ZA987741B - Process for the preparation of oxazaphosphorine-2-amines - Google Patents

Process for the preparation of oxazaphosphorine-2-amines

Info

Publication number
ZA987741B
ZA987741B ZA987741A ZA987741A ZA987741B ZA 987741 B ZA987741 B ZA 987741B ZA 987741 A ZA987741 A ZA 987741A ZA 987741 A ZA987741 A ZA 987741A ZA 987741 B ZA987741 B ZA 987741B
Authority
ZA
South Africa
Prior art keywords
oxazaphosphorine
amines
preparation
Prior art date
Application number
ZA987741A
Other languages
English (en)
Inventor
Ulf Dr Niemeyer
Harald Dr Niegel
Bernhard Prof Kutscher
Ion Dr Neda
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of ZA987741B publication Critical patent/ZA987741B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA987741A 1997-09-06 1998-08-26 Process for the preparation of oxazaphosphorine-2-amines ZA987741B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19739159A DE19739159C1 (de) 1997-09-06 1997-09-06 Verfahren zur Herstellung von Oxazaphosphorin-2-aminen

Publications (1)

Publication Number Publication Date
ZA987741B true ZA987741B (en) 1998-10-08

Family

ID=7841505

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA987741A ZA987741B (en) 1997-09-06 1998-08-26 Process for the preparation of oxazaphosphorine-2-amines

Country Status (19)

Country Link
US (1) US6187941B1 (ja)
EP (1) EP1012152B1 (ja)
JP (1) JP4278859B2 (ja)
CN (1) CN1147498C (ja)
AR (1) AR013467A1 (ja)
AT (1) ATE225797T1 (ja)
BR (1) BR9814266B1 (ja)
CA (1) CA2301104C (ja)
DE (2) DE19739159C1 (ja)
DK (1) DK1012152T3 (ja)
ES (1) ES2185220T3 (ja)
HK (1) HK1030422A1 (ja)
HU (1) HU226887B1 (ja)
IL (1) IL134507A (ja)
IN (1) IN186170B (ja)
PL (1) PL190097B1 (ja)
PT (1) PT1012152E (ja)
WO (1) WO1999012942A1 (ja)
ZA (1) ZA987741B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1607204B (zh) * 2003-10-13 2011-10-26 北京大学 环磷酰胺季铵盐衍生物及其合成和应用
US20110054081A1 (en) * 2009-09-02 2011-03-03 Frank Dierschke Formulation and its use
FR2968662B1 (fr) * 2010-12-10 2013-11-22 Roussy Inst Gustave Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation
US20180086780A1 (en) 2015-04-02 2018-03-29 Przedsiebiorstwo Produkcyjno-Wdrozeniowe Ifotam Sp. Z O.O. Method of production of n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxazaphosphorine-2-amine 2-oxide
CN107936061B (zh) * 2017-12-28 2019-08-06 山东铂源药业有限公司 一种环磷酰胺的合成方法
CN109535201B (zh) * 2019-01-25 2020-04-03 连云港贵科药业有限公司 一种环磷酰胺的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE554888A (ja) * 1956-12-20
DE1645921C3 (de) * 1966-07-11 1978-10-12 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld 2-Oxo-13,2-osazaphosphorinane, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US3732340A (en) * 1966-07-11 1973-05-08 Asta Werke Ag Chem Fab N',o-propylene phosphoric acid ester diamides
GB1235022A (en) * 1969-06-04 1971-06-09 Laeaeke Ag A new method for the production of cyclophosphamide
JPS54157580A (en) * 1978-05-29 1979-12-12 Otsuka Pharmaceut Co Ltd Optically active oxazaphosphorine derivative
JPS54157581A (en) * 1978-05-29 1979-12-12 Otsuka Pharmaceut Co Ltd Oxazaphosphorine derivative
PL119971B1 (en) * 1978-11-06 1982-02-27 Polska Akad Nauk Centrum Process for preparing optically active derivatives of 1,3,2-oxazaphosphorinane,2-oksazofosforinata
JPS5826919B2 (ja) * 1978-11-07 1983-06-06 大塚製薬株式会社 シクロ↓−１，３，２↓−オキサアザホスホル誘導体の製造法
JPS5931787A (ja) * 1982-08-13 1984-02-20 Otsuka Pharmaceut Co Ltd １，３，２−オキサアザホスホリナン−２−オキシド誘導体
PL149593B1 (pl) * 1986-12-18 1990-02-28 Sposób wytwarzania n-acylowych pochodnych 1 , 3 , 2-oksazafosforinanu

Also Published As

Publication number Publication date
IL134507A0 (en) 2001-04-30
JP4278859B2 (ja) 2009-06-17
DE19739159C1 (de) 1999-01-28
HUP0003496A3 (en) 2002-12-28
WO1999012942A1 (de) 1999-03-18
BR9814266A (pt) 2001-10-09
HU226887B1 (en) 2010-01-28
BR9814266B1 (pt) 2009-05-05
CN1147498C (zh) 2004-04-28
CA2301104A1 (en) 1999-03-18
CA2301104C (en) 2009-10-20
ATE225797T1 (de) 2002-10-15
HUP0003496A2 (hu) 2002-11-28
AR013467A1 (es) 2000-12-27
DK1012152T3 (da) 2003-02-10
US6187941B1 (en) 2001-02-13
IN186170B (ja) 2001-06-30
DE59805920D1 (de) 2002-11-14
EP1012152A1 (de) 2000-06-28
PL339188A1 (en) 2000-12-04
ES2185220T3 (es) 2003-04-16
IL134507A (en) 2004-06-20
HK1030422A1 (en) 2001-05-04
EP1012152B1 (de) 2002-10-09
PT1012152E (pt) 2003-02-28
PL190097B1 (pl) 2005-10-31
CN1268950A (zh) 2000-10-04
JP2001515910A (ja) 2001-09-25

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