ZA9810219B - Benzothiazole protein tyrosine kinase inhibitors. - Google Patents

Benzothiazole protein tyrosine kinase inhibitors.

Info

Publication number
ZA9810219B
ZA9810219B ZA9810219A ZA9810219A ZA9810219B ZA 9810219 B ZA9810219 B ZA 9810219B ZA 9810219 A ZA9810219 A ZA 9810219A ZA 9810219 A ZA9810219 A ZA 9810219A ZA 9810219 B ZA9810219 B ZA 9810219B
Authority
ZA
South Africa
Prior art keywords
benzothiazole
tyrosine kinase
kinase inhibitors
protein tyrosine
protein
Prior art date
Application number
ZA9810219A
Other languages
English (en)
Inventor
Jagabandhu Das
Joel C Barrish
John Wityak
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA9810219B publication Critical patent/ZA9810219B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9810219A 1997-11-10 1998-11-09 Benzothiazole protein tyrosine kinase inhibitors. ZA9810219B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6504297P 1997-11-10 1997-11-10

Publications (1)

Publication Number Publication Date
ZA9810219B true ZA9810219B (en) 2000-06-22

Family

ID=22059964

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9810219A ZA9810219B (en) 1997-11-10 1998-11-09 Benzothiazole protein tyrosine kinase inhibitors.

Country Status (25)

Country Link
US (1) US6825355B2 (fr)
EP (1) EP1037632B1 (fr)
JP (1) JP2001522800A (fr)
KR (1) KR20010031912A (fr)
CN (1) CN1290165A (fr)
AR (1) AR017588A1 (fr)
AT (1) ATE315394T1 (fr)
AU (1) AU744281B2 (fr)
BR (1) BR9814956A (fr)
CA (1) CA2309319A1 (fr)
DE (1) DE69833224T2 (fr)
ES (1) ES2256969T3 (fr)
HU (1) HUP0102101A3 (fr)
ID (1) ID24289A (fr)
IL (1) IL135176A0 (fr)
NO (1) NO20002121L (fr)
NZ (1) NZ503491A (fr)
PE (1) PE129799A1 (fr)
PL (1) PL340727A1 (fr)
RU (1) RU2212407C2 (fr)
TR (1) TR200001312T2 (fr)
TW (1) TW510898B (fr)
UY (1) UY25242A1 (fr)
WO (1) WO1999024035A1 (fr)
ZA (1) ZA9810219B (fr)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214836A1 (en) * 1998-05-29 2004-10-28 Cheresh David A. Method of treatment of myocardial infarction
US20060258686A1 (en) * 1998-05-29 2006-11-16 Cheresh David A Method of treatment of myocardial infarction
US20030130209A1 (en) * 1999-12-22 2003-07-10 Cheresh David A. Method of treatment of myocardial infarction
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
EP3222619A1 (fr) * 1999-04-15 2017-09-27 Bristol-Myers Squibb Holdings Ireland Inhibiteurs cycliques de la protéine tyrosine kinase
EP1222187B1 (fr) * 1999-10-06 2004-09-22 Boehringer Ingelheim Pharmaceuticals Inc. Composes heterocycliques utiles comme inhibiteurs de tyrosine kinases
US6506769B2 (en) 1999-10-06 2003-01-14 Boehringer Ingelheim Pharmaceuticals, Inc. Heterocyclic compounds useful as inhibitors of tyrosine kinases
DE19951360A1 (de) * 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
US7101869B2 (en) 1999-11-30 2006-09-05 Pfizer Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
KR20020084116A (ko) * 2000-02-07 2002-11-04 애보트 게엠베하 운트 콤파니 카게 2-벤조티아졸릴 우레아 유도체 및 이의 단백질 키나제억제제로서의 용도
GB0003254D0 (en) * 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
EP1303272B1 (fr) 2000-06-21 2008-02-13 F. Hoffmann-La Roche Ag Derives de benzothiazole pour le traitement de la maladie d'alzheimer et de la maladie de parkinson
ES2299501T3 (es) 2000-08-11 2008-06-01 Boehringer Ingelheim Pharmaceuticals Inc. Compuestos heterociclicos utiles como inhibidores de tirosina-quinasas.
EP1341771A2 (fr) * 2000-11-29 2003-09-10 Glaxo Group Limited Composes chimiques
ES2200617B1 (es) 2001-01-19 2005-05-01 Almirall Prodesfarma, S.A. Derivados de urea como antagonistas de integrinas alfa 4.
HN2002000156A (es) 2001-07-06 2003-11-27 Inc Agouron Pharmaceuticals Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización.
WO2003041708A1 (fr) 2001-11-09 2003-05-22 Boehringer Ingelheim Pharmaceuticals, Inc. Benzimidazoles utilises en tant qu'inhibiteurs de la proteine kinase
US6734179B2 (en) * 2001-12-12 2004-05-11 Hoffmann-La Roche Inc. Benzothiazoles
AU2003209116A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
CN1678311A (zh) 2002-06-27 2005-10-05 诺沃挪第克公司 用作治疗剂的芳基羰基衍生物
MXPA05000130A (es) * 2002-06-27 2005-02-17 Novo Nordisk As Derivados de aril-carbonilo como agentes terapeuticos.
AU2003258061A1 (en) * 2002-08-02 2004-02-23 Salmedix, Inc. Therapeutic inhibitionof protein kinases in cancer cells
WO2004014905A1 (fr) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Composes benzimidazole substitues
JP2006502133A (ja) * 2002-08-10 2006-01-19 アステックス、セラピューティックス、リミテッド サイクリン依存キナーゼ（ｃｄｋ）インヒビターとしての３−（カルボニル）１ｈ−インダゾール化合物
SE0202464D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Use of compounds
SE0202429D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel Compounds
EP2426122A1 (fr) * 2002-10-24 2012-03-07 Merck Patent GmbH Dérivés d'urée de méthylène comme inhibteurs de RAF kinase
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
EP1597256A1 (fr) * 2003-02-21 2005-11-23 Pfizer Inc. Derives d'amino-thiazole substitues par n-heterocyclyle en tant qu'inhibiteurs de la proteine kinase
CA2516931C (fr) * 2003-02-28 2014-09-09 Bayer Pharmaceuticals Corporation Nouveaux derives bicycliques d'uree utiles dans le traitement du cancer et d'autres troubles
WO2004085433A2 (fr) * 2003-03-28 2004-10-07 Pharmacia & Upjohn Company Llc Modulateurs allosteriques positifs du recepteur nicotinique de l'acetylcholine
WO2004100868A2 (fr) * 2003-04-23 2004-11-25 Abbott Laboratories Procede servant a traiter le rejet d'un transplant
JP4860474B2 (ja) 2003-05-20 2012-01-25 バイエル、ファーマシューテイカルズ、コーポレイション Ｐｄｇｆｒによって仲介される病気のためのジアリール尿素
FR2864539B1 (fr) 2003-12-30 2012-10-26 Lvmh Rech Oligonucleotide et son utilisation pour moduler l'expression de la proteine-kinase c isoforme beta-1 comme agent de depigmentation cutanee
CN102516240A (zh) 2004-01-06 2012-06-27 诺和诺德公司 杂芳基脲及其作为葡糖激酶活化剂的用途
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
EP3219709B1 (fr) * 2004-01-30 2020-03-18 Vertex Pharmaceuticals Incorporated Composé intermédiaire de modulateurs de transporteurs de cassette à liaison atp
JP4996926B2 (ja) * 2004-02-05 2012-08-08 プロビオドルグ エージー グルタミニルシクラーゼの新規の阻害剤
DE102004006808A1 (de) * 2004-02-11 2005-09-01 Grünenthal GmbH Substituierte 4,5,6,7-Tetrahydro-benzothiazol-2-ylamin-Verbindungen
WO2005079791A1 (fr) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Derives d'acide thiophene-2-carboxylique (1h-benzimidazol-2 yl)-amide et composes associes utilises comme inhibiteurs de la tec kinase itk (kinase des lymphocites inductibles par l'interleukine -2) pour traiter une inflammation et des troubles immunologiques et allergiques
FR2868421B1 (fr) 2004-04-01 2008-08-01 Aventis Pharma Sa Nouveaux benzothiazoles et leur utilisation comme medicaments
US7550499B2 (en) * 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
AU2005247567B2 (en) 2004-05-24 2010-09-02 F. Hoffmann-La Roche Ag 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
SE0401970D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Novel compounds
US7459563B2 (en) 2004-11-05 2008-12-02 Hoffmann-La Roche Inc. Process for the preparation of isonicotinic acid derivatives
SE0403117D0 (sv) * 2004-12-21 2004-12-21 Astrazeneca Ab New compounds 1
US7514460B2 (en) 2004-12-22 2009-04-07 4Sc Ag Benzazole analogues and uses thereof
KR20070100894A (ko) * 2005-01-19 2007-10-12 브리스톨-마이어스 스큅 컴퍼니 혈전색전성 장애 치료용 ｐ2ｙ1 수용체 억제제로서의2-페녹시-ｎ-(1,3,4-티아디졸-2-일)피리딘-3-아민 유도체및 관련 화합물
EP2457901A1 (fr) * 2005-03-14 2012-05-30 High Point Pharmaceuticals, LLC Dérivés de benzazole, compositions et procédés d'utilisation en tant qu'inhibiteurs de secrétase B
BRPI0609719B8 (pt) 2005-03-23 2021-05-25 Hoffmann La Roche derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2
TW200726764A (en) * 2005-06-27 2007-07-16 Bristol Myers Squibb Co N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
DE602006020871D1 (de) 2005-06-27 2011-05-05 Bristol Myers Squibb Co Lineare harnstoffmimetika-antagonisten des p2y1-rezeptors zur behandlung von thromboseleiden
DE602006017694D1 (de) * 2005-06-27 2010-12-02 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden
WO2007002634A1 (fr) * 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Antagonistes carbocycliques et heherocycliques du recepteur p2y1, utiles pour traiter des etats pathologiques thrombotiques
US7999114B2 (en) 2005-07-08 2011-08-16 Novo Nordisk A/S Dicycloalkylcarbamoyl ureas as glucokinase activators
CA2615938C (fr) 2005-07-14 2014-04-29 Novo-Nordisk A/S Activateurs de l'uree glucokinase
BRPI0616571A2 (pt) 2005-09-27 2011-06-21 Hoffmann La Roche oxadiazolil pirazol-piridiminas como antagonistas de mglur2, processo para sua preparação, composição farmacêutica que os contém e uso dos mesmo
US7960569B2 (en) * 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7910087B2 (en) 2007-03-02 2011-03-22 University Of Massachusetts Luciferins
JP2008222084A (ja) * 2007-03-14 2008-09-25 Yamaha Motor Electronics Co Ltd 電動ゴルフカーのブレーキ劣化検出方法及びこれを用いた電動ゴルフカー
WO2008124393A1 (fr) * 2007-04-04 2008-10-16 Irm Llc Derives de benzothiazole et leur utilisation en tant qu'inhibiteurs des proteines kinases
FR2928547B1 (fr) 2008-03-13 2012-03-09 Lvmh Rech Extrait de l'orchidee brassocattle marcella koss et son utilisation en tant qu'actif de depigmentation cutanee
