ZA98570B - 8-substituted-1,3,8-triaza-spiro[4,5]decan-4-on derivatives - Google Patents

8-substituted-1,3,8-triaza-spiro[4,5]decan-4-on derivatives

Info

Publication number
ZA98570B
ZA98570B ZA98570A ZA98570A ZA98570B ZA 98570 B ZA98570 B ZA 98570B ZA 98570 A ZA98570 A ZA 98570A ZA 98570 A ZA98570 A ZA 98570A ZA 98570 B ZA98570 B ZA 98570B
Authority
ZA
South Africa
Prior art keywords
triaza
decan
spiro
derivatives
substituted
Prior art date
Application number
ZA98570A
Other languages
English (en)
Inventor
Geo Adam
Andrea Cesura
Guido Galley
Francois Jenck
Frederick Monsma
Stephan Roever
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA98570B publication Critical patent/ZA98570B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Lubricants (AREA)
ZA98570A 1997-01-30 1998-01-23 8-substituted-1,3,8-triaza-spiro[4,5]decan-4-on derivatives ZA98570B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97101409 1997-01-30
EP97119311 1997-11-05

Publications (1)

Publication Number Publication Date
ZA98570B true ZA98570B (en) 1998-07-30

Family

ID=26145196

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA98570A ZA98570B (en) 1997-01-30 1998-01-23 8-substituted-1,3,8-triaza-spiro[4,5]decan-4-on derivatives

Country Status (34)

Country Link
US (1) US6071925A (de)
EP (1) EP0856514B1 (de)
JP (1) JP3292457B2 (de)
KR (1) KR100274107B1 (de)
CN (1) CN1113881C (de)
AR (1) AR011576A1 (de)
AT (1) ATE202105T1 (de)
AU (1) AU730147B2 (de)
BR (1) BR9800524B1 (de)
CA (1) CA2226058C (de)
CO (1) CO4920223A1 (de)
CZ (1) CZ27398A3 (de)
DE (1) DE69800896T2 (de)
DK (1) DK0856514T3 (de)
EA (1) EA001357B1 (de)
ES (1) ES2158622T3 (de)
GR (1) GR3036523T3 (de)
HR (1) HRP980043B1 (de)
HU (1) HUP9800138A3 (de)
ID (1) ID19773A (de)
IL (1) IL123036A (de)
MA (1) MA26470A1 (de)
NO (1) NO310026B1 (de)
NZ (1) NZ329627A (de)
PE (1) PE59999A1 (de)
PL (1) PL324571A1 (de)
PT (1) PT856514E (de)
SG (1) SG71077A1 (de)
SI (1) SI0856514T1 (de)
TR (1) TR199800085A2 (de)
TW (1) TW457238B (de)
UY (1) UY24865A1 (de)
YU (1) YU2098A (de)
ZA (1) ZA98570B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT921125E (pt) * 1997-12-05 2002-06-28 Hoffmann La Roche Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
SI0921125T1 (en) * 1997-12-05 2002-04-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro(4,5)decan-4-on derivatives
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
ES2181336T3 (es) * 1998-06-12 2003-02-16 Hoffmann La Roche Espiro(piperidin-4,1'-pirrolo(3,4-c)pirrol).
EP0963985B1 (de) 1998-06-12 2003-03-12 F. Hoffmann-La Roche Ag Di- oder Triazaspiro[4,5]decanderivate
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
CO5150201A1 (es) * 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
ES2237047T3 (es) * 1998-10-23 2005-07-16 Pfizer Inc. Compuestos de 1,3,8-triazaespiro(4,5)decanona como agonistas del receptor orl1.
WO2000031061A1 (fr) * 1998-11-20 2000-06-02 Banyu Pharmaceutical Co., Ltd. Derives de 2-oxo-imidazole
GB9900078D0 (en) * 1999-01-05 1999-02-24 Zeneca Ltd Chemical compounds
GB9914024D0 (en) * 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
WO2001036418A1 (en) * 1999-11-17 2001-05-25 Novo Nordisk A/S Novel triazaspirodecanones with high affinity for opioid receptor subtypes
DE60033071T2 (de) * 1999-12-06 2007-08-23 Euro-Celtique S.A. Triazospiroverbindungen mit nociceptin-rezeptoraffinität
RU2268260C2 (ru) * 2000-03-31 2006-01-20 Ниппон Синяку Ко., Лтд. Производные хиназолина или хинолина и лекарственные средства на их основе
NZ570181A (en) * 2001-04-10 2010-02-26 Ortho Mcneil Janssen Pharm 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
WO2003004034A1 (en) 2001-07-02 2003-01-16 Omeros Corporation Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
PT1491212E (pt) * 2002-03-29 2012-11-16 Mitsubishi Tanabe Pharma Corp Medicamento para distúrbios de sono
US6995168B2 (en) 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
EA009369B1 (ru) * 2002-09-09 2007-12-28 Янссен Фармацевтика, Н.В. Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором
NZ544282A (en) * 2003-05-23 2009-07-31 Zealand Pharma As Triaza-spiro compounds as nociceptin analogues and uses thereof
AR045939A1 (es) 2003-09-25 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
EA200970517A1 (ru) * 2006-11-28 2009-12-30 Янссен Фармацевтика Н.В. Соли 3-(3-амино-2-(r)-гидроксипропил)-1-(4-фторфенил)-8-(8-метилнафталин-1-илметил)-1,3,8-триазаспиро[4,5]декан-4-она
CA2679530C (en) * 2007-03-01 2012-09-25 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
MX2009011006A (es) * 2007-04-09 2009-11-02 Janssen Pharmaceutica Nv Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion.
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
AU2016365400C1 (en) * 2015-12-02 2022-11-10 Astraea Therapeutics, Llc Piperidinyl nociceptin receptor compounds
CN106397225A (zh) * 2016-09-04 2017-02-15 王际菊 一种手性化合物的制备方法
CN106467476A (zh) * 2016-09-04 2017-03-01 王际菊 一种左旋胺基化合物的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US488082A (en) * 1892-12-13 Automatic gut-off for gas bxxenees
JPS5212171A (en) * 1975-07-17 1977-01-29 Yoshitomi Pharmaceut Ind Ltd Process for preparation of cyclohexane derivatives
US4076821A (en) * 1976-02-27 1978-02-28 Yoshitomi Pharmaceutical Industries, Ltd. 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4126687A (en) * 1976-05-17 1978-11-21 Janssen Pharmaceutica N.V. Antiemetic, 1-(benzimidazolyl-alkyl)-piperidine derivatives
US4329353A (en) * 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
SU1095878A3 (ru) * 1980-10-22 1984-05-30 Жансен Фармасетика Н.В. (Фирма) Способ получени производных 1-(4-арилциклогексил)пиперидина или их фармацевтически пригодных солей или их стереоизомерных форм
US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
JPS6012357B2 (ja) * 1984-01-23 1985-04-01 吉富製薬株式会社 脂環式誘導体
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
US5153225A (en) * 1986-12-10 1992-10-06 Bayer Aktiengesellschaft Substituted basic 2-aminotetralin in pharmaceuticals
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
US5039804A (en) * 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
DE4135473A1 (de) * 1991-10-28 1993-04-29 Bayer Ag Triazaspirodecanon-methylchromane
DE4405178A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Substituierte 1,3,8-Triaza-spiro(4,5)-decan-4-on-Derivate als Vorstufen zur Herstellung von Pharmazeutika

Also Published As

Publication number Publication date
HRP980043B1 (en) 2001-12-31
KR19980070900A (ko) 1998-10-26
TW457238B (en) 2001-10-01
DK0856514T3 (da) 2001-09-17
JP3292457B2 (ja) 2002-06-17
BR9800524A (pt) 2000-03-14
GR3036523T3 (en) 2001-12-31
US6071925A (en) 2000-06-06
NO980332D0 (no) 1998-01-26
KR100274107B1 (ko) 2000-12-15
SI0856514T1 (en) 2001-08-31
EP0856514B1 (de) 2001-06-13
HUP9800138A3 (en) 1999-03-01
AU730147B2 (en) 2001-03-01
HUP9800138A2 (hu) 1998-09-28
NO980332L (no) 1998-07-31
TR199800085A3 (tr) 1998-08-21
CN1113881C (zh) 2003-07-09
EP0856514A1 (de) 1998-08-05
AU5280998A (en) 1998-08-06
HU9800138D0 (en) 1998-03-30
IL123036A0 (en) 1998-09-24
HRP980043A2 (en) 1998-12-31
TR199800085A2 (xx) 1998-08-21
EA199800108A1 (ru) 1998-10-29
YU2098A (sh) 2001-03-07
PL324571A1 (en) 1998-08-03
ID19773A (id) 1998-07-30
CA2226058C (en) 2008-01-29
PE59999A1 (es) 1999-07-01
DE69800896D1 (de) 2001-07-19
CZ27398A3 (cs) 1998-08-12
CA2226058A1 (en) 1998-07-30
NO310026B1 (no) 2001-05-07
UY24865A1 (es) 2000-12-29
SG71077A1 (en) 2000-03-21
ES2158622T3 (es) 2001-09-01
EA001357B1 (ru) 2001-02-26
JPH10212290A (ja) 1998-08-11
AR011576A1 (es) 2000-08-30
NZ329627A (en) 1999-11-29
PT856514E (pt) 2001-10-31
IL123036A (en) 2000-12-06
DE69800896T2 (de) 2002-03-28
CO4920223A1 (es) 2000-05-29
ATE202105T1 (de) 2001-06-15
BR9800524B1 (pt) 2008-11-18
MA26470A1 (fr) 2004-12-20
CN1191862A (zh) 1998-09-02

Similar Documents

Publication Publication Date Title
ZA98570B (en) 8-substituted-1,3,8-triaza-spiro[4,5]decan-4-on derivatives
EG24081A (en) 4-Substituted-9-deoxo-9a-aza-9a-homerythromycin derivatives
HUP0003642A3 (en) N-alkanoylphenylalanine derivatives
GB9702194D0 (en) Sulphonide derivatives
ZA987602B (en) N-alkanoylphenylalanine derivatives
PL334847A1 (en) Substituted 3-heterocyclyl-benzoyl derivatives
AP9700954A0 (en) 6-ohenylpyridyl-2-amine derivatives
IL125358A0 (en) 5H-thiazolo [3,2-a] pyrimidine derivatives
SI0921125T1 (en) 1,3,8-Triazaspiro(4,5)decan-4-on derivatives
AP9701156A0 (en) 6-phenylpyridyl-2-amine derivatives
HU9801168D0 (en) Triazinylaminostilbene derivatives
IL127399A0 (en) 1,3,8-Triaza-spiro (4,5) decan-4-on derivatives
HU9901911D0 (en) Diaza-spiro[3,5]nanone derivatives
IL132982A0 (en) Cis-disubstituted aminocycloalkyl-pyrrolidine derivatives
GB9715821D0 (en) Amidino-camptothecin derivatives
HUP0003692A3 (en) Pyrimido[4,5-b]indolyl-alkanecarboxamide derivatives
GB2321457B (en) 5-Aroylnaphthalene derivatives
GB9701628D0 (en) Imino-aza-anthracyclinone derivatives
GB9725541D0 (en) Amino-benzothiazole derivatives
GB9603226D0 (en) Heterocyclyl-ergoline derivatives
GB9600063D0 (en) Guaridine derivatives
ZA983116B (en) Arylsecocholadiene derivatives
HU9800889D0 (en) New naphtylpiperazine derivatives
IL131159A0 (en) 4-Aminoethoxyindazole derivatives
GB9706753D0 (en) Aralkoxy-morphinan derivatives