ZA987676B - 3-amidinoaniline derivatives activated blood coagulation factor X inhibitors and intermediates thereof - Google Patents

3-amidinoaniline derivatives activated blood coagulation factor X inhibitors and intermediates thereof

Info

Publication number
ZA987676B
ZA987676B ZA987676A ZA987676A ZA987676B ZA 987676 B ZA987676 B ZA 987676B ZA 987676 A ZA987676 A ZA 987676A ZA 987676 A ZA987676 A ZA 987676A ZA 987676 B ZA987676 B ZA 987676B
Authority
ZA
South Africa
Prior art keywords
intermediates
inhibitors
blood coagulation
coagulation factor
activated blood
Prior art date
Application number
ZA987676A
Other languages
English (en)
Inventor
Satoshi Akahane
Masahiko Uchida
Hidetoshi Isawa
Norihiko Kikuchi
Tomonaga Ozawa
Horiaki Kobayashi
Yuichiro Kai
Kenji Akahane
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of ZA987676B publication Critical patent/ZA987676B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA987676A 1997-08-27 1998-08-25 3-amidinoaniline derivatives activated blood coagulation factor X inhibitors and intermediates thereof ZA987676B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27185397 1997-08-27

Publications (1)

Publication Number Publication Date
ZA987676B true ZA987676B (en) 1999-02-25

Family

ID=17505799

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA987676A ZA987676B (en) 1997-08-27 1998-08-25 3-amidinoaniline derivatives activated blood coagulation factor X inhibitors and intermediates thereof

Country Status (11)

Country Link
EP (1) EP1020434A4 (fr)
KR (1) KR20010023364A (fr)
CN (1) CN1268116A (fr)
AR (1) AR016868A1 (fr)
AU (1) AU8747598A (fr)
CA (1) CA2301559A1 (fr)
CO (1) CO4970693A1 (fr)
IL (1) IL134394A0 (fr)
PE (1) PE107999A1 (fr)
WO (1) WO1999010316A1 (fr)
ZA (1) ZA987676B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545055B1 (en) 1999-05-24 2003-04-08 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
EP1183235A2 (fr) 1999-05-24 2002-03-06 Cor Therapeutics, Inc. INHIBITEURS DU FACTEUR Xa
DE10041402A1 (de) * 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
EP1095933A1 (fr) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH N-guanidinoalkylamides, procédé de leur préparation, leur utilisation et compositions pharmaceutiques les contenant
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
WO2001064642A2 (fr) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides et inhibiteurs connexes du facteur xa
DE10027025A1 (de) * 2000-05-31 2001-12-06 Merck Patent Gmbh Clycinamide
DE10036121A1 (de) * 2000-07-25 2002-02-07 Merck Patent Gmbh N-Substituierte-1-amino-1,1-dialkyl-carbonsäurederivate
DE10040783A1 (de) 2000-08-21 2002-03-07 Merck Patent Gmbh AZA-Aminosäurederivate (Faktor X¶a¶-Inhibitoren 15)
DE10050723A1 (de) * 2000-10-13 2002-04-25 Merck Patent Gmbh N-Substituierte Aminosäurederivate (Faktor Xa Inhibitoren 12)
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
DE10130374A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Substituierte N-Acyl-anilinderivate, deren Herstellung und deren Verwendung als Arzneimittel
JPWO2003040086A1 (ja) * 2001-11-09 2005-03-03 キッセイ薬品工業株式会社 ５−アミジノ−２−ヒドロキシベンゼンスルホンアミド誘導体、それを含有する医薬組成物、その医薬用途およびその製造中間体
CA2479254A1 (fr) * 2002-03-22 2003-10-02 Kissei Pharmaceutical Co., Ltd. Agent preventif ou therapeutique pour nephropathie
DE10220048A1 (de) * 2002-05-04 2003-11-13 Merck Patent Gmbh Semicarbazidderivate
HUE025683T2 (hu) 2002-12-03 2016-04-28 Pharmacyclics Llc VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok
WO2005034867A2 (fr) 2003-10-09 2005-04-21 Millennium Pharmaceuticals, Inc. Utilisation de benzamides a substitution thioether en tant qu'inhibiteurs du facteur xa
BRPI0512273A (pt) 2004-06-18 2008-02-19 Millennium Pharm Inc inibidores do fator xa
US7329656B2 (en) 2004-10-08 2008-02-12 H. Lundbeck A/S Arylthiobenzylpiperidine derivatives
US7446204B2 (en) 2004-10-08 2008-11-04 H. Lundbeck A/S Amino substituted aryloxybenzylpiperidine derivatives
US20080132507A1 (en) * 2004-10-13 2008-06-05 Eisai R&D Management Co., Ltd. Hydrazide Derivatives
WO2006055951A2 (fr) 2004-11-19 2006-05-26 Portola Pharmaceuticals, Inc. Tetrahydroisoquinolines comme inhibiteurs du facteur xa
WO2006063113A2 (fr) 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. Urees utilisees comme inhibiteurs du facteur xa
JP4900238B2 (ja) 2005-02-02 2012-03-21 味の素株式会社 新規ベンズアミジン化合物
CA2627086C (fr) 2005-11-08 2016-04-05 Millennium Pharmaceuticals, Inc. Nouveaux sels pharmaceutiques et polymorphes d'un inhibiteur du facteur xa
ATE557010T1 (de) 2006-03-24 2012-05-15 Eisai R&D Man Co Ltd Triazolonderivat
PT2077995E (pt) 2006-11-02 2012-05-10 Millennium Pharm Inc Métodos de sintetizar sais farmacêuticos de um inibidor de fator xa
WO2009038157A1 (fr) 2007-09-21 2009-03-26 Eisai R & D Management Co., Ltd. Dérivé de 2,3-dihydroiminoisoindole
KR20110036833A (ko) 2008-07-11 2011-04-11 아지노모토 가부시키가이샤 아미딘 유도체
EA015918B1 (ru) 2010-03-03 2011-12-30 Дмитрий Геннадьевич ТОВБИН УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2606643B2 (ja) * 1992-04-01 1997-05-07 日東紡績株式会社 安息香酸アミジノフェニルエステル誘導体
JPH07330695A (ja) * 1994-04-11 1995-12-19 Green Cross Corp:The 新規カルボン酸誘導体またはその塩、およびその医薬用途
PT892780E (pt) * 1996-02-22 2003-02-28 Bristol Myers Squibb Pharma Co Analogos de m-amidino fenilo como inibidores do factor xa
JPH101467A (ja) * 1996-06-13 1998-01-06 Banyu Pharmaceut Co Ltd ビフェニルアミジン誘導体