CA2757415C (fr) * 2009-04-02 2018-02-06 Merck Patent Gmbh Inhibiteurs de l'autotaxine
CA2758961A1 (fr) 2009-04-27 2010-11-04 High Point Pharmaceuticals, Llc Derives d'isoquinoline substitues, compositions pharmaceutiques et leurs methodes d'utilisation en tant qu'inhibiteurs de .beta.-secretase
CN101701018B (zh) * 2009-11-05 2012-06-13 东南大学 2-(4-氨基喹唑啉基)苯并[d]噻唑类衍生物及其用途
CA2792339A1 (fr) * 2010-03-23 2011-09-29 High Point Pharmaceuticals, Llc Derives d'imidazole[1,2-b]pyridazine substitues, compositions pharmaceutiques et procedes d'utilisation en tant qu'inhibiteurs de beta-secretase
CN108864151A (zh) 2010-11-19 2018-11-23 利亘制药公司 杂环胺及其用途
TWI650321B (zh) * 2011-10-14 2019-02-11 美商安比特生物科學公司 雜環化合物及其使用方法
US9540364B2 (en) * 2012-08-22 2017-01-10 Merck Sharp & Dohme Corp. Benzimidazole tetrahydrofuran derivatives
CN103058954A (zh) * 2013-01-07 2013-04-24 盛世泰科生物医药技术(苏州)有限公司 一种[6-(5-氨基-2-甲基-苯氨基甲酰-苯并噻唑]-氨基甲酸叔丁酯的制备方法
EP2991967A1 (fr) * 2013-03-20 2016-03-09 F. Hoffmann-La Roche AG Dérivés d'urée et leurs utilisations en tant qu'inhibiteurs de la protéine de liaison à un acide gras (fabp)
WO2014168262A1 (fr) * 2013-04-11 2014-10-16 D.D.P. Corporation Inhibiteurs de kinase contenant un squelette cyclopropane
EP2990027A1 (fr) 2014-09-01 2016-03-02 Institut Curie Agents peptidiques blanchissants pour la peau
US10131679B2 (en) 2014-10-31 2018-11-20 Ube Industries, Ltd. Substituted dihydropyrrolopyrazole compound
US10807983B2 (en) 2015-03-16 2020-10-20 Ligand Pharmaceuticals, Inc. Imidazo-fused heterocycles and uses thereof
US10584118B2 (en) 2015-06-22 2020-03-10 Actelion Pharmaceuticals Ltd NADPH oxidase 4 inhibitors
KR102089122B1 (ko) * 2016-08-25 2020-03-13 주식회사 엘지화학 디아민 화합물 및 이를 이용하여 제조된 플렉시블 소자용 기판
CN107021937B (zh) * 2017-03-27 2019-06-21 沈阳药科大学 苯并噻唑甲酰胺类化合物及其应用
JP7123429B2 (ja) * 2017-05-04 2022-08-23 シャンハイ ロングウッド バイオファルマシューティカルズ カンパニー リミテッド 二環式縮合環系ヌクレオカプシド阻害剤および薬物としてｂ型肝炎を治療するためのその使用
CA3067070A1 (fr) * 2017-06-14 2018-12-20 European Molecular Biology Laboratory Composes d'uree ou de carbamate heteroaromatiques bicycliques destines a etre utilises en therapie
AU2018346051B2 (en) * 2017-10-02 2022-11-10 1st Biotherapeutics Inc. Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
MX2020008905A (es) 2018-06-12 2020-12-03 Vtv Therapeutics Llc Usos terapeuticos de activadores de glucoquinasa en combinacion con insulina o analogos de insulinas.
CN115594671B (zh) * 2021-07-08 2024-03-15 沈阳药科大学 苯并噻唑类衍生物及其制备方法和用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966706A (en) * 1971-01-27 1976-06-29 Ciba-Geigy Ag 2,6-Dihydroxy-3-cyano-4-methylpyridine containing azo dyes which contain a functional amino group
JPS50140442A (fr) * 1974-04-16 1975-11-11
JPS5632549A (en) * 1979-08-27 1981-04-02 Toyo Ink Mfg Co Ltd Pigment composition
JPS62194251A (ja) * 1986-02-20 1987-08-26 Konishiroku Photo Ind Co Ltd 保存安定性が改良されたハロゲン化銀写真感光材料
IL90337A0 (en) 1988-05-24 1989-12-15 Pfizer Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
US4970318A (en) * 1988-05-24 1990-11-13 Pfizer Inc. Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
JPH0667923B2 (ja) * 1989-05-11 1994-08-31 東洋紡績株式会社 新規なベンゾチアゾール誘導体
JP2869561B2 (ja) 1989-05-22 1999-03-10 大塚製薬株式会社 血小板粘着抑制剤
US5296486A (en) 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
KR950701329A (ko) * 1993-02-19 1995-03-23 유미꾸라 레이이찌 벤조티아졸술폰아미드 유도체, 그의 제조법 및 그 용도(Benzothiazolesulfornamide derivative, method for preparing the same, and use thereof)
US5496816A (en) 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
HRP960159A2 (en) 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
TW513418B (en) 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
CA2274249A1 (fr) 1996-12-06 1998-06-11 Vertex Pharmaceuticals Incorporated Inhibiteurs de l'enzyme de conversion de l'interleukine-1.beta.
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
EP1054004B1 (fr) 1997-12-15 2008-07-16 Astellas Pharma Inc. Nouveaux derives de pyrimidine-5-carboxamide

Also Published As

Publication number Publication date
DE69833224D1 (en) 2006-04-06
DE69833224T2 (de) 2006-09-28
AU744281B2 (en) 2002-02-21
IL135176A0 (en) 2001-05-20
JP2001522800A (ja) 2001-11-20
PL340727A1 (en) 2001-02-26
HUP0102101A3 (en) 2002-11-28
ES2256969T3 (es) 2006-07-16
BR9814956A (pt) 2000-10-03
AR017588A1 (es) 2001-09-12
NZ503491A (en) 2002-08-28
CN1290165A (zh) 2001-04-04
US20020123484A1 (en) 2002-09-05
KR20010031912A (ko) 2001-04-16
UY25242A1 (es) 2001-08-27
EP1037632A1 (fr) 2000-09-27
US6825355B2 (en) 2004-11-30
EP1037632B1 (fr) 2006-01-11
WO1999024035A1 (fr) 1999-05-20
CA2309319A1 (fr) 1999-05-20
PE129799A1 (es) 2000-03-08
ATE315394T1 (de) 2006-02-15
NO20002121D0 (no) 2000-04-26
NO20002121L (no) 2000-05-09
TR200001312T2 (tr) 2000-09-21
RU2212407C2 (ru) 2003-09-20
HUP0102101A2 (hu) 2001-11-28
EP1037632A4 (fr) 2002-08-21
TW510898B (en) 2002-11-21
ID24289A (id) 2000-07-13
AU1371999A (en) 1999-05-31

Similar Documents

Publication Publication Date Title
ZA9810219B (en) Benzothiazole protein tyrosine kinase inhibitors.
HUS1700048I1 (hu) Szubsztituált 3-cianokinolinok mint protein tirozin kinázok inhibitorai
HK1244797A1 (zh) 環蛋白酪氨酸激酶抑制劑
ZA991721B (en) Heterocyclo-substituted imidazopyrazine protein tyrosine kinase inhibitors.
ZA969646B (en) Protein kinase C inhibitor.
IL142121A0 (en) Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
AU8681798A (en) Imidazoquinoxaline protein tyrosine kinase inhibitors
AU8681698A (en) Imidazoquinoxaline protein tyrosine kinase inhibitors
ZA200202985B (en) Tyrosine kinase inhibitors.
AU2437900A (en) Piperidinylquinolines as protein tyrosine kinase inhibitors
IL141866A0 (en) Pyrrolopyrimidines as protein kinase inhibitors
ZA200108291B (en) Diaminothiazoles and their use for inhibiting protein kinases.
CY2451B1 (en) Fused heterocyclic compunds as protein tyrosine kinase inhibitors.
AU6411698A (en) Substituted 2-anilinopyrimidines useful as protein kinase inhibitors
AU6882598A (en) Protein kinase inhibitor
ATE387448T1 (de) 4,5-pyrazinoxindole als proteinkinasehemmer
AU2576501A (en) Protein kinase inhibitors
EP1012150A4 (fr) Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases
AU2591299A (en) Human protein kinase c inhibitor
GB9803399D0 (en) Protein kinase c
ZA987649B (en) Imidazoquinoxaline protein tyrosine kinase inhibitors.
AU3097299A (en) Nek1-related protein kinase
ZA984213B (en) Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders.