HUP0200438A3 - Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them - Google Patents

Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them

Info

Publication number
HUP0200438A3
HUP0200438A3 HU0200438A HUP0200438A HUP0200438A3 HU P0200438 A3 HUP0200438 A3 HU P0200438A3 HU 0200438 A HU0200438 A HU 0200438A HU P0200438 A HUP0200438 A HU P0200438A HU P0200438 A3 HUP0200438 A3 HU P0200438A3
Authority
HU
Hungary
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
clopidogrel hydrochloride
hydrochloride polymorphs
Prior art date
Application number
HU0200438A
Other languages
English (en)
Original Assignee
Egis Gyogyszergyar Nyilvanosan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan filed Critical Egis Gyogyszergyar Nyilvanosan
Priority to HU0200438A priority Critical patent/HUP0200438A3/hu
Publication of HU0200438D0 publication Critical patent/HU0200438D0/hu
Priority to PL02370038A priority patent/PL370038A1/xx
Priority to JP2003566010A priority patent/JP2005522441A/ja
Priority to AU2002353251A priority patent/AU2002353251A1/en
Priority to EP02788271A priority patent/EP1474427A1/en
Priority to EA200401025A priority patent/EA007119B1/ru
Priority to US10/504,042 priority patent/US20050113406A1/en
Priority to KR10-2004-7012110A priority patent/KR20040079987A/ko
Priority to PCT/HU2002/000157 priority patent/WO2003066637A1/en
Priority to CZ2004901A priority patent/CZ2004901A3/cs
Priority to YU69604A priority patent/YU69604A/sh
Priority to SK336-2004A priority patent/SK3362004A3/sk
Publication of HUP0200438A2 publication Critical patent/HUP0200438A2/hu
Publication of HUP0200438A3 publication Critical patent/HUP0200438A3/hu
Priority to IS7385A priority patent/IS7385A/is
Priority to HRP20040741 priority patent/HRP20040741A2/xx
Priority to BG108868A priority patent/BG108868A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
HU0200438A 2002-02-06 2002-02-06 Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them HUP0200438A3 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
HU0200438A HUP0200438A3 (en) 2002-02-06 2002-02-06 Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
SK336-2004A SK3362004A3 (sk) 2002-02-06 2002-12-20 Polymorfy hydrochloridu clopidogrelu a ich použitie ako antitrombotických zlúčenín
US10/504,042 US20050113406A1 (en) 2002-02-06 2002-12-20 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
PCT/HU2002/000157 WO2003066637A1 (en) 2002-02-06 2002-12-20 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
AU2002353251A AU2002353251A1 (en) 2002-02-06 2002-12-20 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
EP02788271A EP1474427A1 (en) 2002-02-06 2002-12-20 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
EA200401025A EA007119B1 (ru) 2002-02-06 2002-12-20 Полиморфы клопидогреля гидрохлориа и их применение в качестве антитромботических соединений
PL02370038A PL370038A1 (en) 2002-02-06 2002-12-20 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
KR10-2004-7012110A KR20040079987A (ko) 2002-02-06 2002-12-20 클로피도그렐 히드로클로라이드의 다형체 및 이의 항혈전화합물로서의 용도
JP2003566010A JP2005522441A (ja) 2002-02-06 2002-12-20 クロピドグレル塩酸塩の多形体及び抗トロンビン化合物としての使用
CZ2004901A CZ2004901A3 (cs) 2002-02-06 2002-12-20 Polymorfy hydrochloridu clopidogrelu a jejich použití jako antitrombotických sloučenin
YU69604A YU69604A (sh) 2002-02-06 2002-12-20 Polimorfi klopidogrel hlorovodonika i njihova upotreba kao antitrombnih jedinjenja
IS7385A IS7385A (is) 2002-02-06 2004-08-05 Fjölgervingar klópídógrelhýdróklóríðs og notkun þeirra sem andsegaefnasambanda
HRP20040741 HRP20040741A2 (en) 2002-02-06 2004-08-17 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
BG108868A BG108868A (en) 2002-02-06 2004-09-03 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0200438A HUP0200438A3 (en) 2002-02-06 2002-02-06 Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them

Publications (3)

Publication Number Publication Date
HU0200438D0 HU0200438D0 (en) 2002-04-29
HUP0200438A2 HUP0200438A2 (hu) 2003-09-29
HUP0200438A3 true HUP0200438A3 (en) 2003-10-28

Family

ID=89980128

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0200438A HUP0200438A3 (en) 2002-02-06 2002-02-06 Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them

Country Status (15)

Country Link
US (1) US20050113406A1 (hu)
EP (1) EP1474427A1 (hu)
JP (1) JP2005522441A (hu)
KR (1) KR20040079987A (hu)
AU (1) AU2002353251A1 (hu)
BG (1) BG108868A (hu)
CZ (1) CZ2004901A3 (hu)
EA (1) EA007119B1 (hu)
HR (1) HRP20040741A2 (hu)
HU (1) HUP0200438A3 (hu)
IS (1) IS7385A (hu)
PL (1) PL370038A1 (hu)
SK (1) SK3362004A3 (hu)
WO (1) WO2003066637A1 (hu)
YU (1) YU69604A (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
EP1713812A1 (en) * 2004-01-13 2006-10-25 Zentiva, a.s. New crystalline forms of clopidogrel hydrobromide and methods of their preparation
WO2005104663A2 (en) * 2004-03-05 2005-11-10 Ipca Laboratories Limited Industrial process for preparation of clopidogrel hydrogen sulphate
RU2328501C1 (ru) * 2004-04-09 2008-07-10 Ханми Фарм. Ко., ЛТД Кристаллический клопидогрель нафталинсульфонат или его гидрат, способ его получения и содержащая его фармацевтическая композиция
CN1997647A (zh) * 2004-04-20 2007-07-11 赛诺菲-安万特 氯吡格雷盐及其多晶型物
CA2562507A1 (en) * 2004-04-20 2005-11-03 Sanofi-Aventis Polymorphic forms of methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, clopidrogel hydrobromide
WO2005117866A1 (en) * 2004-06-01 2005-12-15 Ivax Pharmaceuticals S.R.O. Amorphous clopidogrel hydrochloride and its antithrombotic use
EP1674468A1 (en) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphs of clopidogrel hydrobromide
EP1693375A1 (en) * 2005-02-21 2006-08-23 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing clopidrogel hydrogen sulfate of form I
WO2007029096A2 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Novel polymorphic forms of clopidogrel hydrochloride
WO2007029080A1 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Preparation of form i of clopidogrel hydrochloride
KR20070066518A (ko) * 2005-12-22 2007-06-27 에스케이케미칼주식회사 고체상 반응을 이용한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR101235117B1 (ko) * 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR100742134B1 (ko) * 2006-02-07 2007-07-24 경동제약 주식회사 결정성Ｓ-(+)-메틸-2-(2-클로로페닐)-2-(6,7-디히드로티에노[3,2-ｃ]피리딘-5(4Ｈ)-일)아세테이트·캄실레이트를 포함하는약학적 조성물
WO2008004249A2 (en) * 2006-07-04 2008-01-10 Msn Laboratories Limited An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
US20100062066A1 (en) * 2006-11-14 2010-03-11 Acusphere, Inc Formulations of Tetrahydropyridine Antiplatelet Agents for Parenteral or Oral Administration
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
US8343995B2 (en) 2007-04-27 2013-01-01 Cydex Pharmaceuticals, Inc. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
US7985859B2 (en) * 2007-05-30 2011-07-26 Wockhardt Ltd. Processes for the preparation of clopidogrel
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
KR20190071006A (ko) 2009-05-13 2019-06-21 사이덱스 파마슈티칼스, 인크. 프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법
CN102120745B (zh) * 2011-01-31 2013-04-10 天津红日药业股份有限公司 一种盐酸氯吡格雷的晶型ⅰ及其制备方法和用途
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102367257B (zh) * 2011-11-21 2014-05-07 天津红日药业股份有限公司 氯吡格雷盐酸盐的单晶晶型，它们的制备及应用
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
US5189170A (en) * 1989-09-29 1993-02-23 Sanofi Process for the preparation of phenylacetic derivatives of thieno-pyridines
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
HU226421B1 (en) * 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides

Also Published As

Publication number Publication date
AU2002353251A1 (en) 2003-09-02
KR20040079987A (ko) 2004-09-16
EP1474427A1 (en) 2004-11-10
HU0200438D0 (en) 2002-04-29
IS7385A (is) 2004-08-05
EA200401025A1 (ru) 2004-12-30
WO2003066637A1 (en) 2003-08-14
US20050113406A1 (en) 2005-05-26
CZ2004901A3 (cs) 2005-02-16
JP2005522441A (ja) 2005-07-28
HRP20040741A2 (en) 2004-12-31
HUP0200438A2 (hu) 2003-09-29
YU69604A (sh) 2006-08-17
BG108868A (en) 2005-09-30
EA007119B1 (ru) 2006-06-30
PL370038A1 (en) 2005-05-16
SK3362004A3 (sk) 2005-03-04

Similar Documents

Publication Publication Date Title
HUP0200438A3 (en) Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
IL165977A (en) Substituted pyrimidinylaminobenzamides , process for the preparation thereof and pharmaceutical compositions comprising the same
IL164798A0 (en) Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them
IL169818A0 (en) Adamantane derivatives, processes for their preparation and pharmaceutical composition containing them
HUP0402264A3 (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines process for preparing them, pharmaceutical compositions containing them and use thereof
IL169500A0 (en) Pyrrolopyridazine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HUP0402161A3 (en) Nicotin-or isonicotin benzothiazole derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0402225A3 (en) Macrolide-compounds, process for their preparation and pharmaceutical compositions containing them
EP1706412A4 (en) Novel pyridine derivatives, process for their preparation and pharmaceutical composition containing them
PL1720544T3 (pl) Nowe pochodne azabicykliczne, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne
HRP20150163T1 (en) Process for the preparation of n-substituted 2-cyanopyrrolidines
IL165012A0 (en) (S)-4-Amino-5-chloro-2-methoxy-N-Ä1-(-tetrahydrofurylcarbonyl)-4-piperidinylmethylÜ-4-piperidinylÜbenzamide, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor
IL154370A0 (en) Solid amorphous mixtures, processes for the preparation thereof and pharmaceutical compositions containing the same
PL394600A1 (pl) Związek winyloazacykloalkanowy, sposób jego wytwarzania i jego zastosowanie oraz kompozycja farmaceutyczna
HUP0401522A2 (en) New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
HUP0201730A2 (en) Thienopyrimidines as phosphodiesterase inhibitors, their use, pharmaceutical compositions containing them and process for the preparation thereof
IL175724A0 (en) Tricyclic imidazopyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HUP0401350A3 (en) Novel imidazopyridine compounds with therapeutic effect, process for their preparation and pharmaceutical compositions containing them
HUP0203976A3 (en) Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
IL163643A0 (en) Oxazolidinone derivatives, processes for their forpreparation, and pharmaceutical compositions containing them
AU2003231920A8 (en) Antiinfectve compounds, process for their preparation and pharmaceutical compositions containing them
HUP0401082A3 (en) Substituted 4-aminocyclohexanols, process for their preparation and pharmaceutical compositions containing them
EP1482937A4 (en) NOVEL TYLOINDICINS AND COMPOUNDS THEREFOR, PHARMACEUTICAL COMPOSITIONS AND METHODS
HUP0401829A3 (en) Substituted (1h)-quinoxalin-2-one compounds and substituted 4-aryl- or 4-heteroarylcyclohexane compounds, process for their preparation and pharmaceutical compositions containing the (1h)-quinoxalin-2-one compounds
HUP0201024A3 (en) Izoindeindolone compounds, process for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU