ZA986358B - Dolastatin 15 derivatives. - Google Patents

Dolastatin 15 derivatives.

Info

Publication number
ZA986358B
ZA986358B ZA9806358A ZA986358A ZA986358B ZA 986358 B ZA986358 B ZA 986358B ZA 9806358 A ZA9806358 A ZA 9806358A ZA 986358 A ZA986358 A ZA 986358A ZA 986358 B ZA986358 B ZA 986358B
Authority
ZA
South Africa
Prior art keywords
dolastatin
derivatives
Prior art date
Application number
ZA9806358A
Other languages
English (en)
Inventor
Bernd Janssen
Teresa Barlozzari
Andreas Haupt
Thomas Zierke
Andreas Kling
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of ZA986358B publication Critical patent/ZA986358B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9806358A 1997-07-18 1998-07-17 Dolastatin 15 derivatives. ZA986358B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives

Publications (1)

Publication Number Publication Date
ZA986358B true ZA986358B (en) 2000-01-17

Family

ID=25406130

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9806358A ZA986358B (en) 1997-07-18 1998-07-17 Dolastatin 15 derivatives.

Country Status (33)

Country Link
US (6) US6143721A (es)
EP (1) EP0991658B1 (es)
JP (4) JP4508413B2 (es)
KR (1) KR100579748B1 (es)
CN (1) CN1268636C (es)
AR (1) AR018501A1 (es)
AT (1) ATE314387T1 (es)
AU (1) AU750120B2 (es)
BG (1) BG65212B1 (es)
BR (1) BR9810911A (es)
CA (1) CA2296036C (es)
CO (1) CO4990967A1 (es)
CY (1) CY1107047T1 (es)
CZ (1) CZ303045B6 (es)
DE (1) DE69832982T2 (es)
DK (1) DK0991658T3 (es)
ES (1) ES2258819T3 (es)
HK (1) HK1029125A1 (es)
HR (1) HRP980397A2 (es)
HU (1) HU228996B1 (es)
ID (1) ID24669A (es)
IL (1) IL133784A (es)
MY (1) MY135057A (es)
NO (1) NO326827B1 (es)
NZ (1) NZ502296A (es)
PL (1) PL197884B1 (es)
PT (1) PT991658E (es)
RU (1) RU2195462C2 (es)
SK (1) SK286581B6 (es)
TR (2) TR200000132T2 (es)
TW (1) TW533217B (es)
WO (1) WO1999003879A1 (es)
ZA (1) ZA986358B (es)

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US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
AU2001227375A1 (en) 2000-02-08 2001-08-20 Herbert T. Nagasawa N-terminal d(-)-penicillamine peptides as aldehyde sequestration agents
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
IL163868A0 (en) 2002-03-22 2005-12-18 Eisai Co Ltd Hermiasterlin derivatives and uses thereof
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
US7659241B2 (en) 2002-07-31 2010-02-09 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
BR122018071808B8 (pt) 2003-11-06 2020-06-30 Seattle Genetics Inc conjugado
EP1828776A4 (en) * 2004-12-09 2010-03-17 Eisai R&D Man Co Ltd TUBULINISOTYPE SEARCH IN CANCER THERAPY WITH HEMIASTERLINANALOGES
EP1883627B1 (en) 2005-05-18 2018-04-18 Pharmascience Inc. Bir domain binding compounds
NZ572836A (en) 2006-05-16 2011-12-22 Pharmascience Inc Iap bir domain binding compounds
PE20090481A1 (es) 2007-07-16 2009-05-18 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso
CR20190516A (es) 2007-07-16 2020-02-18 Genentech Inc ANTICUERPOS ANTI-CD79B E INMUNOCONJUGADOS (Divisional 2015-0040)
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
CN101981055B (zh) 2008-01-31 2016-03-09 健泰科生物技术公司 抗cd79b抗体和免疫偶联物及使用方法
AR079528A1 (es) * 2009-12-18 2012-02-01 Idenix Pharmaceuticals Inc Inhibidores de arileno o heteroarileno 5,5-fusionado del virus de la hepatitis c
WO2011100403A1 (en) 2010-02-10 2011-08-18 Immunogen, Inc Cd20 antibodies and uses thereof
SG10201501095WA (en) 2010-02-12 2015-04-29 Pharmascience Inc Iap bir domain binding compounds
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
DK3122757T3 (da) 2014-02-28 2023-10-09 Hangzhou Dac Biotech Co Ltd Ladede linkere og anvendelse deraf til konjugering
PT3262071T (pt) 2014-09-23 2020-06-16 H Hoffnabb La Roche Ag Métodos de utilização de imunoconjugados anti-cd79b
JP6759326B2 (ja) 2015-07-12 2020-09-23 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 細胞結合分子の共役のための架橋連結体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2016429272A1 (en) 2016-11-14 2019-05-02 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
AU2022338463A1 (en) 2021-09-03 2024-03-21 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
DK0934950T3 (da) * 1991-08-09 2002-07-29 Teikoku Hormone Mfg Co Ltd Tetrapeptidderivat
US5448045A (en) * 1992-02-26 1995-09-05 Clark; Paul C. System for protecting computers via intelligent tokens or smart cards
US5533097A (en) * 1992-02-26 1996-07-02 Motorola, Inc. Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
KR100286242B1 (ko) * 1992-05-20 2001-04-16 스타르크, 카르크 돌라스타틴 유도체
SG67935A1 (en) * 1992-12-16 1999-10-19 Basf Ag Novel peptides the preparation and use thereof
US5554993A (en) * 1994-01-04 1996-09-10 Panasonic Technologies, Inc. Global position determining system and method
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en) * 1995-03-23 1997-04-08 Martin; John R. Dual mode gaming device methods and systems
US5970143A (en) * 1995-11-22 1999-10-19 Walker Asset Management Lp Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
WO1998030297A1 (en) * 1997-01-10 1998-07-16 Silicon Gaming, Inc. Method and apparatus for providing authenticated, secure on-line communication between remote locations
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6554705B1 (en) * 1997-08-22 2003-04-29 Blake Cumbers Passive biometric customer identification and tracking system
US6629591B1 (en) * 2001-01-12 2003-10-07 Igt Smart token
US6438382B1 (en) * 2001-02-14 2002-08-20 Telefonaktiebolaget Lm Ericsson (Publ.) Expedited location determination in analog service areas

