EA200401025A1 - Полиморфы клопидогреля и их применение в качестве антитромботических соединений - Google Patents

Полиморфы клопидогреля и их применение в качестве антитромботических соединений

Info

Publication number
EA200401025A1
EA200401025A1 EA200401025A EA200401025A EA200401025A1 EA 200401025 A1 EA200401025 A1 EA 200401025A1 EA 200401025 A EA200401025 A EA 200401025A EA 200401025 A EA200401025 A EA 200401025A EA 200401025 A1 EA200401025 A1 EA 200401025A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
polymorphos
thrombotic compounds
float
heating
Prior art date
Application number
EA200401025A
Other languages
English (en)
Other versions
EA007119B1 (ru
Inventor
Петер Котаи Надь
Йожеф Баркоци
Дьюла Шимиг
Жужа Сент Кирайи
Тамаш Грегор
Бела Фаркаш
Дьёрди Верецкейне Донат
Кальман Надь
Дьюлане Кортвейесси
Original Assignee
Эгиш Дьёдьсердьяр Рт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Рт. filed Critical Эгиш Дьёдьсердьяр Рт.
Publication of EA200401025A1 publication Critical patent/EA200401025A1/ru
Publication of EA007119B1 publication Critical patent/EA007119B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

Изобретение относится к кристаллическим формам I и II метил-(S)-(+)-(2-хлорфенил)-2-(6,7-дигидро-4H-тиено[3,2c]пиридин-5-ил)ацетата гидрохлорида формулы (I) и его гидратов, к способу их получения и к фармацевтическим композициям, содержащим эти формы. Новые полиморфы согласно изобретению являются ингибиторами агрегации тромбоцитов крови и обладают антитромботическим эффектом.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401025A 2002-02-06 2002-12-20 Полиморфы клопидогреля гидрохлориа и их применение в качестве антитромботических соединений EA007119B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0200438A HUP0200438A3 (en) 2002-02-06 2002-02-06 Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
PCT/HU2002/000157 WO2003066637A1 (en) 2002-02-06 2002-12-20 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds

Publications (2)

Publication Number Publication Date
EA200401025A1 true EA200401025A1 (ru) 2004-12-30
EA007119B1 EA007119B1 (ru) 2006-06-30

Family

ID=89980128

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401025A EA007119B1 (ru) 2002-02-06 2002-12-20 Полиморфы клопидогреля гидрохлориа и их применение в качестве антитромботических соединений

Country Status (15)

Country Link
US (1) US20050113406A1 (ru)
EP (1) EP1474427A1 (ru)
JP (1) JP2005522441A (ru)
KR (1) KR20040079987A (ru)
AU (1) AU2002353251A1 (ru)
BG (1) BG108868A (ru)
CZ (1) CZ2004901A3 (ru)
EA (1) EA007119B1 (ru)
HR (1) HRP20040741A2 (ru)
HU (1) HUP0200438A3 (ru)
IS (1) IS7385A (ru)
PL (1) PL370038A1 (ru)
SK (1) SK3362004A3 (ru)
WO (1) WO2003066637A1 (ru)
YU (1) YU69604A (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
EP1713812A1 (en) * 2004-01-13 2006-10-25 Zentiva, a.s. New crystalline forms of clopidogrel hydrobromide and methods of their preparation
WO2005104663A2 (en) * 2004-03-05 2005-11-10 Ipca Laboratories Limited Industrial process for preparation of clopidogrel hydrogen sulphate
RU2328501C1 (ru) * 2004-04-09 2008-07-10 Ханми Фарм. Ко., ЛТД Кристаллический клопидогрель нафталинсульфонат или его гидрат, способ его получения и содержащая его фармацевтическая композиция
CN1997647A (zh) * 2004-04-20 2007-07-11 赛诺菲-安万特 氯吡格雷盐及其多晶型物
CA2562507A1 (en) * 2004-04-20 2005-11-03 Sanofi-Aventis Polymorphic forms of methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, clopidrogel hydrobromide
WO2005117866A1 (en) * 2004-06-01 2005-12-15 Ivax Pharmaceuticals S.R.O. Amorphous clopidogrel hydrochloride and its antithrombotic use
EP1674468A1 (en) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphs of clopidogrel hydrobromide
EP1693375A1 (en) * 2005-02-21 2006-08-23 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing clopidrogel hydrogen sulfate of form I
WO2007029096A2 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Novel polymorphic forms of clopidogrel hydrochloride
WO2007029080A1 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Preparation of form i of clopidogrel hydrochloride
KR20070066518A (ko) * 2005-12-22 2007-06-27 에스케이케미칼주식회사 고체상 반응을 이용한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR101235117B1 (ko) * 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR100742134B1 (ko) * 2006-02-07 2007-07-24 경동제약 주식회사 결정성Ｓ-(+)-메틸-2-(2-클로로페닐)-2-(6,7-디히드로티에노[3,2-ｃ]피리딘-5(4Ｈ)-일)아세테이트·캄실레이트를 포함하는약학적 조성물
WO2008004249A2 (en) * 2006-07-04 2008-01-10 Msn Laboratories Limited An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
US20100062066A1 (en) * 2006-11-14 2010-03-11 Acusphere, Inc Formulations of Tetrahydropyridine Antiplatelet Agents for Parenteral or Oral Administration
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
US8343995B2 (en) 2007-04-27 2013-01-01 Cydex Pharmaceuticals, Inc. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
US7985859B2 (en) * 2007-05-30 2011-07-26 Wockhardt Ltd. Processes for the preparation of clopidogrel
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
KR20190071006A (ko) 2009-05-13 2019-06-21 사이덱스 파마슈티칼스, 인크. 프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법
CN102120745B (zh) * 2011-01-31 2013-04-10 天津红日药业股份有限公司 一种盐酸氯吡格雷的晶型ⅰ及其制备方法和用途
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102367257B (zh) * 2011-11-21 2014-05-07 天津红日药业股份有限公司 氯吡格雷盐酸盐的单晶晶型，它们的制备及应用
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
US5189170A (en) * 1989-09-29 1993-02-23 Sanofi Process for the preparation of phenylacetic derivatives of thieno-pyridines
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
HU226421B1 (en) * 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides

Also Published As

Publication number Publication date
AU2002353251A1 (en) 2003-09-02
KR20040079987A (ko) 2004-09-16
EP1474427A1 (en) 2004-11-10
HU0200438D0 (en) 2002-04-29
IS7385A (is) 2004-08-05
WO2003066637A1 (en) 2003-08-14
US20050113406A1 (en) 2005-05-26
CZ2004901A3 (cs) 2005-02-16
JP2005522441A (ja) 2005-07-28
HRP20040741A2 (en) 2004-12-31
HUP0200438A3 (en) 2003-10-28
HUP0200438A2 (hu) 2003-09-29
YU69604A (sh) 2006-08-17
BG108868A (en) 2005-09-30
EA007119B1 (ru) 2006-06-30
PL370038A1 (en) 2005-05-16
SK3362004A3 (sk) 2005-03-04

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU