EP1012150A4 - Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases - Google Patents
Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinasesInfo
- Publication number
- EP1012150A4 EP1012150A4 EP98924794A EP98924794A EP1012150A4 EP 1012150 A4 EP1012150 A4 EP 1012150A4 EP 98924794 A EP98924794 A EP 98924794A EP 98924794 A EP98924794 A EP 98924794A EP 1012150 A4 EP1012150 A4 EP 1012150A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- tyrosine kinase
- related disorders
- protein tyrosine
- active against
- against protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4694597P | 1997-05-19 | 1997-05-19 | |
US4708497P | 1997-05-19 | 1997-05-19 | |
US47084P | 1997-05-19 | ||
US46945P | 1997-05-19 | ||
US5662397P | 1997-08-20 | 1997-08-20 | |
US56623P | 1997-08-20 | ||
US6159097P | 1997-10-10 | 1997-10-10 | |
US61590P | 1997-10-10 | ||
PCT/US1998/010174 WO1998052944A1 (fr) | 1997-05-19 | 1998-05-18 | Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1012150A1 EP1012150A1 (fr) | 2000-06-28 |
EP1012150A4 true EP1012150A4 (fr) | 2002-05-29 |
Family
ID=27489113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98924794A Withdrawn EP1012150A4 (fr) | 1997-05-19 | 1998-05-18 | Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1012150A4 (fr) |
AR (1) | AR015685A1 (fr) |
AU (1) | AU7687998A (fr) |
CA (1) | CA2302438A1 (fr) |
WO (1) | WO1998052944A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002536406A (ja) * | 1999-02-12 | 2002-10-29 | カナム メディカル コーポレイション | 細胞増殖の治療用アルキル化剤 |
GB9904103D0 (en) | 1999-02-24 | 1999-04-14 | Zeneca Ltd | Quinoline derivatives |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
PL215901B1 (pl) | 1999-04-15 | 2014-02-28 | Bristol Myers Squibb Co | Cykliczny inhibitor bialkowych kinaz tyrozynowych, jego zastosowanie oraz kompozycja farmaceutyczna zawierajaca taki zwiazek |
US6689883B1 (en) | 1999-09-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
US7977333B2 (en) | 2000-04-20 | 2011-07-12 | Bayer Healthcare Llc | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
US6903101B1 (en) | 2000-08-10 | 2005-06-07 | Bayer Pharmaceuticals Corporation | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity |
GB0322012D0 (en) * | 2003-09-19 | 2003-10-22 | Syngenta Participations Ag | Chemical compounds |
US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
EP1990048A3 (fr) * | 2007-05-08 | 2009-05-06 | Ulrike Wiebelitz | Thérapie pour l'hyperplasie bénigne de la prostate |
BRPI0909625B1 (pt) | 2008-03-17 | 2021-09-08 | Actelion Pharmaceuticals Ltd | Agonista seletivo do receptor s1p1 para o uso como um medicamento, uso de um agonista seletivo do receptor s1p1 e kit contendo diferentes unidades de medicação de um agonista seletivo do receptor s1p1 |
US20140179712A1 (en) | 2012-12-21 | 2014-06-26 | Astrazeneca Ab | Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide |
CN108929271B (zh) * | 2018-06-29 | 2021-08-31 | 中国药科大学 | 酪氨酸酶抑制剂及其制备方法与用途 |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0073973A1 (fr) * | 1981-08-24 | 1983-03-16 | BASF Aktiengesellschaft | Anilides d'acides thiazolyl- et isothiazolyl carboxyliques, procédé pour les préparer et leur utilisation comme fongicides |
EP0418667A2 (fr) * | 1989-09-22 | 1991-03-27 | BASF Aktiengesellschaft | Amides d'acides carboxyliques |
WO1991017748A1 (fr) * | 1990-05-18 | 1991-11-28 | Hoechst Aktiengesellschaft | Amides d'acide carboxylique-4 d'isoxazol et cyanamides acetiques d'hydroxyalkylidene, medicaments contenant ces composes et leur application |
WO1994001408A1 (fr) * | 1992-07-10 | 1994-01-20 | Laboratoires Glaxo S.A. | Derives d'anilide |
US5342851A (en) * | 1992-10-07 | 1994-08-30 | Mcneil-Ppc, Inc. | Substituted thiazole derivatives useful as platelet aggregation inhibitors |
WO1995019169A2 (fr) * | 1994-01-07 | 1995-07-20 | Sugen, Inc. | Traitement de troubles lies au facteur mitogenique plaquettaire tels que les cancers a l'aide d'inhibiteurs du recepteur de facteur mitogenique plaquettaire |
JPH07196637A (ja) * | 1993-11-24 | 1995-08-01 | Mitsui Toatsu Chem Inc | イソチアゾールカルボン酸アミド誘導体の製造法 |
US5476866A (en) * | 1993-10-01 | 1995-12-19 | Roussel Uclaf | Isoxazoles |
WO1996033179A1 (fr) * | 1995-04-21 | 1996-10-24 | Sugen, Inc. | Derives des thioamides et leur utilisation comme inhibiteurs de croissance cellulaire hyper-proliferative |
WO1997011690A2 (fr) * | 1995-09-29 | 1997-04-03 | Microcide Pharmaceuticals, Inc. | Inhibiteurs des voies de regulation |
EP0769296A1 (fr) * | 1995-10-25 | 1997-04-23 | Hoechst Aktiengesellschaft | Utilisation de derivés d'isoxazole et de crotonamide pour la fabrication d'un médicament pour le traitement de cancers |
WO1997040019A1 (fr) * | 1996-04-24 | 1997-10-30 | Celltech Therapeutics Limited | 5-aminopyrazoles utiles comme inhibiteurs selectifs de la proteine tyrosine kinase p56ick |
WO1998028269A1 (fr) * | 1996-12-23 | 1998-07-02 | Du Pont Pharmaceuticals Company | COMPOSES HETEROAROMATIQUES CONTENANT DE L'AZOTE, UTILISES EN TANT QU'INHIBITEURS DU FACTEUR Xa |
WO1998057937A2 (fr) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | INHIBITEURS DU FACTEUR Xa COMPRENANT UN GROUPE A SPECIFICITE P1 NEUTRE |
WO1999024404A1 (fr) * | 1997-11-07 | 1999-05-20 | Amgen Inc. | Composes pyridine substitues presentant une action anti-inflammatoire |
WO1999043657A1 (fr) * | 1998-02-27 | 1999-09-02 | F. Hoffmann-La Roche Ag | Derives de 2-arylethyl-(piperidin-4-ylmethyl)amines |
EP0990645A1 (fr) * | 1997-05-30 | 2000-04-05 | Nippon Kayaku Kabushiki Kaisha | Nouveaux derives sulfonamides |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995024190A2 (fr) * | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Inhibiteurs de tyrosine-kinase receptrice destines a inhiber les troubles lies a la proliferation cellulaire et compositions les contenant |
-
1998
- 1998-05-18 EP EP98924794A patent/EP1012150A4/fr not_active Withdrawn
- 1998-05-18 CA CA002302438A patent/CA2302438A1/fr not_active Abandoned
- 1998-05-18 AU AU76879/98A patent/AU7687998A/en not_active Abandoned
- 1998-05-18 WO PCT/US1998/010174 patent/WO1998052944A1/fr not_active Application Discontinuation
- 1998-05-19 AR ARP980102308 patent/AR015685A1/es unknown
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0073973A1 (fr) * | 1981-08-24 | 1983-03-16 | BASF Aktiengesellschaft | Anilides d'acides thiazolyl- et isothiazolyl carboxyliques, procédé pour les préparer et leur utilisation comme fongicides |
EP0418667A2 (fr) * | 1989-09-22 | 1991-03-27 | BASF Aktiengesellschaft | Amides d'acides carboxyliques |
WO1991017748A1 (fr) * | 1990-05-18 | 1991-11-28 | Hoechst Aktiengesellschaft | Amides d'acide carboxylique-4 d'isoxazol et cyanamides acetiques d'hydroxyalkylidene, medicaments contenant ces composes et leur application |
WO1994001408A1 (fr) * | 1992-07-10 | 1994-01-20 | Laboratoires Glaxo S.A. | Derives d'anilide |
US5342851A (en) * | 1992-10-07 | 1994-08-30 | Mcneil-Ppc, Inc. | Substituted thiazole derivatives useful as platelet aggregation inhibitors |
US5476866A (en) * | 1993-10-01 | 1995-12-19 | Roussel Uclaf | Isoxazoles |
JPH07196637A (ja) * | 1993-11-24 | 1995-08-01 | Mitsui Toatsu Chem Inc | イソチアゾールカルボン酸アミド誘導体の製造法 |
WO1995019169A2 (fr) * | 1994-01-07 | 1995-07-20 | Sugen, Inc. | Traitement de troubles lies au facteur mitogenique plaquettaire tels que les cancers a l'aide d'inhibiteurs du recepteur de facteur mitogenique plaquettaire |
WO1996033179A1 (fr) * | 1995-04-21 | 1996-10-24 | Sugen, Inc. | Derives des thioamides et leur utilisation comme inhibiteurs de croissance cellulaire hyper-proliferative |
WO1997011690A2 (fr) * | 1995-09-29 | 1997-04-03 | Microcide Pharmaceuticals, Inc. | Inhibiteurs des voies de regulation |
EP0769296A1 (fr) * | 1995-10-25 | 1997-04-23 | Hoechst Aktiengesellschaft | Utilisation de derivés d'isoxazole et de crotonamide pour la fabrication d'un médicament pour le traitement de cancers |
WO1997040019A1 (fr) * | 1996-04-24 | 1997-10-30 | Celltech Therapeutics Limited | 5-aminopyrazoles utiles comme inhibiteurs selectifs de la proteine tyrosine kinase p56ick |
WO1998028269A1 (fr) * | 1996-12-23 | 1998-07-02 | Du Pont Pharmaceuticals Company | COMPOSES HETEROAROMATIQUES CONTENANT DE L'AZOTE, UTILISES EN TANT QU'INHIBITEURS DU FACTEUR Xa |
EP0990645A1 (fr) * | 1997-05-30 | 2000-04-05 | Nippon Kayaku Kabushiki Kaisha | Nouveaux derives sulfonamides |
WO1998057937A2 (fr) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | INHIBITEURS DU FACTEUR Xa COMPRENANT UN GROUPE A SPECIFICITE P1 NEUTRE |
WO1999024404A1 (fr) * | 1997-11-07 | 1999-05-20 | Amgen Inc. | Composes pyridine substitues presentant une action anti-inflammatoire |
WO1999043657A1 (fr) * | 1998-02-27 | 1999-09-02 | F. Hoffmann-La Roche Ag | Derives de 2-arylethyl-(piperidin-4-ylmethyl)amines |
Non-Patent Citations (4)
Title |
---|
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002192888, Database accession no. 1576091 (BRN) * |
DATABASE WPI Week 9539, Derwent World Patents Index; AN 1995-299548, XP002192889 * |
J. CHEM. SOC. C (1968), (5), 611-14 * |
See also references of WO9852944A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU7687998A (en) | 1998-12-11 |
AR015685A1 (es) | 2001-05-16 |
EP1012150A1 (fr) | 2000-06-28 |
WO1998052944A1 (fr) | 1998-11-26 |
CA2302438A1 (fr) | 1998-11-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000303 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07D 413/02 A, 7C 07D 231/12 B, 7C 07D 261/18 B, 7C 07D 261/08 B, 7C 07D 413/12 B, 7C 07D 231/14 B, 7C 07D 401/12 B, 7C 07D 407/12 B, 7C 07D 275/02 B, 7C 07D 417/12 B, 7A 61K 31/42 B, 7A 61K 31/415 B, 7A 61K 31/44 B, 7A 61K 31/425 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020411 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 20040204 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: SUGEN, INC. |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060927 |