (WO2010069979A1)
IS (1) IS7385A (WO2010069979A1)
PL (1) PL370038A1 (WO2010069979A1)
SK (1) SK3362004A3 (WO2010069979A1)
WO (1) WO2003066637A1 (WO2010069979A1)
YU (1) YU69604A (WO2010069979A1)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
WO2005068471A1 (en) * 2004-01-13 2005-07-28 Zentiva, A.S. New crystalline forms of clopidogrel hydrobromide and methods of their preparation
US7629465B2 (en) * 2004-03-05 2009-12-08 Ipca Laboratories Ltd. Industrial process for preparation of Clopidogrel hydrogen sulphate
RU2328501C1 (ru) * 2004-04-09 2008-07-10 Ханми Фарм. Ко., ЛТД Кристаллический клопидогрель нафталинсульфонат или его гидрат, способ его получения и содержащая его фармацевтическая композиция
CN1997647A (zh) * 2004-04-20 2007-07-11 赛诺菲-安万特 氯吡格雷盐及其多晶型物
UA83919C2 (en) * 2004-04-20 2008-08-26 Санофи Авентис Polymorphic forms of methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, clopidrogel hydrobromide
EP1750701A1 (en) * 2004-06-01 2007-02-14 IVAX Pharmaceuticals s.r.o. Amorphous clopidogrel hydrochloride and its antithrombotic use
EP1674468A1 (en) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphs of clopidogrel hydrobromide
EP1693375A1 (en) * 2005-02-21 2006-08-23 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing clopidrogel hydrogen sulfate of form I
WO2007029080A1 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Preparation of form i of clopidogrel hydrochloride
WO2007029096A2 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Novel polymorphic forms of clopidogrel hydrochloride
KR20070066518A (ko) * 2005-12-22 2007-06-27 에스케이케미칼주식회사 고체상 반응을 이용한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR101235117B1 (ko) 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR100742134B1 (ko) * 2006-02-07 2007-07-24 경동제약 주식회사 결정성Ｓ-(+)-메틸-2-(2-클로로페닐)-2-(6,7-디히드로티에노[3,2-ｃ]피리딘-5(4Ｈ)-일)아세테이트·캄실레이트를 포함하는약학적 조성물
WO2008004249A2 (en) * 2006-07-04 2008-01-10 Msn Laboratories Limited An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
US20100062066A1 (en) * 2006-11-14 2010-03-11 Acusphere, Inc Formulations of Tetrahydropyridine Antiplatelet Agents for Parenteral or Oral Administration
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
US8343995B2 (en) 2007-04-27 2013-01-01 Cydex Pharmaceuticals, Inc. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
EP2155756B1 (en) * 2007-05-30 2015-08-05 Wockhardt Limited Processes for the preparation of clopidogrel
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
EP3100728B1 (en) 2009-05-13 2019-11-20 Cydex Pharmaceuticals, Inc. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
CN102120745B (zh) * 2011-01-31 2013-04-10 天津红日药业股份有限公司 一种盐酸氯吡格雷的晶型ⅰ及其制备方法和用途
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102367257B (zh) * 2011-11-21 2014-05-07 天津红日药业股份有限公司 氯吡格雷盐酸盐的单晶晶型，它们的制备及应用
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
US5189170A (en) * 1989-09-29 1993-02-23 Sanofi Process for the preparation of phenylacetic derivatives of thieno-pyridines
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
HU226421B1 (en) * 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides

Also Published As

Publication number Publication date
CZ2004901A3 (cs) 2005-02-16
WO2003066637A1 (en) 2003-08-14
HUP0200438A3 (en) 2003-10-28
BG108868A (en) 2005-09-30
EA007119B1 (ru) 2006-06-30
YU69604A (sh) 2006-08-17
HUP0200438A2 (hu) 2003-09-29
HU0200438D0 (en) 2002-04-29
AU2002353251A1 (en) 2003-09-02
EP1474427A1 (en) 2004-11-10
EA200401025A1 (ru) 2004-12-30
HRP20040741A2 (en) 2004-12-31
SK3362004A3 (sk) 2005-03-04
KR20040079987A (ko) 2004-09-16
PL370038A1 (en) 2005-05-16
US20050113406A1 (en) 2005-05-26
IS7385A (is) 2004-08-05

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