CN102596320A - 通过经皮超声波去肾神经治疗高血压的方法和装置 - Google Patents

通过经皮超声波去肾神经治疗高血压的方法和装置 Download PDF

Info

Publication number
CN102596320A
CN102596320A CN2010800492010A CN201080049201A CN102596320A CN 102596320 A CN102596320 A CN 102596320A CN 2010800492010 A CN2010800492010 A CN 2010800492010A CN 201080049201 A CN201080049201 A CN 201080049201A CN 102596320 A CN102596320 A CN 102596320A
Authority
CN
China
Prior art keywords
transducer
wave energy
arteriorenal
ultrasonic
renal artery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2010800492010A
Other languages
English (en)
Other versions
CN102596320B (zh
Inventor
R·J·华金
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recor Medical Inc
Original Assignee
Sound Interventions Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sound Interventions Inc filed Critical Sound Interventions Inc
Publication of CN102596320A publication Critical patent/CN102596320A/zh
Application granted granted Critical
Publication of CN102596320B publication Critical patent/CN102596320B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A61N7/022—Localised ultrasound hyperthermia intracavitary
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1002—Balloon catheters characterised by balloon shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A61B2017/003—Steerable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A61B2017/003—Steerable
    • A61B2017/00318—Steering mechanisms
    • A61B2017/00323—Cables or rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A61B2017/22021—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter electric leads passing through the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1047—Balloon catheters with special features or adapted for special applications having centering means, e.g. balloons having an appropriate shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1068—Balloon catheters with special features or adapted for special applications having means for varying the length or diameter of the deployed balloon, this variations could be caused by excess pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1093—Balloon catheters with special features or adapted for special applications having particular tip characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/0026—Stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0043—Ultrasound therapy intra-cavitary

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Child & Adolescent Psychology (AREA)
  • Surgical Instruments (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

本发明公开了用于阻断沿哺乳动物受试者的肾动脉延伸的肾神经以治疗高血压和相关疾病的装置和方法。例如通过将承载换能器的导管(18)的末梢端推进到肾动脉中而将超声波换能器(30)插入肾动脉(10)中。超声波换能器发射未聚焦超声波以在覆盖肾动脉的至少约0.5cm3的整个相对较大的碰撞体积(11)内将组织加热到足以阻断神经传导但不足以导致组织的快速切除或坏死的温度。可在不定位或聚焦个体肾神经的情况下执行治疗。

Description

通过经皮超声波去肾神经治疗高血压的方法和装置
相关申请的交叉引用
本申请案要求2009年10月30日申请的美国临时专利申请案61/256,429和2010年1月6日申请的美国临时专利申请案61/292,618的申请日权利，该案的公开内容以引用的方式并入本文中。
背景技术
由于种种理由高血压的成功治疗很重要。例如，高血压的成功治疗在防止或限制高血压所导致或加剧的症状(例如，肾病、心率不齐及充血性心力衰竭等)方面具有重大的临床意义。虽然药物疗法可用于治疗高血压，但是不一定成功。一些人对药物疗法治疗具有耐药性或经受来自药物疗法治疗的严重副作用。
可通过阻断围绕肾动脉的肾神经传导来治疗高血压。肾交感神经活性对高血压的发生和持续具有重大影响。当大脑感知肾神经活性增大(表明低血量或血压下降)时，其通过向心脏、肝脏和肾脏增大交感神经活性(其导致心排血量增大；胰岛素抵抗；和最重要的肾脏的肾素产量增大)来进行补偿。肾素刺激血管紧张素的分泌，血管紧张素导致血管收缩，导致血压升高；并且刺激醛甾酮的分泌。醛甾酮导致肾脏增加血液对钠和水的再吸收，增大血量，从而进一步使血压升高。
多年来已证实手术切除肾神经使血压和水潴留降至正常水平；从而使病人的心脏、肝脏和肾脏也能恢复更健康的机能。也证实中断肾神经无严重的有害作用。但是，手术切除肾神经需要大的外科手术，具有非所要的副作用风险。希望的是在无需进行大手术的情况下获得相同的效果。
为了说明与在不引发其它损伤的情况下完成此项任务相关的难处，现将描述肾动脉和肾神经的构造。图1所示的是围绕连接到肾脏6的肾动脉10的肾神经8图。肾交感神经8包括从肾脏6到大脑的肾传入感觉神经和从大脑到肾脏6的肾传出交感神经。此外，图2示出肾动脉10的横截面。肾动脉壁包括下列层：内膜3，其包括内部的单层内皮细胞；中膜5，其是动脉壁的中心；和外膜4，其是外层。还示出了位于外膜4内、肾动脉10的表面上和邻近肾动脉10的肾神经8。从这两个图中可见，肾神经8围绕肾动脉10。不同个体在肾动脉周围的不同位置上具有肾神经8。所以，肾神经可能与肾动脉的中心轴A相距不同径向距离R并且还可能位于围绕肾动脉周围C的不同位置上。通过采用解剖标记来确定肾神经的位置不切实际。此外，难以或无法使用常见的活体内成像技术定位个体肾神经。
无法定位和标定肾神经8使得难以使用非手术技术在不对肾动脉10造成损伤或导致其它副作用的情况下切断肾交感神经活性。例如，向肾神经施加能量的行为可能导致例如狭窄、内膜增生和坏死的结果。其它副作用可能包括血栓症、血小板聚集、纤维蛋白凝块和血管收缩。此外，无法标定和定位肾神经8使得难以确保肾交感神经活性被中断足以实现满意的治疗。
美国专利7,617,005建议使用连接到插入肾动脉中的导管的射频(“RF”)发射器。抵着内膜放置RF发射器并且发射RF能以将肾神经加热到降低碰巧位于发射器紧邻附近的肾神经的活性的温度。为了处理围绕肾动脉的所有肾神经，必须围绕每个肾动脉的内侧重新定位RF发射器源数次。发射器可能漏掉一些肾神经，导致治疗不完全。此外，RF能量源必须接触内膜从而能够加热肾神经，其可能造成单层内皮和内膜损伤或坏死，可能导致内膜增生、肾动脉狭窄和肾动脉剥离。
′005专利还建议使用高强度聚焦超声波来阻断肾神经。据称，所述高强度聚焦超声波能量源围绕肾动脉的轴的360°形式发射超声波能量并且无需接触内膜3。但是，高强度聚焦超声波源以围绕动脉的薄聚焦环形式施加聚焦能量。因为肾神经难以或无法用当前技术可视化和标定以及因为肾神经可能位于与肾动脉的中心轴相距不同径向距离的位置上，所以难以或无法将此薄环与肾神经对齐。对于肾动脉形状或厚度变化较大的病人而言，后一问题更严重。此外，沿神经和动脉的长度方向，薄聚焦环仅可能覆盖每个肾神经的一小部分。由于神经很容易再生长，所以小的治疗区使神经可以在较短时间周期内再接合。
多年来，超声波已被用于提高细胞修复、刺激骨细胞的生长、提高药物至特定组织的输送和使体内组织成像。此外，高强度聚焦超声波已被用于加热和切除体内的肿瘤和组织。组织切除已几乎唯一地通过高强度聚焦超声波执行，因为所发射的超声波能聚焦在特定位置上以允许精确、深入的组织坏死而不影响超声波能必须穿透的周围组织和介入结构。
授予Diederich的美国专利6,117,101论述将高度准直的超声波能而非高强度聚焦超声波用于切除组织以在肺静脉内形成疤环用于阻挡电信号至心脏的传导。
公开内容以引用的方式并入本文中的美国专利公开案20100179424(申请号12/684,067)使用未聚焦超声波治疗二尖瓣反流。在′474公开案中，用未聚焦超声波能加热和缩小与二尖瓣环相关的胶原。这种装置使用可充气气囊以将超声波换能器放置到正确位置，从而标定二尖瓣环。在这种装置中，气囊的一部分接触待加热的组织。
发明内容
本发明的一个方面提供用于阻断人类或非人类哺乳动物受试者体内的肾神经传导的装置。根据本发明的这个方面的装置宜包括被调适来插入哺乳动物受试者的肾动脉中的超声波换能器。超声波换能器需被配置来发射未聚焦超声波能。根据本发明的这个方面的装置还需包括电连接到换能器的启动器。启动器最好被调适来控制超声波换能器以发射未聚焦超声波能到覆盖肾动脉的至少0.5cm3的碰撞体积中从而以足以阻断整个碰撞体积内的肾神经传导的治疗强度施加未聚焦超声波能。如下文进一步所述，这个治疗强度低于组织切割所需的强度。
装置还可以包括具有末梢端和近端的导管，换能器安装到导管邻近末梢端的位置，导管和换能器被构造和配置来在超声波换能器定位在肾动脉内时允许大血流穿过肾动脉。导管可被构造和配置来使换能器保持不与肾动脉壁接触。导管可具有安装在邻近末梢端的位置的可伸展元件(例如气囊、网篮或类似物)。例如，换能器可被调适来以围绕换能器轴的360°圆柱形式发射超声波能，而导管可被构造和配置来使换能器轴与肾动脉轴保持大致平行。
本发明的另一个方面提供用于阻断哺乳动物受试者体内的肾神经传导的方法。根据本发明的这个方面的方法需包括将超声波换能器插入到受试者的肾动脉和启动换能器以将有治疗效力的未聚焦超声波能发射到覆盖肾动脉的至少约0.5cm3的碰撞体积中。需施加超声波能使得有治疗效力的未聚焦超声波能阻断碰撞体积中所有肾神经的传导。例如，启动换能器的步骤可为如此以在将碰撞体积内的实体组织(包括碰撞体积中的肾神经)加热到高于42℃的同时维持肾动脉壁的温度低于65℃。
因为碰撞体积相对较大以及因为整个碰撞体积内的组织宜达到足以阻断神经传导的温度，所以可在不确定肾神经的实际位置和不标定或聚焦肾神经的情况下成功执行根据本发明的这个方面的优选方法。可在不测量组织温度的情况下执行治疗。此外，宜在不导致肾动脉狭窄、内膜增生或可能需要干涉的其它伤害的情况下执行治疗。优选方法和装置可阻断肾神经的相对较长区段以减小神经恢复(该神经恢复可沿阻断区段重新建立传导)的可能性。
本发明的其它方面提供可用于在上述方法和装置中的探针和并入用于执行上述方法的步骤的构件的装置。
附图说明
图1是典型肾动脉和相关结构的解剖图；
图2是描绘肾动脉和神经的一部分的图解横截面图；
图3是描绘根据本发明的一个实施方案的装置的组件的图解视图；
图4是描绘图3所示的装置的一部分的截取图解透视图；
图5是描绘与肾动脉结合的图3和图4的装置的一部分的图解视图；
图6是描绘图3和图4的装置中所使用的组件的部分的功能、块状图解视图；
图7是描绘根据本发明的一个实施方案的方法中所使用的步骤的流程图；
图8是描绘根据图7的方法的操作期间图3和图4的装置的部分的图解视图。
具体实施方式
根据本发明的一个实施方案的装置(图3)包括护套12。护套12通常可以是细长管形式，该细长管具有近端14、末梢端16和近端至末梢端的轴15。如本公开内容中参考用于插入体内的细长元件所使用，术语“末梢端”指的是首先插入体内的一端，即元件行进至体内的前端，而术语“近端”指的是相反的末端。护套12可以是可转向护套。所以，护套可包括已知元件，例如在护套的近端和末梢端之间延伸并且连接到转向控制装置17的一个或多个牵引线(未示出)，其经配置使得操作者启动转向控制装置使护套的末梢端16在横向于轴15的方向上弯曲。
装置还包括导管18，该导管18具有近端20、末梢端22和近端至末梢端的轴，在第3图所描绘的状态中该近端至末梢端的轴与护套的近端至末梢端的轴15重合。导管的近端20需相对坚硬使得其可传递扭矩。所以，通过转动导管18的近端20，导管18的末梢端22可以绕导管18的近端至末梢端的轴旋转。
导管18的末梢端22预成形使得当导管的末梢端在护套12外时，末梢端易于呈现如第3图中22′虚线所示的钩状构造。在此情况下，末梢端22′的旋转运动将绕近端至末梢端的轴摆动弯曲部分。所以，通过旋转导管18的近端，导管18的末梢端22′可以定位为任意径向方向。
导管18具有安装在末梢端22上的气囊24。在其充气状态(图4)下，气囊24具有部分非圆形剖面，其中气囊的一部分82的直径小于肾动脉，而气囊24的另一部分80的形状为非圆形。非圆形部分具有等于或仅稍微小于肾动脉的内径的大直径DMAJ并且具有小于大直径的小直径DMIN。
超声波换能器30(图3和图5)安装在气囊24内邻近导管18的末梢端22的位置。需由陶瓷压电材料形成的换能器30是管状并且具有绕换能器30的近端至末梢端的轴33旋转的圆柱表面形式的外发射表面31。换能器30通常沿轴31具有约2mm至10mm且宜为6mm的轴长。换能器30的外径直径约为1.5mm至3mm且宜为2mm。换能器的实体结构和其安装到导管可例如如公开内容以引用的方式并入本文中的美国专利7,540,846和6,763,722所述。换能器30还具有其内表面和外表面上的导电涂层(未示出)。所以，换能器可以实体安装在金属支撑管84(图5)上，该金属支撑管84接着安装到导管。涂层电接地并且电连接到信号线32。线32从换能器30延伸穿过管腔34。管腔34在导管18的近端与末梢端之间延伸，而线32从换能器30穿过管腔34延伸到导管18的近端14。
换能器30被配置使得换能器中所产生的超声波能主要从外发射表面发射。所以，换能器可包括被配置来将超声波能朝向换能器的内部反射使得所反射的能量加强外表面上的超声波振动的部件。例如，支撑管84和换能器30可被构造使得换能器30的内表面通过间隔(未示出)与由金属形成的支撑管的外表面分隔开。跨换能器的内表面与支撑管的外表面之间间隔的距离可为换能器所发射的超声波能的波长的一半以促进换能器30的高效运行。在本实施方案中，换能器30所产生的超声波能在水隙上反射以加强传播自换能器30的超声波能，从而确保超声波能从换能器30的外表面向外导向。
换能器30还被配置来将撞击外表面31的超声波转化成线32上的电信号。换句话说，换能器30可以充当超声波发射器或超声波接收器。
换能器30被设计来例如在约1MHz至约数十MHz以及通常在约9MHz的频率下运行。换能器30的实际频率通常取决于制造公差而稍作变化。换能器的最佳启动频率可编码在机器可读元件或人可读元件(未示出)，例如附着到导管的数字存储器、条形码或类似组件。或者，可读元件可将识别个体导管的序列号或其它信息编码从而可从可通过通信链路(例如因特网)存取的中心数据库中检索最佳启动频率。
超声波系统20(本文中也被称作启动器)通过插塞接头88(图3)可释放地连接到导管18和换能器30。如图6所见，超声波系统20可包括用户界面40、并入可编程控制装置(例如可编程微处理器(未示出))的控制板42、超声波激发源44和循环装置48。用户界面40与控制板42相互作用，该控制板42与激发源44相互作用以导致按换能器的最佳启动频率经由线32发射电信号到换能器30。控制板42和超声波源44被配置来控制电信号的振幅和定时以控制换能器30所发射的超声波信号的功率级和持续时间。激发源44还被配置来检测换能器30所产生并且出现在线32上的电信号以及将此信号传达到控制板42。
循环装置48连接到导管18内的管腔(未示出)，该管腔接着连接到气囊24。循环装置被配置来使液体(宜为水性液体)穿过导管18循环到气囊24中的换能器30。循环装置48可包括例如用于在受控温度(需为体温或低于体温)下供应液体到气囊24的内部空间的用来装循环冷却剂35的储罐、泵37、冷却管(未示出)或类似物的元件。控制板42与循环装置48介接以控制进出气囊24的液体流动。例如，控制板42可包括电机控制装置，该电机控制装置连接到与泵相关的、用于控制泵37的运行速度的驱动电机。这种电机控制装置可用于例如泵37是容积式泵(例如蠕动泵)的情况。或者或此外，控制电路可包括例如连接在液压管路中用于改变管路对流体流(未示出)的阻力的可控制阀门的结构。超声波系统20还可以包括两个压力传感器38以监控穿过导管18的液体流。一个压力传感器监控液体至末梢导管18的流动以确定是否存在阻塞而另一个压力传感器监控导管18中的泄漏。当气囊处于充气状态时，压力传感器38宜在气囊中维持约3磅/平方英寸(20KPa)的所要压力。
超声波系统20并入读取器46，该读取器46用于读取导管18上的机器可读元件并且将来自此元件的信息传输到控制板46。如上所述，导管上的机器可读元件可包括例如换能器30在特定导管18中的运行频率的信息，以及控制板42可使用此信息设置合适的频率以激发换能器。或者，控制板可被配置来启动激发源44以通过在低功率级下给换能器通电同时在预定频率范围内扫描激发频率(例如8.5Mhz至9.5Mhz)以及监控换能器对此激发的回应来测量换能器运行频率。
超声波系统20可以类似于2009年10月29日申请的、名为“METHOD AND APPARATUSFOR PERCUTANEOUS TREATMENT OF MITRAL VALVE REGURGITATION(PMVR)”的美国临时专利申请案61/256,002(其公开内容以引用的方式并入本文中)中所公开的超声波系统。
图7的流程表中描绘根据本发明的一个实施方案的方法。在人类或非人类哺乳动物受试者(例如病人)准备好(步骤50)、动脉穿刺点(例如股动脉上的位置)准备好(步骤52)以及将导管18连接到超声波系统20(步骤54)后，通过将护套12的末梢端穿过穿刺点插入主动脉来将超声波换能器30插入肾动脉(步骤56)。如图8示意地描绘，当护套的末梢端定位在主动脉内时，在护套内推进导管18直到导管的末梢端从护套中突出。因为导管18的末梢端22预成形成钩状物，所以当尖端在主动脉内被朝向肾动脉10分支旋转且随后被稍微向前推或向后拉时，导管18的末梢端22可以滑入肾动脉10中。通过肾动脉/主动脉分叉的典型角度来促进此动作。基于末梢端22的钩状形状，当导管18的末梢端22在主动脉内被往回拉时容易钩住肾动脉10的分支血管。导管上的气囊24需维持未充气状态直到导管的末梢端设置在肾动脉内的所要位置上。在导管18和换能器30插入期间(步骤56)，医生可以核实换能器30被放置在肾动脉10内，但是在肾脏6或可能存在的肾动脉10的任意分支之前。可使用X射线技术(例如荧光透视法)获得此核实。
一旦导管的末梢端位于肾动脉内的适当位置，泵37即将气囊24带至如图4和图5所描绘的充气状态。在此情况下，气囊的非圆形部分80接合动脉壁，且因此位于肾动脉内的换能器30的中心，换能器的轴33(图5)大致与肾动脉的轴A同轴。但是，气囊不阻挡血流穿过肾动脉。在此情况下，循环装置48维持经冷却的水性液体流动进出气囊24以冷却换能器30。经冷却的气囊还易于冷却肾动脉的内表面。此外，血流持续穿过肾动脉帮助冷却肾动脉的内表面。气囊内的液体流动可包括X射线造影剂以协助气囊的可视化和适当放置的核实。
在下一步骤58中，超声波系统20使用换能器30测量肾动脉10的大小。控制板42和超声波源44启动换能器30以用低功率超声波脉冲“冲击”肾动脉10。此脉冲中的超声波被动脉壁反射到换能器30上作为回波。换能器30将回波转化为线32上的回波信号。超声波系统20随后通过分析回波信号确定动脉10的大小。例如，超声波系统20可以确定换能器启动之间的延时以产生回波信号的“冲击”和返回。在步骤60中，超声波系统20使用测量到的动脉大小来设置将由换能器30在后续步骤中施加治疗超声波能期间所传递的声功率。例如，控制板42可使用将特定回波延迟(以及因此动脉直径)与特定功率级相关联的查找表。通常，动脉直径越大，应当使用的功率越大。肾动脉10的形状或换能器30的居中的变化可能在回波信号中导致一系列延时。超声波系统20可取该范围的平均值以确定肾动脉10的平均大小并且基于平均大小对功率级进行调整。
医生随后通过用户界面40启动治疗(步骤60)。在处理时(步骤64)，超声波系统或启动器20和特别是控制板42和超声波源44启动换能器30以传递有治疗效力的超声波到碰撞体积11(图5)。换能器30所发射的超声波能大致从换能器30向外或远离换能器30径向传播，覆盖绕换能器30的近端至末梢端的轴33和肾动脉的轴A整圈或360°弧度。
超声波换能器30的所选择的运行频率、未聚焦特性、放置、大小和形状允许整个肾动脉10和肾神经位于换能器30的“近场”区域内。在此区域内，由换能器30产生的、向外展开、未聚焦全向(360°)圆柱形波束的超声波易于保持准直并且具有大致等于换能器30的轴长的轴长。对于圆柱形换能器，近场区域的径向范围由表达式L2/λ界定，其中L是换能器30的轴长，而λ是超声波的波长。在与换能器30表面的距离大于L2/λ的位置上，波束开始轴向展开至大的范围。但是，对于小于L2/λ的距离，波束未轴向展开至任何大的范围。所以，在近场区域内，在小于L2/λ的距离处，当未聚焦波束径向展开时，超声波能的强度与相距换能器30表面的距离成比例地线性减小。如本公开内容中所使用，术语“未聚焦”指的是强度未在波束远离换能器30的传播方向上减小的波束。
碰撞体积11大致是圆柱形并且与肾动脉同轴。其从换能器表面延伸到碰撞半径39，其中超声波能的强度太小而无法将组织加热到导致肾神经8阻断的温度范围。碰撞半径39由从换能器30发射的超声波能的剂量确定。碰撞体积11的体积V由下列等式确定：
V＝πr2 2h-πr1 2h
其中
r1＝换能器30的半径
r2＝碰撞区11的半径
h＝换能器30的长度
如上所述，换能器30的长度可在2mm与10mm之间变化，但是宜为6mm以提供宽的肾神经阻断区。换能器30的直径可在1.5mm至3.0mm之间变化，且宜为2.0mm。不仅针对其治疗效果，而且以允许碰撞体积11的半径39宜在5mm至7mm之间以覆盖肾动脉10和邻近肾神经(其都位于3mm到4mm的平均半径内)而不发射破坏性超声波能到超过肾动脉10的结构为目的选择剂量。这将导致至少0.5cm3的碰撞体积11，肾神经阻断的长度精确对应于换能器32的长度。
需选择功率级使得在整个碰撞体积内，实体组织被加热到约42℃或更高达数秒或更长时间，但所有实体组织(包括肾动脉的内膜)需保持低于65℃。所以，在整个碰撞区域内，实体组织(包括所有肾神经)被带至足以阻断神经传导但低于导致组织快速坏死的温度。
研究表明神经损伤在低得多的温度下发生且发生的速度比组织坏死快得多。见以引用的方式并入本文中的Bunch、Jared.T等人的“Mechanisms of Phrenic Nerve Injury DuringRadiofrequency AblaT.ion aT.T.he Pulmonary Vein Orifice”，Journal of CardiovascularElecT.rophysiology，第16卷，第12期，第1318至1325页(2005年12月8日)。由于组织坏死通常在处于65℃或更高的温度下达约10秒或更长时间时发生而肾神经8的阻断通常在肾神经8处于42℃或更高的温度下达数秒或更长时间时发生，所以选择超声波能的剂量以将影响体积11中的温度保持在这些温度之间达数秒或更长时间。超声波能的剂量还需低于在碰撞体积中导致胶原显著收缩所需的剂量。换能器的操作因此提供治疗剂量，其阻断肾神经8而不对肾动脉10造成损伤，例如狭窄、内膜增生、内膜坏死或可能需要干涉的其它伤害。跨肾动脉10的内壁的持续血流确保肾动脉的内膜层3(图2)被冷却。这允许按治疗剂量发射的超声波能主要在肾动脉10的外层而非内膜层3上消散并且转化为热。此外，经冷却的液体循环穿过含有换能器30的气囊24也可以帮助减小从换能器30转移到内膜层3及流经换能器的血液的热。所以，所发射的治疗未聚焦超声波能不损伤内膜且不引发血栓形成，提供更安全的治疗。
为了产生治疗剂量的超声波能，换能器30的声功率输出通常为约10瓦至约100瓦，更常见从约20瓦至约30瓦。功率施加的持续时间通常为约2秒至约一分钟或更长时间，更常见从约10秒到约20秒。可通过数学建模或动物试验确定与特定系统一起使用以实现的所要温度水平的最佳剂量。
未聚焦超声波能的碰撞体积11覆盖整个肾动脉10，包括外膜和紧密围绕的组织，并且因此覆盖围绕肾动脉的所有肾神经。所以可以不加区别地将换能器30放置在肾动脉10中以阻断围绕受试者体内的肾动脉10的所有肾神经8的传导。如本公开内容中所使用，“不加区别”和“不加区别地”指的是未标定、定位或聚焦任何特定肾神经。
根据需要，医生随后可将导管18和换能器30沿肾动脉重新定位(步骤66)并且重新启动治疗68以重新发射有治疗效力的未聚焦超声波能(步骤70)。这在沿肾动脉的长度的额外位置上阻断肾神经并且因此提供更安全和更可靠的治疗。重新定位和重新发射步骤根据需要可执行数次。接下来，医生用换能器30将导管18移动到另一个肾动脉10并且再次针对该动脉10执行整个治疗(步骤72)。在治疗完成后，将导管18从受试者身体内抽出(步骤74)。
可利用上述特征的多种变型和组合。例如，在施加治疗超声波能期间超声波系统20可控制换能器30从而以脉冲函数发射超声波能。脉冲函数导致超声波换能器30按例如50％的工作循环发射超声波能。超声波能的脉冲调制可帮助在增加治疗次数的同时限制组织温度。
在另一个变型中，可省略测量肾动脉大小和调整剂量的步骤(步骤58和72)。在此情况下，换能器仅在对于一般受试者的肾动脉足够的预设功率级下运行。在另一个变型中，可通过除启动换能器30以外的技术，例如通过使用引入肾动脉的造影剂的X射线成像或磁共振成像或使用单独的超声波测量导管测量肾动脉直径。在此情况下，来自单独的测量的数据可用于设置剂量。
在上述特定实施方案中，通过可伸展气囊24的非圆形元件80将换能器30放置在肾动脉的中心。可使用其它居中装置。例如，覆盖换能器的可伸展气囊可以是圆形横截面的直径稍微小于肾动脉10的气囊。这种气囊允许血液继续流动穿过肾动脉10，但是使换能器30大致维持在肾动脉10的中心。在本实施方案中，气囊24是动态的而非装配到肾动脉10，因为围绕气囊24的血液流动导致小的向后和向前移动。这种动态性质允许血液继续到达肾动脉10的所有部位，从而提供冷却以及使内膜3的损伤最小化。在其它实施方案中，导管的末梢端可以包括除气囊以外的可伸展结构，例如可选择性地例如通过在轴向方向上压缩结构而带至径向伸展状态的网篮或金属网结构。网篮可以对超声波无反射性或可以安装在导管上的轴向偏离换能器30的位置上。
在另一个变型中，气囊24可由多孔薄膜形成或包括孔使得在气囊24内循环的经冷却的液体可从气囊24中逸出或喷至肾动脉10内的血流中。进入血流的从气囊24中逸出或喷出的经过冷却的液体可支持与流动血液接触的肾动脉10的内膜的进一步冷却。
通常导管18是一次性、单次使用装置。导管18或超声波系统20可包含阻止在单次使用后再次使用导管18的安全装置。这类安全装置本身在本领域中已知。
在另一个变型中，导管18本身可包括允许医生直接控制导管的末梢端22方向的转向机构。护套可省略。
另一个变型可以是位于导管18的末梢端上、包括超声波换能器30的能量发射单元可以定位在肾静脉中，并且超声波换能器30可包含用于选择性地仅在有限的径向范围内将超声波能从换能器30中导出的反射或阻挡结构以提供超声波能需选择性地从肾静脉中的换能器30导向肾动脉10。当利用静脉方法时，超声波能被导向远离换能器30的外表面传播的区段或波束，通常称作侧发射换能器30配置。例如，超声波换能器30可具有一种构造并且可运行以发射类似于2009年10月29申请的、名为“METHOD AND APPARATUS FORPERCUTANEOUS TREATMENT OF MITRAL VALVE REGURGITATION(PMVR)”的美国临时申请案61/256002(其以引用的方式并入本文中)导向的超声波能5。在这个变型中，导管18引入身体及随后定位为靠近肾脏6的路径与上述动脉方法不同。可使用静脉方法以利用在导管18抽出后闭合组织较少的可能性。
虽然本文中以参考特定实施方案描述本发明，但是应了解这些实施方案只说明本发明的原理和应用。所以，应了解可在不脱离随附申请专利范围所界定的本发明的精神和范围的情况下对说明性实施方案进行多种修改以及设计其它配置。

Claims (35)

1.一种用于阻断哺乳动物受试者体内的肾神经传导的装置，其包括：
超声波换能器，其被调适来插入所述哺乳动物受试者的肾动脉中以及发射未聚焦超声波能；和
启动器，其电连接到所述换能器，所述启动器被调适来控制所述超声波换能器以发射未聚焦超声波能到覆盖所述肾动脉的至少约0.5cm3的碰撞体积中，使得所述未聚焦超声波能以足以阻断整个所述碰撞体积内的肾神经的传导的治疗强度施加。
2.根据权利要求1所述的装置，其中所述启动器被调适来控制所述超声波换能器以按约10瓦至约30瓦的声功率级发射未聚焦超声波能达约10秒至约30秒以在所述碰撞体积中提供约100焦耳至约900焦耳的吸收剂量。
3.根据权利要求1所述的装置，其中所述启动器被调适来控制所述换能器以在整个所述碰撞体积内实现高于42℃的温度的同时维持所述肾动脉壁的温度低于65℃。
4.根据权利要求1所述的装置，其中所述启动器被调适来控制所述超声波换能器以按脉冲函数发射所述未聚焦超声波能。
5.根据权利要求1所述的装置，其中所述超声波换能器被调适来以沿所述肾动脉的所述轴具有至少约2mm的长度的形式发射所述超声波能。
6.根据权利要求1所述的装置，其中所述换能器被调适来在沿着沿所述肾动脉的所述轴具有至少约2mm的长度的整个碰撞体积内按所述治疗强度施加所述超声波能。
7.根据权利要求1所述的装置，其进一步包括具有末梢端和近端的导管，所述换能器安装到所述导管邻近所述末梢端的位置，所述导管和换能器被构造和配置来在所述超声波换能器定位在所述肾动脉内的同时允许大的血流穿过所述肾动脉。
8.根据权利要求7所述的装置，其中所述导管被构造和配置来使所述换能器保持不与所述肾动脉的所述壁接触。
9.根据权利要求7所述的装置，其中所述换能器具有轴，所述导管被构造和配置来使所述换能器的所述轴保持大致与所述肾动脉的所述轴平行，并且所述换能器被调适来以围绕所述换能器的所述轴的360°圆柱形式发射所述超声波能。
10.根据权利要求1所述的装置，其中所述导管包括邻近所述换能器的居中元件，所述居中元件被配置来使所述换能器大致保持在所述肾动脉的中心。
11.根据权利要求10所述的装置，其中所述居中元件包括被调适来接合所述肾动脉的所述壁而基本上不阻挡血流穿过所述肾动脉的可伸展元件。
12.根据权利要求1所述的装置，其中所述超声波换能器被进一步调适来接收超声波能并且产生代表所述所接收的超声波能的信号，且所述启动器被进一步调适来：
控制所述超声波换能器以按低于所述治疗强度的强度发射测量超声波能，从所述换能器中接收代表所反射的测量超声波能的回波信号；
分析所述所接收的回波信号；和
基于所述所接收的回波信号确定所述肾动脉的大小。
13.根据权利要求12所述的装置，其中所述超声波系统被调适来控制所述超声波换能器以取决于所述肾动脉的所述所决定的大小来改变用于发射所述有治疗效力的未聚焦超声波能的所述声功率。
14.一种用于阻断哺乳动物受试者体内的肾神经传导的方法，其包括下列步骤：
将超声波换能器插入所述哺乳动物受试者的肾动脉中；和
启动所述换能器以发射有治疗效力的未聚焦超声波能到覆盖所述肾动脉的至少约0.5cm3的碰撞体积中，使得所述有治疗效力的超声波能阻断所述碰撞体积中的所有所述肾神经的传导。
15.根据权利要求14所述的方法，其中按约10瓦至约30瓦的声功率级发射所述超声波能达约10秒至约30秒以在整个所述碰撞体积中提供约100焦耳至约900焦耳的吸收剂量。
16.根据权利要求14所述的方法，其中执行发射超声波能的步骤以在将所述碰撞区中的所述肾神经加热到高于42℃的同时维持所述肾动脉壁的所述温度低于65℃。
17.根据权利要求14所述的方法，在不确定肾神经的实际位置的情况下执行插入所述超声波换能器和启动所述换能器以发射超声波能的步骤。
18.根据权利要求14所述的方法，其中执行启动所述换能器的步骤使得在每个肾动脉中单次施加所述超声波能可有效阻断围绕所述肾动脉的所有所述肾神经的传导。
19.根据权利要求14所述的方法，其进一步包括下列步骤：
在启动所述换能器的步骤后将所述超声波换能器重新定位在所述肾动脉中；和随后
重复启动所述换能器的步骤。
20.根据权利要求14所述的方法，其中执行启动所述换能器的步骤使得所述超声波能按脉冲函数发射。
21.根据权利要求14所述的方法，执行插入所述超声波换能器的步骤以在所述换能器定位在所述肾动脉内的同时允许大的血流穿过所述肾动脉。
22.根据权利要求14所述的方法，其中执行将所述超声波换能器插入所述肾动脉的步骤使得所述换能器不接触所述肾动脉的所述壁。
23.根据权利要求14所述的方法，其中所述有治疗效力的未聚焦超声波能以围绕所述换能器的360°圆柱形式发射。
24.根据权利要求14所述的方法，其中所述有治疗效力的未聚焦超声波能以沿所述肾动脉的所述轴具有至少约2mm的长度的形式发射。
25.根据权利要求14所述的方法，其中所述有治疗效力的未聚焦超声波能阻断至少约2mm的长度的所述肾神经的传导。
26.根据权利要求14所述的方法，其进一步包括在发射所述有治疗效力的未聚焦超声波能之前将所述超声波换能器放置在所述肾动脉的大致中心的步骤。
27.根据权利要求25所述的方法，其中执行使所述换能器大致居中的步骤以允许基本未减小的血流穿过所述肾动脉。
28.根据权利要求14所述的方法，其进一步包括下列步骤：
按小于所述有治疗效力的超声波能的功率级的功率级施加非治疗超声波能；
接收所反射的非治疗超声波能并且产生代表所述所反射的能量的回波信号；和
在启动所述换能器以施加所述有治疗效力的超声波能的步骤之前基于所述回波信号确定所述肾动脉的大小。
29.根据权利要求28所述的方法，其进一步包括在启动期间调整施加至所述换能器的所述功率的步骤，以至少部分基于在所述确定步骤中所确定的所述肾动脉的所述大小发射有治疗效力的未聚焦超声波能。
30.一种用于肾神经阻断的探针，所述探针包括：
超声波换能器，其被调适来发射未聚焦超声波能；和
导管，其具有末梢端和近端，所述换能器安装到所述导管邻近所述末梢端的位置，所述导管和换能器被构造和配置来允许将所述末梢端和换能器定位在肾动脉内和在所述超声波换能器定位在所述肾动脉内的同时允许大的血流穿过所述肾动脉。
31.根据权利要求30所述的探针，其中所述导管被构造和配置来使所述换能器保持不与所述肾动脉的所述壁接触。
32.根据权利要求30所述的探针，其中所述换能器具有轴，所述导管被构造和配置来使所述换能器的所述轴保持大致与所述肾动脉的所述轴平行，以及所述换能器被调适来以围绕所述换能器的所述轴的360°圆柱形式发射所述超声波能。
33.根据权利要求30所述的探针，其中所述导管包括邻近所述换能器的居中元件，所述居中元件被配置来使所述换能器大致保持在所述肾动脉的中心。
34.根据权利要求33所述的探针，其中所述居中元件包括被调适来接合所述肾动脉的所述壁而基本上不阻挡血流穿过所述肾动脉的可伸展元件。
35.一种用于阻断哺乳动物受试者体内的肾神经传导的装置，其包括：
构件，其用于将超声波换能器定位在所述哺乳动物受试者的肾动脉中；和
构件，其用于启动所述换能器以发射有治疗效力的未聚焦超声波能到覆盖所述肾动脉的至少约0.5cm3的碰撞体积中，使得所述有治疗效力的超声波能阻断所述碰撞体积中的所有所述肾神经的传导。
CN201080049201.0A 2009-10-30 2010-10-29 通过经皮超声波去肾神经治疗高血压的方法和装置 Active CN102596320B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25642909P 2009-10-30 2009-10-30
US61/256,429 2009-10-30
US29261810P 2010-01-06 2010-01-06
US61/292,618 2010-01-06
PCT/US2010/054637 WO2011053757A1 (en) 2009-10-30 2010-10-29 Method and apparatus for treatment of hypertension through percutaneous ultrasound renal denervation

Publications (2)

Publication Number Publication Date
CN102596320A true CN102596320A (zh) 2012-07-18
CN102596320B CN102596320B (zh) 2016-09-07

Family

ID=43302706

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080049201.0A Active CN102596320B (zh) 2009-10-30 2010-10-29 通过经皮超声波去肾神经治疗高血压的方法和装置

Country Status (10)

Country Link
US (5) US9981108B2 (zh)
EP (3) EP2995350B1 (zh)
JP (3) JP5768056B2 (zh)
KR (2) KR101673574B1 (zh)
CN (1) CN102596320B (zh)
AU (2) AU2010313379B2 (zh)
CA (1) CA2779386C (zh)
HK (1) HK1220153A1 (zh)
IL (1) IL219252A0 (zh)
WO (1) WO2011053757A1 (zh)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104107082A (zh) * 2014-07-28 2014-10-22 无锡市贝尔康电子研究所 一种水囊扩张精准可控的超导可视仿生仪
CN104383646A (zh) * 2014-12-12 2015-03-04 黄晶 一种超声介入治疗系统
CN105796173A (zh) * 2014-12-31 2016-07-27 上海形状记忆合金材料有限公司 多声束超声消融导管系统
CN105939758A (zh) * 2013-11-04 2016-09-14 引导干预有限公司 用于以离焦超声执行热支气管成形术的方法和设备
CN113905772A (zh) * 2018-05-08 2022-01-07 阿比奥梅德公司 使用心脏辅助装置改善肾功能
CN115252060A (zh) * 2022-07-01 2022-11-01 深圳心寰科技有限公司 用于治疗慢性阻塞性肺炎的支气管介入超声治疗设备及介入方法

Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
AU2004285412A1 (en) 2003-09-12 2005-05-12 Minnow Medical, Llc Selectable eccentric remodeling and/or ablation of atherosclerotic material
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
JP5219518B2 (ja) 2004-12-09 2013-06-26 ザ ファウンドリー， エルエルシー 大動脈弁修復
US20070233185A1 (en) 2005-10-20 2007-10-04 Thomas Anderson Systems and methods for sealing a vascular opening
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US10499937B2 (en) 2006-05-19 2019-12-10 Recor Medical, Inc. Ablation device with optimized input power profile and method of using the same
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
EP2455035B1 (en) 2006-10-18 2015-11-25 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
AU2007310991B2 (en) 2006-10-18 2013-06-20 Boston Scientific Scimed, Inc. System for inducing desirable temperature effects on body tissue
ES2546773T3 (es) 2006-10-18 2015-09-28 Vessix Vascular, Inc. Energía de RF sintonizada y caracterización eléctrica de tejido para el tratamiento selectivo de tejidos diana
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
KR101719824B1 (ko) 2008-05-09 2017-04-04 호라이라 인코포레이티드 기관지나무 치료용 시스템, 어셈블리 및 방법
WO2010056745A1 (en) 2008-11-17 2010-05-20 Minnow Medical, Inc. Selective accumulation of energy with or without knowledge of tissue topography
EP2376011B1 (en) 2009-01-09 2019-07-03 ReCor Medical, Inc. Apparatus for treatment of mitral valve insufficiency
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US20160059044A1 (en) 2009-10-12 2016-03-03 Kona Medical, Inc. Energy delivery to intraparenchymal regions of the kidney to treat hypertension
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
CN104856757B (zh) 2009-10-27 2017-06-23 赫莱拉公司 具有可冷却的能量发射组件的递送装置
JP5768056B2 (ja) * 2009-10-30 2015-08-26 リコール メディカル インコーポレイテッドＲｅＣｏｒ Ｍｅｄｉｃａｌ， Ｉｎｃ． 経皮的超音波腎神経除去による高血圧症を治療するための方法及び装置
US20110112400A1 (en) * 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
US9149328B2 (en) 2009-11-11 2015-10-06 Holaira, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
AU2011238925B2 (en) 2010-04-09 2016-06-16 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9192790B2 (en) * 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9566456B2 (en) * 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
US20120095371A1 (en) 2010-10-18 2012-04-19 CardioSonic Ltd. Ultrasound transducer and cooling thereof
WO2012052924A1 (en) * 2010-10-18 2012-04-26 CardioSonic Ltd. Separation device for ultrasound element
US9028417B2 (en) 2010-10-18 2015-05-12 CardioSonic Ltd. Ultrasound emission element
US20120215106A1 (en) * 2010-10-18 2012-08-23 CardioSonic Ltd. Tissue treatment
EP2661304A1 (en) * 2010-10-18 2013-11-13 Cardiosonic Ltd. Therapeutics reservoir
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
WO2012100095A1 (en) 2011-01-19 2012-07-26 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
US20120259269A1 (en) 2011-04-08 2012-10-11 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
JP2014525781A (ja) 2011-07-12 2014-10-02 ベルブ メディカル， インコーポレイテッド 腎盂を通した腎神経の脱神経
AU2012283908B2 (en) 2011-07-20 2017-02-16 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
CN103813829B (zh) 2011-07-22 2016-05-18 波士顿科学西美德公司 具有可定位于螺旋引导件中的神经调制元件的神经调制系统
JP6222778B2 (ja) * 2011-07-22 2017-11-01 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． アブレーション装置
US20130053732A1 (en) 2011-08-24 2013-02-28 Richard R. Heuser Devices and methods for treating hypertension with energy
US9186210B2 (en) 2011-10-10 2015-11-17 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
EP2765940B1 (en) 2011-10-11 2015-08-26 Boston Scientific Scimed, Inc. Off-wall electrode device for nerve modulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
WO2013059202A1 (en) 2011-10-18 2013-04-25 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
WO2013058962A1 (en) 2011-10-18 2013-04-25 Boston Scientific Scimed, Inc. Deflectable medical devices
EP3366250A1 (en) 2011-11-08 2018-08-29 Boston Scientific Scimed, Inc. Ostial renal nerve ablation
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
AU2012347470B2 (en) 2011-12-09 2017-02-02 Medtronic Ireland Manufacturing Unlimited Company Therapeutic neuromodulation of the hepatic system
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
JP5898336B2 (ja) 2011-12-23 2016-04-06 べシックス・バスキュラー・インコーポレイテッド 拡張可能なバルーン及び熱感知デバイスを備えた電極パッドを含むデバイス
WO2013101452A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
AU2013215164A1 (en) * 2012-01-30 2014-08-14 Vytronus, Inc. Tissue necrosis methods and apparatus
WO2013157011A2 (en) 2012-04-18 2013-10-24 CardioSonic Ltd. Tissue treatment
CN107693114A (zh) 2012-04-24 2018-02-16 西比姆公司 用于颈动脉体摘除的血管内导管和方法
WO2013165935A1 (en) * 2012-05-03 2013-11-07 Sound Interventions, Inc. Apparatus and method for uniform renal denervation
WO2013169927A1 (en) 2012-05-08 2013-11-14 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
US9402677B2 (en) 2012-06-01 2016-08-02 Cibiem, Inc. Methods and devices for cryogenic carotid body ablation
EP2854681A4 (en) 2012-06-01 2016-02-17 Cibiem Inc PERCUTANEOUS METHODS AND DEVICES FOR CAROTIDE BODY ABLATION
EP2866669A4 (en) 2012-06-30 2016-04-20 Cibiem Inc ABLATION OF CAROTID BODY VIA DIRECTED ENERGY
WO2014022777A1 (en) * 2012-08-03 2014-02-06 Sound Interventions, Inc. Method and apparatus for treatment of hypertension through an ultrasound imaging/therapy catheter
CN104540465A (zh) 2012-08-24 2015-04-22 波士顿科学西美德公司 带有含单独微孔隙区域的球囊的血管内导管
US9173696B2 (en) 2012-09-17 2015-11-03 Boston Scientific Scimed, Inc. Self-positioning electrode system and method for renal nerve modulation
US9333035B2 (en) 2012-09-19 2016-05-10 Denervx LLC Cooled microwave denervation
WO2014047411A1 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
WO2014047454A2 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
US10835305B2 (en) 2012-10-10 2020-11-17 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
WO2014143571A1 (en) 2013-03-11 2014-09-18 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014163987A1 (en) 2013-03-11 2014-10-09 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
EP2968984B1 (en) 2013-03-14 2016-08-17 ReCor Medical, Inc. Ultrasound-based neuromodulation system
WO2014159273A1 (en) 2013-03-14 2014-10-02 Recor Medical, Inc. Methods of plating or coating ultrasound transducers
CN105228546B (zh) 2013-03-15 2017-11-14 波士顿科学国际有限公司 利用阻抗补偿的用于治疗高血压的医疗器械和方法
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
JP6220044B2 (ja) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経アブレーションのための医療用デバイス
US10933259B2 (en) 2013-05-23 2021-03-02 CardioSonic Ltd. Devices and methods for renal denervation and assessment thereof
US9943365B2 (en) 2013-06-21 2018-04-17 Boston Scientific Scimed, Inc. Renal denervation balloon catheter with ride along electrode support
WO2014205399A1 (en) 2013-06-21 2014-12-24 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation having rotatable shafts
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
JP6204579B2 (ja) 2013-07-01 2017-09-27 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経アブレーション用医療器具
US10660698B2 (en) 2013-07-11 2020-05-26 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation
EP3019106A1 (en) 2013-07-11 2016-05-18 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
US9925001B2 (en) 2013-07-19 2018-03-27 Boston Scientific Scimed, Inc. Spiral bipolar electrode renal denervation balloon
EP3024405A1 (en) 2013-07-22 2016-06-01 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
WO2015013205A1 (en) 2013-07-22 2015-01-29 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP4049605A1 (en) 2013-08-22 2022-08-31 Boston Scientific Scimed Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
WO2015035047A1 (en) 2013-09-04 2015-03-12 Boston Scientific Scimed, Inc. Radio frequency (rf) balloon catheter having flushing and cooling capability
US11446524B2 (en) 2013-09-12 2022-09-20 Nuvaira Inc. Systems, devices, and methods for treating a pulmonary disease with ultrasound energy
CN105530885B (zh) 2013-09-13 2020-09-22 波士顿科学国际有限公司 具有气相沉积覆盖层的消融球囊
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
EP3057488B1 (en) 2013-10-14 2018-05-16 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
EP3057520A1 (en) 2013-10-15 2016-08-24 Boston Scientific Scimed, Inc. Medical device balloon
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
US10945786B2 (en) 2013-10-18 2021-03-16 Boston Scientific Scimed, Inc. Balloon catheters with flexible conducting wires and related methods of use and manufacture
CN105658163B (zh) 2013-10-25 2020-08-18 波士顿科学国际有限公司 去神经柔性电路中的嵌入式热电偶
US10390881B2 (en) 2013-10-25 2019-08-27 Denervx LLC Cooled microwave denervation catheter with insertion feature
EP3091922B1 (en) 2014-01-06 2018-10-17 Boston Scientific Scimed, Inc. Tear resistant flex circuit assembly
US20150209107A1 (en) 2014-01-24 2015-07-30 Denervx LLC Cooled microwave denervation catheter configuration
CN106572881B (zh) 2014-02-04 2019-07-26 波士顿科学国际有限公司 热传感器在双极电极上的替代放置
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
EP3116408B1 (en) 2014-03-12 2018-12-19 Cibiem, Inc. Ultrasound ablation catheter
US10925579B2 (en) 2014-11-05 2021-02-23 Otsuka Medical Devices Co., Ltd. Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
US10376308B2 (en) 2015-02-05 2019-08-13 Axon Therapies, Inc. Devices and methods for treatment of heart failure by splanchnic nerve ablation
FR3050117B1 (fr) 2016-04-15 2021-01-15 Carthera Sonde d'ablation thermique ultrasonore
CN106063975A (zh) * 2016-05-26 2016-11-02 冯庆宇 一种腔内超声治疗装置及其控制方法
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
CA3031766A1 (en) 2016-07-29 2018-02-01 Howard Levin Devices, systems, and methods for treatment of heart failure by splanchnic nerve ablation
CN110621345A (zh) 2017-03-20 2019-12-27 索尼维有限公司 肺动脉高压治疗
US10561461B2 (en) 2017-12-17 2020-02-18 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
KR102154695B1 (ko) * 2017-12-28 2020-09-10 주식회사 코어테크 경직장 고강도 집속 초음파 전립선 치료 시술 시 집속초음파 발생장치의 고정과 상대적 위치를 정밀 제어하기 위한 장치
US11116561B2 (en) 2018-01-24 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Devices, agents, and associated methods for selective modulation of renal nerves
EP3743147B1 (en) 2018-01-26 2024-04-10 Axon Therapies, Inc. Device for endovascular ablation of a splanchnic nerve
CA3105282A1 (en) 2018-08-22 2020-02-27 Ran Sela Catheter ultrasound transducer container
CN113825464A (zh) 2019-06-20 2021-12-21 阿克松疗法公司 用于内脏神经的血管内消融的方法和装置
WO2021100142A1 (ja) 2019-11-20 2021-05-27 株式会社Ａｌｉｖａｓ 医療デバイス、医療器具、および処置方法
WO2021146724A1 (en) 2020-01-17 2021-07-22 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
KR20220162745A (ko) 2020-03-31 2022-12-08 에어웨이브 메디컬 인코포레이티드 적분된 a 모드 신호를 사용한 기관지 신경 제거
US20220265302A1 (en) 2021-02-19 2022-08-25 Otsuka Medical Devices Co., Ltd. Selectively insulated ultrasound transducers
EP4108197A1 (en) 2021-06-24 2022-12-28 Gradient Denervation Technologies Systems for treating tissue
US20230026504A1 (en) 2021-07-19 2023-01-26 Otsuka Medical Devices Co., Ltd. Methods and systems for determining body lumen size
US20230026169A1 (en) 2021-07-19 2023-01-26 Otsuka Medical Devices Co., Ltd. Catheter having compliant balloon
US11672595B1 (en) 2022-06-15 2023-06-13 Corveus Medical, Inc. Systems and methods for interrupting nerve activity to treat a medical condition
WO2024057163A1 (en) 2022-09-12 2024-03-21 Otsuka Medical Devices Co., Ltd. Radial access catheter
US20240157093A1 (en) 2022-11-15 2024-05-16 Otsuka Medical Devices Co., Ltd. Tissue treatment catheter having supportive isolation tube
WO2024106546A1 (en) 2022-11-18 2024-05-23 Otsuka Medical Devices Co., Ltd. Method of denervating pulmonary artery

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308356A (en) * 1993-02-25 1994-05-03 Blackshear Jr Perry L Passive perfusion angioplasty catheter
CN1269708A (zh) * 1997-07-08 2000-10-11 加利福尼亚大学董事会 周缘消融装置组件和方法
US20050240126A1 (en) * 1999-09-17 2005-10-27 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
US20070135875A1 (en) * 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
CN101084038A (zh) * 2004-10-05 2007-12-05 阿迪安公司 肾神经调节的方法和装置
WO2008151001A2 (en) * 2007-05-30 2008-12-11 The Cleveland Clinic Foundation Method for treating a renal disease or disorder
CN101472531A (zh) * 2006-06-23 2009-07-01 圣朱德医疗有限公司房颤分公司 消融组织的器械和方法

Family Cites Families (312)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3938502A (en) 1972-02-22 1976-02-17 Nicolaas Bom Apparatus with a catheter for examining hollow organs or bodies with the ultrasonic waves
US4276874A (en) 1978-11-15 1981-07-07 Datascope Corp. Elongatable balloon catheter
US4802490A (en) 1984-11-01 1989-02-07 Johnston G Gilbert Catheter for performing volumetric flow rate determination in intravascular conduits
US4841977A (en) 1987-05-26 1989-06-27 Inter Therapy, Inc. Ultra-thin acoustic transducer and balloon catheter using same in imaging array subassembly
GB8816648D0 (en) 1988-07-13 1988-08-17 Rowland A C Light delivery system
US5344435A (en) 1988-07-28 1994-09-06 Bsd Medical Corporation Urethral inserted applicator prostate hyperthermia
JPH0826437B2 (ja) 1990-08-22 1996-03-13 日本鋼管株式会社 シャドウマスク用Ｆｅ―Ｎｉ合金薄板およびその製造方法
US5108369A (en) 1990-03-15 1992-04-28 Diagnostic Devices Group, Limited Dual-diameter multifunction catheter
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
WO1992020291A1 (en) 1991-05-24 1992-11-26 Applied Medical Resources, Inc. Articulating tissue cutter assembly
US5769812A (en) 1991-07-16 1998-06-23 Heartport, Inc. System for cardiac procedures
GB2258364A (en) 1991-07-30 1993-02-03 Intravascular Res Ltd Ultrasonic tranducer
JPH0568684A (ja) 1991-09-13 1993-03-23 Olympus Optical Co Ltd 超音波治療装置
US5327885A (en) 1991-10-08 1994-07-12 Griffith James M Combination catheter for invasive probe delivery and balloon dilation
US5295992A (en) 1992-03-16 1994-03-22 Othy, Inc. Patella cutting system
CH683718A5 (de) 1992-05-15 1994-04-29 Kk Holding Ag Kombinierter Kraft-, Dehnungs- und Schallemissionsaufnehmer.
US5542916A (en) 1992-08-12 1996-08-06 Vidamed, Inc. Dual-channel RF power delivery system
US5295995A (en) * 1992-08-27 1994-03-22 Kleiman Jay H Perfusion dilatation catheter
US5620479A (en) 1992-11-13 1997-04-15 The Regents Of The University Of California Method and apparatus for thermal therapy of tumors
US5441483A (en) 1992-11-16 1995-08-15 Avitall; Boaz Catheter deflection control
US5400267A (en) 1992-12-08 1995-03-21 Hemostatix Corporation Local in-device memory feature for electrically powered medical equipment
US5423220A (en) 1993-01-29 1995-06-13 Parallel Design Ultrasonic transducer array and manufacturing method thereof
DE69417465T2 (de) 1993-02-05 1999-07-22 Joe W And Dorothy Dorsett Brow Ultraschallballonkatheter für Angioplastik
US5630837A (en) 1993-07-01 1997-05-20 Boston Scientific Corporation Acoustic ablation
US5354200A (en) 1993-09-27 1994-10-11 Michael Klein Temperature gauge for dental drills and method employing same
US5599345A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
JPH07178173A (ja) 1993-12-22 1995-07-18 Kiyoshi Matsuo 人工呼吸具
DE69432510T2 (de) 1993-12-24 2003-12-24 Olympus Optical Co Vorrichtung zur Ultraschalldiagnose und -behandlung, wobei der Brennpunkt der therapeutischen Ultraschallwelle in einer vorbestimmten Lage innerhalb des Ultraschall-Beobachtungsbereiches verriegelt ist
WO1995019143A1 (en) 1994-01-14 1995-07-20 Paul G. Yock And Robert J. Siegel, A Joint Venture Ultrasonic ablation of stenoses and occlusions with imaging guidance
CA2194061C (en) 1994-06-27 2006-04-11 David K. Swanson Systems and methods for sensing temperature within the body
ATE230955T1 (de) 1994-06-27 2003-02-15 Boston Scient Ltd Gewebeablationssystem
JPH0826437A (ja) 1994-07-11 1996-01-30 Fuji Photo Film Co Ltd ワーク移送方法及び移送装置
NL9401184A (nl) 1994-07-19 1996-03-01 Cordis Europ Zuigcatheter.
US6142994A (en) 1994-10-07 2000-11-07 Ep Technologies, Inc. Surgical method and apparatus for positioning a diagnostic a therapeutic element within the body
DE4438799A1 (de) 1994-10-18 1996-04-25 Atotech Deutschland Gmbh Verfahren zum Beschichten elektrisch nichtleitender Oberflächen mit Metallstrukturen
US6063072A (en) 1994-12-08 2000-05-16 Summit Technology, Inc. Methods and systems for correction of hyperopia and/or astigmatism using ablative radiation
US5938645A (en) 1995-05-24 1999-08-17 Boston Scientific Corporation Northwest Technology Center Inc. Percutaneous aspiration catheter system
ATE275880T1 (de) 1995-10-13 2004-10-15 Transvascular Inc Vorrichtung zur umgehung von arteriellen verengungen und/oder zur ausführung anderer transvaskularer eingriffe
US5803083A (en) 1995-11-09 1998-09-08 Cordis Corporation Guiding catheter with ultrasound imaging capability
US5895356A (en) 1995-11-15 1999-04-20 American Medical Systems, Inc. Apparatus and method for transurethral focussed ultrasound therapy
US6419673B1 (en) 1996-05-06 2002-07-16 Stuart Edwards Ablation of rectal and other internal body structures
US5824026A (en) 1996-06-12 1998-10-20 The Spectranetics Corporation Catheter for delivery of electric energy and a process for manufacturing same
US6237605B1 (en) 1996-10-22 2001-05-29 Epicor, Inc. Methods of epicardial ablation
DE69735406T2 (de) 1996-10-25 2006-08-31 Canon K.K. Glasschaltungssubstrat und Verfahren zu dessen Herstellung
JPH10127678A (ja) 1996-10-31 1998-05-19 Olympus Optical Co Ltd 超音波診断治療装置
US5775338A (en) * 1997-01-10 1998-07-07 Scimed Life Systems, Inc. Heated perfusion balloon for reduction of restenosis
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
US5971983A (en) 1997-05-09 1999-10-26 The Regents Of The University Of California Tissue ablation device and method of use
WO1998052465A1 (en) 1997-05-23 1998-11-26 Transurgical, Inc. Mri-guided therapeutic unit and methods
US6251109B1 (en) 1997-06-27 2001-06-26 Daig Corporation Process and device for the treatment of atrial arrhythmia
US6652515B1 (en) 1997-07-08 2003-11-25 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
US6547788B1 (en) * 1997-07-08 2003-04-15 Atrionx, Inc. Medical device with sensor cooperating with expandable member
JP2001514921A (ja) 1997-08-13 2001-09-18 サークス， インコーポレイテッド 組織収縮のための非侵襲性デバイス、方法、およびシステム
JP3634136B2 (ja) 1997-11-26 2005-03-30 三菱電機株式会社 超音波収束装置および超音波液体噴出装置
AU2317899A (en) 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Gerd treatment apparatus and method
US6517534B1 (en) * 1998-02-11 2003-02-11 Cosman Company, Inc. Peri-urethral ablation
WO1999044519A2 (en) 1998-03-02 1999-09-10 Atrionix, Inc. Tissue ablation system and method for forming long linear lesion
US6299583B1 (en) * 1998-03-17 2001-10-09 Cardiox Corporation Monitoring total circulating blood volume and cardiac output
US6905494B2 (en) 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6064902A (en) 1998-04-16 2000-05-16 C.R. Bard, Inc. Pulmonary vein ablation catheter
US6522930B1 (en) 1998-05-06 2003-02-18 Atrionix, Inc. Irrigated ablation device assembly
US7198635B2 (en) 2000-10-17 2007-04-03 Asthmatx, Inc. Modification of airways by application of energy
US6162178A (en) 1998-07-31 2000-12-19 Scimed Life Systems, Inc. Ultrasonic transducer off-aperture connection
JP2000054153A (ja) 1998-08-07 2000-02-22 Murata Mfg Co Ltd 電子部品の電極形成方法
US6355030B1 (en) 1998-09-25 2002-03-12 Cardiothoracic Systems, Inc. Instruments and methods employing thermal energy for the repair and replacement of cardiac valves
JP3316748B2 (ja) 1998-10-20 2002-08-19 株式会社村田製作所 無電解めっき用ホルダおよび無電解めっき方法
US6149596A (en) * 1998-11-05 2000-11-21 Bancroft; Michael R. Ultrasonic catheter apparatus and method
US6152144A (en) 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6277077B1 (en) 1998-11-16 2001-08-21 Cardiac Pathways Corporation Catheter including ultrasound transducer with emissions attenuation
US6102863A (en) * 1998-11-20 2000-08-15 Atl Ultrasound Ultrasonic diagnostic imaging system with thin cable ultrasonic probes
US6607502B1 (en) 1998-11-25 2003-08-19 Atrionix, Inc. Apparatus and method incorporating an ultrasound transducer onto a delivery member
PL197397B1 (pl) 1999-01-15 2008-03-31 Bic Corp Taśma korekcyjna do maskowania substancji drukowanej lub zawierającej tusz
US6097985A (en) * 1999-02-09 2000-08-01 Kai Technologies, Inc. Microwave systems for medical hyperthermia, thermotherapy and diagnosis
JP4565594B2 (ja) * 1999-03-02 2010-10-20 アトリオニクス・インコーポレーテツド 肺口切除器用位置付けシステム
WO2000051683A1 (en) 1999-03-02 2000-09-08 Atrionix, Inc. Atrial ablator having balloon and sensor
US6492762B1 (en) 1999-03-22 2002-12-10 Transurgical, Inc. Ultrasonic transducer, transducer array, and fabrication method
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
US6190377B1 (en) * 1999-05-05 2001-02-20 James A. Kuzdrall Method and apparatus for predictive beam energy control in laser surgery
ATE353001T1 (de) 1999-05-11 2007-02-15 Atrionix Inc Ballonverankerungsdraht
DE60031261T2 (de) 1999-05-11 2007-04-05 Atrionix Inc., Palo Alto System zum positionieren eines katheters
DE60022506T2 (de) 1999-05-12 2006-05-04 Jeneric/Pentron Inc., Wallingford Endodontisches stiftsystem
US20010007940A1 (en) 1999-06-21 2001-07-12 Hosheng Tu Medical device having ultrasound imaging and therapeutic means
US6626899B2 (en) 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
JP2001011126A (ja) 1999-06-28 2001-01-16 Nippon Zeon Co Ltd ディップ成形用ラテックス及びディップ成形物
EP1207788A4 (en) 1999-07-19 2009-12-09 St Jude Medical Atrial Fibrill FABRIC ABLATION TECHNIQUES AND CORRESPONDING DEVICE
JP2003507105A (ja) 1999-08-16 2003-02-25 イコス コーポレイション カテーテルと共に使用するための超音波組立体
JP3848572B2 (ja) 1999-09-10 2006-11-22 プロリズム，インコーポレイテッド 解剖学的組織を閉塞するための装置
CA2384866C (en) 1999-09-28 2012-07-10 Stuart D. Edwards Treatment of tissue by application of energy and drugs
JP2001111126A (ja) 1999-10-13 2001-04-20 Sumitomo Metal Electronics Devices Inc 圧電素子
US20040215235A1 (en) 1999-11-16 2004-10-28 Barrx, Inc. Methods and systems for determining physiologic characteristics for treatment of the esophagus
US6645199B1 (en) 1999-11-22 2003-11-11 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements contact with body tissue and expandable push devices for use with same
US8221402B2 (en) 2000-01-19 2012-07-17 Medtronic, Inc. Method for guiding a medical device
US20020165771A1 (en) 2001-05-07 2002-11-07 Walker Jay S. Method and apparatus for establishing prices for a plurality of products
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
US6913581B2 (en) 2000-03-20 2005-07-05 Paul D. Corl High output therapeutic ultrasound transducer
WO2001070112A1 (en) * 2000-03-20 2001-09-27 Pharmasonics, Inc. High output therapeutic ultrasound transducer
AU2001245971A1 (en) 2000-03-24 2001-10-08 Transurgical, Inc. Apparatus and method for intrabody thermal treatment
US6547946B2 (en) 2000-04-10 2003-04-15 The Regents Of The University Of California Processing a printed wiring board by single bath electrodeposition
DE60138880D1 (de) 2000-05-03 2009-07-16 Bard Inc C R Vorrichtung zur mehrdimensionalen darstellung und ablation bei elektrophysiologischen prozeduren
JP4873816B2 (ja) * 2000-05-16 2012-02-08 アトリオニックス・インコーポレイテッド ガイドワイヤトラッキング機構を備えた先端部可撓性カテーテル
JP4754148B2 (ja) 2000-05-16 2011-08-24 アトリオニックス・インコーポレイテッド 超音波トランスデューサを配送部材に組み込む装置および方法
JP3579326B2 (ja) * 2000-05-25 2004-10-20 オリンパス株式会社 超音波診断装置および超音波診断装置の制御方法
ATE314876T1 (de) 2000-06-20 2006-02-15 Celsion Corp System zur wärmebehandlung der prostata
JP2004503324A (ja) 2000-07-13 2004-02-05 トランサージカル，インコーポレイテッド 膨張性環状レンズによるエネルギー付与装置
CN1241658C (zh) * 2000-07-13 2006-02-15 普罗里森姆股份有限公司 一种在存活对象的体内施加能量的装置
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
JP2002078809A (ja) 2000-09-07 2002-03-19 Shutaro Satake 肺静脈電気的隔離用バルーンカテーテル
US6623452B2 (en) * 2000-12-19 2003-09-23 Scimed Life Systems, Inc. Drug delivery catheter having a highly compliant balloon with infusion holes
US7422586B2 (en) 2001-02-28 2008-09-09 Angiodynamics, Inc. Tissue surface treatment apparatus and method
WO2003099382A1 (en) 2002-05-23 2003-12-04 Gendel Limited Ablation device
US6666858B2 (en) 2001-04-12 2003-12-23 Scimed Life Systems, Inc. Cryo balloon for atrial ablation
AU2002258990A1 (en) 2001-04-23 2002-11-05 Transurgical, Inc. Improvements in ablation therapy
US20040253450A1 (en) 2001-05-24 2004-12-16 Shipley Company, L.L.C. Formaldehyde-free electroless copper plating process and solution for use in the process
US20030092988A1 (en) 2001-05-29 2003-05-15 Makin Inder Raj S. Staging medical treatment using ultrasound
US20020193781A1 (en) * 2001-06-14 2002-12-19 Loeb Marvin P. Devices for interstitial delivery of thermal energy into tissue and methods of use thereof
US6763722B2 (en) 2001-07-13 2004-07-20 Transurgical, Inc. Ultrasonic transducers
US20060116736A1 (en) 2001-07-23 2006-06-01 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity
US6953469B2 (en) 2001-08-30 2005-10-11 Ethicon, Inc, Device and method for treating intraluminal tissue
US20030060813A1 (en) * 2001-09-22 2003-03-27 Loeb Marvin P. Devices and methods for safely shrinking tissues surrounding a duct, hollow organ or body cavity
US6475146B1 (en) * 2001-09-24 2002-11-05 Siemens Medical Solutions Usa, Inc. Method and system for using personal digital assistants with diagnostic medical ultrasound systems
US7285116B2 (en) 2004-05-15 2007-10-23 Irvine Biomedical Inc. Non-contact tissue ablation device and methods thereof
US8974446B2 (en) 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
US20030161805A1 (en) 2001-11-16 2003-08-28 Kobo Products, Inc. Organosilicon treated cosmetic powders, their production and use
US7347852B2 (en) 2001-11-20 2008-03-25 Angiodynamics, Inc. Catheter retention
JP3678195B2 (ja) 2001-12-18 2005-08-03 株式会社村田製作所 電子部品の製造方法、及び電子部品
EP1465701A4 (en) 2002-01-15 2008-08-13 Univ California SYSTEM AND METHOD FOR DIRECTIONAL ULTRASONIC THERAPY OF SKELETAL JOINTS
WO2003061756A2 (en) 2002-01-23 2003-07-31 The Regents Of The University Of California Implantable thermal treatment method and apparatus
US6736835B2 (en) 2002-03-21 2004-05-18 Depuy Acromed, Inc. Early intervention spinal treatment methods and devices for use therein
US7160434B2 (en) 2002-03-22 2007-01-09 Robert E. Moroney, Llc Therapeutic electrolysis device
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US7503904B2 (en) 2002-04-25 2009-03-17 Cardiac Pacemakers, Inc. Dual balloon telescoping guiding catheter
US6793635B2 (en) 2002-06-28 2004-09-21 Ethicon, Inc. Devices having deployable ultrasound transducers and method of use of same
US20130197555A1 (en) 2002-07-01 2013-08-01 Recor Medical, Inc. Intraluminal devices and methods for denervation
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US20060100514A1 (en) 2002-07-08 2006-05-11 Prorhythm, Inc. Cardiac ablation using microbubbles
US6866662B2 (en) 2002-07-23 2005-03-15 Biosense Webster, Inc. Ablation catheter having stabilizing array
US6712767B2 (en) 2002-08-29 2004-03-30 Volcano Therapeutics, Inc. Ultrasonic imaging devices and methods of fabrication
US7189229B2 (en) 2002-09-16 2007-03-13 Prorhythm, Inc. Balloon alignment and collapsing system
US6907884B2 (en) * 2002-09-30 2005-06-21 Depay Acromed, Inc. Method of straddling an intraosseous nerve
US7837676B2 (en) 2003-02-20 2010-11-23 Recor Medical, Inc. Cardiac ablation devices
US20040163655A1 (en) 2003-02-24 2004-08-26 Plc Systems Inc. Method and catheter system applicable to acute renal failure
WO2004091255A1 (ja) 2003-04-01 2004-10-21 Olympus Corporation 超音波振動子及びその製造方法
US20040230116A1 (en) 2003-05-12 2004-11-18 Pharmasonics, Inc. Method and apparatus for detection of ultrasound transducer failure in catheter systems
JP2004363304A (ja) 2003-06-04 2004-12-24 Toshiba Corp 半導体装置の検査方法及び検査装置
US7678104B2 (en) 2003-07-17 2010-03-16 Biosense Webster, Inc. Ultrasound ablation catheter and method for its use
US7670335B2 (en) 2003-07-21 2010-03-02 Biosense Webster, Inc. Ablation device with spiral array ultrasound transducer
US6911935B2 (en) * 2003-08-15 2005-06-28 Siemens Milltronics Process Instruments Inc. Field interchangeable level measurement system
AU2004285412A1 (en) 2003-09-12 2005-05-12 Minnow Medical, Llc Selectable eccentric remodeling and/or ablation of atherosclerotic material
US7396336B2 (en) 2003-10-30 2008-07-08 Sherwood Services Ag Switched resonant ultrasonic power amplifier system
EP1692081A2 (en) 2003-11-29 2006-08-23 Cross Match Technologies, Inc. Piezoelectric device and method of manufacturing same
US8425417B2 (en) 2003-12-05 2013-04-23 Dexcom, Inc. Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device
US7854733B2 (en) * 2004-03-24 2010-12-21 Biosense Webster, Inc. Phased-array for tissue treatment
WO2006005093A1 (de) 2004-07-12 2006-01-19 Mlu - Monitoring Für Leben Und Umwelt Ges. M.B.H. Messeinrichtung und verfahren zum messen mindestens eines unweltparameters
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
ATE511805T1 (de) 2004-09-13 2011-06-15 Biosense Webster Inc Ablationsvorrichtung mit phasengesteuertem array- ultraschallwandler
WO2006033232A1 (ja) 2004-09-21 2006-03-30 Olympus Corporation 超音波振動子、超音波振動子アレイ、及び超音波内視鏡装置
US8521295B2 (en) * 2004-09-23 2013-08-27 Michael D. Laufer Location and deactivation of muscles
WO2006033331A1 (ja) 2004-09-24 2006-03-30 Olympus Corporation 超音波振動子、超音波振動子アレイ、及び超音波内視鏡装置
WO2006044662A2 (en) 2004-10-14 2006-04-27 Prorhythm, Inc. Ablation devices and methods with ultrasonic imaging
JP4559936B2 (ja) 2004-10-21 2010-10-13 アルプス電気株式会社 無電解めっき方法およびこの方法を用いた回路形成方法
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
JP2006161116A (ja) 2004-12-08 2006-06-22 Konica Minolta Holdings Inc 無電解めっきによる電極形成方法及びインクジェットヘッドの製造方法
US8162858B2 (en) 2004-12-13 2012-04-24 Us Hifu, Llc Ultrasonic medical treatment device with variable focal zone
US20060155269A1 (en) 2005-01-12 2006-07-13 Prorhythm, Inc. Epicardial ablation using focused ultrasound
CN100450563C (zh) * 2005-01-31 2009-01-14 重庆海扶(Hifu)技术有限公司 向体内管腔输入介质、管腔导入以及超声波阻挡装置
EP1821368A4 (en) 2005-03-01 2010-12-29 Panasonic Corp CONNECTOR BETWEEN SUBSTRATES AND CIRCUIT BOARD DEVICE USING SAME BETWEEN SUBSTRATES
US20060241523A1 (en) 2005-04-12 2006-10-26 Prorhythm, Inc. Ultrasound generating method, apparatus and probe
US20060270976A1 (en) 2005-05-31 2006-11-30 Prorhythm, Inc. Steerable catheter
US20090118125A1 (en) * 2005-06-15 2009-05-07 Nissan Chemical Industries, Ltd. Water Dispersible Agricultural Chemical Granules and Method of Producing the Same
EP2662044B1 (en) 2005-07-21 2018-10-31 Covidien LP Systems for treating a hollow anatomical structure
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US8734438B2 (en) 2005-10-21 2014-05-27 Covidien Ag Circuit and method for reducing stored energy in an electrosurgical generator
US20070124458A1 (en) 2005-11-30 2007-05-31 Cisco Technology, Inc. Method and system for event notification on network nodes
US20070203547A1 (en) * 2005-12-15 2007-08-30 Costello Benedict J Medical device identification
CA2574934C (en) 2006-01-24 2015-12-29 Sherwood Services Ag System and method for closed loop monitoring of monopolar electrosurgical apparatus
US20070175359A1 (en) 2006-02-01 2007-08-02 Kilnam Hwang Electroless gold plating solution and method
US8790281B2 (en) * 2006-04-20 2014-07-29 The Regents Of The University Of California Method of thermal treatment of myolysis and destruction of benign uterine tumors
US20100198065A1 (en) 2009-01-30 2010-08-05 VyntronUS, Inc. System and method for ultrasonically sensing and ablating tissue
EP2540246B8 (en) 2006-05-12 2020-10-07 Vytronus, Inc. Device for ablating body tissue
WO2007135875A1 (en) 2006-05-19 2007-11-29 Daikin Industries, Ltd. Silicone-containing thermoplastic fluororesin composition, article molded therefrom, and process for preparing silicone-containing thermoplastic fluororesin composition
US10499937B2 (en) 2006-05-19 2019-12-10 Recor Medical, Inc. Ablation device with optimized input power profile and method of using the same
DE602007011813D1 (de) 2006-06-28 2011-02-17 Ardian Inc Systeme für wärmeinduzierte renale Neuromodulation
US7652411B2 (en) 2006-09-18 2010-01-26 Medicis Technologies Corporation Transducer with shield
ES2546773T3 (es) 2006-10-18 2015-09-28 Vessix Vascular, Inc. Energía de RF sintonizada y caracterización eléctrica de tejido para el tratamiento selectivo de tejidos diana
US8192363B2 (en) 2006-10-27 2012-06-05 Ekos Corporation Catheter with multiple ultrasound radiating members
JP4513802B2 (ja) 2006-12-20 2010-07-28 セイコーエプソン株式会社 印刷装置
JP2008214669A (ja) 2007-03-01 2008-09-18 Matsushita Electric Ind Co Ltd 電子部品のめっき装置およびめっき方法
US7581296B2 (en) 2007-04-11 2009-09-01 Ge Inspection Technologies, Lp Acoustic stack for ultrasonic transducers and method for manufacturing same
WO2008128070A2 (en) 2007-04-11 2008-10-23 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
US10183183B2 (en) 2007-04-13 2019-01-22 Acoustic Medsystems, Inc. Acoustic applicators for controlled thermal modification of tissue
JP5461988B2 (ja) 2007-07-02 2014-04-02 株式会社Ｊｃｕ 金属積層ポリイミド基盤及びその製造方法
EP2166951A2 (en) 2007-07-11 2010-03-31 Koninklijke Philips Electronics N.V. Ultrasonic assembly with adjustable fluid lens
DE102007046951B3 (de) 2007-10-01 2009-02-26 B. Braun Melsungen Ag Vorrichtung zum Einführen eines Medikaments in einen Infusionsbehälter
US8439907B2 (en) 2007-11-07 2013-05-14 Mirabilis Medica Inc. Hemostatic tissue tunnel generator for inserting treatment apparatus into tissue of a patient
US8115367B2 (en) 2007-11-26 2012-02-14 Sii Nanotechnology Inc. Piezoelectric actuator provided with a displacement meter, piezoelectric element, and positioning device
US9107690B2 (en) 2007-12-03 2015-08-18 Covidien Ag Battery-powered hand-held ultrasonic surgical cautery cutting device
US10492854B2 (en) 2007-12-05 2019-12-03 Biosense Webster, Inc. Catheter-based acoustic radiation force impulse system
WO2009077939A1 (en) 2007-12-14 2009-06-25 Koninklijke Philips Electronics N.V. Adjustable lens system for real-time applications
US8562600B2 (en) 2007-12-27 2013-10-22 St. Jude Medical, Atrial Fibrillation Division, Inc. Integration of control software with a medical device and system
US20090248011A1 (en) 2008-02-28 2009-10-01 Hlavka Edwin J Chronic venous insufficiency treatment
US20090228003A1 (en) 2008-03-04 2009-09-10 Prorhythm, Inc. Tissue ablation device using radiofrequency and high intensity focused ultrasound
KR101719824B1 (ko) * 2008-05-09 2017-04-04 호라이라 인코포레이티드 기관지나무 치료용 시스템, 어셈블리 및 방법
US8133222B2 (en) 2008-05-28 2012-03-13 Medwaves, Inc. Tissue ablation apparatus and method using ultrasonic imaging
US8197413B2 (en) 2008-06-06 2012-06-12 Boston Scientific Scimed, Inc. Transducers, devices and systems containing the transducers, and methods of manufacture
US9155588B2 (en) 2008-06-13 2015-10-13 Vytronus, Inc. System and method for positioning an elongate member with respect to an anatomical structure
US20100152582A1 (en) 2008-06-13 2010-06-17 Vytronus, Inc. Handheld system and method for delivering energy to tissue
US20090312693A1 (en) 2008-06-13 2009-12-17 Vytronus, Inc. System and method for delivering energy to tissue
WO2009152354A1 (en) 2008-06-14 2009-12-17 Vytronus, Inc. System and method for delivering energy to tissue
US10363057B2 (en) 2008-07-18 2019-07-30 Vytronus, Inc. System and method for delivering energy to tissue
US20100049099A1 (en) 2008-07-18 2010-02-25 Vytronus, Inc. Method and system for positioning an energy source
AU2009292987A1 (en) 2008-09-22 2010-03-25 Vessix Vascular, Inc Inducing desirable temperature effects on body tissue using alternate energy sources
US8414508B2 (en) 2008-10-30 2013-04-09 Vytronus, Inc. System and method for delivery of energy to tissue while compensating for collateral tissue
US9033885B2 (en) 2008-10-30 2015-05-19 Vytronus, Inc. System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion
US9192789B2 (en) 2008-10-30 2015-11-24 Vytronus, Inc. System and method for anatomical mapping of tissue and planning ablation paths therein
US8475379B2 (en) 2008-11-17 2013-07-02 Vytronus, Inc. Systems and methods for ablating body tissue
US8923970B2 (en) 2008-12-09 2014-12-30 Nephera Ltd. Stimulation of the urinary system
CN102307618B (zh) 2008-12-09 2014-03-12 内费拉有限公司 泌尿系统的刺激
US8882672B2 (en) 2008-12-29 2014-11-11 Perseus-Biomed Inc. Method and system for tissue imaging and analysis
US8870772B2 (en) 2008-12-29 2014-10-28 Perseus-Biomed Inc. Method and system for tissue recognition
US8864669B2 (en) 2008-12-29 2014-10-21 Perseus-Biomed Inc. Method and system for tissue imaging and analysis
US8712550B2 (en) 2008-12-30 2014-04-29 Biosense Webster, Inc. Catheter with multiple electrode assemblies for use at or near tubular regions of the heart
US20100168739A1 (en) 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8808345B2 (en) 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
EP2376011B1 (en) 2009-01-09 2019-07-03 ReCor Medical, Inc. Apparatus for treatment of mitral valve insufficiency
JP2010184913A (ja) 2009-02-13 2010-08-26 Freunt Ind Co Ltd 微生物または生物由来物質含有微細粒子およびその製造方法
KR101764439B1 (ko) 2009-04-22 2017-08-02 머케이터 메드시스템즈, 인크. 국소 혈관 운반으로 고혈압을 치료하는 구아네티딘의 용도
US8287472B2 (en) 2009-04-30 2012-10-16 Boston Scientific Scimed, Inc. Ultrasound heater-agitator for thermal tissue treatment
KR101619380B1 (ko) 2009-05-14 2016-05-11 삼성디스플레이 주식회사 식각액 조성물 및 이를 이용한 어레이 기판의 제조방법
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
EP2344039B1 (en) 2009-10-12 2015-11-25 Kona Medical, Inc. Energetic modulation of nerves
US20110257563A1 (en) 2009-10-26 2011-10-20 Vytronus, Inc. Methods and systems for ablating tissue
US20120209118A1 (en) * 2009-10-30 2012-08-16 Sound Interventions Method and apparatus for non-invasive treatment of hypertension through ultrasound renal denervation
JP5768056B2 (ja) 2009-10-30 2015-08-26 リコール メディカル インコーポレイテッドＲｅＣｏｒ Ｍｅｄｉｃａｌ， Ｉｎｃ． 経皮的超音波腎神経除去による高血圧症を治療するための方法及び装置
US20110112400A1 (en) 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
US20110263921A1 (en) 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
WO2011088399A1 (en) 2010-01-18 2011-07-21 Stanford University Method and apparatus for radioablation of regular targets such as sympathetic nerves
EP2525715A4 (en) 2010-01-19 2014-06-04 Medtronic Ardian Luxembourg S R L METHODS AND APPARATUS FOR RENAL NEUROMODULATION BY STEREOTACTIC RADIOTHERAPY
CN102892454B (zh) 2010-01-26 2016-01-20 迈克尔·A·埃文斯 用于去神经支配的方法、装置以及药剂
US9743980B2 (en) 2010-02-24 2017-08-29 Safepass Vascular Ltd Method and system for assisting a wire guide to cross occluded ducts
US20110257562A1 (en) 2010-04-01 2011-10-20 Alan Schaer Method and apparatus employing ultrasound energy to remodulate vascular nerves
AU2011238925B2 (en) 2010-04-09 2016-06-16 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
JP5649322B2 (ja) 2010-04-12 2015-01-07 三菱電機株式会社 半導体装置および半導体装置の製造方法
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
CN103096826B (zh) 2010-04-26 2016-07-20 美敦力阿迪安卢森堡有限公司 用于肾神经调节的导管设备、系统和方法
US20120065554A1 (en) 2010-09-09 2012-03-15 Michael Pikus Dual Balloon Ablation Catheter with Vessel Deformation Arrangement for Renal Nerve Ablation
US20120095371A1 (en) 2010-10-18 2012-04-19 CardioSonic Ltd. Ultrasound transducer and cooling thereof
WO2012052924A1 (en) 2010-10-18 2012-04-26 CardioSonic Ltd. Separation device for ultrasound element
EP2661304A1 (en) 2010-10-18 2013-11-13 Cardiosonic Ltd. Therapeutics reservoir
US9566456B2 (en) 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
US20120215106A1 (en) 2010-10-18 2012-08-23 CardioSonic Ltd. Tissue treatment
CN103313671B (zh) 2010-10-25 2017-06-06 美敦力Af卢森堡有限责任公司 用于神经调节治疗的估算及反馈的装置、系统及方法
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
WO2012068471A1 (en) 2010-11-19 2012-05-24 Boston Scientific Scimed, Inc. Renal nerve detection and ablation apparatus and method
US10016233B2 (en) 2010-12-06 2018-07-10 Biosense Webster (Israel) Ltd. Treatment of atrial fibrillation using high-frequency pacing and ablation of renal nerves
US9308041B2 (en) 2010-12-22 2016-04-12 Biosense Webster (Israel) Ltd. Lasso catheter with rotating ultrasound transducer
JP2014512882A (ja) 2011-02-18 2014-05-29 リコール メディカル インコーポレイテッド 超音波を用いる腎臓神経除去装置
EP2521593B1 (en) 2011-03-15 2015-12-09 Kona Medical, Inc. Energetic modulation of nerves
EP2696791A4 (en) 2011-04-13 2014-10-29 Vytronus Inc INTEGRATED ABLATION AND ASSIGNMENT SYSTEM
EP2717795A4 (en) 2011-06-06 2015-01-28 St Jude Medical NIERENDENVIERUNG SYSTEM AND METHOD
US20140200489A1 (en) 2011-09-01 2014-07-17 Perseus-Biomed Inc Method and system for tissue modulation
US20130090650A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Renal nerve ablation cooling device and technique
JP5898336B2 (ja) 2011-12-23 2016-04-06 べシックス・バスキュラー・インコーポレイテッド 拡張可能なバルーン及び熱感知デバイスを備えた電極パッドを含むデバイス
AU2013215164A1 (en) 2012-01-30 2014-08-14 Vytronus, Inc. Tissue necrosis methods and apparatus
AU2013230776B2 (en) * 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Immune system neuromodulation and associated systems and methods
WO2013150777A1 (ja) * 2012-04-05 2013-10-10 テルモ株式会社 血管挿入型治療デバイス
US9439722B2 (en) 2012-05-09 2016-09-13 Biosense Webster (Israel) Ltd. Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
WO2014012053A1 (en) 2012-07-13 2014-01-16 Boston Scientific Scimed, Inc. Off -wall electrode devices for nerve modulation
US20140025069A1 (en) 2012-07-17 2014-01-23 Boston Scientific Scimed, Inc. Renal nerve modulation catheter design
WO2014036160A2 (en) 2012-08-28 2014-03-06 Boston Scientific Scimed, Inc. Renal nerve modulation and ablation catheter electrode design
CN104768487A (zh) 2012-09-13 2015-07-08 波士顿科学西美德公司 肾脏神经调节球囊及其制造和使用方法
EP2938401A2 (en) 2012-12-31 2015-11-04 Perseus-Biomed Inc. Phased array energy aiming and tracking for ablation treatment
US20140249524A1 (en) 2013-03-01 2014-09-04 Boston Scientific Scimed, Inc. System and method for performing renal nerve modulation
USD712353S1 (en) 2013-03-04 2014-09-02 Medtronic Ardian Luxembourg S.A.R.L. Generator system
USD697036S1 (en) 2013-03-04 2014-01-07 Medtronic Ardian Luxembourg S.A.R.L. Remote control
USD712352S1 (en) 2013-03-04 2014-09-02 Medtronic Ardian Luxembourg S.A.R.L. Generator
USD712833S1 (en) 2013-03-04 2014-09-09 Medtronic Ardian Luxembourg S.A.R.L. Generator system
USD708810S1 (en) 2013-03-04 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Generator cart
EP2968931B1 (en) 2013-03-12 2022-03-16 Boston Scientific Scimed, Inc. Medical systems and methods for modulating nerves
US8876813B2 (en) 2013-03-14 2014-11-04 St. Jude Medical, Inc. Methods, systems, and apparatus for neural signal detection
EP2968984B1 (en) 2013-03-14 2016-08-17 ReCor Medical, Inc. Ultrasound-based neuromodulation system
WO2014159273A1 (en) 2013-03-14 2014-10-02 Recor Medical, Inc. Methods of plating or coating ultrasound transducers
JP6220044B2 (ja) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経アブレーションのための医療用デバイス
US9179973B2 (en) 2013-03-15 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods for renal denervation utilizing balloon catheter
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
US9770606B2 (en) * 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
EP2907464A1 (en) 2014-02-12 2015-08-19 Perseus-Biomed Inc. Methods and systems for treating nerve structures
US9795780B2 (en) * 2014-12-18 2017-10-24 Abbott Cardiovascular Systems Inc. System for denervation
AU2016262085B2 (en) * 2015-05-12 2020-10-22 National University Of Ireland Galway Devices for therapeutic nasal neuromodulation and associated methods and systems