Also Published As

Publication number Publication date
AU8747598A (en) 1999-03-16
CO4970693A1 (es) 2000-11-07
CN1268116A (zh) 2000-09-27
IL134394A0 (en) 2001-04-30
KR20010023364A (ko) 2001-03-26
EP1020434A4 (fr) 2000-11-15
WO1999010316A1 (fr) 1999-03-04
PE107999A1 (es) 1999-11-24
EP1020434A1 (fr) 2000-07-19
AR016868A1 (es) 2001-08-01
CA2301559A1 (fr) 1999-03-04

Similar Documents

Publication Publication Date Title
ZA987676B (en) 3-amidinoaniline derivatives activated blood coagulation factor X inhibitors and intermediates thereof
HUP9800634A3 (en) P-amidino-benzylamide derivatives as thrombin inhibitors, intermediates and use thereof
EP0983482A4 (fr) Appareil de cartographie vasculaire et son procede d'utilisation
IL135008A0 (en) Expandable ligator catheter having multiple electrode leads, and method of use
EP1024130A4 (fr) Derives de biphenyl-5-acide alcanoique et leurs applications
HUP0002493A3 (en) Use of colchinol derivatives as vascular damaging agents and certain new compounds
HUP9700602A3 (en) New inhibitors of bone-resorption and vitronectine-receptor-antagonists
AU7250098A (en) Anastomosis system and method of use
IL122186A (en) Heterocycles as inhibitors of leucotype adhesion and as vla-4-antagonists
PL350822A1 (en) Disposable wiper-cloth and method of making same
EP0831800A4 (fr) DERIVES D'ARYLSULFONYLAMINOBENZENE ET LEUR UTILISATION COMME INHIBITEURS DU FACTEUR Xa
HK1023832A1 (en) Clinical and/or surgical training apparatus
HUP0104500A3 (en) Thrombin inhibitor dipeptide derivatives and their use
IL122813A0 (en) Thrombin inhibitors their preparation and use
IL133490A0 (en) New amidino derivatives and their use as thrombin inhibitors
AU4717301A (en) Catheter assembly and method of use
PL350826A1 (en) Disposable wiper-cloth and method of making same
IL126093A0 (en) Promotion of regeneration of organized tissues
AU4204697A (en) Tetrahydroisoquinoline derivatives and their pharmaceutical use
AU8662198A (en) Activated forms of notch and methods based thereon
AU7277598A (en) Energy delivery of catheter and method for the use thereof
ZA983065B (en) Inhibitors of protein farnesyltranferase
NO994736D0 (no) FremgangsmÕte for bestemmelse av aktiverte blodkoaguleringsfaktorer i plasma og plasmaderivater
AU2529799A (en) Benzofuran-4-carboxamides and their therapeutic use
AU6120298A (en) 2-peperazinone-1-acetic acid derivatives and their use