Also Published As

Publication number Publication date
IL133784A0 (en) 2001-04-30
JP2009137967A (ja) 2009-06-25
US6143721A (en) 2000-11-07
IL133784A (en) 2005-09-25
EP0991658B1 (en) 2005-12-28
TR200103545T2 (tr) 2002-06-21
CZ303045B6 (cs) 2012-03-07
JP4508413B2 (ja) 2010-07-21
ES2258819T3 (es) 2006-09-01
JP2009137968A (ja) 2009-06-25
BG65212B1 (bg) 2007-07-31
US20130046077A1 (en) 2013-02-21
ID24669A (id) 2000-07-27
CA2296036C (en) 2007-05-01
HUP0004234A3 (en) 2001-08-28
NO326827B1 (no) 2009-02-23
CO4990967A1 (es) 2000-12-26
HRP980397A2 (en) 1999-04-30
BR9810911A (pt) 2000-08-01
DE69832982T2 (de) 2006-08-24
PL197884B1 (pl) 2008-05-30
WO1999003879A1 (en) 1999-01-28
US7662786B2 (en) 2010-02-16
BG104089A (en) 2000-12-29
JP5047935B2 (ja) 2012-10-10
DE69832982D1 (de) 2006-02-02
JP2012211164A (ja) 2012-11-01
HUP0004234A2 (hu) 2001-05-28
AR018501A1 (es) 2001-11-28
AU750120B2 (en) 2002-07-11
KR100579748B1 (ko) 2006-05-15
SK286581B6 (sk) 2009-01-07
PT991658E (pt) 2006-05-31
CN1264388A (zh) 2000-08-23
TR200000132T2 (tr) 2000-05-22
EP0991658A1 (en) 2000-04-12
US20060270606A1 (en) 2006-11-30
KR20010021998A (ko) 2001-03-15
RU2195462C2 (ru) 2002-12-27
JP2001515010A (ja) 2001-09-18
CZ2000176A3 (en) 2001-06-13
US20030153505A1 (en) 2003-08-14
HK1029125A1 (en) 2001-03-23
CY1107047T1 (el) 2012-09-26
DK0991658T3 (da) 2006-05-15
CN1268636C (zh) 2006-08-09
ATE314387T1 (de) 2006-01-15
US8163698B2 (en) 2012-04-24
US20100099843A1 (en) 2010-04-22
US6458765B1 (en) 2002-10-01
NO20000231L (no) 2000-01-17
US7084110B2 (en) 2006-08-01
NZ502296A (en) 2002-02-01
AU8475898A (en) 1999-02-10
PL338144A1 (en) 2000-09-25
NO20000231D0 (no) 2000-01-17
HU228996B1 (hu) 2013-07-29
JP5122429B2 (ja) 2013-01-16
SK187999A3 (en) 2000-09-12
CA2296036A1 (en) 1999-01-28
TW533217B (en) 2003-05-21
MY135057A (en) 2008-01-31

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