ZA992972B - N-(3-ethynylphenylamino)-6, 7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate. - Google Patents

N-(3-ethynylphenylamino)-6, 7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate.

Info

Publication number
ZA992972B
ZA992972B ZA9902972A ZA992972A ZA992972B ZA 992972 B ZA992972 B ZA 992972B ZA 9902972 A ZA9902972 A ZA 9902972A ZA 992972 A ZA992972 A ZA 992972A ZA 992972 B ZA992972 B ZA 992972B
Authority
ZA
South Africa
Prior art keywords
ethynylphenylamino
methoxyethoxy
monohydrate
bis
quinazolinamine mesylate
Prior art date
Application number
ZA9902972A
Other languages
English (en)
Inventor
Douglas John Meldrum Allen
Timothy Norris
Jeffrey William Raggon
Dinos Paul Santafianos
Ravi Mysore Shanker
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ZA992972B publication Critical patent/ZA992972B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9902972A 1998-04-29 1999-04-28 N-(3-ethynylphenylamino)-6, 7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate. ZA992972B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8344198P 1998-04-29 1998-04-29

Publications (1)

Publication Number Publication Date
ZA992972B true ZA992972B (en) 2000-10-30

Family

ID=22178359

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9902972A ZA992972B (en) 1998-04-29 1999-04-28 N-(3-ethynylphenylamino)-6, 7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate.

Country Status (41)

Country Link
EP (1) EP1076652B1 (cs)
JP (1) JP4652569B2 (cs)
KR (1) KR100668412B1 (cs)
CN (2) CN1298396A (cs)
AP (1) AP1252A (cs)
AR (1) AR018201A1 (cs)
AT (1) ATE295839T1 (cs)
AU (1) AU759691C (cs)
BR (1) BR9910025A (cs)
CA (1) CA2330447C (cs)
CO (1) CO5060467A1 (cs)
CZ (1) CZ298230B6 (cs)
DE (1) DE69925366T2 (cs)
DZ (1) DZ2777A1 (cs)
EA (1) EA002836B1 (cs)
EG (1) EG24000A (cs)
ES (1) ES2238825T3 (cs)
GT (1) GT199900063A (cs)
HN (1) HN1999000057A (cs)
HU (1) HU227569B1 (cs)
ID (1) ID27198A (cs)
IL (1) IL139172A0 (cs)
MA (1) MA26624A1 (cs)
ME (1) MEP42008A (cs)
MX (1) MXPA00010610A (cs)
MY (1) MY136033A (cs)
NO (1) NO317301B1 (cs)
NZ (1) NZ508154A (cs)
OA (1) OA11769A (cs)
PA (1) PA8471001A1 (cs)
PE (1) PE20000441A1 (cs)
PL (1) PL196940B1 (cs)
RS (1) RS50081B (cs)
SA (1) SA99200216B1 (cs)
TN (1) TNSN99079A1 (cs)
TR (1) TR200003166T2 (cs)
TW (1) TWI248437B (cs)
UA (1) UA60363C2 (cs)
UY (1) UY26099A1 (cs)
WO (1) WO1999055683A1 (cs)
ZA (1) ZA992972B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706721B1 (en) 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
YU13200A (sh) 1999-03-31 2002-10-18 Pfizer Products Inc. Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
UA74803C2 (uk) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
US7132427B2 (en) 2001-06-21 2006-11-07 Ariad Pharmaceuticals, Inc. Quinazolines and uses thereof
US7078409B2 (en) 2002-03-28 2006-07-18 Beta Pharma, Inc. Fused quinazoline derivatives useful as tyrosine kinase inhibitors
GB0223854D0 (en) * 2002-10-12 2002-11-20 Astrazeneca Ab Therapeutic treatment
US7148231B2 (en) * 2003-02-17 2006-12-12 Hoffmann-La Roche Inc. [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
EP2348110B1 (en) 2003-05-30 2013-03-27 OncoTherapy Science, Inc. Process for screening a drug response in cancer patients
KR100753385B1 (ko) 2003-06-10 2007-08-30 에프. 호프만-라 로슈 아게 1,3,4-트리아자-페날린 및 1,3,4,6-테트라아자페날린유도체
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
BRPI0510717B8 (pt) 2004-05-06 2021-05-25 Bioresponse Llc uso de 3,3' diindolilmetano (dim) ou 2-(indol-3-ilmetil)-3,3´-diindolilmetano (ltr)
CA2593084C (en) 2004-12-30 2014-03-18 Bioresponse, Llc Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
WO2008012105A1 (en) 2006-07-28 2008-01-31 Synthon B.V. Crystalline erlotinib
US8586621B2 (en) 2006-10-27 2013-11-19 Michael A. Zeligs Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
CA2682013C (en) * 2007-04-04 2015-06-30 Cipla Limited Process for preparation of erlotinib and its pharmaceutically acceptable salts
WO2009007984A2 (en) 2007-07-11 2009-01-15 Hetero Drugs Limited An improved process for erlotinib hydrochloride
US20100136116A1 (en) 2007-08-17 2010-06-03 Hetero Drugs Limited Novel hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form b
KR101132937B1 (ko) * 2008-10-01 2012-04-06 주식회사종근당 Ｎ-(3-에티닐페닐)-6,7-비스(2-메톡시에톡시)-4-퀴나졸린아민 납실레이트 염
CN102438995B (zh) 2009-03-26 2014-12-17 兰贝克赛实验室有限公司 厄洛替尼或其药学上可接受的盐的制备工艺
WO2011068404A2 (en) 2009-12-02 2011-06-09 Ultimorphix Technologies B.V. Administration of n-(3-ethynylphenylamino)-6,7-bis(2- methoxyethoxy)-4-quinazolinamine mesylate salt by inhalation
DE202010006543U1 (de) 2010-05-07 2010-09-09 Ratiopharm Gmbh Erlotinibresinat
HU230483B1 (hu) 2011-10-10 2016-07-28 Egis Gyógyszergyár Nyrt. Erlotinib sók
US9593083B2 (en) 2012-09-04 2017-03-14 Shilpa Medicare Limited Crystalline erlotinib hydrochloride process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243082A (en) * 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
JP2994165B2 (ja) * 1992-06-26 1999-12-27 ゼネカ・リミテッド キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
GB9323290D0 (en) * 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
WO1996030347A1 (en) * 1995-03-30 1996-10-03 Pfizer Inc. Quinazoline derivatives
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines

Also Published As

Publication number Publication date
KR20010078710A (ko) 2001-08-21
PA8471001A1 (es) 2000-09-29
GT199900063A (es) 2000-10-20
IL139172A0 (en) 2001-11-25
MXPA00010610A (es) 2002-07-02
NO20005453D0 (no) 2000-10-27
ATE295839T1 (de) 2005-06-15
UY26099A1 (es) 2001-12-28
YU66100A (sh) 2003-07-07
CA2330447C (en) 2009-06-30
NO20005453L (no) 2000-12-20
PL196940B1 (pl) 2008-02-29
AP9901523A0 (en) 1999-06-30
HUP0101818A3 (en) 2002-05-28
CZ20003974A3 (en) 2001-05-16
CA2330447A1 (en) 1999-11-04
DE69925366T2 (de) 2006-03-09
DZ2777A1 (fr) 2003-12-01
AU759691B2 (en) 2003-04-17
CZ298230B6 (cs) 2007-08-01
AU2850999A (en) 1999-11-16
AP1252A (en) 2004-02-25
ES2238825T3 (es) 2005-09-01
TWI248437B (en) 2006-02-01
SA99200216B1 (ar) 2006-06-04
KR100668412B1 (ko) 2007-01-12
CO5060467A1 (es) 2001-07-30
NO317301B1 (no) 2004-10-04
TNSN99079A1 (fr) 2005-11-10
CN1298396A (zh) 2001-06-06
UA60363C2 (uk) 2003-10-15
TR200003166T2 (tr) 2001-02-21
BR9910025A (pt) 2000-12-26
CN101219999A (zh) 2008-07-16
WO1999055683A1 (en) 1999-11-04
MA26624A1 (fr) 2004-12-20
EP1076652A1 (en) 2001-02-21
HN1999000057A (es) 1999-09-29
AR018201A1 (es) 2001-10-31
HU227569B1 (en) 2011-08-29
EP1076652B1 (en) 2005-05-18
OA11769A (en) 2005-07-25
PL343766A1 (en) 2001-09-10
HK1037180A1 (en) 2002-02-01
JP4652569B2 (ja) 2011-03-16
MY136033A (en) 2008-07-31
RS50081B (sr) 2009-01-22
PE20000441A1 (es) 2000-05-23
HUP0101818A1 (hu) 2002-03-28
ID27198A (id) 2001-03-08
JP2002513009A (ja) 2002-05-08
MEP42008A (en) 2011-02-10
EA002836B1 (ru) 2002-10-31
EA200001112A1 (ru) 2001-04-23
NZ508154A (en) 2003-07-25
AU759691C (en) 2004-04-29
EG24000A (en) 2008-03-19
DE69925366D1 (de) 2005-06-23

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