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308356A (en) * 1993-02-25 1994-05-03 Blackshear Jr Perry L Passive perfusion angioplasty catheter
CN1269708A (zh) * 1997-07-08 2000-10-11 加利福尼亚大学董事会 周缘消融装置组件和方法
US20050240126A1 (en) * 1999-09-17 2005-10-27 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
US7510536B2 (en) * 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
US20070135875A1 (en) * 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
CN101084038A (zh) * 2004-10-05 2007-12-05 阿迪安公司 肾神经调节的方法和装置
CN101472531A (zh) * 2006-06-23 2009-07-01 圣朱德医疗有限公司房颤分公司 消融组织的器械和方法
WO2008151001A2 (en) * 2007-05-30 2008-12-11 The Cleveland Clinic Foundation Method for treating a renal disease or disorder

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105939758A (zh) * 2013-11-04 2016-09-14 引导干预有限公司 用于以离焦超声执行热支气管成形术的方法和设备
CN104107082A (zh) * 2014-07-28 2014-10-22 无锡市贝尔康电子研究所 一种水囊扩张精准可控的超导可视仿生仪
CN104107082B (zh) * 2014-07-28 2017-10-20 无锡市贝尔康电子研究所 一种水囊扩张精准可控的超导可视仿生仪
CN104383646A (zh) * 2014-12-12 2015-03-04 黄晶 一种超声介入治疗系统
CN104383646B (zh) * 2014-12-12 2020-04-24 黄晶 一种超声介入治疗系统
CN105796173A (zh) * 2014-12-31 2016-07-27 上海形状记忆合金材料有限公司 多声束超声消融导管系统
CN105796173B (zh) * 2014-12-31 2018-08-28 上海形状记忆合金材料有限公司 多声束超声消融导管系统
CN113905772A (zh) * 2018-05-08 2022-01-07 阿比奥梅德公司 使用心脏辅助装置改善肾功能
CN115252060A (zh) * 2022-07-01 2022-11-01 深圳心寰科技有限公司 用于治疗慢性阻塞性肺炎的支气管介入超声治疗设备及介入方法

Also Published As

Publication number Publication date
KR20160130329A (ko) 2016-11-10
US20120232436A1 (en) 2012-09-13
US9981108B2 (en) 2018-05-29
KR20120101658A (ko) 2012-09-14
US20150290427A1 (en) 2015-10-15
US20180361117A1 (en) 2018-12-20
HK1220153A1 (zh) 2017-04-28
JP2013509266A (ja) 2013-03-14
JP2015107333A (ja) 2015-06-11
CN102596320B (zh) 2016-09-07
AU2016200432A1 (en) 2016-02-18
JP6412790B2 (ja) 2018-10-24
US20140031727A1 (en) 2014-01-30
EP2995350A1 (en) 2016-03-16
EP2493569B1 (en) 2015-09-30
EP2995350B1 (en) 2016-08-03
EP3132828A1 (en) 2017-02-22
US9943666B2 (en) 2018-04-17
JP6571719B2 (ja) 2019-09-04
KR101988708B1 (ko) 2019-06-12
US11185662B2 (en) 2021-11-30
AU2016200432B2 (en) 2017-11-09
IL219252A0 (en) 2012-06-28
AU2010313379B2 (en) 2015-11-05
JP5768056B2 (ja) 2015-08-26
US20220126062A1 (en) 2022-04-28
AU2010313379A1 (en) 2012-06-07
US10039901B2 (en) 2018-08-07
WO2011053757A1 (en) 2011-05-05
EP2493569A1 (en) 2012-09-05
CA2779386C (en) 2018-09-11
JP2017196461A (ja) 2017-11-02
EP3132828B1 (en) 2017-10-11
KR101673574B1 (ko) 2016-11-07
CA2779386A1 (en) 2011-05-05

Similar Documents

Publication Publication Date Title
CN102596320A (zh) 通过经皮超声波去肾神经治疗高血压的方法和装置
US9192790B2 (en) Focused ultrasonic renal denervation
US20160287912A1 (en) Method and apparatus for performance of thermal bronchiplasty with unfocused ultrasound
US11565135B2 (en) Method and apparatus for pulmonary interventions
WO2014022777A1 (en) Method and apparatus for treatment of hypertension through an ultrasound imaging/therapy catheter
WO2024081159A1 (en) Method and apparatus for treatment of pulmonary conditions

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: RECOR MEDICAL, INC.

Free format text: FORMER OWNER: SOUND INTERVENTIONS INC.

Effective date: 20150805

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20150805

Address after: American California

Applicant after: RECOR MEDICAL INC.

Address before: Stoney Brooke, New York, USA

Applicant before: Sound Interventions Inc.

C14 Grant of patent or utility model
GR01 Patent grant